• Asian-Australasian Journal of Animal Sciences
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• v.25 no.7
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• pp.1021-1028
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• 2012

Peripheral blood mononuclear cells (PBMCs) discriminate microbial pathogens and induce T-cell responses of appropriate effector phenotype accordingly. Toll-like receptors (TLRs), in part, mediate this microbial recognition and differentiation while the development of T-cell effector functions critically depends on the release of Th1- or Th2- type cytokines. In the present study, buffalo PBMCs were stimulated under in vitro culture conditions by Bacillus subtilis cell wall petidoglycan, a TLR2 ligand, in a dose- and time- dependent manner. The expression of TLR2 as well as the subsequent differential induction of the Th1 and Th2 type cytokines was measured. Stimulation was analyzed across five doses of peptidoglycan ($10{\mu}g/ml$, $20{\mu}g/ml$, $30{\mu}g/ml$, $40{\mu}g/ml$ and $50{\mu}g/ml$) for 3 h, 12 h, 24 h and 36 h incubation periods. We observed the induction of TLR2 expression in a dose- and time-dependent manner and the peptidoglycan induced tolerance beyond $30{\mu}g/ml$ dose at all incubation periods. The correlation between peptidoglycan stimulation and TLR2 induction was found positive at all doses and for all incubation periods. Increased production of all the cytokines was observed at low doses for 3 h incubation, but the expression of IL-4 was relatively higher than IL-12 at the higher antigen doses, indicating tailoring towards Th2 response. At 12 h incubation, there was a pronounced decrease in IL-4 and IL-10 expression relative to IL-12 in a dose- dependent manner, indicating skewing to Th1 polarization. The expression of IL-12 was highest for all doses across all the incubation intervals at 24 h incubation, indicating Th1 polarization. The relative expression of TNF-${\alpha}$ and IFN-${\gamma}$ was also higher while that of IL-4 and IL-10 showed a decrease. For 36 h incubation, at low doses, relative increase in the expression of IL-4 and IL-10 was observed which decreased at higher doses, as did the expression of all other cytokines. The exhaustion of cytokine production at 36 h indicated that PBMCs became refractory to further stimulation. It can be concluded from this study that the cytokine response to sPGN initially was of Th2 type which skews, more pronouncedly, to Th1 type with time till the cells become refractory to further stimulation.

• Korean Journal of School Psychology
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• v.16 no.2
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• pp.207-230
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• 2019

This study examined the effect of Attention Feedback Awareness and Control Training(A-FACT) on attention bias and generalized anxiety symptoms in college students. A total of 31 college students with at least 10 points on the Generalized Anxiety Disorder 7-item (GAD-7) scale or at least 56 points on the Korean version of the Penn State Worry Questionnaire (K-PSWQ) with attention bias were randomly assigned to one of three groups: A-FACT( n = 11), Attention Bias Modification (ABM)(n = 10) and Active Placebo Control (APC)(n = 10). Participants in A-FACT group received real-time feedback on attention bias based on their Baseline Neutral Response time(BNR) during A-FACT using a dot probe task. Participants in the ABM group received standard ABM, and those in the APC performed a dot probe task that they were informed was a program to reduce attention bias, but feedback was not provided. A total of eight sessions was conducted twice a week over a 4-week period. After every two sessions, GAD-7, K-PSWQ and K-STAI were rated. The effect of attention bias modification training was rated by changes in the Attention Bias Score(ABS), and in GAD-7, K-PSWQ and K-STAI scores. The results of repeated measure ANOVA indicated that the A-FACT group showed a significant decrease in ABS as well as in GAD-7, K-PSWQ and K-STAI scores compared to the other groups. Current results suggest that self-regulatory control of attention, that is, recognition of bias through feedback in A-FACT, may be effective in alleviating attention bias and generalized anxiety symptoms by recognizing bias through feedback on bias in attention bias modification training.

• Journal of Distribution Science
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• v.17 no.2
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• pp.53-69
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• 2019

Purpose - National scientific technology R&D investment is exceeding 60 trillion won per year, and the results of patent applications and technology transfers are visually improving. However, despite the improving research results of national R&D, the practical results of technology startups are mediocre. It is now time to expand the construction of the technology commercialization ecosystem, where the expansion of national R&D leads to the results of technology startups. Therefore, this study discussed the measures to increase the competitiveness of technology startups through the factual survey of the companies that benefitted from R&D support programs. Research design, data, and methodology - This study targeted 996 companies that benefitted from the R&D projects of the Technology Transfer Center for National R&D Programs, and deducted itemized issues through the survey replies. Survey questions were prepared to estimate the national R&D results, and the technology recognition path, the purpose of detailed introduction of the technology, investment of the commercialization fund, economic results, and the factors of success and failure were analyzed. Results - As for the recognition rate of technology during the process of corporate technology commercialization through the technology transfer, recognition through project participation showed a high response rate, and diverse implications of technology commercialization were deducted through the analysis of economic results. As for the resolution alternatives, the proliferation of technology commercialization platform that can create excellent technology for the companies in early stages and the measure of expanding the distribution of technology infrastructure were suggested. In this study, public technology commercialization strategy is established, and the innovative marketing strategy is presented. Conclusions - This study reveal that the result of creating scientific technology jobs should be deducted, in order to produce the revolutionary results of job creation by suggesting the success models of technology commercialization based on domestic scientific technology. In particular, even though the support systems for public research results are being diversely suggested, accurate studies on their actual conditions are currently lacking. Therefore, this study suggest realistic political alternatives to assure results in the process of public technology commercialization, by examining the current state of public research results of R&D support institutions and diagnosing the issues.

• Journal of dental hygiene science
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• v.7 no.4
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• pp.287-293
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• 2007

As a result of having surveyed and analyzed recognition and requirement of dental hygienists for Academic Credit Bank System, the recognition on Academic Credit Bank System accounted for 70.8%, and in terms of information media recognized, surrounding people were the highest with 52.4%. And, in case of the response as saying of being willing to participate, an opportunity of acquiring a bachelor's degree accounted for 24.0%, and in case of the response as saying of being unwilling to participate, the lack of time that will take part in education activity accounted for 13.7%, thereby having been surveyed to be the most preferential choice, respectively. The importance by sphere in course programs was indicated to be the sphere of preventive dental treatment with 3.61, the sphere of dental management with 3.38, the sphere of oral health education with 3.09, the sphere of medical-treatment coordination with 2.82, and the sphere of community dental health with 2.11 in order. The importance by field of sphere in course programs was indicated to be high in the field of oral health education by subject with 2.30 for the field of sphere in oral health education, in the field of plaque control and oral prophylaxis with 3.53 for the field of sphere in preventive dental treatment, in the field of management of the fluoride mouth-rinsing programme with 2.86 for the field of sphere in community dental health, in the field of counselling with 3.24 for the field of sphere in dental management, and in the field of medical-treatment assistance with 1.53 for the field of sphere in medical-treatment coordination.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.4
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• pp.1543-1561
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• 2020

Taxonomy of human brain activity is a complicated rather challenging procedure. Due to its multifaceted aspects, including experiment design, stimuli selection and presentation of images other than feature extraction and selection techniques, foster its challenging nature. Although, researchers have focused various methods to create taxonomy of human brain activity, however use of multivariate pattern analysis (MVPA) for image recognition to catalog the human brain activities is scarce. Moreover, experiment design is a complex procedure and selection of image type, color and order is challenging too. Thus, this research bridge the gap by using MVPA to create taxonomy of human brain activity for different categories of images, both colored and gray scale. In this regard, experiment is conducted through EEG testing technique, with feature extraction, selection and classification approaches to collect data from prequalified criteria of 25 graduates of University Technology PETRONAS (UTP). These participants are shown both colored and gray scale images to record accuracy and reaction time. The results showed that colored images produces better end result in terms of accuracy and response time using wavelet transform, t-test and support vector machine. This research resulted that MVPA is a better approach for the analysis of EEG data as more useful information can be extracted from the brain using colored images. This research discusses a detail behavior of human brain based on the color and gray scale images for the specific and unique task. This research contributes to further improve the decoding of human brain with increased accuracy. Besides, such experiment settings can be implemented and contribute to other areas of medical, military, business, lie detection and many others.

• Journal of Biomedical Engineering Research
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• v.28 no.5
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• pp.676-683
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• 2007

A non-invasive respiratory gated radiotherapy system like those based on external anatomic motion gives better comfortableness to patients than invasive system on treatment. However, higher correlation between the external and internal anatomic motion is required to increase the effectiveness of non-invasive respiratory gated radiotherapy. Both of invasive and non-invasive methods need to track the internal anatomy with the higher precision and rapid response. Especially, the non-invasive method has more difficulty to track the target position successively because of using only image processing. So we developed the system to track the motion for a non-invasive respiratory gated system to accurately find the dynamic position of internal structures such as the diaphragm and tumor. The respiratory organ motion tracking apparatus consists of an image capture board, a fluoroscopy system and a processing computer. After the image board grabs the motion of internal anatomy through the fluoroscopy system, the computer acquires the organ motion tracking data by image processing without any additional physical markers. The patients breathe freely without any forced breath control and coaching, when this experiment was performed. The developed pattern-recognition software could extract the target motion signal in real-time from the acquired fluoroscopic images. The range of mean deviations between the real and acquired target positions was measured for some sample structures in an anatomical model phantom. The mean and max deviation between the real and acquired positions were less than 1mm and 2mm respectively with the standardized movement using a moving stage and an anatomical model phantom. Under the real human body, the mean and maximum distance of the peak to trough was measured 23.5mm and 55.1mm respectively for 13 patients' diaphragm motion. The acquired respiration profile showed that human expiration period was longer than the inspiration period. The above results could be applied to respiratory-gated radiotherapy.

• The Journal of the Acoustical Society of Korea
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• v.14 no.1
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• pp.31-39
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• 1995

In this paper, we have constructed phoneme discriminant filters [PDF] according to the linear discriminant function. These discriminant filters do not follow the heuristic rules by the experts but the mathematical methods in iterative learning. Proposed system. is based on the piecewise linear classifier and error correction learning method. The segmentation of speech and the classification of phoneme are carried out simutaneously by the PDF. Because each of them operates independently, some speech intervals may have multiple outputs. Therefore, we introduce the unified coefficients by the output unification process. But sometimes the output has a region which shows no response, or insensitive. So we propose time windows and median filters to remove such problems. We have trained this system with the 549 monosyllables uttered 3 times by 3 male speakers. After we detect the endpoint of speech signal using threshold value and zero crossing rate, the vowels and consonants are separated by the PDF, and then selected phoneme passes through the following PDF. Finally this system unifies the outputs for competitive region or insensitive area using time window and median filter.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.2
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• pp.269-276
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• 2016

Recently the organizations related construction express frequently their opinion to MOLIT at the time of introducing the ICEC grade system and converting a system from responsibility supervision (RS) to construction management (CM). However there was no data to investigate the recognition of road construction engineers about the policy change. In this study, a questionnaire survey was conducted and analyzed twice to the road construction engineers on the CM and ICEC grading system at the Korea Institute of Construction Technology Education. The trend of response from the road construction engineers was verified through the survey separately from other institutions. This study analyzed the results and introduced a desirable policy proposal to promote an international competitiveness of the engineering industry.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.473-479
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• 2020

This study examined the meaning of the experiences of university students majoring in occupational therapy, where their practice was discontinued due to COVID-19, and to provide basic data for future measures. This study was a phenomenological study. The subjects of this study were seven students. Interviews were analyzed according to Colaizzi data analysis. As a result of an interview, it was organized into 17 themes, six themes clusters, and two categories. The themes clusters were indifference, problem recognition, wandering, coping, aftermath, and anticipation for coping. The students experienced a confused and frustrating situation after recognizing the problem of COVID-19 and experienced anxiety and regret as they experienced the interruption of their fieldwork. The students expected all universities to implement a batch and quick response at the same time. In the future, a systematic communication and delivery system is needed to quickly prepare and implement countermeasures at the same time as institutions, associations, and universities.

• International Journal of Highway Engineering
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• v.10 no.4
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• pp.127-138
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• 2008

Vehicles have recently become one of the main factors affecting our quality of life, and the needs of vehicles are still increasing. As a result, the growth of vehicles generate more crashes every year. One main factor for vehicle crashes is uncareful driving behaviors. Especially, drowsy or fatigue driving behaviors explain about 10-20% of the crashes, and they cause serious results because of the delay of response time and the decrease of object-recognition. Therefore, this research conducted real time image processing tests in order to study how cellular phone usages and drowy(or fatigue) drives affect driving behaviors. A vehicle simulator was used for this research, and the faceLAB 4.5 of Seeing Machines for eye image tracking tests using a small camera was installed in the front of the simulator, and normal and drowsy(or fatigue) driving patterns were analyzed.