• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5111-5113
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• 2015

Background: To investigate the diagnostic and treatment methods for Chinese patients with gastrointestinal stromal tumor (GIST). Materials and Methods: From January 2004 to June 2014, patients diagnosed with primary GIST and treated by a single medical team in the Department of Digestive Disease of XuYi Hospital of Traditional Chinese Medicine were retrospectively recruited. Re-examination and follow-up was conducted regularly and abdominal enhanced CT, blood biochemistry and responses to surgery or imatinib were recorded. Results: A total of 15 patients were enrolled, including 9 male and 6 female patients, with an average age of 54 years (ranging from 32-81 years). The primary symptoms were abdominal uncomfortable in 5 patients, abdominal pain in 6 patients as well as nausea and vomiting in 4 patients. One patient was diagnosed with bowl obstruction at the first visit. All patients were treated with surgery, and tumor site was confirmed 1 esophagus, 6 stomach, 4 small bowel, and 4 colorectal and all patients were pathologically diagnosed with GIST. Immunochemical test positive for CD 117 was found 12 patients, and positive for CD 34 in7 patients. The median follow-up time was 24 months (range of 3-63). Three metastasis were confirmed 1.5, 2 and 2.6 years postoperatively. Three patients were treatment by imatinib postoperatively. Conclusions: Surgery remains the main treatment method for Chinese patients with GIST and imatinib could be feasible and safe for treating Chinese patients with GIST.

• 한국산림과학회지
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• 제97권4호
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• pp.467-477
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• 2008

도시 근교림지역 임도의 이용객에 대한 설문지 조사 분석을 통하여 도시 근교림지역 임도의 이용객 행태 및 휴양적 이용가치를 분석하였다. 도시 근교림지역의 임도 이용객은 1주일에 3일 정도 그곳을 방문하였으며, 재방문 의향이 높게 나타났다. 도시 근교림의 임도가 도시민의 산책이나 등산로로서 건강증진 목적으로 가장 많이 이용되고 있었으며, 임도가 산림휴양에 큰 도움이 된다고 생각하고 있었다. 임도 시설물에 대한 만족도는 보통이상으로 나타났다. 도시 근교림지역 임도의 휴양적 이용가치는 153.2원으로 평가되었으며, 임도의 이용요금을 징수한다면 1인당 약 150원이 적정하다는 것을 알 수 있었다.

• 대한원격탐사학회지
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• 제34권4호
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• pp.625-638
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• 2018

In this paper, we derive i) a function to estimate snow cover fraction (SCF) from a MODIS satellite image that has a wide observational area and short re-visit period and ii) a function to determine snow depth from the estimated SCF map. The SCF equation is important for estimating the snow depth from optical images. The proposed SCF equation is defined using the Gaussian function. We found that the Gaussian function was a better model than the linear equation for explaining the relationship between the normalized difference snow index (NDSI) and the normalized difference vegetation index (NDVI), and SCF. An accuracy test was performed using 38 MODIS images, and the achieved root mean square error (RMSE) was improved by approximately 7.7 % compared to that of the linear equation. After the SCF maps were created using the SCF equation from the MODIS images, a relation function between in-situ snow depth and MODIS-derived SCF was defined. The RMSE of the MODIS-derived snow depth was approximately 3.55 cm when compared to the in-situ data. This is a somewhat large error range in the Republic of Korea, which generally has less than 10 cm of snowfall. Therefore, in this study, we corrected the calculated snow depth using the relationship between the measured and calculated values for each single image unit. The corrected snow depth was finally recorded and had an RMSE of approximately 2.98 cm, which was an improvement. In future, the accuracy of the algorithm can be improved by considering more varied variables at the same time.

• 디지털융복합연구
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• 제15권9호
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• pp.137-146
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• 2017

본 연구에서는 커피전문점의 애플리케이션 특성이 고객들의 재구매 의사 결정에 미치는 영향을 살펴보았다. 커피품질, 서비스 품질, 물리적 환경을 커피 전문점의 주요 서비스 품질로 고려하였고, 개인화, 유용성, 경제성, 편리함을 애플리케이션의 주요 특성으로 고려하였다. 이 애플리케이션 특성은 고객 만족과 재구매 의도 사이를 조절하는 역할을 담당할 것으로 예상하였다. 커피 전문점에 자주 방문하면서 관련 매장 애플리케이션을 가지고 있는 382명 을 대상으로 연구 모형을 검증하였으며, PLS를 활용하여 연구 모형을 분석하였다. 제안한 연구 모형은 고객 만족 분산의 48.1%를 설명하였고, 재구매 의도 분산의 41.6%를 설명하였다. 분석 결과, 개인화와 편리함은 고객들의 재구매 의사 결정에 유의한 조절 효과를 보였다. 커피 품질과 물리적 환경은 고객 만족에 유의한 영향을 미쳤지만, 서비스 품질은 고객 만족에 유의한 영향을 미치지 못했다. 브랜드 이미지는 고객 만족과 재구매 의도에 유의한 영향을 미쳤다.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2001년도 International Symposium on Food,Nutrition and Health for 21st Century
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• pp.52-60
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• 2001

Purpose: We performed a randomized, double-blind, placebo-controlled trial in mild to moderate myopia patients to evaluate the benefit of taking a nutrient supplement containing anthocyanoside oligomers for improving nocturnal visiual function and/or clinical symptoms. Methods: The subjects included have refractive error between -lD(Diopters) $\~$-8D in both eyes, symptoms of decreased night vision and asthenopia based on the scoring result of a pre-structured questionnaire, and abnormal results of mesopic contrast sensitivity(MCS) screening test showing abnormal curve of contrast sensitivity in the middle and high frequency level, between 6.0 and 30.0 CPD(Cycles per degree) at mesopic condition(-2$\~$0 log cd/$m^2$). Total 60 people who qualified the criteria above were enrolled and the subjects were instructed to take the investigational product (anthocyanoside or placebo) twice daily for a 4 week period. The enrolled subjects were investigated for nocturnal vision performance by MCS and clinical symptoms at their first visit and re-evaluated at post-intervention (4 weeks later). MCS was measured and improvement of contrast threshold level according to each CPD was calculated by subtracting initial values from final values. Age, refractive error, and MCS were compared between the placebo and anthocyanoside. Results: After 4 weeks of drug administration 22 of the anthocyanoside group showed symptom improvement compared to 1 of the placebo group (p=0.000). Contrast sensitivity levels according to each CPD before and after drug treatment showed significant improvement in the anthocyanoside group but not in the placebo group. Mean MCS change of anthocyanoside group is 2.41$\pm$1.91 which showed significant improvement compared to -0.40$\pm$2.47 of the placebo group(p=0.000). MCS changes of anthocyanoside group showed significant improvement compared to placebo group in all levels of CPD(p<0.05). During our investigation none of the subjects complained of specific side effects related to anthocyanoside use. Conclusion: Our results show that under careful selection of people with significant symptoms and definite MCS abnormalities, anthocyanoside oligomers may improve the subjective symptoms and objective MCS results.

• 사상체질의학회지
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• 제27권2호
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• pp.222-230
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• 2015

Objectives The purpose of this study is to design a research to find clinical factors involved in the decision-making process for determining the constitutional prescription based on prospective clinical data. Methods We have created a draft of the case report form. Therefore, seven constitutional experts was interviewed for additional items to be important used to determine the constitutional prescription in clinic. Interviews were done from December 2012 to March 2014, experts per person 2-3 times, took time of about 120 minutes per interview. Since then, we developed the final case report form through the expert meeting. At the same time, the developing the electronic case report form (eCRF) and the protocol to collect constitutional treatment cases was also discussed. Results & Conclusions The items of the case report form were subject general, lifestyle, health measurement, record of expert, prescription and evaluation after medication. The part of the clinical symptoms of the record of expert allowed to be recorded in the 5-point scale for the collection of quantitative data as much as possible. Assuming a re-visit of the patient, if necessary, twice the recording were to be possible. At the same time, the eCRF and the protocol to collect constitutional treatment cases were also developed. In this study, it will be able to more objectively standardize the medical decision making process that the experts of constitutional prescription decision. As a result, it will be possible to provide the standardized constitutional medical services.

• 한국지역지리학회지
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• 제8권1호
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• pp.20-39
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• 2002

본 연구는 우리나라의 대표적인 테마파크인 에버랜드를 사례로 급격한 관광수요 및 환경 변화에 대응하는 과정에서의 관광목적지 수명주기별 특성을 분석하였다. 에버랜드의 수명주기 단계는 일반적 지표(이용객수와 매출액)와 보조 지표(이용객수 속성과 이용객 유형)를 기준으로, 농원에서 위락공원으로의 변화가 진행된 초기개발기(1976${\sim}$1980년대 중반까지), 위락공원적 성격의 강화와 함께 테마파크로의 변화가 시작된 성장기(1980년대 중반${\sim}$1990년대 초반), 테마파크의 기반을 다졌으나 자원의 진부화가 진행되어 복합 테마파크화로의 변화를 계획한 성숙기(1990년대 초반${\sim}$1990년대 중반), 복합테마파크화의 실천 및 테마리조트파트로의 도약을 지향하는 재활성기(1990년대 중반이후)로 구분된다. 에버랜드는 새로운 시설 및 이벤트의 도입 또는 개선을 통하여 끊임없이 혁신을 행함으로써 현재 시장권도 서울중심에서 경기, 인천, 충북, 대전 등 전국으로 확대되고, 외국방문객도 급증하고 있다.

• 대한응급의학회지
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• 제29권5호
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• pp.399-407
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• 2018

Objective: Regionalization is one of the principal subjects for the advancement of rural emergency medical service systems in South Korea. This study shows the characteristics of interhospital transfer and status of the incidence of three major emergency disorders (acute myocardial infarction [AMI], acute stroke, and severe trauma) in one local province. Methods: A retrospective study was conducted for patients with three major emergency disorders who visited emergency medical facilities in one local province from January 2013 to December 2015, on the basis of the National Emergency Department Information System (NEDIS) data. Results: The incidence of three major emergency disorders had increased annually. Patients with each of these disorders tended to choose distinguishing methods of visiting emergency medical facilities. AMI patients tended to visited emergency medical facilities using private cars or on foot, while severe trauma patients usually visited by 119 ambulance, and acute stroke patients used 119 ambulance and private car in similar amounts. Overall, 65% of AMI patients were treated in intraregional medical facilities, but about 70% of acute stoke and severe trauma patients were transferred outside of the region. Conclusion: Because each of these disorders has an individual characteristic, it is difficult to expect a solution for the problems associated with emergency disorders just by assuring the availability of medical resources. Based on regionalization, a policy to provide the optimal treatment for those emergency disorders should be developed by planning public medical service systems based on the individual characteristics of emergency disorders, the standardized transfer plans of emergency patients and the assurance for mobilization and sharing of confined medical resources.

• 디지털융복합연구
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• 제17권10호
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• pp.265-271
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• 2019

국민 소득의 증가로 인해 문화 생활에 대한 관심이 크게 증가하면서 전국 미술관의 수도 함께 증가하고 있다. 하지만 다른 서비스에 비해 미술관 만족도는 상대적으로 낮은 편이다. 본 논문에서는 미술관 만족도를 높이기 위해 임베디드 시스템 환경에서 머신러닝에 기반한 관중들의 선호도에 관련된 정보를 제공하는 서비스를 제안한다. 제안된 알고리즘은 라즈베리 파이를 이용하여 임베디드 시스템을 구현했다. 관람자가 선호하는 작품과 유사한 작품을 찾아내기 위해 머신러닝을 이용하였고 여러 머신러닝 모델을 비교하여 임베디드 시스템에 적용 가능한 모델을 선정했다. 관람자의 취향에 맞는 정보를 활용하여 갤러리 전시 내용을 효과적으로 구성하여 전시 만족도를 높이고 이는 미술관 재 방문율을 높일 수 있을 것이다.

• Journal of Genetic Medicine
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• 제17권2호
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• pp.62-67
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• 2020

Purpose: Eliglustat is an oral substrate reduction therapy (SRT) approved for adults with Gaucher disease type I (GD1) who are extensive, intermediate, or poor CYP2D6 metabolizers. Here we report one-year experience of eliglustat switch therapy from long-term enzyme replacement therapy (ERT) in three adult patients with GD1. Materials and Methods: Medical history, clinical (hemoglobin concentration, platelet count, and bone mineral density) and biochemical parameters (angiotensin converting enzyme, total acid phosphatase, and lyso-gb1) of the patients were collected and evaluated by retrospective review of medical records at every 3, 6, or 12 month after switch to SRT. Results: Patient 1 was a 43-year old female diagnosed GD1 and her clinical and biochemical parameters were stabilized for more than 20 years by ERT. Due to the burden of regular hospital visit, she switched to SRT. During one-year of SRT, clinical parameters and biomarkers were maintained stable. However, after suffering acute febrile illness during SRT, she decided to re-switch to ERT due to concerns about drug interaction. Patient 2 was 41-year old male, younger brother of patient 1 and Patient 3 was 31-year old male. They switched to SRT in clinically stable condition with long-term ERT. The one-year SRT was tolerable without specific safety issue and the clinical parameters were maintained stable. Conclusion: One-year eliglustat therapy in three adult patients with GDI was generally tolerable and effective for maintaining the clinical parameters and biomarkers. However, the drug compliance, concurrent drug interactions, and long-term safety of eliglustat should be carefully monitored.