• Advances in Traditional Medicine
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• 제4권3호
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• pp.187-195
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• 2004

A number of plants from different geographical origins have been shown to possess antioxidant activity. Some of them have been developed as natural antioxidant formulations for food, cosmetic and other applications. Bangladeshi flora is a rich source of a range of plant species, many of which are medicinal plants, and have been used in the preparations of the Unani and Ayurvedic traditional medicines. There are no, or just a few, reports on any systematic screening of the extracts of Bangladeshi plants for free radical scavenging activity using DPPH assay available to date. As part of our on-going search for biological activity in Bangladeshi plants, Kadam (Anthocephalus chinensis), Goran (Ceriaps decandra), Swarnalata (Cuscuta reflexa), Gab (Diospyros peregrina), Sundari (Heritiera fomes), Dhundul (Xylocarpus granatum) and Possur (Xylocarpus mekongensis) have been selected for the assessment of their free radical scavenging activity, and studies on the contents of alkaloids, anthraqunones, flavonoids and tannins in these extracts. Most of these species have been used in traditional medicine in Bangladesh and other countries for the treatment of various illnesses ranging from common cold to cancer. All extracts, except the methanol extract of Cuscuta reflexa, displayed significant free radical scavenging activity in the DPPH assay $(RC_{50}$ values within the range of $2.75\;{\times}\;10^{-2}\;to\;4.7\;{\times}\;10^{-3}\;mg/mL)$. Among these extracts, the methanol extract of Xylocarpus granatum exhibited the most potent activity $(4.7\;{\times}\;10^{-3}\;mg/mL)$ and that of Cuscuta reflexa had the least activity $(1.64\;{\times}\;10^{-1}\;mg/mL)$. While none of these plants showed positive tests with Dragendorff's reagent, presence of low to moderate amounts of phenolic compounds, e.g. anthraquinones, flavonoids and tannins was evident in all of these plants, except for the methanolic extracts of C. reflexa and the barks of D. peregrina, which did not display any evidence for the presence of flavonoids and anthraquinones, respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3241-3245
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• 2015

Purpose: To examine the effectiveness of mitomycin-C and chemo-hyperthermia in combination for patients with high-risk non-muscle-invasive bladder cancer. Materials and Methods: Between November 2011-September 2013, 43 patients with high-risk non-muscle-invasive bladder cancer undergoing adjuvant chemo-hyperthermia in two centers were evaluated retrospectively. Treatment consisted of 6 weekly sessions, followed by 6 sessions. Recurrence and progression rate, recurrence-free interval and side effects were examined. Analyzed factors included age, gender, smoking status, AB0 blood group, body mass index, T stage and grade, concominant CIS assets. The associations between predictors and recurrence were assessed using multivariate Cox proportional hazard analyses. Results: A total of 40 patients completed induction therapy. Thirteen (32.5%) were diagnosed with tumor recurrence. Median follow-up was 30 months (range 9-39). Median recurrence-free survival was 23 months (range 6-36). The Kaplan-Meier-estimated recurrence-free rates for the entire group at 12 and 24 months were 82% and 61%. There was no statistically significant difference between patient subgroups. Cox hazard analyses showed that an A blood type (OR=6.23, p=0.031) was an independent predictor of recurrence-free. Adverse effects were seen in 53% of patients and these were frequently grades 1 and 2. Conclusions: Intravesical therapy with combination of mitomycin-C and chemohyperthermia seems to be appropriate in high-risk patients with non-muscle-invasive bladder cancer who cannot tolerate or have contraindications for standard BCG therapy.

• 대한조선학회논문집
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• 제34권4호
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• pp.12-20
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• 1997

자유표면상을 항주하는 고속쌍동선의 저항성능 추정을 위한 포텐설기저 패널법을 개발하였다. 물체표면에 법선 다이폴과 쏘오스를 자유표면에는 쏘오스를 분포하였고, 선형화된 자유표면조건을 고속으로 진행하는 쌍동선에 적용하였다. 쌍동선이 고속으로 진행할 때 dernihull 사이의 내부유동과 쌍동선 주위의 외부유동의 속도차이로 인해 발생하는 해의 불안정성을 해결하기 위해 선미에 Kutta 조건을 적용하였다. 수치계산결과의 검증과 화류수조에서 고속선형에 대한 저항시험 가능성을 확인하기 위한 목적으로 회류수조에서 모형시험을 수행하였다. 모형시험 및 수치계산결과는 동일한 실험을 수행한 Insel[l]의 실험결과와 비교하였다. 이를 통해 회류수조에서의 실험결과가 정성적으로 타당한 결과를 보이고 있음을 확인하였다. 수치계산결과는 Kutta 조건을 사용함으로써 고속에서도 안정된 계산결과를 얻을 수 있었다. 선형화된 사유표면조건을 고속선에 적용한 본 연구결과는 모형시험결과에 비해 작게 나타났으나, 정성적으로 티당한 결과를 주고 있어 고속쌍동선의 선형설계에 적용될 수 있음음 보였다.

• Journal of Korean Neurosurgical Society
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• 제66권2호
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• pp.162-171
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• 2023

Objective : The goal of this study was to analyze the clinical outcomes of endoscopic third ventriculostomy (ETV) and endoscopic septostomy when shunt malfunction occurs in a patient who has previously undergone placement of a ventriculoperitoneal shunt. Methods : From 2001 to 2020 at Seoul National University Children's Hospital, patients who underwent ETV or endoscopic septostomy for shunt malfunction were retrospectively analyzed. Initial diagnosis (etiology of hydrocephalus), age at first shunt insertion, age at endoscopic procedure, magnetic resonance or computed tomography image, subsequent shunting data, and follow-up period were included. Results : Thirty-six patients were included in this retrospective study. Twenty-nine patients, 18 males and 11 females, with shunt malfunction underwent ETV. At the time of shunting, the age ranged from 1 day to 15.4 years (mean, 2.4 years). The mean age at the time of ETV was 13.1 years (range, 0.7 to 29.6 years). Nineteen patients remained shunt revision free. The 5-year shunt revision-free survival rate was 69% (95% confidence interval [CI], 0.54-0.88). Seven patients, three males and four females, with shunt malfunction underwent endoscopic septostomy. At the time of shunting, the age ranged from 0.2 to 12 years (mean, 3.9 years). The mean age at the time of endoscopic septostomy was 11.9 years (range, 0.5 to 29.5 years). Four patients remained free of shunt revision or addition. The 5-year shunt revision-free survival rate was 57% (95% CI, 0.3-1.0). There were no complications associated with the endoscopic procedures. Conclusion : The results of our study demonstrate that ETV or endoscopic septostomy can be effective and safe in patients with shunt malfunction.

• 한국해양공학회지
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• 제36권2호
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• pp.83-90
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• 2022

This paper presents the minimum submergence depth of an underwater vehicle that can remove the effect of free surface on the resistance of the underwater vehicle. The total resistance of the underwater vehicle in fully submerged modes comprises only viscous pressure and friction resistances, and no wave resistance should be present, based on the free surface effect. In a model test performed in this study, the resistance is measured in the range of 2 to 10 kn (1.03-5.14 m/s) under depth conditions of 850 mm (2.6D) and 1250 mm (3.8D), respectively, and the residual resistance coefficients are compared. Subsequently, resistance analysis is performed via computational fluid dynamics (CFD) simulation to investigate the free surface effect based on various submergence depths. First, the numerical analysis results in the absence of free surface conditions and the model test results are compared to show the tendency of the resistance coefficients and the reliability of the CFD simulation results. Subsequently, numerical analysis results of submergence depth presented in a reference paper are compared with the model test results. These two sets of results confirm that the resistance increased due to the free surface effect as the high speed and depth approach the free surface. Therefore, to identify a fully submerged depth that is not affected by the free surface effect, case studies for various depths are conducted via numerical analysis, and a correlation for the fully submerged depth based on the Froude number of an underwater vehicle is derived.

• 한국실내디자인학회논문집
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• 제26권3호
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• pp.13-24
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• 2017

Promoting barrier-free living environments is necessary in residential facilities on which senior citizens rely most of their lives. Safety of elder people can be reassured by a certification system based on the existing barrier-free certification program in public facilities. The range of certification does not cover all living area, but is limited to the bathroom, which is a sanitary space. Given the nature of BIM modeling, an existing multi-family building was selected and modeled, as the certification process requires all the necessary information and various viewport. BIM modeling of the bathroom was conducted in accordance with the requirements of the certification for barrier-free living environment. The results suggested that there is a need for a removal of thresholds, larger doors, better selection of finishing materials, sufficient room for a wheelchair, larger space next to the toilet, and the availability of an emergency bell and grab bars. Such information supports the potentials of BIM modeling, and it is expected that an automated certification system would be established in the foreseeable future.

• Journal of Advanced Research in Ocean Engineering
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• 제1권4호
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• pp.198-210
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• 2015

This paper presents the damage assessment of a free-fall dropped object on the seabed. The damage to a dropped object totally depends on the relationship between the impact energy and the soil strength at the mudline. In this study, unexpected dropping scenarios were first assumed by varying the relevant range of the impact velocity, structure geometry at the moment of impact, and soil strength profile along the penetration depth. Theoretical damage assessments were then undertaken for a free-fall dropping event with a fixed final embedment depth for the structure. This paper also describes the results of a three-dimensional large deformation finite element analysis undertaken for the purpose of validation. The analyses were carried out using the coupled Eulerian-Lagrangian approach, modifying the simple elastic-perfectly plastic Tresca soil model. The validation exercises for each dropping scenario showed good agreement, and the present numerical approach was capable of predicting the behavior of a free-fall dropped object.

• 한국생산제조학회지
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• 제26권3호
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• pp.328-336
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• 2017

The exit surface of a lens is designed using a three-dimensional free-form expression in order to easily modify a curved surface. This enables the design of numerical values and mathematical things using three-dimensional free-form expression, and enhances precision because it can be fine-tuned via numerical control. The standard of "Classification of Luminaire Light Distribution" for outdoor lighting fixtures by IESNA is adopted in order to examine the correlation between three-dimensional free-form surface expression and lighting performance. The variation of light distribution type and range is analyzed using the values of maximum light intensity and 50% light intensity. The actual tolerance occurs owing to parameters such as the thickness of the lens, the distance between LEDs, and the movement of the center of the incident surface; the effects of changes in these parameters on the performance are compared and analyzed.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.990-995
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• 1990

A minimum-time trajectory planning for two robot arms with designated paths and coordination is proposed. The problem considered in this paper is a subproblem of hierarchically decomposed trajectory planning approach for multiple robots : i) path planning, ii) coordination planning, iii) velocity planning. In coordination planning stage, coordination space, a specific form of configuration space, is constructed to determine collision region and collision-free region, and a collision-free coordination curve (CFCC) passing collision-free region is selected. In velocity planning stage, normal dynamic equations of the robots, described by joint angles, velocities and accelerations, are converted into simpler forms which are described by traveling distance along collision-free coordination curve. By utilizing maximum allowable torques and joint velocity limits, admissible range of velocity and acceleration along CFCC is derived, and a minimum-time velocity planning is calculated in phase plane. Also the planning algorithm itself is converted to simple numerical iterative calculation form based on the concept of neural optimization network, which gives a feasible approximate solution to this planning problem. To show the usefulness of proposed method, an example of trajectory planning for 2 SCARA type robots in common workspace is illustrated.

• 분석과학
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• 제8권4호
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• pp.895-900
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• 1995

Urinary free and acetylated polyamine profiles have been investigated for their potential usefulness as biochemical markers of cancer in a control of group comprised of healthy volunteers (32 cases) and patients with various types of cancers(48 cases). The nine (5 free and 4 acetylated) endogeneous polyamines were simultaneously determined by a sensitive capillary gas chromatography/nitrogen-phosphorus detector (GC/NPD). The newly modified (simple and convenient) method was developed and the compounds were isolated by adsorption onto silica gel and derivatized by heptafluorobutyric anhydride to enhance their specificity on gas chromatograms. The good quality-control data were obtained through the precision and accuracy test and the recovery range of them was 48.6 ~ 101.2 %. The Korean reference values of urinary polyamines were established and significant differences were found in cancer patients compared with normal subjects. Also, to eliminate subject variations, precursors to product concentration ratios were compared between cancer patients and control group. The ratios of both putrescine to spermidine and total (free plus acetylated) putrescine to total spermidine were significantly greater in cancer patients than in normal subjects.