• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.354-361
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• 2005

Physical parameters such as porosity and effective porosity are important physical parameters that determine the transfer and movement of water and solutes in porous media. Various methods of determining these parameters have been developed, with varying degrees of accuracy and applicability. Most of the existing methods produce static results. They do not produce instantaneous and real time of porosity and effective porosity in a porous media. In this study, a new permittivity method called Frequency Domain Reflectometry with Vector analyzer (FDR-V) is proposed to determine the porosity and effective porosity of some sand samples in the laboratory. The advantage of the FDR-V method is that it instantaneously determines the temporal variation of dielectric constants of porous media. Then, the porosity and the effective porosity of porous media are computed using well established empirical equations. Results obtained from the FDR-V method compared favorably with results from other permittivity methods such as gravimetric, injection and replacement tests. The ratio of effective porosity to porosity was $85{\sim}92%$, when FDR-V was used. This value compared favourably with 90%, which has been usually quoted in previous studies. Considering the convenience and its applicability, the measurement system of FDR-V permittivity holds a great potential in porous media and contaminant transport studies.

• Nutrition Research and Practice
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• 제10권3호
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• pp.265-273
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• 2016

BACKGROUND/OBJECTIVES: The inhibitory effect of Hijikia fusiforme (HF) extracts on degenerative osteoarthritis was examined in primary cultured rat cartilage cells and a monosodium iodoacetate (MIA)-induced osteoarthritis rat model. MATERIALS/METHODS: In vitro, cell survival and the expression of matrix metalloproteinases (MMPs), collagen type I, collagen type II, aggrecan, and tissue inhibitor of metalloproteinases (TIMPs) was measured after $H_2O_2$ ($800{\mu}M$, 2 hr) treatment in primary chondrocytes. In vivo animal study, osteoarthritis was induced by intra-articular injection of MIA into knee joints of rats, and then RH500, HFE250 and HFE500 were administered orally once a day for 28 days. To determine the anti-inflammatory effects of HFE, nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$) expression were measured. In addition, real-time PCR was performed to measure the genetic expression of MMPs, collagen type I, collagen type II, aggrecan, and TIMPs. RESULTS: In the in vitro assay, cell survival after $H_2O_2$ treatment was increased by HFE extract (20% EtOH). In addition, anabolic factors (genetic expression of collagen type I, II, and aggrecan) were increased by HFE extract (20% EtOH). However, the genetic expression of MMP-3 and 7, known as catabolic factors were significantly inhibited by treatment with HFE extract (20% EtOH). In the in vivo assay, anabolic factors (genetic expression of collagen type I, II, aggrecan, and TIMPs) were increased by oral administration of HFE extract. However, the genetic expression of MMP-3 and 7, known as catabolic factors, and production of NO and $PGE_2$ were significantly inhibited by treatment with oral administration of HFE extract. CONCLUSION: HFE extract inhibited articular cartilage degeneration through preventing extracellular matrix degradation and chondrocyte injury.

• 공업화학
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• 제8권2호
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• pp.286-291
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• 1997

항암제로 탁월한 효능이 있는 taxol을 정상 액체 크로마토그래피를 이용하여 주목나무의 추출물에서 분리하였다. Taxol을 분리하기 위해 시료 주입량은 $5{\mu}l$에서 $100{\mu}l$로 변화시키고, 이동상 유속은 1ml/min로 고정하여 일정 용매법으로 실험을 하였다. 실험에 사용된 이동상은 헥산, 에탄올, 메탄올, 1-프로판올, 이소프로판올이었다. Taxol과 유사한 성질를 갖는 표준시료 cephalomannine, taxol, 10-deacetyltaxol의 혼합물에서 taxol을 분리하였다. Cephalomannine, taxol, 10-deacetyltaxol 혼합물의 분리 실험 결과로 taxol의 분리 최적 조건은 2성분계에서 헥산/에탄올의 부피 조성비가 96/4이며, 3성분계에서는 헥산/1-프로판올/메탄올의 부피 조성비가 96/2/2이었다. 분리시간은 2성분계에서 80분인데 비해 3성분계에서는 50분으로 적은 용매를 사용하여 분리할 수 있었다. 위에서 얻는 실험조건으로 실제 주목나무의 추출물 $1{\mu}g$에서 taxol를 분리할 수 있었다.

• Biomolecules & Therapeutics
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• 제26권2호
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• pp.218-223
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• 2018

The liver is an essential organ for the detoxification of exogenous xenobiotics, drugs and toxic substances. The incidence rate of non-alcoholic liver injury increases due to dietary habit change and drug use increase. Our previous study demonstrated that Ecklonia stolonifera (ES) formulation has hepatoprotective effect against alcohol-induced liver injury in rat and tacrine-induced hepatotoxicity in HepG2 cells. This present study was designated to elucidate hepatoprotective effects of ES formulation against carbon tetrachloride ($CCl_4$)-induced liver injury in Sprague Dawley rat. Sixty rats were randomly divided into six groups. The rats were treated orally with ES formulation and silymarin (served as positive control, only 100 mg/kg/day) at a dose of 50, 100, or 200 mg/kg/day for 21 days. Seven days after treatment, liver injury was induced by intraperitoneal injection of $CCl_4$ (1.5 ml/kg, twice a week for 14 days). The administration of $CCl_4$ exhibited significant elevation of hepatic enzymes (like AST and ALT), and decrease of antioxidant related enzymes (superoxide dismutase, glutathione peroxidase and catalase) and glutathione. Then, it leaded to DNA damages (8-oxo-2'-deoxyguanosine) and lipid peroxidation (malondialdehyde). Administration of ES formulation inhibited imbalance of above factors compared to $CCl_4$ induced rat in a dose dependent manner. Real time PCR analysis indicates that CYP2E1 was upregulated in $CCl_4$ induced rat. However, increased gene expression was compromised by ES formulation treatment. These findings suggests that ES formulation could protect hepatotoxicity caused by $CCl_4$ via two pathways: elevation of antioxidant enzymes and normalization of CYP2E1 enzyme.

• 한국정보통신학회논문지
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• 제16권11호
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• pp.2446-2452
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• 2012

국내외의 배출가스 규제 강화에 부합하기위하여, 사용자 의도에 따른 연료 분사시기와 분사량 조절이 가능한 커먼레일 ECU를 제어할 수 있는 알고리즘 개발의 필요에 따라서 본 논문에서는 커먼레일 엔진 전용 ECU에 적용할 수 있는 노킹 판별 및 엔진 밸런스 보정이 가능한 노킹 진단 알고리즘을 구현하여 시뮬레이터로 개발하였다. 또한 운전자가 직접 차량을 진단하는 운전자 중심의 진단 서비스를 제공하고자 시뮬레이터의 결과를 OBD-II 표준에 의거하는 차량 위주의 진단기로 개발하고자 한다. 이를 위해 자동차 고장진단 신호 및 센서 출력 신호를 송수신하는 유선 시스템과 무선 시스템인 블루투스 모듈을 이용하여 실시간 통신이 제공될 수 있는 OBD-II 진단기 S/W 설계방안을 제안함으로써 차량의 연비향상 및 유해가스 저감을 통한 엔진의 효율성 향상을 실현하도록 한다.

• 한국세라믹학회지
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• 제43권4호
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• pp.259-263
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• 2006

The applicability of UPT (Ultrasound Pulse Thermography) for real-time defect detection of the ceramic heating plate is described. The ceramic heating plate with superior insulation and high radiation is used to control the water temperature in underwater environment. The underwater temperature control system can be damaged owing to the short circuit, which resulted from the defect of the ceramic heating plate. A high power ultrasonic energy with pulse duration of 280 ms was injected into the ceramic heating plate in the vertical direction. The ultrasound excited vibration energy sent into the component propagate inside the sample until they were converted to the heat in the vicinity of the defect. Therefore, an injection of the ultrasound pulse wave which results in heat generation, turns the defect into a local thermal wave transmitter. Its local emission is monitored and recorded via the thermal infrared camera at the surface which is processed by image recording system. Measurements were Performed on 4 kinds of samples, composed of 3 intact plates and the defect plate. The observed thermal image revealed two area of crack in the defective ceramic heating plate.

• 전기학회논문지
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• 제66권11호
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• pp.1584-1590
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• 2017

This paper presents a implementation method of reliable speed limitation controller considering motor parameter variation in high speed operation. In spinning process of drum washing machine, speed increase has to be limited when unallowable imbalance mass is detected. Otherwise, severe noise and vibration can happen because noise and vibration are proportional to imbalance mass. To detect imbalance mass, d-axis current magnitude is used. However, we have to compensate for back-emf and power supply variation by means of detecting them because d-axis current is affected by both of them. On the other hand, we have to carefully estimate back-emf because back-emf is affected by stator resistance variation and inverter voltage error. Stator resistance variation can happen by manufacturing process for mass production or temperature variation in running. And there are inverter voltage errors between command voltage from micro-computer to inverter and real voltage from inverter to motor because of rising and falling time delay and turn-on resistance of power semiconductor switch. To solve this problem, we propose 2-step align current injection method which is to inject step-wise current right before starting. By this method, we can simply obtain stator resistance by ratio of voltage without inverter voltage error and current, and we can measure inverter voltage error. So we can obtain more exact model current, and then by simple calculation with compensation gain, we can estimate more accurate motor back-emf. We show that this method works well. It is verified through experiments.

• Smart Structures and Systems
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• 제15권3호
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• pp.769-785
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• 2015

Although timber structures have been extensively used in underground temporary supporting system, their actual performance is poorly understood, resulting in potentially conservative and over-engineered design. In this paper, a novel wireless sensor technology, SmartPlank, is introduced to monitor the field performance of timber structures during underground construction. It consists of a wooden beam equipped with a streamlined wireless sensor node, two thin foil strain gauges and two temperature sensors, which enables to measure the strain and temperature at two sides of the beam, and to transmit this information in real-time over an IPv6 (6LowPan) multi-hop wireless mesh network and Internet. Four SmartPlanks were deployed at the London Underground's Tottenham Court Road (TCR) station redevelopment site during the Stair 14 excavation, together with seven relay nodes and a gateway. The monitoring started from August 2013, and will last for one and a half years until the Central Line possession in 2015. This paper reports both the short-term and long-term performances of the monitored timber structures. The grouting effect on the short-term performance of timber structures is highlighted; the grout injection process creates a large downward pressure on the top surface of the SmartPlank. The short and long term earth pressures applied to the monitored structures are estimated from the measured strains, and the estimated values are compared to the design loads.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.1
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• pp.141-144
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• 2006

The deviations in the injection orbital parameters, resulting from launcher dispersions, need to be estimated and used for autonomous satellite operations. For the proposed small satellite mission of the university there will be two GPS receivers onboard the satellite to provide the instantaneous orbital state to the onboard data handling system. In order to meet the power requirements, the satellite will be sun-tracking whenever there is no imaging operation. For imaging activities, the satellite will be maneuvered to nadir-pointing mode. Due to such different modes of orientation the geometry for the GPS receivers will not be favorable at all times and there will be instances of poor geometry resulting in no output from the GPS receivers. Onboard the satellite, the orbital information should be continuously available for autonomous switching on/off of various subsystems. The paper presents the strategies to make use of small arcs of data from GPS receivers to compute the mean orbital parameters and use the updated orbital parameters to calculate the position and velocity whenever the same is not available from GPS receiver. Thus the navigation message from the GPS receiver, namely the position vector in Earth-Centered-Earth-Fixed (ECEF) frame, is used as measurements. As for estimation, two techniques - (1) batch least squares method, and (2) Kalman Filter method are used for orbit estimation (in real time). The performance of the onboard orbit estimation has been assessed based on hardware based multi-channel GPS Signal simulator. The results indicate good converge even with short arcs of data as the GPS navigation data are generally very accurate and the data rate is also fast (typically 1Hz).

• 센서학회지
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• 제24권6호
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• pp.385-391
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• 2015

In this paper, we propose a new method to infiltrate $Fe_3O_4$-nanoparticles into a porous silicon film and a monitoring technique to detect packing density of nanoparticles within the film. Recently, research to use porous silicon as a drug carrier or a new functional sensor material by infiltrating $Fe_3O_4$-nanoparticles has been extensively performed. However, it is still necessary to enhance the packing density and to develop a monitoring technique to detect the packing density in real time. In this light, we forcibly injected a nanoparticle solution into a rugate-structured free-standing porous silicon (FPS) film by applying a pressure difference between the two sides of the film. We found that the packing density by the pressure-infiltration method proposed in this paper is enhanced, relative to that by the previous diffusion method. Moreover, a continuous shift in wavelength of the rugate reflectance peak measured from the film surface was observed while the nanoparticle solution was being injected. By exploiting this phenomenon, we could qualitatively monitor the packing density of $Fe_3O_4$-nanoparticles within the FPS film with the injection volume of the nanoparticle solution.