• BMB Reports
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• v.41 no.6
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• pp.479-484
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• 2008

In the present study, we demonstrate that ephrin-A5 is able to induce a transient increase of MAP kinase activity in PC12 cells. However, the effects of ephrin-A5 on the MAP kinase signaling pathway are about three-fold less than that of EGF. In addition, we demonstrate that EphA4 is the only Eph member expressed in PC12 cells, and that tyrosine phosphorylation induced by ephrin-A5 treatment is consistent with the magnitude and longevity of MAP kinase activation. Experiments using the Ras dominant negative mutant N17Ras reveal that Ras plays a pivotal role in ephrin-A5-induced MAP kinase activation in PC12 cells. Importantly, we found that the EphA4 receptor is rapidly internalized by endocytosis upon engagement of ephrin-A5, leading to a subsequent reduction in the MAP kinase activation. Together, these data suggest a novel regulatory mechanism of differential Ras-MAP kinase signaling kineticsexhibited by the forward signaling of EphA4 in PC12 cells.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.61-61
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• 2011

하천에서의 홍수 피해 발생을 예방하기 위한 대책은 크게 구조적인 대책과 비구조적인 대책으로 나눌 수 있다. 구조적인 대책은 댐이나 제방과 같이 하천을 중심으로 수공구조물을 설치하여 직접적인 홍수 발생을 억제하는 대책이지만, 비구조적인 대책은 무형의 체계를 통해 하천에서의 홍수발생을 억제하는 대책이다. 비구조적인 대책 가운데 대표적인 것이 홍수 예 경보인데, 한강홍수통제소에서는 1974년부터 홍수 예 경보시스템을 구축하여 운영하고 있다. 본 연구에서는 남한강 유역에 대한 홍수 방어능력 검토와 홍수 방어대책 강구에 필요한 충주 댐 수문 운영이 가능한 수리학적 홍수추적 모형을 구축하였으며, 충주댐을 중심으로 상 하류 구간에서 수위증가를 억제하기 위한 수문 운영기법을 검토하고자 하였다. 이를 위해 남한강 상류에 위치한 영월2 수위관측소로부터 팔당댐까지의 대상구간에 대해 최근 이루어진 하도측량자료를 이용하여 수리학적 모형을 구축하였다. 구축된 모형에 대해 2006년 홍수사상을 적용하여 모형의 보정을 실시하였으며, 2003년부터 2008년까지의 홍수사상을 대항으로 검증을 실시하였다. 충주댐 수문 운영은 HEC-RAS 모형 내의 E.C.G(Elevation Controlled Gate) 기법과 Rule Operation 기법을 이용하여 남한강 주요 지점에서의 홍수의 증가에 대한 억제효과를 검토하였다.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.5
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• pp.48-55
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• 2002

An Internet-based software called the Repair Advisory Service (RAS) was developed to assist aircraft composite repair. The RAS takes advantage of the web user interface and provides estimation of the failure loads of repaired composite laminates and Structural Repair Manual (SRM) with search capability. In this paper, a failure model of lap repair is discussed as an example of the modules in the RAS. The model takes into account anisotropy of each ply in the laminate and in the repair ply, and non-elastic behavior of the interlayer between the laminate and the repair patch. Failure loads calculated by the model were compared with test data, and a good agreement was found between the results of the model and the test.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.11a
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• pp.28-33
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• 1993

Regulation of nerve growth factor (NGF)-induced neuronal differentiation by GTPase activating protein(GAP) and its mechanism were investigated in rat pheochromocytoma cell line, PCl2. Overexpression of GAP caused the delay in the onset of neurite outgrowth of PCl2 eel Is in response to NGF. GAP has been known to inhibit p21$\^$ras/, the activated form of which induces neuronal differentiation. Therefore, the activity of p21$\^$ras/ was compared in control cells and cells overexpressing GAP indirectly by measuring the activities of B-Raf and MAP kinase that are known to be positively regulated by p21$\^$ras/. Surprisingly, NGF-induced activities of these two proteins were the same in control eells and GAP-overexpressing cells. Activities of Trk, PLC-r and SMC that act at a site upstream to p21$\^$ras/ in NGF signal transduction pathway were not also affected by GAP overexpression. Interestingly, however, the extent of tyrosine phosphorylation of SNT was found to be remarkably low in cells overexpressing GAP. It has been shown previously that neurotrophins and not mitogens induce SNT tyrosine phosphorylation in PCl2 cells. Thus it is possible that the timing of NGF-induced neuronal differntiation may be in part regulated by SNT and the slower onset of neurite outgrowth in cells overexpressing GAP may be through the inhibition of SNT by GAP.

• Proceedings of the Korean Society of Disaster Information Conference
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• 2016.11a
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• pp.221-222
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• 2016

습지는 생태자원의 보고로 다양한 생물종의 서식지를 제공하며, 습지 생태계는 어느 생태계보다 생산성이 높다. 습지는 잦은 수위변동으로 인해 습지의 식물은 수위의 영향을 많이 받는다. 따라서, 식물종의 특징과 최적의 생육환경과의 관계를 규명하기 위해 수위에 따른 식물의 서식환경을 분석해야 한다. 본 연구에서는 자연생태계가 잘 발달되어 있는 남한강의 비내섬 습지에 대해 유황분석을 하였고 유황에 따른 유량을 모의하였다. 모의된 유량과 HEC-RAS 모형을 이용하여 유황별 홍수위를 산정하였으며, RAS Mapper를 이용하여 침수심과 침수구역을 모의하였다. 이를 통해 침수심에 영향을 많이 받는 식물의 서식환경을 분석하였다. 버드나무군락은 침수가 발생하지 않는 지역 및 0~0.8m의 침수심, 물억새군락은 침수가 발생하지 않는 지역 및 0~0.4m의 침수심, 쑥-망초군락과 달뿌리풀군락은 0~0.4m의 침수심, 그리고 환삼덩굴군락은 0~0.8m의 침수심이 발생하는 지역에서 서식하는 것으로 분석되었다. 본 연구의 결과는 유황에 따른 침수심에 대한 식생서식환경을 분석한 것으로 식생을 고려한 인공습지 조성이나 하천설계에 있어 기초적인 자료가 될 것으로 기대된다.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.1084-1085
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• 2006

We studied formation of nanostructured $TiB_2$-Cu composites under shock wave conditions. We investigated the influence of preliminary mechanical activation (MA) of Ti-B-Cu powder mixtures on the peculiarities of the reaction between Ti and B under shock wave. In the MA-ed mixture the reaction proceeded completely while in the non-activated mixture the reagents remained along with the product . titanium diboride. The size of titanium diboride particles in the central part of the compact was 100-300 nm.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2001.10a
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• pp.117-120
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• 2001

In this paper, a contention-based reservation MAC protocol is proposed for non-real-time bursty traffic services in the wireless ATM networks. In order to reduce the collisions of the reservation request packets, the base station scheduler calculates the transmission probability using the number of RAS minislots and the estimated load of the reservation request packets. And it broadcasts the calculated transmission probability through the downlink control channel. Mobile terminals, which have a traffic burst, select randomly a RAS minislot and transmit the reservation request packet with the received transmission probability. The reservation request packet contains the number of packets in the buffer. The base station allocates slots based on the buffer status of the received reservation request packets.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.158-158
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• 2019

Recent studies show the possibility of more frequent extreme events as a result of the changing climate. These weather extremes, such as excessive rainfall, result to debris flow, river overflow and urban flooding, which post a substantial threat to the community. Therefore, an effective flood model is a crucial tool in flood disaster mitigation. In recent years, a number of flood models has been established; however, the major challenge in developing effective and accurate inundation models is the inconvenience of running multiple models for separate conditions. Among the solutions in recent researches is the development of the combined 1D-2D flood modeling. The coupled 1D-2D river flood modeling allows channel flows to be represented in 1D and the overbank flow to be modeled over two-dimension. To test the efficiency of this approach, this research aims to assess the capability of HEC-RAS model's implementation of the combined 1D-2D hydraulic simulation of river overflow inundation, and compare with the results of GERIS and FLUMENS 2D flood model. Results show similar output to the flood models that had used different methods. This proves the applicability of the HEC-RAS 1D-2D coupling method as a powerful tool in simulating accurate inundation for flood events.

• Nuclear Engineering and Technology
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• v.53 no.1
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• pp.253-257
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• 2021

This work demonstrates the use of baromembrane method based on reverse osmosis (RO) process. The method is realized on mobile complex, which allows to concentrate and determine ultra-low activity of radionuclides in water cooling ponds of Russian nuclear fuel cycle enterprises. The existence level of radionuclide background creates difficult conditions for identification the contribution of liquid discharges enterprise, as standard monitoring methods have a very high detection level for radionuclides. Traditional methods for determining the background radionuclides concentrations require the selection of at least 500 liters (l) of water, followed by their evaporation to form a dry residue. This procedure with RO membranes requires at least 5 days. It is possible to reduce the time and energy spent on evaporation of hundreds of water liters by pre-concentrating radionuclides in a smaller sample volume with baromembrane method. This approach allows preliminary concentration of water samples from 500 l volume till 20 l volume during several hours. This approach is universal for the concentration of dissolved salts of any heavy metals, other organic compounds and allows the preparation of water countable samples in much shorter time compared to the traditional evaporation method.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.11
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• pp.3083-3098
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• 2023

As demands for efficient and echo-friendly production of marine products increase, smart aquaculture based on information and communication technology (ICT) has become a promising trend. The smart aquaculture is expected to control fundamental farm environment variables including water temperature and dissolved oxygen (DO) levels with less human intervention. A recirculating aquaculture system (RAS) is required for the smart aquaculture which utilizes a purification tank to reuse water drained from the water tank while blocking the external environment. Elaborate water treatment should be considered to properly operate RAS. However, analyzing the water treatment performance is a challenging issue because fish farm circumstance continuously changes and recursively affects water fluidity. To handle this issue, we introduce computational fluid dynamics (CFD) aided water treatment analysis including water fluidity and the solid particles removal efficiency. We adopt RAS parameters widely used in the real aquaculture field to better reflect the real situation. The simulation results provide several indicators for users to check performance metrics when planning to select appropriate RAS without actually using it which costs a lot to operate.