• 한국습지학회지
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• 제24권1호
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• pp.38-43
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• 2022

스마트(Smart) 하수처리장은 하수처리 전 과정에 대한 ICT 기반의 실시간 모니터링, 원격 제어 관리 및 지능화 체계를 구축하여 안전하고 깨끗한 물환경을 조성하는 것을 의미한다. 이러한 스마트 하수처리장의 핵심이 되는 기술이 계측기를 활용한 운전제어 기술이라 할 수 있다. 본 연구진은 국내에서 진행중인 하수처리장 지능화 연구사업들을 참고하여 지능화사업 구축 시 필요한 운전제어 기술들을 분석하고 제시하였다. 분석 결과 규모별 제어, 반류수 제어, 연계처리수 제어, 약품량 제어, 동절기 운영제어, 총 유기탄소 제어까지 총 6개의 제거 기술에 대해 제시하였다. 규모별로는 소규모와 중규모 대규모로 구분할 수 있는 기준을 제시하였고, 반류수 제어의 경우 반류수를 관리할 수 있는 수질 및 유량 센서의 위치를 제시하였다. 연계처리수 제어의 경우 연계처리수가 하수처리장에 미치는 영향과 제어 지점을 제시하였으며, 약품주입량 제어의 경우 지능형 하수처리장 도입에 따라 약품 주입량을 최적화할 수 있는 시스템을 제시하였다. 동절기 운영의 경우 수온 저하에 따른 질산화 저하를 고려하였을 때 제어해야 하는 센서와 펌프를 제시하였다. 총 유기탄소 제어의 경우 향후 오염총량제를 고려한 연동 시스템을 제시하였다. 이러한 운전제어 시나리오들은 향후 지능형 하수처리 알고리즘과 시나리오에 사용될 기초자료로 활용될 수 있을 것으로 판단된다.

• 약학회지
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• 제57권5호
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• pp.330-336
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• 2013

"The Act on Medication Treatment of Sexual Impulse of Sex Offenders" known as chemical castration has been effective since July 2011 in Korea. According to the law, monitoring of male sex hormone in urine is enforced to request National Forensic Service more than once a month after injection of medicine designed to reduce sex impulse. We established a rapid and sensitive method for the monitoring of testosterone (T) and epitestosterone (E) in human urine by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Three mL of urine was pretreated by solid-phase extraction for purification and performed enzymatic hydrolysis. The pretreated samples were extracted twice with 2 ml of ethyl acetate and n-hexane (2 : 3). The separation was applied on Thermo Hypersil GOLD C18 column ($1.9{\mu}m$, $100{\times}2.1mm$). A gradient elution of methanol and water of 0.1% formic acid were used as mobile phase and the retention time was less than 10 min. LC-MS/MS system coupled with an electrospray ionization source was performed in multiple reaction monitoring mode. The transitions of the analytes executed as following: m/z $289{\rightarrow}97$, 109 for T and E, m/z $292{\rightarrow}109$ for $T-d_3$ and $E-d_3$ as internal standards. The validation results of the method were satisfactory. The limits of detection were 0.05 ng/ml and the limits of quantification were 0.1 ng/ml. This method was successfully applied to real human urine sample. The developed method will be useful for monitoring T/E ratio in urine of sex offenders.

• 대한한방내과학회지
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• 제35권4호
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• pp.519-531
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• 2014

Objectives: Diabetic nephropathy is the most common cause of end stage renal disease. Transforming growth factor (TGF)-${\beta}1$, type IV collagen, advanced glycation end-products (AGEs), and angiotensin II type 1 receptor (AT1) are the main factors of diabetic nephropathy. We investigated the effects of Prunus on renal function and histopathological changes of diabetic nephropathy rat model induced by unilateral nephrectomy and streptozotocin. Methods: Diabetes was induced in male Sprague-Dawley rats ($290{\pm}10g$) by injecting streptozotocin (55 mg/kg) into the tail vein after unilateral nephrectomy. Rats were divided into 3 groups (n=6): normal, control, and Prunus. After 8 weeks of oral administration of Prunus extract on the Prunus group from 3 days after streptozotocin injection, we checked weight, 24 hrs urine, blood biochemistry and renal tissue to evaluate renal function and histopathological changes by examining parameters including albuminuria, BUN, creatinine, cholesterol, low density lipoprotein (LDL), triglyceride, TGF-${\beta}1$, type IV collagen, AGEs, and AT1. We also measured mRNA expression of TGF-${\beta}1$, type IV collagen, AGEs, and AT1 by Real Time polymerase chain reaction (RT-PCR). Results: Prunus decreased the amount of 24 hrs proteinuria, and inhibited histopathological changes of diabetic nephropathy including the expression and accumulation of TGF-${\beta}1$, type IV collagen and AGEs which could promote development of diabetic nephropathy. Prunus also inhibited mRNA expression of TGF-${\beta}1$, type IV collagen. Conclusions: These findings suggest that Prunus might protect the renal function and inhibit the development of renal injury by regulating factors including TGF-${\beta}1$, type IV collagen, AGEs, except AT1, so Prunus can be used for diabetic patients to prevent the progression of diabetic nephropathy.

• Imaging Science in Dentistry
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• 제49권4호
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• pp.301-306
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• 2019

Purpose: This report presents a procedure for performing power Doppler ultrasound-guided sialography using the phenomenon of increased blood flow and illustrates its application to practical patient cases. Materials and Methods: The salivary gland was scanned using ultrasound equipment (GE LOGIQ5 Expert^® device; GE Medical Systems, Milwaukee, WI, USA) to identify pathological findings related to the patient's chief complaint. To identify the orifice of the main duct, it should be cannulated using a lacrimal dilator. After inserting the catheter into the cannulated main duct, the position of the catheter within the duct was confirmed by ultrasound. A contrast agent was injected until the patient felt fullness, and ultrasound (B-mode) was used to confirm whether the contrast agent filled the main canal and secondary and tertiary ducts. Then, power Doppler ultrasound was performed to determine whether the salivary gland had increased blood flow. Results: In 2 cases in this report, a power Doppler ultrasound scan showed a significant increase in blood flow after contrast medium injection, which was not observed on a preoperative scan. Conclusion: Power Doppler ultrasound was found to be a simple, safe, and effective tool for real-time sialography monitoring.

• Asian-Australasian Journal of Animal Sciences
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• 제23권4호
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• pp.456-464
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• 2010

RNA interference (RNAi) is an acknowledged useful and effective tool to study gene function in various cells. Here, we suppressed the Connexin 43 (Cx 43) gene expression during in vitro development of ovine pre-implantation embryos using the RNAi method. The 353 bp Cx 43 double-stranded RNA was microinjected into in vitro fertilized ovine zygotes, and the levels of target mRNA and protein were investigated. Control groups included uninjected zygotes or those injected with RNase-free water. The dsRNA injection resulted in the specific reduction of Cx 43 transcripts as analyzed by quantitative real-time RT-PCR and decreased protein levels as shown by Western blot analysis at the blastocyst stage. Microinjection of Cx 43 dsRNA led to 20.3%, 21.7% and 34.5% blastocyst rates and 19.2%, 37.5% and 41.3% hatched blastocyst rates in Cx 43 dsRNA-injected, water-injected and uninjected groups, respectively. Then the RNAi could not significantly affect cell number and cell death rates of blastocysts. Therefore, suppression of Cx 43 dsRNA and proteins did not apparently affect the development potential of ovine pre-implantation embryos but may play a role in embryo quality. RNAi technology is a promising approach to study gene function in early ovine embryogenesis.

• 인터넷정보학회논문지
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• 제17권4호
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• pp.43-50
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• 2016

본 논문은 차량용 지능형 네트워크에서 각광 받게 될 이더넷중심의 프로토콜과 데이터 전송 시 임의의 오류에 내성이 있는 알고리즘을 제안하였다. 동시에 시뮬레이션과 실험을 통해 구현과 검증을 시도하여 시스템의 유용성을 증명하였다. 기존의 차량 통신 서비스 시스템에 적용시키기 위한 알고리즘에 대하여 문헌 조사하고 최종적으로 새로운 알고리즘을 구현하였다. 실제 차량용 실시간 데이터의 경우 임의의 값이 불규칙적으로 발생하기 때문에 임의의 데이터를 생성하여 실험을 진행하고 payload의 설정을 표준 형식에 맞추었다. 구현된 알고리즘의 성능을 확인하고자 기존의 알고리즘에서 단일 데이터에서부터 혼합형 (Hybrid-type) 데이터까지 확인하였을 때의 문제점을 확인하고 제안하는 알고리즘의 실효성을 확인하였다.

• Journal of Korean Neurosurgical Society
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• 제52권3호
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• pp.228-233
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• 2012

Objective : Chronic neck or back pain can be managed with various procedures. Although these procedures are usually well-tolerated, a variety of side effects have been reported. In this study we reviewed cases of unexpected temporary adverse events after blocks and suggest possible causes. Methods : We reviewed the records of patients treated with spinal pain blocks between December 2009 and January 2011. The types of blocks performed were medial branch blocks, interlaminar epidural blocks and transforaminal epidural blocks. During the first eight months of the study period (Group A), 2% mepivacaine HCL and triamcinolone was used, and during the last six months of the study period (Group B), mepivacaine was diluted to 1% with normal saline. Results : There were 704 procedures in 613 patients. Ten patients had 12 transient neurologic events. Nine patients were in Group A and one was in Group B. Transient complications occurred in four patients after cervical block and in eight patients after lumbar block. Side effects of lumbar spine blocks were associated with the concentration of mepivacaine (p<0.05). The likely causes were a high concentration of mepivacaine in five patients, inadvertent vascular injection in three patients, intrathecal leak of local anesthetics in one, and underlying conversion disorder in one. Conclusion : Spinal pain blocks are a good option for relieving pain, but clinicians should always keep in mind the potential for development of inevitable complications. Careful history-taking, appropriate selection of the anesthetics, and using real-time fluoroscopy could help reduce the occurrence of adverse events.

• 한국정보과학회논문지:소프트웨어및응용
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• 제34권12호
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• pp.1011-1020
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• 2007

독립적으로 개발된 상용 컴포넌트들을 소스 코드 수정 없이 조립하여 재사용하기 위해서는 컴포넌트간 인터페이스 불일치 문제를 해결해야 한다. 본 논문에서는 이러한 문제를 해결하기 위한 새로운 컴포넌트 모델 및 조립 방법을 제안한다. 제안한 컴포넌트 모델은 각 컴포넌트가 서비스를 제공하는 하위 컴포넌트의 인터페이스에 의존하는 대신 서비스 요청에 관한 인터페이스를 독자적으로 정의하여 내장하고 이를 메타데이타로 노출한다. 조립 시에는 컴포넌트들의 요청 및 서비스 제공 인터페이스에 대한 메타데이타를 읽어 글루 컴포넌트 템플릿 코드를 자동 생성하여 인터페이스 정합에 필요한 중재 코드를 삽입하는 구조이다. 또 프레임워크에서 컴포넌트들에 대한 인스턴스를 관리하고 런타임시 의존성 주입 방식으로 조립을 수행하며, 글루 컴포넌트를 미들웨어 서비스 포인트 및 실시간 모니터링 포인트로 활용하는 방안도 제안한다. 이와 한께 본 논문은 제안한 컴포넌트 모델에 따르는 컴포넌트를 개발하고 조림하는 도구를 구현하여, 실용 가능성을 입증하였다.

• Fisheries and Aquatic Sciences
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• 제19권4호
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• pp.18.1-18.10
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• 2016

In this study, to clarify the function of $PoPLC-{\beta}1$, in response to stress challenge, we examined the $PoPLC-{\beta}1$ expression pattern in response to external stress (pathogen-associated molecular pathogen challenge and environmental challenge including temperature and salinity). $PoPLC-{\beta}1$ expression analysis of tissue from olive flounder showed that the messenger RNA (mRNA) was predominantly expressed in the brain, heart, eye, liver, spleen, and stomach. We also tested the mRNA expression of the $PoPLC-{\beta}1$ in the spleen and kidney of olive flounder by RT-PCR and real-time PCR following stimulation with lipopolysaccharide (LPS), concanavalin A (ConA), or polyinosinic:polycytidylic acid (PolyI:C) and compared with the inflammatory cytokines IL-1b and IL-6 in the stimulated flounder tissues. Each of the spleen and kidney and mRNA transcripts of $PoPLC-{\beta}1$ were increased 30- and 10-fold than normal tissue at 1-6 h post injection (HPI) with PolyI:C when the expression of $PoPLC-{\beta}1$ transcript was similar to LPS and ConA. We also tested the expression of $PoPLC-{\beta}1$ in response to temperature and salinity stress. The expression of $PoPLC-{\beta}1$ also was affected by temperature and salinity stress. Our results provide clear evidence that the olive flounder $PLC-{\beta}1$ signal pathways may play a critical role in immune function at the cellular level and in inflammation reactions. In addition, $PLC-{\beta}1$ appears to act as an oxidative-stress suppressor to prevent cell damage in fish.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.158-163
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• 2005

Competitive electricity markets necessitate equitable methods for allocating transmission usage in order to set transmission usage charges and congestion charges in an unbiased and an open-accessed basis. So in competitive markets it is usually necessary to trace the contribution of each participant to line usage, congestion charges and transmission losses, and then to calculate charges based on these contributions. A UPFC offers flexible power system control, and has the powerful advantage of providing, simultaneously and independently, real-time control of voltage, impedance and phase angle, which are the basic power system parameters on which sys-tem performance depends. Therefore, UPFC can be used efficiently and flexibly to optimize line utilization and increase system capability and to enhance transmission stability and dampen system oscillations. In this paper, a mathematical approach to allocate the contributions of system users and UPFCs to transmission system usage is presented. The paper uses a dc-based load flow modeling of UPFC-inserted transmission lines in which the injection model of the UPFC is used. The relationships presented in the paper showed modified distribution factors that modeled impact of utilizing UPFCs on line flows and system usage. The derived relationships show how bus voltage angles are attributed to each of changes in generation, injections of UPFC, and changes in admittance matrix caused by inserting UPFCs in lines. The relationships derived are applied to two test systems. The results illustrate how transmission usage would be affected when UPFC is utilized. The relationships derived can be adopted for the purpose of allocating usage and payments to users of transmission network and owners of UPFCs used in the network. The relationships can be modified or extended for other control devices.