• 한국식품영양과학회지
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• 제35권5호
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• pp.583-587
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• 2006

당 및 lysine 혹은 당-lysine 혼합모델 수용액에서 감마선 조사에 의한 갈변도 변화 및 화학적 특성을 연구한 결과 감마선 조사에 의한 비효소적 갈변반응은 당 및 아미노산 단독 환경에서는 일어나지 않았으며, 당-아민 환경에서 진행되는 것으로 나타났다. 당-lysine 혼합용액의 감마선 조사에 의한 갈변 반응성은 당의 종류에 따라 다르게 나타났으나, 당의 감소와 갈변도 사이의 상관관계는 없었다. 비환원당인 sucrose는 감마선 조사에 의해 환원력이 생성되었으며, 다른 당에 비해 높은 갈변 반응성을 나타냈다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2001년도 제40차 춘계학술대회 및 연수교육
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• pp.4-10
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• 2001

The radionuclide therapy is a protocol for tumor control by administering radionuclides as the cytotoxic agents. Radionuclides concentrated at the site of cancerous lesion are expected to kill the cancerous cells with minimal injury to the normal tissue. The efficacy of every radionuclide treatment can be evaluated by examining the toxicity to the lesion differentiated from that to the normal tissue. Radiation dosimetry is the procedure of quantitating the energy absorbed by target volumes of interest. Dosimetric information plays an indicator of the expected radiation damage and thus the therapeutic efficacy. This paper summarizes the dosimetric aspects in radionuclide therapy in terms of radionuclides of use, radiation dosimetry methodology and considerations for each treatment in practical use.

• 대한디지털의료영상학회논문지
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• 제12권1호
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• pp.59-64
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• 2010

We examined the accuracy and efficiency of phantom by applying the designed phantom in order to check daily quality assurance easily by objective criteria and to confirm daily quality assurance of linear accelerator, simulator, and CT-simulator. The results of 10 weeks of linear accelerator output dose using American Association of Physicists in Medicine(AAPM) daily quality assurance guide were measured within ${\pm}1%$ of error. Mechanical check of laser alignment, optical distance indicator(ODI), CT scanner laser and alignment of gantry lasers with the center of imaging plane were measured within ${\pm}1mm$. Daily average working time for daily quality assurance of radiation therapy equipments was 38 minutes. The designed phantom was easy to install and daily quality assurance was possible with only one installation. The aspects reproducibility and efficiency as well as accuracy of quality assurance were excellent.

• 한국농공학회지
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• 제45권3호
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• pp.84-93
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• 2003

Photoreactivation of microorganism following UV-disinfection is one of the research topics of interest in assessing the UV-disinfection performance. Apparent photoreactivation was examined under fluorescent lamp and solar radiation as well as in darkness. Total coliform, fecal coliform, and Escherichia coli were used as indicator microorganisms, and their concentration was monitored with time after UV-disinfection. Under the darkness, their initial concentration of 10∼30 MPN/100 mL increased to the level of 100 MPN/100 mL after 24 hours, which implied that part of damaged microorganisms by UV-disinfection might be repairable with time. Under the fluorescent lamp, photoreactivation was more apparent that their concentration increased up to 1,000 MPN/100 mL which might significantly impair the water uses specially in reuse of reclaimed wastewater. However, their concentration further decreased down to below 2 MPN/100 mL under the solar radiation primarily due to additional disinfection by solar radiation rather than photoreactivation. Samples not disinfected by UV-disinfection also demonstrated substantial decrease of their concentration under solar radiation from about 5,000 MPN/100 mL to less than 30 MPN/100 mL in 24 hours. But direct reuse of effluent without disinfection is not recommended because natural decay by solar radiation may take time and be affected by climatic conditions. The result suggests that photoreactivation of pathogenic microorganisms may not be concerned in agricultural reuse of reclaimed wastewater because solar radiation may provide further disinfection after UV-disinfection.

• 한국대기환경학회지
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• 제15권5호
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• pp.545-554
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• 1999

We would like to develop a short-term model to predict the time-related concentration of ozone whose reaction mechanism is complex. The paper targets Seoul where an ozone alert system has recently been employed. In order to develop a short-term prediction model for ozone, we suggested the Ozone Peak Indicator(OPI), an equivalent of the potential daily maximum ozone concentration, with precursors being the only limiting factor, and we calculated the Ozone Peak Indicarot as OPI={$rac{(O_3)_{max}cdot(H_{eH})_{max}(Rad)_{max}$ to preclude the influence of mixing height and solar radiation on the daily maximum ozone concentration. The OPI on the day of the prediction is to be calcultated by using the relation between OPI and the initial value of precursors. The basic prediction formula for time-related ozone concentration was established as $O_3(1)={(OPI)cdot Rad(t-2)H_{eH}}$, using the OPI, solar radiation two hours before prediction and mixing height. We developed, along with the basic formula for predicting photochemical oxidants, "SEOM"(Seoul Empirical Oxidants Model), a Fortran program that helps predict solar radiation and mixing height needed in the prediction of ozone pollution. When this model was applied to Seoul and an analysis of the correlation between the observed and the predicted ozone concentrations was made through SEOM, there appeared a very high correlation, with a coefficient of 0.815. SEOM can be described as a short-term prediction model for ozone concentration in large cities that takes into account the initial values of precursors, and changes in solar radiation and mixing height. SEOM can reflect the local characteristics of a particular and region can yield relatively good prediction results by a simple data input process.t process.

• 한국치위생학회지
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• 제9권2호
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• pp.111-124
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• 2009

This study analyzes through the review of literature and laws the exposure time, clinical frequency, and radiation exposure of intraoral and extraoral radiography as well as of panoramic radiography performed by dental hygienists in dental clinics, compares the dental radiology curriculums of radiological science and dental hygiene departments, and proposes the expansion of dental hygienists' radiography operations. The radiology curriculums were compared between the radiological science and dental hygiene departments of colleges. For new analysis by radiography for dental diagnosis, the exposure time, radiation absorbed dose, effective dose, and number of days of natural radiation were compared by the type of oral radiation films and radiographical techniques proposed by domestic and international studies. The exposure time of panoramic radiography is 15 seconds and it takes about two minutes for completion, whereas the exposure time of the standard radiography is 0.2~0.8 seconds and it takes 10 times longer for completion of the radiography of full mouth than the panoramic radiography. The standard radiography can cause distortions of radiation at severely curved parts of dental arch and palatopharyngeal reflex. However, panoramic radiography can be performed even for lock jaw patients, causes less inconvenience to patients and is much simpler than the standard radiography. The percentage of dental clinics where radiography is performed by dental hygienists was 92.0%, and the percentage of standard film radiography by dental hygienists was 98% whereas the percentage of panoramic radiography by dental hygienists was 92%. For the absorbed dose which is an indicator of radiation exposure, the When the effective dose which is an indicator of the danger of radiation exposure was converted to the number of days of natural radiation, it was 3.3 days for panoramic radiography, but 13.9 days for the full mouth standard radiography by bisecting angle technique which was 4.2 times longer than the panoramic radiography. There were two colleges that had a dental radiology course with two credits in the departments of radiological science. The credits for dental radiology courses in the department of dental hygiene ranged varied by college, ranging from 3 to 8; on average, the theory course was 2.2 credits and the practice course was 2.02 credits. To summarize the above results, the percentage of dental clinics where panoramic radiography is performed by dental hygienists under the guidance of dentists is high. Panoramic radiography has become an essential facility for dental clinics. It is faster than standard film radiography and less dangerous due to low radiation exposure. Panoramic radiography is a simple mechanical job that does not require training of oral radiography by radiotechnologist. Because panoramic radiography is one of major operations which must be performed at all times in dental clinics, it must be designated as intraoral technique rather than extraoral technique, or legalized for inclusion in the scope of operations of dental hygienists.

• Journal of Radiation Protection and Research
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• 제40권3호
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• pp.168-173
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• 2015

이 연구에서 후쿠시마 원전 폭발과 같은 사고 발생 시 방사선이나 방사성 핵종에 의한 생물학적 영향을 평가할 수 있는 야생 동물지표로서 성축 등줄쥐(A. a. coreae) 활용 가능성을 평가하였다. 이 연구를 위하여 야외 채집한 등줄쥐를 실험실에서 교배하고 생산된 새끼가 약 40주령이 되었을 때 털 색깔, 외부형태, 두개골, 치아 특성을 관찰하고 분류학적 특성을 정리하였다. 방사선에 대한 신체 반응도를 평가하기 위하여 방사선 조사(0, 0.5, 1, 2 Gy) 24시간 후에 장기무게를 관찰한 결과 흉선만이 감소하였다. 방사선에 민감한 장기 가운데 하나인 비장 세포고사는 선량에 비례하여 증가하였지만, 0.5 Gy 조사된 개체에서는 감소하였다. 앞으로 야생 등줄쥐 신체 장기별 방사선 민감도 차이를 세포 및 분자생물학적 수준에서 해석함으로써 방사선 피폭 사고시 신체영향을 평가할 수 있는 방법론 도출이 가능할 것이라 생각된다.

• 대한수의학회지
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• 제41권1호
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• pp.99-104
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• 2001

불의의 방사선 피폭 환자의 체내 방사선 피폭선량의 예측을 위한 방사선 생물학적 선량측정 개발의 일환으로 저선량 피폭환자의 체내 피폭선량 측정 지표로서의 미소핵 분석법 이용 가능성을 평가하기 위하여 코발트-60 감마선을 0.25 Gy에서 1 G의 선량을 인체 말초 혈액에 조사한 후 임파구내에 미소핵의 수적 변화를 형태학적으로 관찰하였다. 저선량에 피폭된 임파구에서 미소핵이 관찰되었으며, 선량에 따른 수적인 변화도 나타났다. 저선량 피폭에 대한 미소핵의 수적 변화에 대한 선량-반응 곡선은 $Y=(0.02{\pm}0.0009)+(0.033{\pm}0.010)D+(0.012{\pm}0.012)D^2$의 식을 얻었으며, linear quadratic model 이였다. 이상의 결과에서 미소핵의 발생 빈도와 피폭 선량간에 유의한 효과가 있는 것으로 확인되었다. 그리고 정상대조군에서는 세포당 $0.02{\pm}0.0009$개가 관찰되었다. 따라서 말초 임파구를 이용한 미소핵 분석법은 저선량 피폭환자의 체내 피폭선량 측정은 물론 방사선 방호제의 검색 및 방사선 민감도 검사를 위한 방사선 생물학적 지표로 이용 가능하며, 특히 이 방법은 간편하고 정확하며 재현성이 있는 방법으로 불의의 방사선 피폭 사고시 체내 피폭선량을 예측하는 좋은 지표로 사용되어질 수 있을 것으로 사료됨.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5889-5893
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• 2014

Over-expression of epidermal growth factor receptor (EGFR) has been identified as a common feature associated with clinical outcome in many types of cancer, including squamous cell carcinoma of the oesophagus (SCCO). However, the clinical importance of EGFR over-expression in SCCO remains unsettled as conflicting results exist. Therefore we carried out the present meta-analysis of published studies for clarification. A total of 13 studies including 1, 150 patients were enrolled. EGFR over-expression was positive in 722 of these cases. With EGFR over-expression, patients had higher depth of invasion, vascular invasion, and poor prognosis. However, expression had no relation with degree of differentiation, histological grade, lymph node metastasis, clinical stage or lymphatic invasion. EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients. Targeting therapy to EFGR should be considered to the combined treatment in SCCO.

• 천문학회보
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• 제40권1호
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• pp.46.2-46.2
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• 2015

Modern methods in determining the value of the Hubble constant are divided into two main ways: the classical distance ladder method and the inverse distance ladder method. The classical distance ladder method is based on Cepheid calibrated Type Ia supernovae (SNe Ia), which are known as powerful distance indicator. The inverse distance ladder method uses cosmic microwave background radiation, which emitted from the high-z universe, and the cosmological model. Recent estimations of the Hubble constant based on these two methods show a $2{\sim}3{\sigma}$ difference, which called the "Hubble tension". It is currently an issue in the modern cosmology. We have been working on the luminosity calibration of SNe Ia based on the Tip of the Red Giant Branch (TRGB), which is a precise population I distance indicator. We present the TRGB distance estimates of 5 SNe Ia host galaxies with the archival Hubble Space Telescope image data. We derive the mean absolute maximum magnitude of 5 SNe Ia and the value of the Hubble constant. Cosmological implications of our estimate will be discussed.