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The Effect of Mirror Therapy to Improve Upper Extremity Function in Stroke Patients: A Meta-analysis

  • Se-Ra Min;Tae-Hoon Kim
    • International Journal of Internet, Broadcasting and Communication
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    • v.16 no.1
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    • pp.92-98
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    • 2024
  • This meta-analysis systematically reviewed studies on mirror therapy focused on arm and hand function in stroke patients, aiming to comprehensively assess the efficacy of mirror therapy interventions and furnish empirical support for its potential application and future development in the context of stroke rehabilitation. A rigorous search for articles published in international journals up to the year 2022 was conducted. Various assessment tools were employed to calculate effect sizes, evaluating the impact of mirror therapy on arm and hand function in stroke patients. Utilizing a random-effects model, mean effect sizes were determined, yielding a total effect size of 0.545. The effect sizes for the Brunnstrom Recovery Stage (BRS), Box and Block Test (BBT), Modified Barthel Index (MBI), Fugl-Meyer Assessment (FMA), and grip strength test were 0.957, 0.596, 0.490, 0.488, and 0.417, respectively. In summary, we suggest that mirror therapy engenders positive changes in functional recovery among stroke patients, establishing a foundation for its tailored clinical application based on individual subject characteristics.

Differentially Up-expressed Genes Involved in Toluene Tolerance in Pseudomonas sp. BCNU106 (유기용매 내성 세균 Pseudomonas sp. BCNU106 균주에서 차별적으로 상향 발현되는 유전자군의 톨루엔 내성과의 연관성)

  • Joo, Woo Hong;Bae, Yun-Ui;Kim, Da Som;Kim, Dong Wan
    • Journal of Life Science
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    • v.30 no.1
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    • pp.88-95
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    • 2020
  • Using a random arbitrarily primed polymerase chain reaction, messenger RNA expression levels were assessed after exposure to 10% (v/v) toluene for 8 hr in solvent-tolerant Pseudomonas sp. BCNU 106. Among the 100 up-expressed products, 50 complementary DNA fragments were confirmed to express repeatedly; these were cloned and then sequenced. Blast analysis revealed that toluene stimulated an adaptive increase in the gene expression level in association with transcriptions such as LysR family of transcriptional regulators and RNA polymerase factor sigma-32. The expression of catalase and Mn2+/Fe2+ transporter genes functionally associated with inorganic ion transport and metabolism increased, and the increased expression of type IV pilus assembly PilZ and multi-sensor signal transduction histidine kinase genes, functionally categorized into signal transduction and mechanisms, was also demonstrated under toluene stress. The gene expression level of beta-hexosaminidase in association with carbohydrate transport and metabolism increased, and those of DNA polymerase III subunit epsilon, DNA-3-methyladenine glycosylase II, DEAD/DEAH box helicase domain-containing protein, and ABC transporter also increased after exposure to toluene in DNA replication, recombination, and repair, and even in defense mechanism. In particular, the RNAs corresponding to the ABC transporter, Mn2+/Fe2+ transporter, and the β-hexosaminidase gene were confirmed to be markedly induced in the presence of 10% toluene. Thus, defense mechanism, cellular ion homeostasis, and biofilm formation were shown as essential for toluene tolerance in Pseudomonas sp. BCNU 106.

Fourth Graders Engaged in Sampling: A Case Study (초등학교 4학년 학생들의 표집활동 분석: 사례연구)

  • Park, Min-Sun;Ko, Eun-Sung
    • School Mathematics
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    • v.16 no.3
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    • pp.503-518
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    • 2014
  • This study examines fourth graders engaged in three concrete activities involving sampling from finite populations. The first included a survey of popular foods for school meals. The second had them take samples from a box containing white and black marbles to predict how many white and black marbles were in the box. The final activity required them to predict how many times the Korean letter '가' would appear in a Korean story book. The results show that the participants can experience and notice different ideas related to samples and sampling in different activities. In the first activity, they acknowledged that samples are useful for obtaining the information about populations. A population survey is difficult and is not overly useful. In the second activity, they recognized that samples cannot be identical to their population but that the information from a group of samples is similar to the information of the population. In the last activity, they devised some ideas about random sampling even though the ideas were immature.

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Identification of genes related to intramuscular fat content of pigs using genome-wide association study

  • Won, Sohyoung;Jung, Jaehoon;Park, Eungwoo;Kim, Heebal
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.2
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    • pp.157-162
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    • 2018
  • Objective: The aim of this study is to identify single nucleotide polymorphisms (SNPs) and genes related to pig IMF and estimate the heritability of intramuscular fat content (IMF). Methods: Genome-wide association study (GWAS) on 704 inbred Berkshires was performed for IMF. To consider the inbreeding among samples, associations of the SNPs with IMF were tested as random effects in a mixed linear model using the genetic relationship matrix by GEMMA. Significant genes were compared with reported pig IMF quantitative trait loci (QTL) regions and functional classification of the identified genes were also performed. Heritability of IMF was estimated by GCTA tool. Results: Total 365 SNPs were found to be significant from a cutoff of p-value <0.01 and the 365 significant SNPs were annotated across 120 genes. Twenty five genes were on pig IMF QTL regions. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, forkhead box protein O1, ectodysplasin A receptor, ring finger protein 149, cluster of differentiation, tyrosine-protein phosphatase non-receptor type 1, SRY (sex determining region Y)-box 9 (SOX9), MYC proto-oncogene, and macrophage migration inhibitory factor were related to mitogen-activated protein kinase pathway, which regulates the differentiation to adipocytes. These genes and the genes mapped on QTLs could be the candidate genes affecting IMF. Heritability of IMF was estimated as 0.52, which was relatively high, suggesting that a considerable portion of the total variance of IMF is explained by the SNP information. Conclusion: Our results can contribute to breeding pigs with better IMF and therefore, producing pork with better sensory qualities.

Nutritional Survey on the School Children Box lunch -Based in K Elementary school children in Seoul- (학령기 아동의 도시락 영양섭취실태에 관한 연구 -서울 K 국민학교를 중심으로-)

  • 이보경
    • Journal of the Korean Home Economics Association
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    • v.26 no.4
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    • pp.43-52
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    • 1988
  • This study is intended to reveal the nutritional realities of school children due to their box lunch. The samples were chosen at random from the third grade to the sixth grade children in an elementary school in Seoul : 122 male and 111 female children, 233 children in all. among the subjects, 44.3% have a family of four, 34.3% have over 500,000 won of family income a month, and 44.3% of their mothers graduated from a high school. The average intake of calories is 573.6 Kcal, and the ratios of the calory intakes to the recommended amounts are 90.6% in the third grade children and from the fourth grade to the sixth grade, 79.5% in the male children and 82.9% in the female children. The average consumption of protein is 21.0g and the ratio of animal protein is 41.4%. the ratio of energy yield nutrients is 67.4% : 14.5 : 18.0 (carbohydrate : protein " fat). Considering the recommended amounts, the intake of protein is enough; the consumption of vit, A, thiamine, niacin are appropriate;and the intake of calories, Riboflabin and ascorbic acid, calcium, iron are deficient. Even though there is no significant difference between the socioeconomic factors (the standard of education of the subjects' mothers and family income0 and the intakes of calories and protein, there is a tendency that the consumption of protein intake si more abundant in the middle class than in any other class. The subjects' distribution of the physical growth index, is as follows; A (6.9%), B(19.3%), C(48.5%), D(13.7%) and E (11.6%). As the subjects' intake of calcium increases, the weight shows significant improvement (p<0.001). As the consumption of calories increases, the physical development shows significant improvement (p<0.05), and the weight shows significant increase (p<0.001).

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Reliability Analysis of Composite Girder Designed by LRFD Method for Positive Flexure (하중저항계수설계법(LRFD)으로 설계된 강합성 거더의 휨에 대한 신뢰도해석)

  • Shin, Dong-Ku;Kim, Cheon-Yong;Paik, In-Yeol
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.26 no.3A
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    • pp.539-546
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    • 2006
  • The reliability analysis of simply-supported composite plate girder and box girder bridges under positive flexure is performed. The bridges are designed based on the AASHTO-LRFD specification. A performance function for flexural failure is expressed as a function of such random variables as flexural resistance of composite section and design moments due to permanent load and live load. For the flexural resistance, the statistical parameters obtained by analyzing over 16,000 samples of domestic structural steel products are used. Several different values of statistical parameters with the bias factor in the range of 0.95-1.05 and the coefficient of variation in the range of 0.15-0.25 are used for the live-load moment. Due to the lack of available domestic measured data on the dead load moment, the same values of statistical properties used in the calibration of AASHTO-LRFD are applied. The reliability indices for the composite plate girder and box girder bridges with various span lengths are calculated by applying the Rackwitz-Fiessler technique.

A modified U-net for crack segmentation by Self-Attention-Self-Adaption neuron and random elastic deformation

  • Zhao, Jin;Hu, Fangqiao;Qiao, Weidong;Zhai, Weida;Xu, Yang;Bao, Yuequan;Li, Hui
    • Smart Structures and Systems
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    • v.29 no.1
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    • pp.1-16
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    • 2022
  • Despite recent breakthroughs in deep learning and computer vision fields, the pixel-wise identification of tiny objects in high-resolution images with complex disturbances remains challenging. This study proposes a modified U-net for tiny crack segmentation in real-world steel-box-girder bridges. The modified U-net adopts the common U-net framework and a novel Self-Attention-Self-Adaption (SASA) neuron as the fundamental computing element. The Self-Attention module applies softmax and gate operations to obtain the attention vector. It enables the neuron to focus on the most significant receptive fields when processing large-scale feature maps. The Self-Adaption module consists of a multiplayer perceptron subnet and achieves deeper feature extraction inside a single neuron. For data augmentation, a grid-based crack random elastic deformation (CRED) algorithm is designed to enrich the diversities and irregular shapes of distributed cracks. Grid-based uniform control nodes are first set on both input images and binary labels, random offsets are then employed on these control nodes, and bilinear interpolation is performed for the rest pixels. The proposed SASA neuron and CRED algorithm are simultaneously deployed to train the modified U-net. 200 raw images with a high resolution of 4928 × 3264 are collected, 160 for training and the rest 40 for the test. 512 × 512 patches are generated from the original images by a sliding window with an overlap of 256 as inputs. Results show that the average IoU between the recognized and ground-truth cracks reaches 0.409, which is 29.8% higher than the regular U-net. A five-fold cross-validation study is performed to verify that the proposed method is robust to different training and test images. Ablation experiments further demonstrate the effectiveness of the proposed SASA neuron and CRED algorithm. Promotions of the average IoU individually utilizing the SASA and CRED module add up to the final promotion of the full model, indicating that the SASA and CRED modules contribute to the different stages of model and data in the training process.

Generating Test Cases of Stateflow Model Using Extended RRT Method Based on Test Goal (테스트 목표 기반의 향상된 RRT 확장 기법을 이용한 Stateflow 모델 테스트 케이스 생성)

  • Park, Hyeon Sang;Choi, Kyung Hee;Chung, Ki Hyun
    • KIPS Transactions on Software and Data Engineering
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    • v.2 no.11
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    • pp.765-778
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    • 2013
  • This paper proposes a test case generation method for Stateflow model using the extended RRT method. The RRT method which has been popularly used for planning paths for complex systems also shows a good performance for test case generation. However, it does not consider the test coverage which is important for test case generation. The proposed extension method hires the concept of test goal achievement to increase test coverage and drives RRT extension in the direction that increases the goal achievement. Considering the concept, a RRT distance metric, random node generation method and modified RRT extension algorithm are proposed. The effectiveness of proposed algorithm is compared with that of the typical RRT algorithm through the experiment using the practical automotive ECUs.

Global Sensitivity Analysis of Joints for Plug-in Digital Framework (플러그인 디지털 프레임웍을 위한 연결부 전역민감도 해석)

  • Lee, Dooho;Won, Young-Woo;Kwon, Jong-Hyun
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.5
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    • pp.483-488
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    • 2016
  • Plug-In Digital Framework is a system response analysis tool that is employed when system components are composed of black-box modules. Generally, the dynamic characteristics of joints between the system components significantly affect system responses, and they lead to displacement- and frequency-dependent stiffness and loss factor. Thus, the sensitivity of each joint parameters should be estimated from a global perspective. In this study, we introduce a global sensitivity analysis procedure under the Plug-In Digital Framework. To efficiently calculate the system responses, we introduce the frequency response function (FRF)-based substructuring method. Using the random balance designs (RBD), we generate the system responses and estimate the global first-order sensitivities for each joint stiffness. We apply the proposed global sensitivity analysis method to an interior noise problem of a passenger car, and we evaluate the efficiency of the global sensitivity analysis method.

A Dynamic Analysis of PSC Box Bridge Varying Span Lengths for Increased Speeds of KTX (고속철 속도변화에 대한 PSC박스 교량의 경간길이 별 동적해석)

  • Oh, Soon Taek;Lee, Dong Jun;Shim, Young Woo;Yun, Jun Kwan
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.15 no.4
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    • pp.204-211
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    • 2011
  • A dynamic analysis procedure is developed to provide a better estimation of the dynamic responses of bridge during the passage of high speed railway vehicles. Particularly, a three dimensional numerical model including the structural interaction between high speed vehicles, bridges and railway endures to analyse accurately and evaluate with in-depth parametric studies for dynamic responses of various bridge span lengths running KTX railway locomotive up to increasing maximum speed(450km/h). Three dimensional frame element is used to model the simply supported pre-stressed concrete (PSC) box bridges for four span lengths(40~25m). Track irregularity employed as a stationary random process from the given spectral density functions and irregularities of both sides of the track are assumed to have high correlation. The high-speed railway vehicle (KTX) is used as 38-degree of freedom system. Three displacements (Vertical, lateral, and longitudinal) as well as three rotational components (Pitching, rolling, and yawing) are considered in the 38-degree of freedom model. The dynamic amplification factors are evaluated by the developed procedure under various traveling conditions, such as track irregularity camber, train speed and ballast. The dynamic analysis such as Newmark-${\beta}$ and Runge-Kutta methods which are able to analyse considering the dynamic impact factors are compared and contrasted.