• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.112-112
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• 2003

Voltage-gated $K^{+}$ (Kv) channels represent a structurally and functionally diverse group of membrane proteins. These channels play an important role in determining the length of the cardiac action potential and are the targets for antiarrhythmic drugs. Many $K^{+}$ channel genes have been cloned from human myocardium and functionally contribute to its electrical activity. One of these channels, Kv1.5, is one of the more cardiovascular-specific $K^{+}$ channel isoforms identified to date and forms the molecular basis for an ultra-rapid delayed rectifier $K^{＋}$ current found in human atrium. Thus, the blocker of hKv1.5 is expected to be an ideal antiarrhythmic drug for atrial fibrillation. Chelidonine was isolated from Chelidonium majus L. We examined the effect of chelidonine on the hKv1.5 current expressed in Ltk-cells using whole cell mode of patch clamp techniques. Chelidonine selectively inhibited the hKv1.5 current expressed in Ltk-cells in a concentration-dependent manner, whereas did not affect the HERG current expressed in HEK-293 cells. Additionally, chelidonine reduced the tail current amplitude recorded at -50 mV after 250 ms depolarizing pulses to +60 mV, and slowed the deactivation time course resulting in a 'crossover' phenomenon when the tail currents recorded under control conditions and in the presence of chelidonine were superimposed. We found that chelidonine also inhibited the $K^{+}$ current in isolated human atrial myocytes where hKv1.5 channels were predominantly expressed. Furthermore, we examined the effects of chelidonine on the action potentials in rabbit hearts using conventional microelectrode technique. Chelidonine prolonged the action potential durations (APD) of atrial, ventricular myocytes and Purkinje fibers in a dose-dependent manner. However, the effect of chelidonine on atrial APD was frequency-dependent whereas the effect of chelidonine on the APDs of ventricular myocytes and Purkinje fibers was not frequency- dependent. Also, the selective action of chelidonine on heart was more potent than dofetilide, $K^{+}$ channel blocker.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.3
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• pp.75-84
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• 2005

Since an unexpected fault of induction motor drive systems can cause serious troubles in many industrial applications, which the technique is required to diagnose faults of a voltage-fed PWM inverter for induction motor drives. The considered fault types are rectifier diodes, switching devices and input terminals with open-circuit faults, and the signal for diagnosis is derived from motor currents. The magnitude of dq-current trajectory is used for the feature extraction of a fault and PCA LDA are applied to diagnose. Also, we show results with respect to the execution time because of the possibility to use that a diagnosis software is embedded in the controllers of medium and small size induction motors drive for real-time diagnosis. After we performed various simulations for the fault diagnosis of the inverter, the usefulness of proposed algerian was verified.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.8 no.11
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• pp.523-530
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• 2018

It has been studied over the long time for the high efficiency and high power density of the power converter. It is possible to obtain higher power conversion efficiency and small volume by increasing switching frequency, however, the switching loss is also increased. The soft switching technique can overcome of the above deficiency. The design and analysis method for ZVS(Zero Voltage Switching) Phase Shifte Full bridge converter is presented in this paper. The power transfer depends on the phase difference between two legs of the power stage and the maximum power conversion efficiency is achieved by the optimum leakage inductance value. The waveform of the current and voltage of the operational mode is analysed and the corresponding switch status is plotted as on/off status. A ZVS full bridge converter for a communication rectifier with 2kW output power is implemented and its performance are verified through PSIM software simulation and experimental results.

• Journal of IKEEE
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• v.20 no.1
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• pp.45-53
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• 2016

This paper presents a CMOS interface circuit for vibration energy harvesting with MPPT (Maximum Power Point Tracking). In the proposed system a PMU (Power Management Unit) is employed at the output of a DC-DC boost converter to provide a regulated output with low-cost and simple architecture. In addition an MPPT controller using FOC (Fractional Open Circuit) technique is designed to harvest maximum power from vibration devices and increase efficiency of overall system. The AC signal from vibration devices is converted into a DC signal by an AC-DC converter, and then boosted through the DC-DC boost converter. The boosted signal is converted into a duty-cycled and regulated signal and delivered to loads by the PMU. A full-wave rectifier using active diodes is used as the AC-DC converter for high efficiency, and a DC-DC boost converter architecture using a schottky diode is employed for a simple control circuitry. The proposed circuit has been designed in a 0.35um CMOS process, and the designed chip occupies $915{\mu}m{\times}895{\mu}m$. Simulation results shows that the maximum power efficiency of the entire system is 83.4%.