• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.399-400
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• 2013

• Biomedical Science Letters
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• v.19 no.2
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• pp.98-104
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• 2013

Radiation is one of the major therapy for the removal of cancer cells. The results of the radiation therapy depend on the radio-resistance of cancer cells. For the effective treatment in these radio-resistant cancers, the use of chemicals that act on cancer cells is known to enhance the cytotoxic effects of radiation therapy. In this study, I investigated the effect of potassium cyanate (KCN) on the irradiated-colorectal cancer cell line, HCT 116 cells. KCN induces the carbamylation of proteins and can change the biological activity of various human cells. To understand the effect of KCN on the radiosensitivity of HCT 116 cells, I examined alteration of the cell cycle, generation of reactive oxygen species (ROS), cell viability, apoptosis and intracellular signaling proteins in the irradiated cells with/without KCN treatment. Combination treatment caused significant increase in sub $G_0/G_1$ and ROS generation in HCT 116 cells. KCN inhibited the proliferation and cell viability in irradiated HCT 116 cells. KCN-induced apoptosis of irradiated cells was processed via the activation of caspase 3 and caspase 9. Apoptosis-associated signal proteins, including Bax and Bcl-2 were regulated by irradiation with KCN treatment. Taken together, these results may indicate that KCN enhances the radiosensitivity of radio-resistant cell and then has a synergistic effect on radiation therapy in colorectal cancer.

• Journal of Convergence Korean Medicine
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• v.1 no.1
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• pp.35-44
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• 2021

Objectives: The purpose of this study is to investigate the effect of ultrasound therapy on left knee pain and instability diagnosed with Baker's cyst in a 25-year-old male patient. Methods: Patient was treated with Radio frequency ablation treatment on left knee from Naeseulan (EX-LE4) to Wijoong (BL40). The effect of radio frequency ablation was assessed by Visual Analog Scale (VAS), Western Ontario and McMaster Universities (WOMAC) and Euro Qol-5 Dimension Index (EQ-5D Index). The treatment was executed one time a day everyday form May 28th to June 1st of 2020. Patient was observed from May 26th to June 1st. Results: After five sessions of radio frequency ablation, VAS of left posterior knee pain was improved while no improvement was discovered at left medial knee. In Korean WOMAC scale, only subscale of weight bearing and walking around plain were improved. EQ-5D did not show any improvement. Conclusion: The results suggest that radio frequency ablation treatment can be a valuable option in treating knee pain and daily living function. Further study seems to be needed based on long-term intervention.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.599-603
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• 2014

Background: Reproductive cancers are those that affect the human organs that are involved in producing offspring. An attempt is made in the present communication to assess the magnitude and pattern of reproductive cancers, including their treatment modalities, in India. The cancer incidence data related to reproductive cancers collected by five population-based urban registries, namely Bangalore, Bhopal, Chennai, Delhi and Mumbai, for the years 2006-08 were utilized. The reproductive cancers among females constituted around 25% of the total and around 9% among males. Among females, the three major contributors were cervix (55.5%), ovary (26.1%) and corpus uteri (12.4%). Similarly among males, the three major contributors were prostate (77.6%), penis (11.6%) and testis (10.5%). For females, the AAR of reproductive cancers varied between 30.5 in the registry of Mumbai to 37.3 in the registry of Delhi. In males, it ranged between 6.5 in the registry of Bhopal to 14.7 in the registry of Delhi. For both males and females, the individual reproductive cancer sites showed increasing trends with age. The leading treatment provided was: radio-therapy in combination with chemo-therapy for cancers of cervix (48.3%) and vagina (43.9%); surgery in combination with chemo-therapy (54.9%) for ovarian cancer; and surgery in combination with radio-therapy for the cancers of the corpus uteri (39.8%). In males, the leading treatment provided was hormone-therapy for prostate cancer (39.6%), surgery for penile cancer (81.3%) and surgery in combination with chemo-therapy for cancer of the testis (57.6%).

• Physical Therapy Korea
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• v.10 no.1
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• pp.15-27
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• 2003

Therapeutic ultrasound is commonly applied for deep heating in physical therapy setting. However, it is difficult to determine the exact application dosage and to confirm the immediate heating effect. Microwave Radio-Thermometer (MRT) can measure the temperature by the electromagnetic energy in the microwave region of the object that emits above absolute zero temperature. MRT was used for early diagnosis of breast cancer since it was not harmful, non-invasive, and non-ionizing to the human body. The purposes of this study were to investigate how accurately 1.1 GHz RTM (RES Ltd. Russia) measures the change of average temperature in the tissue, and to determine the depth of temperature change measurement. Therapeutic ultrasound was applied (continuous wave for 5 minutes, 1 MHz, intensity of 1.5 $W/cm^2$ [in vitro] and 1.0 $W/cm^2$ [in vivo]) in four different conditions: (1) 30 cases of in vitro specimen of pork, (2) 30 cases of in vitro specimen of pork ankle joint, (3) 10 cases of in vivo canine thigh, and (4) 30 cases of in vivo human body. Intraclass Correlation Coeffients (ICC[3,1]) between average needle probe thermometer below surface and MRT temperature was revealed as followed: (1) Before ultrasound application ICCs ranges above .8 in specimen of pork (15 mm underneath the skin) and above .82 in specimen of pork ankle joint (10~30 mm underneath the skin). (2) After ultrasound application ICCs ranges above .7 in both specimens of pork and pork ankle joint. (3) Before ultrasound application ICCs ranges above .8 in canine thigh (20 mm underneath the skin). (4) After ultrasound application ICCs ranges above .82 in canine thigh. The temperature of the human body increased significantly with the mean of $15^{\circ}C$ in muscle tissue and with the mean of $3.5^{\circ}C$ in joint (p<.00). It was revealed that the average depth of temperature measurement of the tissue by MRT was in between 10 and 35 mm, and determined that the proper temperature measurement band was $36.5{\sim}37.0^{\circ}C$.

• Physical Therapy Rehabilitation Science
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• v.11 no.4
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• pp.493-501
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• 2022

Objective: The purpose of this study is to present basic data for appropriate therapeutic intervention by confirming changes in the autonomic nervous system and pain by applying high-frequency deep diathermy to the lower abdomen in patients with primary dysmenorrhea. Design: A randomized controlled clinical trial. Methods: Thirty-eight women aged 18-50 years who complained of regular menstrual cycles (24-32 days) and primary dysmenorrhea symptoms were randomly assigned to a high-frequency therapy group (5, 7, or 9 mins) and a superficial heat therapy group (20 min). High frequency treatment group: The subject was in a supine position, and radio frequency was applied to the lower abdomen below the umbilicus. The radio frequency therapy device used in this study uses a 300 kHz capacitive electrode and a 500 kHz resistive electric transfer to deliver deep heat. Superficial heat treatment Group: Subjects applied a hot pack to the lower abdomen for 20 minutes while lying on their back. Evaluations were made of Heart rate variability and Visual Analogue Scale. Results: In subjects with menstrual pain, there was a significant difference in pain between the high-frequency therapy group and the superficial heat therapy group (p=0.026). However, there was no significant difference between the autonomic nervous system and the stress resistance (p>0.05). Conclusions: As a result of this study, high-frequencytreatment using radiofrequency was effective in relieving pain because it can penetrate deeper tissues than conventional hot packs using superficial heat. In particular, it was found that the optimum effect was obtained when high frequency was applied forfive-seven minutes.

• The Korean Nurse
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• v.10 no.4 s.54
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• pp.59-61
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• 1971

• BMB Reports
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• v.47 no.2
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• pp.51-59
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• 2014

Cellular senescence is a physiological process of irreversible cell-cycle arrest that contributes to various physiological and pathological processes of aging. Whereas replicative senescence is associated with telomere attrition after repeated cell division, stress-induced premature senescence occurs in response to aberrant oncogenic signaling, oxidative stress, and DNA damage which is independent of telomere dysfunction. Recent evidence indicates that cellular senescence provides a barrier to tumorigenesis and is a determinant of the outcome of cancer treatment. However, the senescence-associated secretory phenotype, which contributes to multiple facets of senescent cancer cells, may influence both cancer-inhibitory and cancer-promoting mechanisms of neighboring cells. Conventional treatments, such as chemo- and radiotherapies, preferentially induce premature senescence instead of apoptosis in the appropriate cellular context. In addition, treatment-induced premature senescence could compensate for resistance to apoptosis via alternative signaling pathways. Therefore, we believe that an intensive effort to understand cancer cell senescence could facilitate the development of novel therapeutic strategies for improving the efficacy of anticancer therapies. This review summarizes the current understanding of molecular mechanisms, functions, and clinical applications of cellular senescence for anticancer therapy.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.24 no.2
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• pp.451-457
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• 1994

Malignant fibrous histiocytoma(MFH) is relatively rare in the oro-maxillofacial region, particularly in the oral cavity. MFH usually arise in the extremities, the thigh being the most common site. The incidence of malignant fibrous histiocytoma in bones is rather low compared with that in soft tissues. MFH is predominant in the 40s and 50s. Histologically, the lesion are said to show high cellularity with fibrous stroma, cellular and nuclear pleomorphism, an admixture of fibroblast-like spindle cells which tend to be arranged in whorls or cartwheel or storiform patterns, rounded mononuclear cells and multinucleated giant cells. The cells frequently have abundant eosinophilic cytoplasm which has a foamy or vesicular appearance. Treatment consists of varying combinations of radiation therapy, chemotherapy, and surgery. We have observed a case of malignant fibrous histiocytoma occured in the right maxilla of 32-year-old woman.