• Journal of Ginseng Research
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• v.15 no.2
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• pp.112-116
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• 1991

The metabolic fate of ginsenosides including gastrointestinat absorption, organ distribution, excretion and metabolism in liver was investigated by tracer studies using the radio-labeled ginsenosides. 3H-ginsenosides were shown to be absorbed from the mouse digestive tract and then to be excreted rapidly into urine and/or bile. Bile juice was concluded to play a significant role in absorption of ginsenosides. The total concentration of radioactivity persisted in tissues 24 hrs after oral administration was less than 1.3% of the administered dose and Rbl showed the highest value. The concentrations of radioactivity were relatively high in the liver and kidney. After administration of Rbl radioactivity was detected in the brain. After oral administration of 8H-ginsenosides, major component excreted into urine was found to be the intact ginsenosides and decomposed and/or metabolized products were found in GIT in the case of Rbl. 3H-ginsenoside Rbl was shown to be metabolized in the liver and the metabolite was suggested to be an acylated compound of Rbl by a certain organic acid.

• Nuclear Engineering and Technology
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• v.4 no.3
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• pp.229-240
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• 1972

Radioisotopes and their related techniques have recently been applied for scientific conservation works of cultural property and resulted many excellent findings or conservation data which could never be achieved by means of other techniques. Radiocarbon dating have widely been applied for dating the antique of organic origin, whereas the determination of radioactive contents in metal, ceramics, environmental soil, and classical objects could be able to afford many useful informations on the age, genuiness, and archeological significances as it had been produced. Trace quantity of contents of each antique have successfully been analyzed by means of radioactivation analysis or radio active tracer techniques, which could afford important technical data and results for tile conservation of each object. Radiography have also been applied for detecting the internal defects of metal objects and furthermore $\beta$-and ${\gamma}$-ray radiography were proved to be effective for such thin material as textile, painting, and fibres. In this article the detailed principle and procedures of each technique were presented so that the society could be able to make efforts to familiarize all concerns with these modern trends of the conservation techniques of cultural property.

• Transactions of the Korean Society of Automotive Engineers
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• v.7 no.5
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• pp.81-88
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• 1999

In order to understand the relationship between the phase angle of piston ring and oil consumption was measured by analyzing $CO_2$concentration in exhaust gas. The use of hydrogen fuel not gasoline makes this possible because all of the carbon component in exhaust gas can be assumed to be produced from oil. As a result of experiment, it is known that the oil consumption varies periodically and a specific location of ring end gap was found at each peak of oil consumption. Therefore, it was found that the oil consumption was not constant even at the same operating conditions and this is because the relative locations of top and 2'nd ring end gap change arbitrarily.

• Journal of The Korean Astronomical Society
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• v.52 no.3
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• pp.83-88
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• 2019

Using ALMA observations of the $^{13}CN$ and DCN lines in the massive star-forming region G33.92+0.11A, we investigate the CN/HCN abundance ratio, which serves as a tracer of photodissociation chemistry, over the whole observed region. Even considering the uncertainties in calculating the abundance ratio, we find high ratios (${\gg}1$) in large parts of the source, especially in the outer regions of star-forming clumps A1, A2, and A5. Regions with high CN/HCN ratios coincide with the inflows of accreted gas suggested by Liu et al. (2015). We conclude that we found strong evidence for interaction between the dense gas clumps and the accreted ambient gas which may have sequentially triggered the star formation in these clumps.

• Biomedical Engineering Letters
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• v.8 no.4
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• pp.383-392
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• 2018

For prompt gamma ray imaging for biomedical applications and environmental radiation monitoring, we propose herein a multiple-scattering Compton camera (MSCC). MSCC consists of three or more semiconductor layers with good energy resolution, and has potential for simultaneous detection and differentiation of multiple radio-isotopes based on the measured energies, as well as three-dimensional (3D) imaging of the radio-isotope distribution. In this study, we developed an analytic simulator and a 3D image generator for a MSCC, including the physical models of the radiation source emission and detection processes that can be utilized for geometry and performance prediction prior to the construction of a real system. The analytic simulator for a MSCC records coincidence detections of successive interactions in multiple detector layers. In the successive interaction processes, the emission direction of the incident gamma ray, the scattering angle, and the changed traveling path after the Compton scattering interaction in each detector, were determined by a conical surface uniform random number generator (RNG), and by a Klein-Nishina RNG. The 3D image generator has two functions: the recovery of the initial source energy spectrum and the 3D spatial distribution of the source. We evaluated the analytic simulator and image generator with two different energetic point radiation sources (Cs-137 and Co-60) and with an MSCC comprising three detector layers. The recovered initial energies of the incident radiations were well differentiated from the generated MSCC events. Correspondingly, we could obtain a multi-tracer image that combined the two differentiated images. The developed analytic simulator in this study emulated the randomness of the detection process of a multiple-scattering Compton camera, including the inherent degradation factors of the detectors, such as the limited spatial and energy resolutions. The Doppler-broadening effect owing to the momentum distribution of electrons in Compton scattering was not considered in the detection process because most interested isotopes for biomedical and environmental applications have high energies that are less sensitive to Doppler broadening. The analytic simulator and image generator for MSCC can be utilized to determine the optimal geometrical parameters, such as the distances between detectors and detector size, thus affecting the imaging performance of the Compton camera prior to the development of a real system.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.2
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• pp.172-180
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• 2008

PET/CT fused image with anatomical and functional information have improved medical diagnosis and interpretation. This fusion has resulted in more precise localization and characterization of sites of radio-tracer uptake. However, a motion during whole-body imaging has been recognized as a source of image quality degradation and reduced the quantitative accuracy of PET/CT study. The respiratory motion problem is more challenging in combined PET/CT imaging. In combined PET/CT, CT is used to localize tumors and to correct for attenuation in the PET images. An accurate spatial registration of PET and CT image sets is a prerequisite for accurate diagnosis and SUV measurement. Correcting for the spatial mismatch caused by motion represents a particular challenge for the requisite registration accuracy as a result of differences in PET/CT image. This paper provides a brief summary of the materials and methods involved in multiple investigations of the correction for respiratory motion in PET/CT imaging, with the goal of improving image quality and quantitative accuracy.

• Nuclear Engineering and Technology
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• v.45 no.1
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• pp.61-66
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• 2013

Among the radioactive wastes generated from the nuclear power plant, a radioactive nuclide such as $^{129}I$ is classified as a difficult-to-measure (DTM) nuclide, owing to its low specific activity. Therefore, the establishment of an analytical procedure, including a chemical separation for $^{129}I$ as a representative DTM, becomes essential. In this report, the adsorption and recovery rate were measured by adding $^{125}I$ as a radio-isotopic tracer ($t_{1/2}$ = 60.14 d) to the simulation sample, in order to measure the activity concentration of $^{129}I$ in a pressurized-water reactor primary coolant. The optimum condition for the maximum recovery yield of iodine on the anion exchange resins (AG1 x2, 50-100 mesh, $Cl^-$ form) was found to be at pH 7. In this report, the effect of the boron content in a pressurized-water reactor primary coolant on the separation process of $^{129}I$ was examined, as was the effect of $^3H$ on the measurement of the activity of iodine. As a result, no influence of the boron content and of the simultaneous $^3H$ presence was found with activity concentrations of $^3H$ lower than 50 Bq/mL, and with a boron concentration of less than 2,000 ${\mu}g/mL$.

• Journal of Korean Neurosurgical Society
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• v.30 no.11
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• pp.1320-1323
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• 2001

SAPHO syndrome is an acronym for an increasingly recognized syndrome of synovitis, acne, pustulosis, hyperostosis, and osteitis. Most of the previously reported case are from Japan and Europe. The authors report a case of SAPHO syndrome in Korean female who presented with extrasternal neurologic symptoms. A 60-year-old female with thoracic and right chest wall pain presented with the sternocostoclavicular hyperostosis, and recurrent aseptic osteitis. Previously, she had hystrectomy and thyroidectomy due to uterine malignancy 25 years ago. Also, she started to take medications for palm and sole pustulosis 7 days prior to admission. Through evaluation of clinical, radiological, serological studies, studies was done along with bone needle biopsy for the biological reassessment. The hyperostosis was found in the pedicles of thoracic 8, 9, 10 vertebrae and sternoclavicular joint. Radio-isotope bone scan showed an accumulation of tracer in thoracic vertebra. The bone biopsy from these site showed increased osseous turnover, thickening of trabeculae accompanied by mild acculuation of granulation tissue and round cell infiltration, compatible with mild chronic inflammation with marrow fibrosis. The patient showed good response to conservative management. The authors report a case of SAPHO syndrome with thoracic radiculopathy. It is considered that SAPHO syndrome is related to spondyloarthropathy, and appears to have benign disease process with good prognosis.

• Journal of Gastric Cancer
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• v.11 no.1
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• pp.38-45
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• 2011

Purpose: Bone metastasis from stomach cancer occurs only rarely and it is known to have a very poor prognosis. This study examined the clinical characteristics and prognosis of patients who were diagnosed with stomach cancer and bone metastasis. Materials and Methods: The subjects were 19 patients who were diagnosed with stomach cancer at Hanyang University Medical Center from June 1992 to August 2010 and they also had bone metastasis. The survival rate according to many clinicopathologic factors was retrospectively analyzed. Results: 11 patients out of 18 patients (61%) who received an operation were in stage IV and the most common bone metastasis location was the spine. Bone scintigraphy was mostly used for diagnosing bone metastasis and PET-CT and magnetic resonance imaging were used singly or together. The serum alkaline phosphatase at the time of diagnosis had increased in 12 cases and there were clinical symptoms (bone pain) in 16 cases. Treatment was given to 14 cases and it was mostly radiotherapy. There were 2 cases of discovering bone metastasis at the time of diagnosing stomach cancer. The interval after operation to the time of diagnosing bone metastasis for the 18 cases that received a stomach cancer operation was on average $14.9{\pm}17.3$ months and the period until death after the diagnosis of bone metastasis was on average $3.8{\pm}2.6$ months. As a result of univariate survival rate analysis, the group that was treated for bone metastasis had a significantly better survival period when the bone metastasis was singular rather than multiple, as compared to the non-treatment group, yet both factors were not independent prognosis factors on multivariate survival analysis. Conclusions: An examination to confirm the status of bone metastasis when conducting a radio-tracer test after the initial diagnosis and also after an operation is needed for stomach cancer patients, and bone scintigraphy is the most helpfully modality. Making the diagnosis at the early stage and suitable treatments are expected to enhance the survival rate and improve the quality of life even for the patients with bone metastasis.

• Nuclear Engineering and Technology
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• v.27 no.5
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• pp.767-774
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• 1995

Behavior of radionuclides such $^{60}$ Co, $^{54}$ Mn and $^{137}$ Cs in the incineration Process was Studied by trial burns of simulated wastes with radio-isotope tracers. Behavior of nonvolatiles, $^{60}$ Co and $^{54}$ Mn, was similar to that of particulate matters in the process. Decontamination factors(DFs) for $^{60}$ Co and $^{54}$ Mn were 4.7$\times$10$^{5}$ and 6.2$\times$10$^{5}$ , respectively. Behavior of semivolatile radio-isotope, $^{137}$ Cs, was temperature dependent. DFs for $^{l37}$Cs at In different incineration temperature of 85$0^{\circ}C$ and $700^{\circ}C$ were 2.8$\times$10$^3$ and 2.6$\times$10$^4$, respectively. Trial bums of dry active waste(DAW) transported from nuclear power station(NPS) Kori 3,4 were also performed. DF for gross $\beta$/${\gamma}$ radioactivity in DAW was 1.1$\times$10$^{5}$ . This was a little higher than the estimated value, which was calculated from the tracer test results and nuclides distribution in the DAW. Average emission concentration was 0.019 Bq/N $m^3$, which could meet the maximal permissible concentration(MPC) in stack emission.n.