• KSBB Journal
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• 제15권5호
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• pp.415-422
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• 2000

Enzymatic resolution is becoming increasingly important in the production of optically active pharmaceutical drugs and is now challenging the traditional synthetic methods for production of a variety of chiral intermediates and products. This article reviews the recent advances in chirotechnology using enzymes as a catalyst to resolve chiral compounds. The review focuses on the recent trends in chirotechnology and the application of enzymes to the production of industrially valuable pharmaceutical drugs.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3209-3212
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• 2012

Introduction: Colorectal carcinoma (CRC) is the most common gastrointestinal malignancy in the older population, but it is also quite frequent among young adults in developing countries. The aim of this study was to update the trends of clinicopathological features of CRC in young Nepalese. Methods: A retrospective comparative study on the data retrieved from the surgical records of all patients between 20 to 39 years of age with CRC was carried out for periods of 5 years each from 1999 to 2003 (early) and 2004 to 2008 (recent), treated at Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Results: The number of young adults with CRC increased from 28 to 34. However, the proportion of young patients in both groups was 28% of all CRC patients. The mean ages were $34{\pm}4.7$ and $31.8{\pm}5.1$ years in early and recent 5 years, respectively, and the male female ratio changed from 2:3 to 4:3. Abdominal pain as the most common presenting symptom was replaced by bleeding per rectum in recent years. The mean duration from onset of symptoms to seeking medical advice decreased from 7.8 months to 5.6 months in recent years. More patients (85.3%) were subjected to endoscopic examination in recent years than early years (60.7%) and right colonic cancer increased from 10.7% to 26.5%. However, the rectum was the commonest site in both early (71.4%) and recent (50%) groups. CRC was detected significantly at an earlier stage (7.1% vs 32.4%) in recent years with large proportion of modified Dukes B stage. Poorly differentiated adenocarcinoma was the predominant histology in both groups (50% vs 60.7%). Curative resection had risen in recent years (39.3% vs 73.6%). Conclusion: CRC among Nepalese young adults accounts for a high incidence (28%) of all CRC cases. Although right sided colonic cancer has been increasing, rectum is the commonest site. There is also an increasing trend for diagnosis at earlier stages of the disease which can be treated with curative intent.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3951-3955
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• 2015

Background: Colorectal cancer mortality has started to decrease in several developed countries in Asia. The current study aimed to present the long-term trends in colorectal cancer mortality in Korea using joinpoint analysis and age-period-cohort modeling. Materials and Methods: The number of colorectal cancer deaths and the population for each 5-year age group were obtained from Statistics Korea for the period 1984-2013 for adults 30 years and older. Joinpoint regression analysis was conducted to determine changes in trends in age-standardized mortality rates, and age-period-cohort analysis was performed to describe trends in colorectal cancer mortality using the intrinsic estimator method. Results: In men, the age-standardized mortality rate for colorectal cancer increased from 1984 to 2003, and the mortality rates stabilized thereafter, whereas the mortality rate of colorectal cancer in women has decreased since 2004. The age-specific mortality rate of colorectal cancer increased in both men and women over time, whereas decreases in the age-specific mortality rate in younger cohorts were observed. In the age-period-cohort analysis, old age and recent period were associated with higher mortality for both men and women. The birth cohort born after 1919 showed reduced colorectal cancer mortality in both men and women. Conclusions: Our study showed a recent decreasing trend in colorectal cancer mortality in women and a stable trend in men after 2003-2004. These changes in colorectal cancer mortality may be attributed to birth cohort effects.

• 한국융합학회논문지
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• 제9권3호
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• pp.153-163
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• 2018

본 연구의 목적은 국내에서 이루어진 자폐스펙트럼장애아동을 대상으로 한 로봇 활용 융합연구동향을 살펴보는 것이다. 이를 위하여 최근에 장애 아동의 교육적, 치료적 중재에 연구되고 있는 로봇연구 동향을 살펴보고자 하였다. 연구방법으로, 자폐를 키워드로 2009년 이후에 발표된 논문을 검색하여 총 17편의 연구 논문을 최종 선정하였고, 활용로봇, 독립변인, 종속변인 유형, 연구방법을 바탕으로 하여 주제별 범주로 묶어 내용 분석하였다. 연구결과, 그 중 자폐아동을 위한 로봇개발은 발전이 빠른 분야 중 하나이며, 자폐스펙트럼장애아동의 중재에 유용한 것으로 나타났다. 연구를 통해 향후 로봇활용의 일반화를 촉진할 수 있는 적용 절차 및 단계 등에 대한 세분화된 접근이 필요함을 알 수 있었다.

• 대한지리학회지
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• 제47권4호
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• pp.490-513
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• 2012

이 연구에서는 최근의 한국인에 의한 기후 연구 경향을 파악하고자 하였다. 이를 위해 한국연구재단 등재 학술지 6종과 국제학술지 4종을 분석하였으며, 연구기간은 2001년부터 2011년까지이다. 최근 기후변화에 대한 연구가 급증하였으며, 강수량 변동에 대한 연구는 꾸준히 이루어지고 있다. 기후변화 연구 중 기상학자는 특성과 예측에, 지리학자는 특성과 영향에 집중하였다. 응용 및 생물기후학 분야에서는 기후변화에 관한 관심의 증대로 농업, 축산업, 식생, 보건 등에 대한 기후변화의 영향 연구가 증가하였다. 기후지 분야의 연구는 꾸준히 수행되고 있으나 최근 감소 추세이다.

• 대한조선학회논문집
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• 제42권2호
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• pp.151-158
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• 2005

The concept of recent cruise ship design is changing rapidly according to the expansion of cruise fleet sizes, emphasis on passenger safety and tightened requirements for ecotourism. In this view point, this study focuses on investigative analysis for the recent trends in cruise ship design and construction. Based on the shipyard production logs and the cruise industry's annual news, the data for principal dimensions of newly built cruise ships, their hull forms and propulsion devices and the characteristics of cabin and public spaces are collected and analysed. As expected, it is found that the size of cruise ships is growing and the design concept is becoming more leisure-oriented for all ages rather than lust sightseeing. For producing a greater ton/pax ratio, the adoption of podded electric propulsion system, outside cabins and balcony spaces is a common trend in recent cruise ship design.

• Journal of Korea Trade
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• 제27권1호
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• pp.176-191
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• 2023

Purpose - When recovered through arbitration a contractual penalty that is disproportionately high can become grounds for challenging an arbitral award or an obstacle to its enforcement within Russian jurisdiction. This article investigates how violation of the principle of proportionality can affect the enforcement and challenging of arbitral awards in Russia. Based on the examination of the current legislation, along with the analysis of recent court cases on the subject, the ultimate object of this article is to discern practical recommendations for Korean practitioners who are looking to challenge and/or enforce arbitral awards in Russian courts. Design/methodology - The research process included the reviewing of current Russian legislation conducted in concurrence with academic literature review, searching and analyzing recent court cases where the relevant legal provisions and concepts were applied, and formulating practical implications of the research at its final stage. Findings - Through its relation to the principle of fairness/justice the authors establish the connection between the principle of proportionality and the public policy of Russia. Analysis of recent court cases showed two conflicting trends of whether a disproportionate penalty can be considered a public policy violation. The authors offer practical recommendations on how to substantiate a relevant claim regarding contractual penalty reduction by the court, depending on the desired outcome. Originality/value - The article contains an up-to-date summary of the legal provisions on the principle of proportionality of civil liability in Russia and identifies the most recent trends in court practice on the issue that is not covered by existing studies.

• International Journal of Vascular Biomedical Engineering
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• 제1권2호
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• pp.42-47
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• 2003

• 한국주조공학회지
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• 제11권4호
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• pp.276-282
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• 1991

• 한국주조공학회지
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• 제7권4호
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• pp.327-335
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• 1987