• Title/Summary/Keyword: Rap1b

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A Clothing-Ergonomics Study on the Variation of Upper Arm Skin Surface According to Arm Movements - on the arm movements to the vertical direction in front and in side - (신체동작에 따른 상지형태변화에 관한 피복인간공학적 연구 - 전방수직동작과 측방수직동작을 중심으로 -)

  • Kim Hae-Kyung;Park Eun-Joo;Jeon Eun-Kyung
    • Journal of the Korean Society of Clothing and Textiles
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    • v.13 no.1 s.29
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    • pp.49-58
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    • 1989
  • A clothing-erogonomics study was performed to investigate the difference of the upper arm skin skin surface and the relationship among the three aspects of upper arm (height of sleeve rap, sleeve width and armhole girth) by changing arm movements. Plaster cast was used for this experimental research. Arm movements consist of 9 types; just carmly standing on ($0^{\circ}$), and each 4 types ($45^{\circ},\;90^{\circ},\;135^{\circ},\;180^{\circ}$) to the vertical direction in front and in side. The results were as follows; 1) As the arm-movement angle increased, the height of sleeve cap decreased and that ratio was largest in the portion A-B3. 2) The steeve width was enlarged with the increment of movement angle in all portions of upper arm except B1-B5. 3) As increasing the movement angle, the whole armhole girth decreased and the ratio o(front armhole girth (F-A) was larger than that of back. 4) In the vertical direction in front, the height o( the sleeve caps was larger, the sleeve widths were smaller than in the vertical direction in side in all movement types, but there was no significant difference in arm-hole girth between the two cases. 5) There were significantly negative relationships between measurements in height of sleeve cap and those in sleeve width, and also between those in height of sleeve cap and in arm-hole girth. And significantly positive relationships were found between neasurements in height of sleeve cap and those in arm-hole girth.

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Optical, thermal and gamma ray attenuation characteristics of tungsten oxide modified: B2O3-SrCO3-TeO2-ZnO glass series

  • Hammam Abdurabu Thabit;Abd Khamim Ismail;M.I. Sayyed;S. Hashim;I. Abdullahi;Mohamed Elsafi;K. Keshavamurthy;G. Jagannath
    • Nuclear Engineering and Technology
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    • v.56 no.1
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    • pp.247-256
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    • 2024
  • The glass series modified by tungsten oxide was created using the compounds (75-x) B2O3- 10SrCO3- 8TeO2- 7ZnO - xWO3, where x = 0, 1, 5, 10, 22, 27, 34, and 40% mole percentage. A UV-visible spectrophotometer and thermogravimetric-differential thermal analysis (TG-DTA) methods were employed to characterize the specimen's optical and phase transition attributes, respectively. The mass-attenuation coefficient (AC) of all created glasses from BSTZW0 to BSTZ7 was estimated using Geant4 code from 0.05 to 3 MeV and compared to the XCOM software results, with a relative difference of less than 2% between the two results. The increase of WO3 percentage lead to an increase in the Linear-AC at each studied energy, and this is mainly due to the fact that the higher the percentage of WO3 in the glass increases its density which causes an increase in the Linear-AC, so an energy of 0.06 MeV, as an example, the values of the Linear-AC was 4.009, 4.509, 5.442, 6812, 8.564, 9.856, 10.999 and 11.628 cm-1 form BSTZW0 too BSTZW7, respectively. The Half-VL (value layer), Mean-FP (free path), Tenth-VL, and Radiation attenuation performance (RAP) were also calculated for the current BSTZW-glass samples and revealed that BSTZW7 had the best gamma ray attenuation performance at all discussed energies when compared to other studied glass samples.

The Transmembrane Adaptor Protein LIME Is Essential for Chemokine-Mediated Migration of Effector T Cells to Inflammatiory Sites

  • Park, Inyoung;Son, Myongsun;Ahn, Eunseon;Kim, Young-Woong;Kong, Young-Yun;Yun, Yungdae
    • Molecules and Cells
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    • v.43 no.11
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    • pp.921-934
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    • 2020
  • Lck-interacting transmembrane adaptor 1 (LIME) has been previously identified as a raft-associated transmembrane protein expressed predominantly in T and B lymphocytes. Although LIME is shown to transduce the immunoreceptor signaling and immunological synapse formation via its tyrosine phosphorylation by Lck, a Src-family kinase, the in vivo function of LIME has remained elusive in the previous studies. Here we report that LIME is preferentially expressed in effector T cells and mediates chemokine-mediated T cell migration. Interestingly, in LIME-/- mice, while T cell receptor stimulation-dependent proliferation, differentiation to effector T cells, cytotoxic T lymphocyte (CTL) function and regulatory T lymphocyte (Treg) function were normal, only T cell-mediated inflammatory response was significantly defective. The reduced inflammation was accompanied by the impaired infiltration of leukocytes and T cells to the inflammatory sites of LIME-/- mice. More specifically, the absence of LIME in effector T cells resulted in the reduced migration and defective morphological polarization in response to inflammatory chemokines such as CCL5 and CXCL10. Consistently, LIME-/- effector T cells were found to be defective in chemokine-mediated activation of Rac1 and Rap1, and dysregulated phosphorylation of Pyk2 and Cas. Taken together, the present findings show that LIME is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites.

Crystal structure of unphosphorylated Spo0F from Paenisporosarcina sp. TG-14, a psychrophilic bacterium isolated from an Antarctic glacier

  • Lee, Chang Woo;Park, Sun-Ha;Jeong, Chang Sook;Lee, Chang Sup;Hong, Jong Wook;Park, Hyun Ho;Park, Hyun;Park, HaJeung;Lee, Jun Hyuck
    • Biodesign
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    • v.6 no.4
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    • pp.84-91
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    • 2018
  • Spo0F is a response regulator that modulates sporulation, undergoes phosphorylation for phosphorelay signal transduction, and interacts with various regulatory proteins; however, the mechanisms through which phosphorylation induces structural changes and regulates interactions with binding partners remain unclear. Here, we determined the unphosphorylated crystal structure of Spo0F from the psychrophilic bacterium Paenisporosarcina sp. TG-14 (PaSpo0F) and established a phosphorylation-state structural model. We found that PaSpo0F underwent structural changes (Lys54 and Lys102) by phosphorylation and generated new interactions (Lys102/Gln10 and Lys54/Glu84) to stabilize the ${\beta}4/{\alpha}4$ and ${\beta}1/{\alpha}1$ loop structures, which are important target-protein binding sites. Analysis of Bacillus subtilis Spo0 variants revealed movement by BsSpo0F Thr82 and Tyr84 residues following interaction with BsSpo0B, providing insight into the movement of corresponding residues in PaSpo0F (Thr80 and Tyr82), with further analysis of BsSpo0F/BsRapH interaction revealing alterations in the ${\beta}4/{\alpha}4$ loop region. These results suggest that phosphorylation-induced structural rearrangement might be essential for PaSpo0F activation and expand the understanding of Spo0F-specific activation mechanisms during sporulation.

Early Rate Adaptation Protocol in DiffServ for Multimedia Applications (멀티미디어 서비스를 위한 DiffServ 망에서의 빠른 혼잡 제어 알고리즘)

  • Park Jonghun;Yoo Myungsik
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.30 no.1B
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    • pp.39-46
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    • 2005
  • As the multimedia application traffic takes more portion in the internet traffic, it is necessary to control the network congestion through the congestion control protocol. In addition, the QoS-enabled networks such as DiffServ become an indispensable technology when running the multimedia applications. However, the previously proposed end-to-end congestion control algorithms take the round trip time to react the network congestion. Thus, as the RTT becomes larger, the reaction against the congestion gets delayed further, while the network congestion gets worse. In addition the performance of end-to-end congestion control algorithm is degraded if the QoS-enabled network runs the congestion control mechanism in the network level without any coordination between them. In this paper, we propose the early rate adaptation protocol for the DiffServ network which effectively linke the congestion control algorithm at the host and the congestion mechanism in the network together. By taking advantage of early congestion notification from the network it is possible to react the network congestion more quickly and effectively.

Current status of Brassica A genome analysis (Brassica A genome의 최근 연구 동향)

  • Choi, Su-Ryun;Kwon, Soo-Jin
    • Journal of Plant Biotechnology
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    • v.39 no.1
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    • pp.33-48
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    • 2012
  • As a scientific curiosity to understand the structure and the function of crops and experimental efforts to apply it to plant breeding, genetic maps have been constructed in various crops. Especially, in the case of Brassica crop, genetic mapping has been accelerated since genetic information of model plant $Arabidopsis$ was available. As a result, the whole $B.$ $rapa$ genome (A genome) sequencing has recently been done. The genome sequences offer opportunities to develop molecular markers for genetic analysis in $Brassica$ crops. RFLP markers are widely used as the basis for genetic map construction, but detection system is inefficiency. The technical efficiency and analysis speed of the PCR-based markers become more preferable for many form of $Brassica$ genome study. The massive sequence informative markers such as SSR, SNP and InDels are also available to increase the density of markers for high-resolution genetic analysis. The high density maps are invaluable resources for QTLs analysis, marker assisted selection (MAS), map-based cloning and comparative analysis within $Brassica$ as well as related crop species. Additionally, the advents of new technology, next-generation technique, have served as a momentum for molecular breeding. Here we summarize genetic and genomic resources and suggest their applications for the molecular breeding in $Brassica$ crop.