• Bulletin of the Korean Chemical Society
• /
• 제31권6호
• /
• pp.1609-1614
• /
• 2010

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Standard in vitro test was chosen using a rat brain homogenate as the source of AChE. Screening of reactivation potency was performed with two concentration of reactivator (1000 ${\mu}M$ and 10 ${\mu}M$). Results were compared to established reactivators pralidoxime, methoxime, HI-6, trimedoxime and obidoxime. More than 30 novel reactivators performed equal or better reactivation ability of POX-inhibited AChE compared to currently used reactivators. The structure-activity relationship for reactivators of paraoxon-inhibited AChE was developed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제41권6호
• /
• pp.357-360
• /
• 2015

Herpes zoster virus (HZV) infections are caused by reactivation of the varicella zoster virus. Reactivation symptoms commonly affect the thoracolumbar trunk, and rarely affect the mandibular branches of the trigeminal nerve. When the mandibular branches are involved, lesions appear proximal to the innervation area. This condition may be associated with exfoliation of the teeth and osteonecrosis of the jawbone. We report a case of mandibular osteomyelitis after herpes zoster infection and we present a review of the literature on mandibular-branch involvement of HZV-related osteonecrosis.

• 농촌계획
• /
• 제12권4호
• /
• pp.33-42
• /
• 2006

Recently, Korean government has been initiating various schemes for reactivation of the marginal farmland use. However, although about ten years have passed from the introduction of the marginal farmland redevelopment projects in 1995, there have been very few research works on their systematic and objective appraisal. Therefore, this study checked the statutory concept and development schemes of the marginal farmland, firstly. Ant through case studies on 5 completed project sites and questionnaire/interview surveys on local government officers/private developers, problems and suggestions on project implementation were analysed. Finally, in consideration with analysed results and suggestions together, tentative project directions and reaction schemes on marginal farmland development were proposed.

• 대한건축학회연합논문집
• /
• 제9권3호
• /
• pp.1-8
• /
• 2007

Heidegger's speculation on "Disclosure" makes it possible to know on image expression fundamentally. "Disclosure" means that the 'earth' and the 'world' are not fixed into one, but harmonize dynamically with each other under continuous mutual tension and mutual support. When they are well-weaved with each other, the two ways are collectively defined as "disclosure Image". In regard to the technique, the study analyzed 'allegory' and 'reactivation'. The former refers to showing image potentially, while the latter means embodying and revealing image apparently. Le Corbusier's late Architecture provides a simultaneous reactivation of various images through continuous cross-weaving rather than being inclined to either the earth or the world.

• 한국암반공학회:학술대회논문집
• /
• 한국암반공학회 2006년도 춘계학술발표회 논문집
• /
• pp.177-184
• /
• 2006

• Bulletin of the Korean Chemical Society
• /
• 제29권1호
• /
• pp.208-210
• /
• 2008

• 한국응용곤충학회:학술대회논문집
• /
• 한국응용곤충학회 2005년도 춘계 학술발표회
• /
• pp.149-149
• /
• 2005

• 대한바이러스학회지
• /
• 제29권3호
• /
• pp.165-174
• /
• 1999

To investigate viral pathogenesis and in vivo efficacy of acyclovir (ACV) in mouse HSV-1 encephalitis models, female BALB/c mice aged 5 weeks were inoculated with strain F either intranasally (IN) or intracerebrally (IC). ACV-treatment by intraperitomeal injection with 0, 5, 10 and 25 mg/kg b.i.d. for 6 days was commenced 1 h after infection. Body weight and signs of clinical disease were noted daily up to 2 weeks. $ED_{50}$ of ACV in IN infection was <5 mg/kg and 14.1 mg/kg in IC infection. Tissues of central nervous system were collected from 2 mice per group everyday up to 5 day p.i. and the virus titers were measured. In IN infection model, high titers in eyes and trigeminal nerves were observed. ACV-treatment showed significant reduction of the titers in all the isolated. In IC infection model, cerebrum, cerebellum and brain stem showed high virus titers. ACV-treatment showed less significant reduction of virus titers than that in IN infection model. Reactivation of explanted trigeminal nerves from mice 30 day p.i. was monitored. In all of ACV treated mice reactivation was observed, i.e. even the highest dose of ACV did not inhibit the establishment of viral latency.

• BMB Reports
• /
• 제49권4호
• /
• pp.220-225
• /
• 2016

Cancer cells have different characteristics due to the genetic differences where these unique features may strongly influence the effectiveness of therapeutic interventions. Here, we show that the spontaneous reactivation of extracellular signalregulated kinase (ERK), distinct from conventional ERK activation, represents a potent mechanism for cancer cell survival. We studied ERK1/2 activation in vitro in SW480 colorectal cancer cells. Although ERK signaling tends to be transiently activated, we observed the delayed reactivation of ERK1/2 in epidermal growth factor (EGF)-stimulated SW480 cells. This effect was observed even after EGF withdrawal. While phosphorylated ERK1/2 translocated into the nucleus following its primary activation, it remained in the cytoplasm during late-phase activation. The inhibition of primary ERK1/2 activation or protein trafficking, blocked reactivation and concurrently increased caspase 3 activity. Our results suggest that the biphasic activation of ERK1/2 plays a role in cancer cell survival; thus, regulation of ERK1/2 activation may improve the efficacy of cancer therapies that target ERK signaling.

• 터널과지하공간
• /
• 제30권4호
• /
• pp.335-358
• /
• 2020

본 연구에서는 TOUGH-FLAC 연동해석기법을 통해 단층의 수리역학적 거동을 평가할 수 있는 수치해석 모델을 제안하였다. 이는 국제공동연구 DECOVALEX-2019 Task B의 일환으로 수행되었으며, 불투수성 암반 내 유체 주입으로 인한 단층의 재활성을 예측하고 주변 암반의 수리역학적 안정성을 평가할 수 있는 해석모델을 개발하는 데에 그 목적이 있다. 본 연구에서는 TOUGH2 수리유동모델과 FLAC3D의 역학적 인터페이스 모델의 연동을 통해 단층의 역학적 거동을 보다 합리적으로 구현할 수 있는 해석기법을 제안하고, 벤치마크 해석과 스위스 Mont Terri 지하연구시설 현장시험에 적용하여 그 타당성과 유효성을 검증하였다. 개발된 해석 모델은 유체의 주입으로 인한 단층 내 압력 분포의 발달, 역학적 변형에 따른 수리간극의 변화, 변위와 응력 등 단층의 수리역학적 거동을 적절히 재현할 수 있는 것으로 나타났다.