• Title/Summary/Keyword: Reference Standards

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Probabilistic analysis of Italian extreme winds : Reference velocity and return criterion

  • Ballio, G.;Lagomarsino, S.;Piccardo, G.;Solari, G.
    • Wind and Structures
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    • v.2 no.1
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    • pp.51-68
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    • 1999
  • Applying and extending some preceding researches, this paper proposes a map of Italian extreme winds assigning the reference velocity, i.e., the wind velocity averaged over 10 minutes, at 10 m height, in a flat open terrain, with 50 years mean return period, depending on the site and the altitude. Furthermore, an objective criterion is formulated by which the actual values of the local wind velocity are given as a function of the reference velocity. The study has been carried out in view of the revision of the Italian Standards dealing with safety and loads and the introduction of the aeolic Italian map into Eurocode 1.

Collaborative Study for the Establishment of KFDA Reference Standard for Somatropin (KS 98/674) (재조합 사람성장호르몬(소마트로핀)의 KFDA 표준품(KS 98/674) 설정 연구)

  • Shin, Won;Joung, Jee-Won;Jin, Jae-Ho;Bristow, Adrian F.;Sohn, Yeo-Won
    • YAKHAK HOEJI
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    • v.45 no.2
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    • pp.227-236
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    • 2001
  • The complexity and variability of both the biologicals and the bioassays used to test them led to the use of the reference standard- a sample of the product of defined purity and potency, against which all preparations of that product must be calibrated. In order to prepare and establish KFDA reference standard for recombinant human growth hormone (somatropin), somatropin substance was filled in ampoules in National Institute for Biological Standards and Control (NIBSC). The candidate KFDA reference standard for somatropin (designated as 98/674) was evaluated to determine the suitability of serving as a KFDA reference standard for somatropin by the collaborative study, in which 10 laboratories participated. Physicochemical analysis and in vivo bioassay were performed by direct comparison with the international somatropin standard 88/624. 98/674 was identified as somatropin by SDS-PAGE, IEF, peptide mapping, and HPLC. Determination of somatropin content by SE-HPLC yielded a mean estimate of 2.01 mg somatropin per ampoule. Data from the study also yielded mean values of 0.39 $\pm$ 0.26% for high molecular weight impurities by SE-HPLC and mean values of 2.13 $\pm$ 1.29% for somatropin related proteins by RP-HPLC. Estimates of relative potency by weight gain bioassay in the hypophysectomised rats showed that relative potency of KS 98/674 was 1.07 aganist IS 88/624. Based on the results of the collaborative study, the candidate reference standard for somatropin is suitable to serve as a KFDA reference standard for somatropin.

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Perceptive Gap among Interest Groups to Significance of the Installation Standards of Churches' Convenience Facilities for the Elderly (고령자를 위한 교회 편의시설 설치기준의 중요도에 대한 주체별 인식의 간극)

  • Lee, Jong-Hee;Kim, Duk-Su
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.19 no.1
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    • pp.47-57
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    • 2013
  • Purpose: The purpose of this study is to provide reference points for the improvement work of churches' convenience facilities for the elderly. To do this, the study generates survey results, showing that the perception to significance of churches' convenience facilities is different among survey constituents. Method: The survey method was utilized. The study population for survey includes the aged believer over 65 years old, pastors, and architecture and/or interior design experts. The questionnaire was devised while consulting existing regulations regarding convenience facilities in general. Results: It is found that the perception to significance of installation standards for convenience facilities is different among survey constituents. Specifically, while the older believer group is perceived that installation standards for the small group meeting room of 'other facility' is comparatively more important, the pastor group and the expert group perceive that the 'intermediate facility' and 'inner facility' are more important. Implications: Participants involved in an improvement project of churches' convenience facilities may have a different perception about their importance due mainly to the degree of usage and the difference of perspectives. This study, therefore, can be used as a reference point for prioritizing improvement works of churches' convenience facilities for the elderly.

Construction and Comparison Measurement of Triple Point Water Cells for using Key Comparison and Evaluation of Uncertainty (핵심국제비교용 물의 삼중점 셀 제작과 비교 실험 및 불확도 평가)

  • Kang, Kee-Hoon;Kim, Yong-Gyoo;Gam, Kee-Sool
    • Journal of Sensor Science and Technology
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    • v.13 no.2
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    • pp.114-120
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    • 2004
  • The $Comet{\acute{e}}$ Consultatif de $Thermom{\acute{e}}trie$ (CCT) under the Comete International des Poids et Measures (CIPM) has decided to perform the Key Comparison (KC) for triple point of water cells used as a reference fixed point of thermometry at the 21st meeting held at November 2001, and the Bureau International des Poids et Measures (BIPM) has been nominated as a KC coordinator. According to the KC protocol prepared by BIPM, KRISS performed the KC experiments and evaluate a uncertainty. The temperature difference between two reference cells for the Korea Research Institute of Standards and Science (KRISS) and a test cell for the transfer standard, which is moved to BIPM was 0.024 mK and the combined standard uncertainty evaluated 0.055 mK.

Development of an Isotope-Dilution Liquid Chromatography/Mass Spectrometric Method for the Accurate Determination of Acetaminophen in Tablets

  • Shin, Hyun-Ju;Kim, Byung-Joo;Lee, Joon-Hee;Hwang, Eui-Jin
    • Bulletin of the Korean Chemical Society
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    • v.31 no.12
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    • pp.3663-3667
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    • 2010
  • Acetaminophen (N-acetyl-p-aminophenol) is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometric method based on LC/MS was developed as a candidate reference method for the accurate determination of acetaminophen in pharmaceutical product. After spiking an isotope labeled acetaminophen (acetyl-$^{13}C_2$, $^{15}N$-acetaminophen) as an internal standard, tablet extracts were analyzed by LC/MS in a selected reaction monitoring (SRM) mode to detect ions at m/z $152{\rightarrow}110$ and m/z $155{\rightarrow}111$ for acetaminophen and acetyl-$^{13}C_2$, $^{15}N$-acetaminophen, respectively. The repeatability and reproducibility of the developed ID/LC-MS method were tested for the validation and assessment of metrological quality of the method.

Evaluation of Growth between Breast-Fed and Formula-Fed Korean Infants from 1 to 3 Postpartum Months -Compared with the Korean Standard and NCHS Reference- (모유영양아와 인공영양아의 1~3개월의 성장발육 상태 평가-한국 표준치와 NCHS Reference간의 비교-)

  • 최경숙;구재옥
    • Korean Journal of Community Nutrition
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    • v.3 no.4
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    • pp.533-541
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    • 1998
  • This study compares the growth performance(weight-for-age Z-score, height-for-age Z-score, weight-for-height Z-score) of one- to three- month-old Korean infants(n=232) with the Korean standard(1994) and NCHS reference(1983). The weight-for-age Z-scores(WAZ) by the Korean standard were -2∼1,5 for males and -3∼1 for females. The NCHS reference, WAZ results were -1∼2.5 and -2.5∼3.5 for males and females, respectively. The WAZ compared Korean standard showed no subjects with overnutrition. But 1.3% of the infants showed signs of malnutrition. Comparison with NCHS reference revealed that 0.4% of the infants were malnourished and 7.0% of the infants were overnourished. The WAZ of formula-fed infants were distributed higher than breast-fed infants, but that was not significant. The height-for-age Z-score(HAZ) by the Korean standard were -4.5%∼1.5% for males and -4∼1.5% for females. According to the NCHS reference, HAZ were -2.5%∼2.5% and -3∼3 for males and females, respectively. When the WAZ was compared with the Korean standard, there was no overnutrition but 16% of the infants showed signs of malnutrition. The NCHS reference, revealed that 6.9% of the infants were malnourished and 1.8% of the infants were ovemourished. The weight-for-height Z-scores(WHZ) by the Korean standard were -2∼5 for males and -2.5∼5 for females. The NCHS reference WAZ scores were -1∼4 and -1.5∼4.5 for males and females, respectively. When the WHZ was compared with the Korean standard, 2.2% of infants were malnourished and 19.5% were overnourished. There were no malnourished subjects according to the NCHS reference and 19.1% of the infants were overnourished. When the three Z-scores are considered together, 92.0% of the infants should a normal growth status, there was no malnutrition, and 8.0% of the infants were overnourished. The growth performance was evaluated differently according to the type of standards. Thus, it is necessary to set proper growth standards for infants, according to which classification of feeding methods is chosen. A longterm and careful assessment of infants's growth performances to develop any group of standards.

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Measurement of the Reverberation Time of Rooms with Reference to Other Acoustical Parameters (실내공간의 잔향시간과 음향변수 측정방법)

  • 오양기;주진수;정광용;김선우
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2001.11a
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    • pp.392-396
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    • 2001
  • Revision of KS, Korean Standards, is currently actively discussed. It is just the time for a new world class standards under the new system with WTO, World Trade Organization. This paper is a part of “Researchs on the Standards in the Building Acoustic Field”, as one of KS revision projects. The aim of this study is to define the requirements for measuring the reverberation time and other major room acoustical parameters.

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Accurate Measurement of Arsenic in Laver by Gravimetric Standard Addition Method Combined with High Resolution Inductively Coupled Plasma Mass Spectrometry

  • Lee, Kyoung-Seok;Kim, Hyeon-Ji;Yim, Yong-Hyeon;Kim, Jeongkwon;Hwang, Euijin
    • Mass Spectrometry Letters
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    • v.5 no.2
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    • pp.57-61
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    • 2014
  • A gravimetric standard addition method combined with internal standard calibration has been successfully developed for the accurate analysis of total arsenic in a laver candidate reference material. A model equation for the gravimetric standard addition approach using an internal standard was derived to determine arsenic content in samples. Handlings of samples, As standard and internal standard were carried out gravimetrically to avoid larger uncertainty and variability involved in the volumetric preparation. Germanium was selected as the internal standard because of its close mass to the arsenic to minimize mass-dependent bias in mass spectrometer. The ion signal ratios of $^{75}As^+$ to $^{72}Ge^+$ (or $^{73}Ge^+$) were measured in high resolution mode ($R{\geq}10,000$) to separate potential isobaric interferences by high resolution ICP/MS. For method validation, the developed method was applied to the analysis of arsenic content in the NMIJ 7402-a codfish certified reference material (CRM) and the result was $37.07mg{\cdot}kg^{-1}{\pm}0.45mg{\cdot}kg^{-1}$ which is in good agreement with the certified value, $36.7mg{\cdot}kg^{-1}{\pm}1.8mg{\cdot}kg^{-1}$. Finally, the certified value of the total arsenic in the candidate laver CRM was determined to be $47.15mg{\cdot}kg^{-1}{\pm}1.32mg{\cdot}kg^{-1}$ (k = 2.8 for 95% confidence level) which is an excellent result for arsenic measurement with only 2.8 % of relative expanded uncertainty.

Convergence Study on Big Data Competency Reference Model (빅데이터 직무능력 참조모형에 관한 융합적 연구)

  • Noh, Kyoo-Sung;Park, Seong Taek;Park, Kyung-Hye
    • Journal of Digital Convergence
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    • v.13 no.3
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    • pp.55-63
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    • 2015
  • South Korean Government confirmed the creation of competency-centered society as a key national issue and announced development and utilization plan of NCS(National Competency Standards) On May 21, 2013. As a part of the government's plans, they had been developed NCS about 833 jobs by 2014. But Big Data related job, as an emerging job, cannot be seen as a reliable form of job yet. As, at the major industrialized countries and the domestic, education and job competency models of knowledge and skills to take advantage of various types of Big Data have coming, it is a situation that is certainly not settled and more or less in confusion. In this study, for the purpose to present the Big Data Competency reference model for companies and organizations to effectively leverage Big Data, we have presented this reference model and summarized competency elements units such as 20 knowledges and 15 skills of Big Data competency.