• Title/Summary/Keyword: Radioactive tracer

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Sequential Copolypeptides (Ⅲ). Synthesis and Characterization of Poly ($\gamma$-benzyl-L-glutamyl-$\gamma$-benzyl-L-glutamyl-glycine)

  • Choi, Sang-Up;Kang, Joon-Kil
    • Bulletin of the Korean Chemical Society
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    • v.1 no.3
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    • pp.78-82
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    • 1980
  • Solutions of $Cd^{2+}$, $Co^{2+}$ and $Ni^{2+}$ were mixed with the solutions of hydroxycarboxylic acids such as salicylic, lactic and mandelic acids in the presence of cation exchange resin at room temperature. The distribution ratios of the metal ions between resin and solution were measured, using radioactive metal ions as tracer. From the observed variation of the distribution ratios with the acid anion concentrations, it was concluded that $Cd^{2+}$, $Co^{2+}$ and $Ni^{2+}$ formed the one-to-one complexes with salicylate, lactate and mandelate ions in aqueous, 20 % ethanol-water and 20 % acetone-water solutions. The results of the present study indicated that the relative stabilities of the metal-acid complexes in solution increased in the order: $Cd^{2+}$ <$Co^{2+}$ <$Ni^{2+}$ complexes. Salicylate

Bilateral Inguinal Hernias Detected by Peritoneal Scintigraphy during the Evaluation of Scrotal Swelling in a Patient on Continuous Ambulatory Peritoneal Dialysis (지속적 복막 투석 환자의 음낭부종 검사시 복막 신티그라피에 의해 발견된 양측성 서혜부 탈장)

  • Lim, Seok-Tae;Sohn, Myung-Hee
    • The Korean Journal of Nuclear Medicine
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    • v.35 no.1
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    • pp.81-82
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    • 2001
  • A 47-year-old man with end-stage renal disease due to diabetic nephropathy underwent a peritoneal scintigraphy to evaluate the cause of recently developed scrotal swelling. Two liters of dialysate mixed with 111 MBq of Tc-99m sulfur colloid were administered into the peritoneal cavity via the dialysis catheter. Various anterior images of the abdomen and pelvis were obtained at 15 min, 2 hr and 4 hr after the tracer instillation. At 15 min, anterior images of the abdomen and pelvis demonstrated linear tracts of activity through both inguinal canals, which were more prominent in the right side (A). Images at 2 hr revealed a passage of the radioactive fluid into the right hemiscrotum. At the same time, there was a considerable accumulation of activity in the right inguinal canal (B). In the delayed image, there was a progressive accumulation of activity in the inguinal canals and a prominent passage of the tracer into the scrotum (C). Both abdominal and inguinal hernias are commonly associated with continuous ambulatory peritoneal dialysis (CAPD). Overall incidence of CAPD-induced hernia ranges from 2.7% to 25%.$^{1)}$ Inguinal hernias were frequently manifested as scrotal swelling. Leakages of dialysate fluid into the scrotum has been noted in CAPD patients with scrotal swelling, with or without clinical findings of inguinal hernia.$^{1,2)}$ In the present case, the right side had leakage from a clinical inguinal hernia and the left side, leakage from a subclinial inguinal hernia. A subclinical inguinal hernia was easily demonstrable with peritoneal scintigraphy. Peritoneal scintigraphy is extremely helpful in the evaluation of scrotal swelling in a patient on CAPD.

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Flow Characteristics Analysis of the Decontamination Device with Mixing and Diffusion Using Radio-Isotopes Tracer (방사성 동위원소를 이용한 제염제 혼합확산장치의 유동특성분석)

  • Oh, Daemin;Kang, Sungwon;Kim, Youngsug;Jung, Sunghee;Moon, Jinho;Park, Jangguen
    • Journal of Korean Society of Environmental Engineers
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    • v.39 no.5
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    • pp.282-287
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    • 2017
  • The purpose of this study was predicted the effects of mixing and diffusion due to the operation of the apparatus before the development of the mixed diffusion device for the decontamination absorbent to minimize the influence of contaminant inflow due to radiation accident. The tracer used for the flow characteristics was $^{68}Ga$, $^{99m}Tc$, which is a radioactive isotope, and 2 inch NaI radiation detector was used to detect it. The impeller of the decontamination mixed diffusion system applied to this study was made into three types and the mixing diffusion effect was compared. As a result of analyzing the flow characteristics of the radio-isotope with decontamination mixed diffusion device, mixing, diffusion and flow pattern were obtained. The radial mixing type impeller was able to diffuse to the water surface by the upflow flow, and the fin structure was adjusted for finding optimal conditions. The model 3 type consists of a fin guiding part and an auxiliary fin so that the diffusion speed is higher than that of other types of impellers. It also showed a short time to reach complete mixing.

Analysis of $^{99}Tc$ and Its Activity Level in the Korean Soil (한국 토양의 $^{99}Tc$ 분석 및 방사능 농도 준위)

  • Lee, Chang-Woo;Chung, Kun-Ho;Cho, Young-Hyun;Kang, Mun-Ja;Lee, Wan-No;Kim, Hee-Reyoung;Choi, Geun-Sik
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.7 no.1
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    • pp.25-31
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    • 2009
  • An analytical method of $^{99}Tc$ concentration in soil was set up and discussed considering the $^{99}Tc$ concentration in Korean soil measured with its analytical method. A selective TEVA resin was used to separate and purify the $^{99}Tc$ in the soil sample. $^{99m}Tc$ from a commercial $^{99}Mo/^{99m}Tc$ generator was used as a yield tracer for the chemical separation of $^{99}Tc$ and its problem when using $^{99m}Tc$ as a tracer was discussed. The chemical recovery yield of $^{99}Tc$ was above 70%. The optimum conditions of inductively coupled plasma mass spectrometry system(ICP-MS) were set up to determine the $^{99}Tc$ after the separation process. The minimum detectable activity(MDA) was 15 mBq/kg-dry in this analytical procedure. The $^{99}Tc$ concentration in soils of Jeju and Kori were measured in the rage of 33.73-89.16 mBq/kg-dry. Those values were less than those reported in other countries and seemed to be originated from atmospheric fallout.

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Spectrophotometric Determination of Iridium After Extraction of the Stannous-Chloro Complex by High Molecular Weight Amine (고분자량 아민에 의한 이리듐 제1염화주석 착물에 추출 및 분광광도법에 의한 이리듐의 정량법)

  • Kang Hyung Kun;Koo Soon Chung
    • Journal of the Korean Chemical Society
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    • v.19 no.5
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    • pp.343-350
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    • 1975
  • About 20${\sim}$100${\mu}g$ iridium have been extracted quantitatively as stannous-chloro Complex from aqueous solution by Alamine-336, a high molecular weight tertiary amine, dissolved in benzene. The extractability was confirmed by radioactive tracer of iridium-192. The spectrophotometric measurements of the extracted species at 322.5 nm indicate the feasibility of this method to be used as an analytical procedure for the determination of micro amount of iridium. An anion model of stannous-chloro complex of iridium has been postulated to account for the extraction mechanism.

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AN ELECTRON MICROSCOPIC RADIOAUTOGRAPHIC STUDY OF PROTEIN SYNTHESIS IN VITRO IN THE PALATAL MUCOSA OF THE RAT

  • KIM Hyun Joo
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.17 no.1
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    • pp.51-87
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    • 1987
  • The incorporation of ³H-proline by epithelial and connective tissue elements of rat palatal mucosae was studied in order to investigate the relative levels of protein synthesis by the epithelium and underlying connective tissue cells. Following a sixty minutes incorporation of the radioactive tracer in vitro, it was found that the suprabasal cells had most grains per unit area. Furthermore, the grains were more concentrated over the cytoplasm than the nucleus. This was in contrast with the labeling of basal cells which had twice as many grains over the nucleoplasm than that over the cytoplasm. In intermediate cells; i.e., the spinous layer, the number of silver grains per unit area was decreased from that of the suprabasal cells. In areas where desmosomes were more prominent, many grains were in touch with such desmosomes. However, the labeling appeared to be reduced as soon as the cells became flattened. Moreover, the epidermal keratohyalin granules were relatively free of grains. Except for certain intercellular surfaces the keratinized cells were generally free of grains. On the connective tissue side, silver grains were primarily localized over the fibroblasts with occasional grains being found over palatal muscle cells, neural elements and so on. Most grains over collagenous fibers were found in relation to mature collagen fibrils. Thus, protein synthesis in isolated mucosae of the rat palate appeared to take place both in epithelial and connective elements. There were no apparent tissue alterations caused by the in vitro incorporation procedure utilized under conditions of this study.

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AN ELECTRON MICROSCOPIC, RADIOAUTOGRAPHIC STUDY OF ERYTHROPOIESIS IN VITRO

  • MYUNG No Chul
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.17 no.1
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    • pp.27-49
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    • 1987
  • Using ³H-proline as a radioactive tracer, the relationship between the ultrastructural differentiation and the site of protein synthesis has been investigated in developing red blood corpuscles. The general ultra-structure of erythropoietic cells in differentiation after 60 minutes of in vitro labeling has confirmed the results from previous investigations by Bessis, M., Thiery, J. and others. In dividing nuclei more than two-thirds of the labeling were present at the interface between heterochromatin and euchromatin. In less differentiated cells most of the grains in interphase cells was localized over the nucleus. As the cells continued to develope beyond a stage where cytoplasmic density was clearly increased over other cell lines in bone marrow, the majority of grains localized over the cytoplasmic area was decreased in more mature cells, as judged by the density of cytoplasm, and the structural changes in mitochondria, Golgi complex and polysomal configurations. These results show; 1) that the cytoplasm of erythroblast series does not change under in vitro conditions employed in the study; 2) that protein synthesis in the nucleus occurs largely at the interface between euchromatin and heterochromatin in active nuclei; and 3) that cytoplasmic synthesis of proteins continues to take place well into the normoblast stage solong as the physically visible polysomes are present in maturing red blood corpuscles.

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Uncertainty Evaluation of the Estimated Release Rate for the Atmospheric Pollutant Using Monte Carlo Method (Monte Carlo 방법을 이용한 대기오염 배출률 예측의 불확실성 평가)

  • Jeong, Hyo-Joon;Kim, Eun-Han;Suh, Kyung-Suk;Hwang, Won-Tae;Han, Moon-Hee
    • Journal of Environmental Science International
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    • v.15 no.4
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    • pp.319-324
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    • 2006
  • Release rate is one of the important items for the environmental impact assessment caused by radioactive materials in case of an accidental release from the nuclear facilities. In this study, the uncertainty of the estimated release rate is evaluated using Monte Carlo method. Gaussian plume model and linear programming are used for estimating the release rate of a source material. Tracer experiment is performed at the Yeoung-Kwang nuclear site to understand the dispersion characteristics. The optimized release rate was 1.56 times rather than the released source as a result of the linear programming to minimize the sum of square errors between the observed concentrations of the experiment and the calculated ones using Gaussian plume model. In the mean time, 95% confidence interval of the estimated release rate was from 1.41 to 2.53 times compared with the released rate as a result of the Monte Carlo simulation considering input variations of the Gaussian plume model. We confirm that this kind of the uncertainty evaluation for the source rate can support decision making appropriately in case of the radiological emergencies.

False-positive I-131 Uptake in Meningioma (갑상선암 환자에서 관찰된 뇌수막종의 위양성 옥소 섭취)

  • Jeong, Shin-Young;Seo, Ji-Hyoung;Bae, Jin-Ho;Hwang, Jeong-Hyun;Ahn, Byeong-Cheol;Lee, Jae-Tae;Lee, Kyu-Bo
    • The Korean Journal of Nuclear Medicine
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    • v.38 no.3
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    • pp.272-273
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    • 2004
  • We experienced a case with meningioma showing false positive I-131 uptake. A 55-years old female patient underwent high dose (150 mCi) radioactive iodine therapy to ablate remnant tissue after total thyroidectomy for papillary thyroid cancer. in addition to intense tracer uptake in thyroid bed, there was mild but focal abnormal uptake in left frontal lobe of the brain on post-therapy I-131 whole body scan. Subsequent brain MR imaging showed single mass lesion in left frontal lobe and the mass was resected under the impression of brain metastasis of thyroid carcinoma. Pathologic report confirmed meningioma from the surgical specimen.

Infarction of Renal Transplant with Extrarenal Excretion of Tc-99m $MAG_3$ Demonstrated by Renal Scintigraphy (Tc-99m $MAG_3$ 신장스캔에서 신외 배설과 함께 발견된 이식신 경색)

  • Lim, Seok-Tae;Kim, Min-Woo;Sohn, Myung-Hee
    • The Korean Journal of Nuclear Medicine
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    • v.37 no.3
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    • pp.199-201
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    • 2003
  • A 38-year-old woman with end stage renal disease received a living related donor-renal transplant to the right iliac fossa. She developed anuria a week later Tc-99m $MAG_3$ renal scintigraphy demonstrated no perfusion, uptake, or excretion of the radioactive tracer from the renal transplant. The expected area of the renal allograft appeared as a photopenic area with increased rim activity. The gallbladder and bowel activities were observed on delayed images at 24 hours. There was no blood flow within the renal artery on renal doppler examination. This case shows total absence of perfusion and function in the infarcted renal transplant with extrarenal excretion of Tc-99m $MAG_3$ caused by acute renal artery thrombosis.