• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.392-399
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• 2016

Objective : Brain metastases in gynecologic cancer (ovarian, endometrial, and cervical cancer) patients are rare, and the efficacy of Gamma Knife Radiosurgery (GKRS) to treat these had not been evaluated. We assessed the efficacy of GKRS and prognostic factors for tumor control and survival in brain metastasis from gynecologic cancers. Methods : This retrospective study was approved by the institutional review board. From May 1995 to October 2012, 26 women (mean age 51.3 years, range 27-70 years) with metastatic brain tumors from gynecologic cancer were treated with GKRS. We reviewed their outcomes, radiological responses, and clinical status. Results : In total 24 patients (59 lesions) were available for follow-up imaging. The median follow-up time was 9 months. The mean treated tumor volume at the time of GKRS was $8185mm^3$ (range $10-19500mm^3$), and the median dose delivered to the tumor margin was 25 Gy (range, 10-30 Gy). A local tumor control rate was 89.8% (53 of 59 tumors). The median overall survival was 9.5 months after GKRS (range, 1-102 months). Age-associated multivariate analysis indicated that the Karnofsky performance status (KPS), the recursive partitioning analysis (RPA) classification, and the number of treated lesions were significant prognostic factors for overall survival (HR=0.162, p=0.008, HR=0.107, p=0.038, and HR=2.897, p=0.045, respectively). Conclusion : GKRS is safe and effective for the management of brain metastasis from gynecologic cancers. The clinical status of the patient is important in determining the overall survival time.

• Journal of Korean Neurosurgical Society
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• 제46권3호
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• pp.245-251
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• 2009

Objective : The authors analyzed the effectiveness and therapeutic response of Novalis shaped beam radiosurgery for metastatic brain tumors, and the prognostic factors which influenced the outcome. Methods : We performed a retrospective analysis of 106 patients who underwent 159 treatments for 640 metastatic brain lesions between January 2000 and April 2008. The pathologies of the primary tumor were mainly lung (45.3%), breast (18.2%) and GI tract (13.2%). We classified the patients using Radiation Therapy Oncology Group Recursive Partitioning Analysis (RPA) and then analyzed the survival and prognostic factors according to the Kaplan Meier method and univariate analysis. Results : The overall median actuarial survival rate was 7.3 months from the time of first radiosurgery treatment while 1 and 2 year actuarial survival estimates were 31% and 14.4%, respectively. Median actuarial survival rates for RPA classes I, II, and III were 31.3 months, 7.5 months and 1.7 months, respectively. Patients' life spans, higher Karnofsky performance scores and age correlated closely with RPA classes. However, sex and the number of lesions were not found to be significantly associated with length of survival. Conclusion : This result suggests that Novalis radiosurgery can be a good treatment option for treatment of the patients with brain metastases.

• 한국정보통신학회논문지
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• 제21권9호
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• pp.1635-1641
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• 2017

본 논문에서는 격자 부호화 3차원 직교 주파수분할다중화 시스템을 제시하고 성능을 분석한다. 여기서는 격자 부호화를 위한 3차원 신호성상도에 대한 집합분할 기법도 제시한다. 부호율이 R = 1/3과 2/3인 회귀 체계적 컨볼루션 부호와 3차원 8진 성상도를 이용하여 격자 부호화된 제안된 시스템은 부호화되지 않은 직교 주파수분할다중화 시스템에 비하여 최대 7.8 dB까지 오류성능이 향상될 수 있음을 이론적으로 계산하였다. 또한 컴퓨터 모의실험을 통하여 제시된 이론적 분석과 거의 일치하는 결과를 도출함으로써 이론적 분석이 정확한 것을 확인하였다. 따라서 제안된 격자 부호화 3차원 직교 주파수분할다중화 시스템은 대역폭의 증가 없이 고품질 디지털 전송을 달성할 수 있는 효과적인 방법인 것으로 사료된다.

• Journal of the Korean Data and Information Science Society
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• 제25권6호
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• pp.1253-1262
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• 2014

회귀나무 (regression tree)는 독립변수로 이루어진 공간을 재귀적으로 분할하고 해당 영역에서 종속변수의 최선의 예측값을 찾고자 하는 비모수적 방법론이다. 회귀나무 모형이 제안된 이래 로지스틱 회귀나무모형이나 분위수 회귀나무모형과 같이 유연하고 다양한 모형적합을 위한 연구가 진행되어 왔다. 최근에 들어서는 Sela와 Simonoff (2012)의 RE-EM 알고리즘, Loh와 Zheng (2013)의 GUIDE 등 패널데이터와 관련하여 진일보한 나무모형 알고리즘도 제안되었다. 본 논문에서는 각 알고리즘을 소개하고 특징을 살펴보는 한편, 실험 데이터를 생성하여 평균제곱오차 (mean squared error)를 바탕으로 예측력을 비교하였다. 분석결과, RE-EM 알고리즘의 예측력이 상대적으로 우수하게 나타났다. 이 알고리즘을 통해 기업경기실사지수 업종별 패널자료를 분석한 결과 최근의 업황에 가장 큰 영향을 미치는 요소는 매출 실적으로 나타났으며 매출 상위 그룹의 경우 비제조업이 제조업에 비해 업황에 대한 판단이 긍정적인 것으로 나타났다.

• Radiation Oncology Journal
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• 제33권3호
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• pp.207-216
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• 2015

Purpose: Stereotactic radiosurgery (SRS) has been introduced for small-sized single and oligo-metastases in the brain. The aim of this study is to assess treatment outcome, efficacy, and prognostic variables associated with survival and intracranial recurrence. Materials and Methods: This study retrospectively reviewed 123 targets in 64 patients with non-small cell lung cancer (NSCLC) treated with SRS between January 2006 and December 2012. Treatment responses were evaluated using magnetic resonance imaging. Overall survival (OS) and intracranial progression-free survival (IPFS) were determined. Results: The median follow-up was 13.9 months. The median OS and IPFS were 14.1 and 8.9 months, respectively. Fifty-seven patients died during the follow-up period. The 5-year local control rate was achieved in 85% of 108 evaluated targets. The 1- and 2-year OS rates were 55% and 28%, respectively. On univariate analysis, primary disease control (p < 0.001), the Eastern Cooperative Oncology Group (ECOG) performance status (0-1 vs. 2; p = 0.002), recursive partitioning analysis class (1 vs. 2; p = 0.001), and age (<65 vs. ${\geq}65$ years; p = 0.036) were significant predictive factors for OS. Primary disease control (p = 0.041) and ECOG status (p = 0.017) were the significant prognostic factors for IPFS. Four patients experienced radiation necrosis. Conclusion: SRS is a safe and effective local treatment for brain metastases in patients with NSCLC. Uncontrolled primary lung disease and ECOG status were significant predictors of OS and intracranial failure. SRS might be a tailored treatment option along with careful follow-up of the intracranial and primary lung disease status.

• 대한수학교육학회지:수학교육학연구
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• 제27권3호
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• pp.537-555
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• 2017

본 논문은 선행 연구에서 제시한 이분모 분수 덧셈의 핵심 아이디어에 대한 지도 방향과 그 가능성을 탐색하기 위해 한국과 싱가포르 교과서를 비교 분석하였다. 이를 위해 한국과 싱가포르에서 분수의 덧셈과 관련된 내용인 동치분수, 분수의 크기 비교, 분수의 덧셈의 지도 계열 및 지도 시기를 살펴보고 이분모 분수 덧셈의 핵심 아이디어인 전체 단위의 고정성, 공통 측정 단위의 필요성, 재귀적 분할과 이분모 분수 덧셈의 알고리즘의 연결과 관련하여 시각적 표현이 어떻게 제시되어 있는지를 비교 분석하였다. 분석 결과, 한국에 비해 싱가포르는 분수의 덧셈과 관련된 내용을 보다 점진적이고 체계적으로 지도하고 있음을 확인하였다. 싱가포르 교과서에 제시된 다양한 시각적 모델은 이분모 분수 덧셈의 핵심 아이디어 지도 방향에 구체적인 시사점을 제공하였다. 본 연구 결과를 토대로 우리나라에서 보다 점진적이고 체계적인 분수 덧셈 교육이 이루어지기를 기대한다.

• Radiation Oncology Journal
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• 제30권2호
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• pp.53-61
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• 2012

Purpose: To determine feasibility of RapidArc in sequential or simultaneous integrated tumor boost in whole brain radiation therapy (WBRT) for poor prognostic patients with four or more brain metastases. Materials and Methods: Nine patients with multiple (${\geq}4$) brain metastases were analyzed. Three patients were classified as class II in recursive partitioning analysis and 6 were class III. The class III patients presented with hemiparesis, cognitive deficit, or apraxia. The ratio of tumor to whole brain volume was 0.8-7.9%. Six patients received 2-dimensional bilateral WBRT, (30 Gy/10-12 fractions), followed by sequential RapidArc tumor boost (15-30 Gy/4-10 fractions). Three patients received RapidArc WBRT with simultaneous integrated boost to tumors (48-50 Gy) in 10-20 fractions. Results: The median biologically effective dose to metastatic tumors was 68.1 $Gy_{10}$ and 67.2 $Gy_{10}$ and the median brain volume irradiated more than 100 $Gy_3$ were 1.9% (24 $cm^3$) and 0.8% (13 $cm^3$) for each group. With less than 3 minutes of treatment time, RapidArc was easily applied to the patients with poor performance status. The follow-up period was 0.3-16.5 months. Tumor responses among the 6 patients who underwent follow-up magnetic resonance imaging were partial and stable in 3 and 3, respectively. Overall survival at 6 and 12 months were 66.7% and 41.7%, respectively. The local progression-free survival at 6 and 12 months were 100% and 62.5%, respectively. Conclusion: RapidArc as a component in whole brain radiation therapy for poor prognostic, multiple brain metastases is an effective and safe modality with easy application.

• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.299-303
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• 2011

Objective : Brainstem metastases are rarely operable and generally unresponsive to conventional radiation therapy or chemotherapy. Recently, Gamma Knife Radiosurgery (GKRS) was used as feasible treatment option for brainstem metastasis. The present study evaluated our experience of brainstem metastasis which was treated with GKRS. Methods : Between November 1992 and June 2010, 32 patients (23 men and 9 women, mean age 56.1 years, range 39-73) were treated with GKRS for brainstem metastases. There were metastatic lesions in pons in 23, the midbrain in 6, and the medulla oblongata in 3 patients, respectively. The primary tumor site was lung in 21, breast in 3, kidney in 2 and other locations in 6 patients. The mean tumor volume was $1,517mm^3$ (range, 9-6,000), and the mean marginal dose was 15.9 Gy (range, 6-23). Magnetic Resonance Imaging (MRI) was obtained every 2-3 months following GKRS. Follow-up MRI was possible in 24 patients at a mean follow-up duration of 12.0 months (range, 1-45). Kaplan-Meier survival analysis was used to evaluate the prognostic factors. Results : Follow-up MRI showed tumor disappearance in 6, tumor shrinkage in 14, no change in tumor size in 1, and tumor growth in 3 patients, which translated into a local tumor control rate of 87.5% (21 of 24 tumors). The mean progression free survival was 12.2 months (range, 2-45) after GKRS. Nine patients were alive at the completion of the study, and the overall mean survival time after GKRS was 7.7 months (range, 1-22). One patient with metastatic melanoma experienced intratumoral hemorrhage during the follow-up period. Survival was found to be associated with score of more than 70 on Karnofsky performance status and low recursive partitioning analysis class (class 1 or 2), in terms of favorable prognostic factors. Conclusion : GKRS was found to be safe and effective for management of brainstem metastasis. The integral clinical status of patient seems to be important in determining the overall survival time.

• Journal of Korean Neurosurgical Society
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• 제54권2호
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• pp.107-111
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• 2013

Objective : We investigated the effectiveness of stereotactic gamma knife Radiosurgery (GKR) for radioresistant brain metastases with the impact upon histology. Methods : Between April 2004 and May 2011, a total of 23 patients underwent GKR for 67 metastatic brain tumors from 12 renal cell cancers, 5 sarcomas and 6 melanomas. The mean age was 56 years (range, 18 to 79 years). Most of the patients were classified as the Radiation Therapy Oncology Group recursive partitioning analysis class II (91.3%). The synchronous metastasis was found in 6 patients (26.1%) and metachronous metastasis in 17 patients (73.9%). We analyzed the local control rate, intracranial progression-free survival (PFS) and overall survival (OS). Results : The mean tumor volume for GKR was 2.24 cc and the mean prescription dose was 19.4 Gy (range, 10 to 24) to the tumor margin. Out of metachronous metastases, the median duration to intracranial metastasis was 3.3 years in renal cell cancer (RCC), 2.4 years in melanoma and 1.1 years in sarcoma (p=0.012). The total local control rate was 89.6% during the mean 12.4 months follow-up. The six-month and one-year local control rate was 90.2% and 83% respectively. Depending on the pathology, the control rate of RCC was 95.7%, sarcoma 91.3% and melanoma 80.5% during the follow-up. The common cause of local failure was the tumor bleeding in melanoma. The median PFS and OS were 5.2 and 8.4 months in RCC patients, 6.5 and 9.8 months in sarcoma, and 3.8 and 5.1 months in melanoma. Conclusion : The GKR can be one of the effective management options for the intracranial metastatic tumors from the radioresistant tumors. The melanoma showed a poor local control rate compared to other pathologies because of the hemorrhage.

• 한국산학기술학회논문지
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• 제17권8호
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• pp.8-16
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• 2016

본 논문은 대형구조물의 형상관리를 위해 3D 레이저 스캐닝을 이용하여 옥트리기반 구조물 형상정보 가시화를 진행하였다. 이를 위해 3D스캔데이터를 옥트리 데이터 구조로 변환할 수 있는 프로세스를 정립하고, 메쉬기법과 래스터/백터변환 처리를 통해 점(point) 데이터가 2차원 면 형태를 거처 3D객체로 생성되는 프로세스를 진행하였다. 생성된 3D객체는 옥트리 데이터 구조로 전달할 수 있는 형식인 Binary file type로 변환하는 작업이 진행되었고, 변환된 Binary file을 옥트리 최상의 노드인 Root노드로 전달하였다. Root 노드를 시작으로 옥트리 내부에서의 세부분할 작업 후 내부노드 데이터 저장과 비어있는 영역제거를 통해 옥트리기반 구조물 형상정보모델을 구축하였다. 본 연구가 수행된 Test-bed는 성균관대학교 내에 위치한 강교량 구조물로, 구축된 옥트리기반 형상정보는 스캔데이터를 89.3% 압축하였으며 독일의 사무용빌딩, 대학캠퍼스와 미국 소재 단과대학건물 스캔데이터와의 비교를 통하여 옥트리 데이터 압축률을 확인하였다. 본 연구를 통해 대형구조물 및 복층터널의 내부형상정보관리를 위한 형상정보 가시화의 기반을 마련하였으며, 형상정보 가시화를 통해 구조물 모니터링 및 유지관리 효율을 높일 수 있을 것이라 기대한다.