• Nuclear Engineering and Technology
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• 제54권4호
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• pp.1449-1455
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• 2022

A radiotracer investigation was carried out in a Thermal Stratification Test Facility (TSTF) with objectives of investigating the dispersion and diffusion of radionuclide and effectiveness of the thermocline to minimize the radionuclide content in the hot water layer. Technetium-99m (^99mTc) as sodium pertechnetate was used as a radiotracer in the investigation. Qualitative analysis showed that a thermocline is formed within the TSTF and is effective in preventing the transport of radionuclide from bottom section to the top section of the facility. It was found that the radiotracer injected at the bottom of the pool took about 17.4 h to disperse from bottom to the top of the facility. The results of the investigation helped in understanding the effectiveness of hot water layer and thus to minimize the pool top radiation levels.

• 대한방사성의약품학회지
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• 제5권2호
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• pp.152-157
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• 2019

Polo-like kinase 1 (Plk1) is crucial regulator of cell cycle progression during mitosis. It is known to highly overexpress in many different tumor types, and has been implicated as a potential antimitotic cancer target. The phosphopeptide, Pro-Leu-His-Ser-p-Thr (PLHSpT), was shown a high level of affinity and specificity for the polo-box domain (PBD) of Plk1. However, the peptide has the limitation of cell permeability. We designed the derivatives to enhance the limitation of PLHSpT using drug delivery system. In addition, we synthesized and evaluated its radiotracer for tumor diagnosis. This review discusses the derivative and radiotracer that are suitable for tumor treatment and diagnosis for PBD of Plk1.

• Nuclear Engineering and Technology
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• 제49권1호
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• pp.196-208
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• 2017

This study presents an experimental work in a petrochemical company for scanning a buried pipeline using $Tc^{99m}$ radiotracer based on the measured velocity changes, in order to determine the flow reduction along a pipeline. In this work, $Tc^{99m}$ radiotracer was injected into the pipeline and monitored by sodium iodide scintillation detectors located at several positions along the pipeline. The flow velocity has been calculated between every two consecutive detectors along the pipeline. Practically, six experiments have been carried out using two different data acquisition systems, each of them being connected to four detectors. During the fifth experiment, a bypass was discovered between the scanned pipeline and another buried parallel pipeline connected after the injection point. The results indicate that the bypass had a bad effect on the volumetric flow rate in the scanned pipeline.

• 방사선산업학회지
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• 제5권4호
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• pp.317-323
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• 2011

Radioisotopes have been widely used throughout industry to optimize processes, solve problems and improve product quality. A gamma scanning technique using radiation via sealed source (Co-60) was carried out in order to investigate vertical density profile of catalyst regenerator of RFCCU. Also through the radiotracer experiments, the flow characteristics of catalyst was measured. The catalyst samples were irradiated with neutron in HANARO reactor to produce lanthanum-140 to be used as radiotracer for tracing the catalyst itself in catalyst regenerator of RFCCU. The radiotracer was monitored around the catalyst regenerator using collimated NaI scintillation detectors. The results of the experiments were used to diagnose the performance of the RFCCU.

• 방사선산업학회지
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• 제9권3호
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• pp.131-135
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• 2015

The flow characteristics of fluid were measured using radioactive tracer in pilot scale digester with tray motion mixer. In consideration of the detection volume of the detector and the size of the digester, 20 detectors were installed in the digester. The radioactive tracer eluted 8 mCi of $^{68}Ga$ from $^{68}Ge/^{68}Ga$ generator was injected into the digester bottom. After radiotracer injection, the flow pattern was measured on the basis of the initial movement of the tracer until its diffusion completely. Most of tracer moved to the wall along the bottom of the digester, and then rose along the wall. The other tracer moved up along the mixer, and then moved to the wall direction along the surface.

• 대한방사성의약품학회지
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• 제5권1호
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• pp.36-47
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• 2019

Hypoxia-inducible factor-1 ($HIF-1{\alpha}$) is a transcription factor activated in response to low oxygen level, and is highly expressed in many solid tumors. Moreover, $HIF-1{\alpha}$ is a representative biomarker of hypoxia and also helps to maintain cell homeostasis under hypoxic condition. Most solid tumors show hypoxia, which induces poor prognosis and resistance to conventional cancer therapies. Thus, early diagnosis of hypoxia with positron emission tomography (PET) radiotracer would be highly beneficial for management of malignant solid tumors with effective cancer therapy. YC-1 is a most promising candidate among several $HIF-1{\alpha}$ inhibitors. As an effort to develop a hypoxia imaging tool as a PET radiotracer, we designed and synthesized [$^{18}F$]DFYC based on potent derivative of YC-1 and performed preliminary in vitro cell uptake study. [$^{18}F$]DFYC showed a significant accumulation in SKBR-3 cells among other cancer cells, proving as a good lead to develop a hypoxic solid tumor such as breast cancer.

• 한국해안해양공학회지
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• 제16권3호
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• pp.162-170
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• 2004

산업공정의 가동 중 효율 및 문제점 진단을 위한 방사성동위원소 추적자 이용기술과 기반장비의 연구결과를 바탕으로 연안에서 표사의 거동 추적실험을 수행하였다. 이를 위하여 원자로에서 중성자 조사를 통하여 방사화되는 소량의 iridium을 포함하는 표지모래를 사용하였다. 표지모래는 산화물 제조법으로 제조되었으며, 실험 현지의 자연사(2.65)와 유사한 비중(=2.6)을 갖도록 하였다. 방사화된 표지모래를 운반하고 실험 현장에서 해저에 투입할 수 있도록 전용 용기와 투입된 표지모래로부터 방출되는 방사선을 검출하기 위한 계측장비를 제작하였다. 또한, GPS로부터 수신되는 위치신호와 해저의 계측장비로부터 전송되는 방사선 계측신호를 동시에 수신할 수 있는 데이터 수집장치와 컴퓨터 응용프로그램을 제작하였다. 표지모래의 시간에 따른 공간적 분포변화를 측정하기 위하여 각 투입지점에 대하여 3회씩 추적실험을 실시하였다. 실험 결과데이터는 방사선 계측의 실제 위치를 계산하여 반영하고 방사성추적자의 자연감쇄 효과를 보정한 후 분석에 활용되었다. 방사성 표지모래를 이용한 시범실험으로부터 방사성추적자 기술의 연안환경의 보존과 개발을 위한 중요한 역할의 가능성을 확인하였다.

• Journal of Radiation Protection and Research
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• 제32권3호
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• pp.117-122
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• 2007

지속적인 하수 발생량의 증가와 시설 부지비용의 상승효과로 인해 하수처리시설 중 가장 많은 면적을 차지하고 있는 침전조의 효율향상이 중요한 문제로 부각되고 있다. 본 연구에서는 선행연구로 수행한 최종 침전조 구조의 최적화를 위한 CFD(computational fluid dynamics) 모델링 결과를 실험적으로 검증하기 위해, 방사성추적자를 이용하여 정류벽 설치 유무에 따른 침전조 유동분포 변화를 측정하였다. 실제 하수처리장 침전조 설계제원을 바탕으로 수리학적 상사(1/21)를 고려하여 침전조 모형장치를 제작($L{\times}W{\times}H:2.6{\times}0.4{\times}0.2m$)하였으며, 방사성추적자로 Tc-99m 약 $30{\sim}40\;mCi$를 사용하였다. 실험결과, 최종 침전조 내부에 정류벽을 설치함으로써 바닥으로의 강한 밀도류와 출구 방향으로의 슬러지 휩쓸림 현상이 감소되었으며, 슬러지의 침전영역(settling zone)이 증가됨을 방사성추적자를 이용하여 성공적으로 가시화하여 확인하였다. 또한 정류벽 설치로 인하여 단락류가 전체 유출수에서 차지하는 부분이 48 %에서 32 %로 현저히 감소하고, 이의 슬러지 평균체재시간 또한 940 sec에서 810 sec로 감소되는 유동특성을 정량적으로 분석할 수 있었다 이는 선행연구로 실시한 CFD 모델을 이용 침전조 최적설계 조건도출 연구와 일치하는 결과로서, 방사성추적자 기술이 신규로 침전조를 설계할 때나 기존 시설의 성능개선을 위한 구조변경 후 이의 검증을 위해 중요한 자료로 활용될 수 있음을 확인하였다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2006년도 제45차 춘계학술대회
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• pp.29-35
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• 2006

• Toxicological Research
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• 제8권2호
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• pp.303-316
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• 1992