• Genomics & Informatics
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• 제17권3호
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• pp.26.1-26.12
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• 2019

Identification of fusion gene is of prominent importance in cancer research field because of their potential as carcinogenic drivers. RNA sequencing (RNA-Seq) data have been the most useful source for identification of fusion transcripts. Although a number of algorithms have been developed thus far, most programs produce too many false-positives, thus making experimental confirmation almost impossible. We still lack a reliable program that achieves high precision with reasonable recall rate. Here, we present FusionScan, a highly optimized tool for predicting fusion transcripts from RNA-Seq data. We specifically search for split reads composed of intact exons at the fusion boundaries. Using 269 known fusion cases as the reference, we have implemented various mapping and filtering strategies to remove false-positives without discarding genuine fusions. In the performance test using three cell line datasets with validated fusion cases (NCI-H660, K562, and MCF-7), FusionScan outperformed other existing programs by a considerable margin, achieving the precision and recall rates of 60% and 79%, respectively. Simulation test also demonstrated that FusionScan recovered most of true positives without producing an overwhelming number of false-positives regardless of sequencing depth and read length. The computation time was comparable to other leading tools. We also provide several curative means to help users investigate the details of fusion candidates easily. We believe that FusionScan would be a reliable, efficient and convenient program for detecting fusion transcripts that meet the requirements in the clinical and experimental community. FusionScan is freely available at http://fusionscan.ewha.ac.kr/.

• 한국소음진동공학회논문집
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• 제12권11호
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• pp.833-839
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• 2002

As the demand for slim laptops requires low-height optical disc drives, vibration problems of optical disc drives are of great concern. Additionally, with the decrease of a track width and a depth of focus in high density drives, studies on vibration resonance between mechanical parts become more important. From the vibration point of view, the performance of optical disc drives is closely related with the relative displacement between a disc and an objective lens which is controlled by servo mechanism. In other words, to read and write data properly, the relative displacement between an optical disc and an objective lens should be within a certain limit. The relative displacement is dependent on not only an anti-vibration mechanism design but also servo control capability. Good servo controls can make compensation for poor mechanisms, and vice versa. In a usual development process, robustness of the anti-vibration mechanism is always verified with the servo control of an objective lens. Engineers partially modify servo gain margin in case of a data reading error. This modification cannot correct the data reading error occasionally and the mechanism should be redesigned more robustly. Therefore it is necessary to verify a mechanism with respect to the possible servo gain plot. In this study we propose the experimental verification method for anti-vibration mechanism with respect to the existing servo gain plot. Thismethod verifies axial vibration characteristics of optical disc drives on the basis of transmissibility. Using this method, we verified our mechanism and modified the mechanism for better anti-vibration characteristics.

• 지질공학
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• 제32권2호
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• pp.221-239
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• 2022

플랜트, 토목 및 건축 사업에서 말뚝 설계 시 어려움을 겪는 주된 요인은 지반 특성의 불확실성이다. 특히 표준관입시험을 통해 구한 N치가 설계 시 주요 입력값이나 짧은 입찰기간과 광범위한 구역에서 다수의 현장시험을 실시하는 것은 실제적으로 어려운 상황이다. 본 연구에서는 인공지능(AI)을 가지고 회귀분석을 적용하여 N치를 예측하는 연구를 수행하였으며, 최소한의 시추자료를 학습시킨 후 표준관입시험을 실시하지 못한 곳에서 N치를 예측하는데 그 목적이 있다. AI의 학습 성능을 높이기 위해서는 빅 데이터가 중요하며, 금회 연구 시 부족한 시추자료를 빅 데이터화 하는데 '원형증강법'을 적용하여 시추반경 2 m까지 가상 N치를 생성시키는 작업을 선행하였다. AI 모델 중 인공신경망, 의사결정 나무, 오토 머신러닝을 각각 적용하였으며 이 중 최적의 모델을 선택하였다. 최적의 모델을 선택하는 방법은 세 가지의 예측된 AI 모델 중 최소 오차값을 가지는 것이다. 이를 위해 폴란드, 인도네시아, 말레이시아에서 수행한 6개 프로젝트를 대상으로 표준관입시험의 실측N치와 AI의 예측N치를 비교하여 타당성 여부를 연구하였고, 연구 결과 AI 예측값에 대한 신뢰도가 높은 것으로 분석되었다. AI 예측값을 가지고 미시추 구간에서 지반특성을 파악 할 수 있었으며 3차원 N치 분포도를 사용하면 최적의 구조물 배치가 가능함을 확인하였다.