• Journal of fish pathology
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• v.20 no.3
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• pp.201-209
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• 2007

Viral hemorrhagic septicemia (VHS) is one of the most serious viral disease of farmed rainbow trout and some marine fishes in Europe and North America. It has been reported in various marine fish species of Asian countries and induced cause mass mortality in Japanese flounder (Paralichthys olivaceus) culturing in Korea. The aims of this study were to monitor VHSV in wild marine fishes and to give critical information for controling the disease through prophylactic methods. Prevalence of the viral disease, geological distribution and reservoir of the virus were investigated using wild marine fishes captured in southern coast and east china sea for two years. (Reverse Transcriptase Polymerase Chain Reaction) RT-PCR results showed that VHSV were detected in 17 (10.6%) out of 160 fish. G gene sequences of viral strains isolated in this study were closely related to that of a reference strain, KVHS01-1, belonging to VHSV genotype Ⅰ. The results suggest that some of wild marine fishes are VHSV carriers and may spread the pathogen directly to fish farmed in coastal area.

• Journal of fish pathology
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• v.20 no.3
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• pp.211-220
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• 2007

Red sea bream iridovirus disease (RSIVD) cause massive economic losses in marine aquaculture industry in Korea. The causative agent of this disease (RSIV) infects a wide range of fish species. The aims of this study were to monitor RSIV in wild marine fishes and to give critical information for controling the disease through prophylactic methods. Prevalence of the viral disease, geological distribution and reservoir of the virus were investigated using wild marine fishes captured in southern coast and east china sea for two years. (Polymerase Chain Reaction) PCR results showed that RSIV were detected in 39 (24.3%) out of 160 fish. MCP gene sequences of viral strains isolated in this study were closely related to that of a reference strain, red seabream-K, belonging to Megalocytivirus subgroup Ⅲ. The results suggest that some of wild marine fishes are RSIV carriers and may spread the pathogen directly to fish farmed in coastal area.

• Korean Journal of Remote Sensing
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• v.34 no.5
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• pp.787-799
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• 2018

Accurate and effective mapping is critical step to monitor the spatial distribution and change of flood inundated area in large scale flood event. In this study, we try to suggest methods to use low spatial resolution satellite optical imagery for flood mapping, which has high temporal resolution to cover wide geographical area several times per a day. We selected the Sebou watershed flood in Morocco that was occurred in early 2010, in which several hundred $km^2$ area of the Gharb lowland plain was inundated. MODIS daily surface reflectance product was used to detect the flooded area. The study area showed several distinct spectral patterns within the flooded area, which included pure turbid water and turbid water with vegetation. The flooded area was extracted by thresholding on selected band reflectance and water-related spectral indices. Accuracy of these flooding detection methods were assessed by the reference map obtained from Landsat-5 TM image and qualitative interpretation of the flood map derived. Over 90% of accuracies were obtained for three methods except for the NDWI threshold. Two spectral bands of SWIR and red were essential to detect the flooded area and the simple thresholding on these bands was effective to detect the flooded area. NIR band did not play important role to detect the flooded area while it was useful to separate the water-vegetation mixed flooded classes from the purely water surface.

• Journal of the Korean Institute of Gas
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• v.1 no.1
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• pp.27-32
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• 1997

Continual monitoring of abnormal operating conditions i a key issue in maintaining high product quality and safe operation, since the undetected process abnormality may lead to the undesirable operations, finally producing low quality products, or breakdown of equipment. The statistical projection method recently highlighted has the advantage of easily building reference model with the historical measurement data in the statistically in-control state and not requiring any detailed mathematical model or knowledge-base of process. As the complexity of process increases, however, we have more measurement variables and recycle streams. This situation may not only result in the frequent occurrence of process Perturbation, but make it difficult to pinpoint trouble-making causes or at most assignable source unit due to the confusing candidates. Consequently, an ad hoc skill to monitor and diagnose in plat-wide scale is needed. In this paper, we propose a hierarchical plant-wide monitoring methodology based on hierarchical decomposition and principal component analysis for handling the complexity and interactions among process units. This have the effect of preventing special events in a specific sub-block from propagating to other sub-blocks or at least delaying the transfer of undesired state, and so make it possible to quickly detect and diagnose the process malfunctions. To prove the performance of the proposed methodology, we simulate the Tennessee Eastman benchmark process which is operated continuously with 41 measurement variables of five major units. Simulation results have shown that the proposed methodology offers a fast and reliable monitoring and diagnosis for a large scale chemical plant.

• Journal of Navigation and Port Research
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• v.39 no.3
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• pp.165-172
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• 2015

The class of Dynamic Positioning System is divided in 3 classes depending on its redundancy and reliability according to IMO and classification society. There are 3 DP classes such as DP Class 1, 2 and 3 according to IMO MSC/Circ. 645. Higher DP class vessel has higher reliability, since redundancy concept is applied to the DP vessel depending on its DP class and can operate more safely. There are not enough information about DP class notation, which are needed when a company builds a new or buys second hand DP vessel or modifies DP classes, even the Korean shipyard is building a lot of DP vessels now. Also, the practical case of DP vessel modification, which had been done in Korea, to meet DP notation of IMO and classification society, will be helpful for DP vessel modification and sales industry development in Korea as a new business. As such this research identified what kind of requirements need to be taken into account to be from DP class 1 to DP class 2. The real DP class modification case is used to identify the requirements of DP class upgrade. Through the FMEA the redundancy concept on power system, thruster system and DP control system need to apply for DP class upgrade. The power system have to keep its DP function even if just a single fault happens on the generator or switchboard. Also, the PMS is required to monitor and control power system. Ship's Surge, Sway and Yaw movements can be controlled by the remaining thruster system after a single thruster fails. Lastly, multiple installation of PRS, sensors and DP control system are required to keep DP ability after a single fault on the DP control systems.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.65-71
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• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

• Archives of design research
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• v.20
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• pp.111-120
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• 1997

Recently, rapidly increasing internet Websites are providing us with the new kinds of multimedia informations without borders acting as the center for exchanging informations. Such new media informations through the internet passes informations via light on the monitor and provides the various informations, with the differentiation from the traditional printing media, it can be searched with electronic commands in limited space. In the process of adapting the new technologies, new media has successfully responded to the fast change and the development of its needs by experiencing the trials and errors, steadily establishing the stable position with its new information transferring and exchanging methods. The representative hompage of websites of information transformations means the first page containing no lower directories and consist of titles, icons, symbols and addresses and can design them in consideration of graphical process, planning, contents and others. Such hompages are very important since the graphical images shows its visual expressions deciding the total meanings of the hompages. In this research, we have analyzed the visual factors of frequencies, ratio of areas, distributions, alignment methodologies on layouts of hompages consisting titles, icons, contents and symbols, etc. from randomly picked samples of 161 hompages of websites in the internets of various areas. Generally, the homepages are designed with graphical expressions in personal way and the feedbacks and responses of such may differs, but we think, this can be used as reference materials for the analysis of new media in objective way. Also, it can be used as the base informations for arrangement and planning of designs with the characteristics of graphics and Graphic User Interfaces in the background which are implemented over internet.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.8 no.4
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• pp.293-301
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• 2010

Optical fiber cable, as a sensor, was installed on the wall of KAERI(Korea Atomic Energy Research Institute) Underground Research Tunnel(KURT) in order to monitor the physical stability of the tunnel, which was constructed for technical development and demonstration of radioactive waste disposal. This monitoring system has two simultaneous measurements of temperature and strain over time using Brillouin backscatter. According to the results of the monitoring from Jan. 2008 to Nov. 2009, there is no significant displacement or movement at the tunnel wall However, the cumulative volume of total strain increased slightly as time passes with the comparison of the reference observation, which was measured in Jan. 2008. The change in cumulative volume of total strain indicates that the strain level had been affected by saturation and de-saturation phenomena due to groundwater fluctuation at several points at KURT. This system is based on the distributed sensing technique concept, not point sensing. By using this system, a displacement can be detected with the range from $20{\mu}{\varepsilon}$ to $28,000{\mu}{\varepsilon}$ every 1m interval in minimum. A temperature variation can be monitored at every 0.5m interval with the resolution of 0.01 in minimum. Based on the study, this monitoring system is potentially applicable to long term monitoring systems for radioactive waste disposal project as well as other structures and underground openings.

• Journal of Navigation and Port Research
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• v.36 no.6
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• pp.475-480
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• 2012

In order to establish eLoran (enhanced Long Range Navigation) system, it needs the advancement of receiver, transmitter, data channel addition for Loran information, differential Loran sites for compensating Loran-c signal and ASFs (Additional Secondary Factors) database, etc. In addition, the precise synchronization of transmitting station to the UTC (Coordinated Universal Time) is essential if Loran delivers the high absolute accuracy of navigation demanded for maritime harbor entrance. For better timing synchronization to the UTC among transmitting stations, it is necessary to measure and monitor the transmission delay of the station, and the correction information of the transmitting station should be provided to the user's receivers. In this paper we presented the measurement method of absolute delay of Pohang Loran transmitting station and developed a time delay measurement system and a phase monitoring system for Loran station. We achieved -2.23 us as a result of the absolute phase delay of Pohang station and the drift of Loran pulse of the station was measured about 0.3 us for a month period. Therefore it is necessary to measure the delay offset of transmitting station and to compensate the drift of the Loran signal for the high accuracy application of PNT (Positioning, Navigation and Timing).

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.1
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• pp.38-47
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• 2011

This study focused on health risk assessment via multi-routes of As exposure to establish a target cleanup level (TCL) in abandoned mines. Soil, ground water, and rice samples were collected near ten abandoned mines in November 2009. The As contaminations measured in all samples were used for determining the probabilistic health risk by Monte-Carlo simulation techniques. The human exposure to As compound was attributed to ground water ingestion. Cancer risk probability (R) via ground water and rice intake exceeded the acceptable risk range of $10^{-6}{\sim}10^{-4}$ in all selected mines. In particular, the MB mine showed the higher R value than other mines. The non-carcinogenic effects, estimated by comparing the average As exposure with corresponding reference dose were determined by hazard quotient (HQ) values, which were less than 1.0 via ground water and rice intake in SD, NS, and MB mines. This implied that the non-carcinogenic toxic effects, due to this exposure pathway had a greater possibility to occur than those in other mines. Besides, hazard index (HI) values, representing overall toxic effects by summed the HQ values were also greater than 1.0 in SD, NS, JA, and IA mines. This revealed that non-carcinogenic toxic effects were generally occurred. The As contaminants in all selected mines exceeded the TCL values for target cancer risk ($10^{-6}$) through ground water ingestion and rice intake. However, the As level in soil was greater than TCL value for target cancer risk via inadvertent soil ingestion pathway, except for KK mine. In TCL values for target hazard quotient (THQ), the As contaminants in soil did not exceed such TCL value. On the contrary, the As levels in ground water and polished rice in SD, NS, IA, and MB mines were also beyond the TCL values via ground water and rice intake. This study concluded that the health risks through ground water and rice intake were greater than those though soil inadvertent ingestion and dermal contact. In addition, it suggests that the abandoned mines to exceed the risk-based TCL values are carefully necessary to monitor for soil remediation.