• Korean Journal of Clinical Pharmacy
• /
• v.25 no.4
• /
• pp.273-279
• /
• 2015

Objective: Codeine may result in death or respiratory depression in children, particularly who are rapid metabolizer of CYP2D6, therefore it should be used cautiously among children under 12 years of age. This study was to investigate the prescribing pattern of codeine among children according to the age group, prescribed diagnosis, type of medical service and medical specialties. Method: We used Korea Health Insurance Review and Assessment Service-National Patient Sample (HIRA-NPS) database. Study subjects included inpatients or outpatients, who were prescribed codeine between January, 1, 2011 and December, 31, 2011. Contraindicated use of codeine was defined as the use of codeine at least one times under aged 12. Age groups were subclassified according to the <2 years, 2-4 years, 5-8 years, and 9-11 years. Frequently prescribed diagnosis (ICD-10), type of medical service, and medical specialties were also described among codeine users under aged 12. Results: Codeine users were 6,411 inpatients (9,958 prescriptions), and 3,397 outpatients (6,258 prescriptions), respectively. Codeine prescription under 12 years of age were 2.1% (210 prescriptions) among inpatients, and 12.3% (776 prescriptions) among outpatients (p-value<0.05). Outpatient prescriptions of codeine under 12 aged were issued mostly from primary care clinics and frequent diagnosis were unspecified bronchopneumonia (51.6%), and vasomotor rhinitis (23.7%). Conclusion: This study found prescribing of codeine under 12 aged is common in outpatient and primary clinics. Nationwide and community-based efforts should be needed to reduce inappropriate prescribing among children.

• Journal of Advanced Navigation Technology
• /
• v.27 no.1
• /
• pp.133-138
• /
• 2023

As a side effect of recent rapid climate change and global warming, the frequency and scale of flood disasters are increasing worldwide. In Korea, the water level of the Han River is a major management target for preventing flood disasters in Seoul, the capital of Korea. In this paper, to improve the water level prediction of the Han River based on machine learning, we perform a comprehensive assessment of the quality of related dataset and propose data preprocessing methods to improve it. Specifically, we improve the dataset in terms of completeness, validity, and accuracy through missing value processing and cross-correlation analysis. In addition, we conduct a performance evaluation using random forest and LightGBM to analyze the effect of the proposed data improvement method on the water level prediction performance of the Han River.

• Journal of Environmental Impact Assessment
• /
• v.33 no.1
• /
• pp.42-51
• /
• 2024

Recently, as e-commerce has been activated and the demand for daily logistics services has increased due to the COVID-19 pandemic, the development of small logistics facilities has increased rapidly. Logistics facilities are concentrated in certain areas in Gyeonggi-do, where transportation is convenient, with large hinterland cities, showing a rapid increase. This study analyzed development characteristics such as development scale, development method, floor area ratio, and use area for a total of 259 logistics facilities developed in three local governments: Anseong, Yeoju, and Icheon. Logistics facilities developed in a specific area are developed in the form of undeveloped development in non-urban areas, causing damage to the national land environment and social conflict. This study proposed institutional improvement measures and evaluation guidelines for eco-friendly development that can solve problems such as indiscriminate development, environmental impact, and conflicts with residents caused by logistics facility development.

• Korean Journal of Remote Sensing
• /
• v.36 no.2_1
• /
• pp.179-197
• /
• 2020

Topographic normalization reduces the terrain effects on reflectance by adjusting the brightness values of the image pixels to be equal if the pixels cover the same land-cover. Topographic effects are induced by the imaging conditions and tend to be large in high mountainousregions. Therefore, image analysis on mountainous terrain such as estimation of wildfire damage assessment requires appropriate topographic normalization techniques to yield accurate image processing results. However, most of the previous studies focused on the evaluation of topographic normalization on satellite images with moderate-low spatial resolution. Thus, the alleviation of topographic effects on multi-temporal high-resolution images was not dealt enough. In this study, the evaluation of terrain normalization was performed for each band to select the optimal technical combinations for rapid and accurate wildfire damage assessment using PlanetScope images. PlanetScope has considerable potential in the disaster management field as it satisfies the rapid image acquisition by providing the 3 m resolution daily image with global coverage. For comparison of topographic normalization techniques, seven widely used methods were employed on both pre-fire and post-fire images. The analysis on bi-temporal images suggests the optimal combination of techniques which can be applied on images with different land-cover composition. Then, the vegetation index was calculated from the images after the topographic normalization with the proposed method. The wildfire damage detection results were obtained by thresholding the index and showed improvementsin detection accuracy for both object-based and pixel-based image analysis. In addition, the burn severity map was constructed to verify the effects oftopographic correction on a continuous distribution of brightness values.

• Korean Journal of Environmental Biology
• /
• v.41 no.4
• /
• pp.683-696
• /
• 2023

The conservation of wetland ecosystems has a significant role in climate change. Notably, the Han River Protected Area, including the Siam-ri wetland and Janghang wetland, provides high biodiversity value. Thus, it is necessary to comprehensively evaluate the function and value of wetland ecosystems. This study evaluated the ecosystem services of Siam-ri and Janghang Wetlands located in the Han River Protected Area using the Rapid Assessment Wetland Ecosystem Services approach, a function-oriented ecosystem analysis. The results were calculated using the Ecosystem Services Index formula to analyze wetland ecosystem services. We also assessed the key ecosystem services based on a focus group interview. We identified that the supporting and cultural services index scores were relatively high in the study area. The results can provide helpful information for sustainable wetland conservation, conservation planning as primary data, and raising awareness for the Han River Protected Area.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.8 no.4
• /
• pp.43-51
• /
• 2005

Due to rapid and reckless economic development, natural resources of the national land have been damaged and polluted. Accordingly, the necessity for environment-friendly development has been on the rise and many have made efforts to assess the environmental value of the national land. This study divides the conservation areas by means of using relative elevation, slope, and development of housing land based on environmental evaluation of the national land. The relative elevation is obtained by the difference of altitude at the edge of the forest patch extracted from the land cover classification map based on the ridgeline, and the slope is obtained by environment-oriented land suitability analysis. The development of housing land is classified in accordance with the progress of each project. Twenty-six evaluation criteria are divided into five different grades using the minimal indicator approach and then sub-divided into ten grades by means of using the following two scenarios. The first one uses the weight of input materials while the second one relies on the size of patches that are emphasized in landscape ecology. Consequently, such a study demonstrated the following results. The method relying on the weight of input materials revealed the limitation of emphasizing input materials excessively, whereas the method of considering the size of patches resulted in the division of conservation areas that embody regional characteristics. This study is meaningful in that it classifies the conservation areas by reflecting the regional characteristics and the ecological values of animals and plants.

• Environmental Engineering Research
• /
• v.17 no.1
• /
• pp.35-39
• /
• 2012

In this study, multiparametric flow cytometry (FCM) was installed to enumerate the diagnosis of Pseudomonas aeruginosa ATCC 10145 and Escherichia coli K12 (IFO 3301). The nucleic acids (DNA/RNA) were double stained by a LIVE/DEAD bacLight viability kit, involving green SYTO 9 and red propidium iodide (PI), based on the permeability of two chemicals according to the integrity of plasma membrane. As the results showed, the gate for dead bacteria was defined as the range of $0.2{\times}10^0$ to $6.0{\times}10^1$ photo multiplier tube (PMT) 2 fluorescence (X-axis) and $2.0{\times}10^0$ to $2.0{\times}10^2$ PMT 4 fluorescence (Y-axis), and the gate for live bacteria was defined as the range of $6.0{\times}10^0$ to $6.0{\times}10^2$ PMT 2 fluorescence (X-axis) and $2.0{\times}10^0$ to $4.0{\times}10^2$ PMT 4 fluorescence (Y-axis). In the comparison of the number of the tested bacteria detected by FCM (viability assessment) and plate culture (cultivability assessment), the number of bacteria detected by FCM well represented the number of bacteria that was detected by the colony forming unit (CFU) counting method when bacteria were exposed to isopropyl alcohol and silver/copper cations. Consequently, it is concluded that the application of FCM to monitor the functional effect of disinfectants on the physiological status of target bacteria can offer more rapid and reliable data than the plate culture colony counting method.

• Journal of the Korean Society of Tobacco Science
• /
• v.29 no.2
• /
• pp.110-117
• /
• 2007

In vitro toxicity tests such as cytotoxicity, mutagenicity and genotoxicity assay are useful for evaluating the relative toxicity of smoke or smoke condensates obtained from different cigarette configurations. A major disadvantage of these tests is relatively time-consuming, complicated and expensive. Recently, a cell-free glutathione consumption assay (GCA) as a rapid and simple screening method for the toxicity assessment of smoke has been reported by Cahours et al. (CORESTA, 2006). This study was carried out to assess the GCA application capable of predicting the toxicity of gas/vapor phase (GVP) of cigarette smoke and to identify individual compounds responsible for the glutathione (GSH) consumption in smoke. Each GVPs from 2R4F, standard cigarette, carbon filter cigarette (ExC) and new carbon filter cigarette (ExN), test cigarettes were collected by automatic smoking machine and evaluated the relative toxicity by GCA and neutral red uptake (NRU) assay. Toxic compounds existed in smoke were also chosen, relative toxicities of these compounds were screened by using two methods and compared individually. The overall order of toxicity by GCA was 2R4F > ExC > ExN, which was consistent with the result of Neutral Red Uptake assay. The levels of carbonyl compounds of ExN were lower than those of 2R4F and ExC, indicating that GSH consumption was associated with carbonyl compound yields. A major toxicant under current study is acrolein, which contributed to more than half of the GSH consumption. Collectively, the toxicity of GVP determined by GCA method may be mainly attributed to acrolein.

• Journal of Environmental Impact Assessment
• /
• v.10 no.3
• /
• pp.235-243
• /
• 2001

Since the middle of 1990s, in Korea a few researches on the optimal management technologies combining numerical model and GIS for the management of water environment in drinking watershed area and reservoir such as Paldang Lake have been carried out. In this study, the integrated water environment management system was been suggested to efficiently reflect the public awareness of the environment by integrating the web based distributed data collection system, GIS, public hearing system and water quality model. As all the components of the system have been developed using the World Wide Web and all data have been collected from the relevant agencies through the Internet, the water quality model could be implemented on the web directly. In consequence, the environmental geographic information in Paldang Lake could be acquired and analyzed through the Internet. The system can rapidly respond to the public right to know on environment, so the public will willingly participate in the governmental projects on environment. To verify the usability of the developed system, it has been applied to Paldang Lake. Especially when the web based model has been used, users can easily and confidentially get the prediction results by applying the minimum number of parameters for the water quality model. This model will provide clearness and scientific bases in the process of water quality prediction for the sensitive sites where there are critical conflicts between the residents and the developers. In this study, rapid water environment management technique without spatial and time limit has been suggested, which can contribute to the efforts on the government and the public participation.

• Korean Journal of Remote Sensing
• /
• v.37 no.6_2
• /
• pp.1891-1900
• /
• 2021

Fine particulate matter (FPM; diameter ≤ 2.5 ㎛) is frequently found in metropolitan areas due to activities associated with rapid urbanization and population growth. Many adolescents spend a substantial amount of time at school where, for various reasons, FPM generated outdoors may flow into indoor areas. The aims of this study were to estimate FPM concentrations and categorize types of FPM in schools. Meteorological and chemical variables as well as satellite-based aerosol optical depth were analyzed as input data in a random forest model, which applied 10-fold cross validation and a grid-search method, to estimate school FPM concentrations, with four statistical indicators used to evaluate accuracy. Loose and strict standards were established to categorize types of FPM in schools. Under the former classification scheme, FPM in most schools was classified as type 2 or 3, whereas under strict standards, school FPM was mostly classified as type 3 or 4.