• Nuclear Engineering and Technology
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• 제54권12호
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• pp.4698-4707
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• 2022

As part of the ICRP Task Group 103 project, we developed ten thyroid models for the pediatric mesh-type reference computational phantoms (MRCPs). The thyroid is not only a radiosensitive target organ needed for effective dose calculation but an important source region particularly for radioactive iodines. The thyroid models for the pediatric MRCPs were constructed by converting those of the pediatric voxel-type reference computational phantoms (VRCPs) in ICRP Publication 143 to a high-quality mesh format, faithfully maintaining their original topology. At the same time, we improved several anatomical parameters of the thyroid models for the pediatric MRCPs, including the mass, overlying tissue thickness, location, and isthmus dimensions. Absorbed doses to the thyroid for the pediatric MRCPs for photon external exposures were calculated and compared with those of the pediatric VRCPs, finding that the differences between the MRCPs and VRCPs were not significant except for very low energies (<0.03 MeV). Specific absorbed fractions (target ⟵ thyroid) for photon internal exposures were also compared, where significant differences were frequently observed especially for the target organs/tissues close to the thyroid (e.g., a factor of ~1.2-~327 for the thymus as a target) due mainly to anatomical improvement of the MRCP thyroid models.

• Animal cells and systems
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• 제5권4호
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• pp.267-274
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• 2001

Calpains are a family of cysteine proteases existing primarily in two forms designated by the $Ca^{2+}$ concentration needed for activation in vitro, $\mu$-calpain (calpain-I) and m-calpain (calpain-II). The physiologica1 roles of calpains remain unclear. Many groups have proposed a role for calpains In apoptosis, but their patterns of activation are not well characterized. Calpains have been implicated in neutrophil apoptosis, glucocorticoid-induced thymocyte apoptosis, as well as many other apoptotic pathways. Calpain activation in apoptosis is usually linked upstream or downstream to caspase activation, or in a parallel pathway alongside caspase activation. Calpains have been suggested to be involved in DNA fragmentation (via endonuclease activation), but also as effector proteases that cleave cellular proteins involved in DNA repair, membrane associated proteins and other homeostatic regulatory proteins. Recently, our laboratory demonstrated $\mu$-calpain activation in NAD(P)H: quinone oxidoreducatse 1 (NQO1)-expressing cells after exposure to $\beta$-lapachone, a novel quinone and potential chemo- and radio-therapeutic agent. Increased cytosolic $Ca^{2+}$ in NQO1-expressing cells after $\beta$-lapachone exposures were shown to lead to $\mu$-calpain activation. In turn, $\mu$-calpain activation was important for substrate proteolysis and DNA fragmentation associated with apoptosis. Upon activation, $\mu$-calpain translocated to the nucleus where it could proteolytically cleave PARP and p53. We provided evidence that $\beta$-lapachone-induced, $\mu$-calpain stimulated, apoptosis did not involve any of the known caspases; known apoptotic caspases were not activated after $\beta$-lapachone treatment of NQO1-expressing cells, nor did caspase inhibitors have any effect on $\beta$-1apachone-induced cell death. Elucidation of processes by which $\beta$-1apachone-stimulated $\mu$-calpain activation and calpains ability to activate endonucleases and induce apoptosis independent of caspase activity will be needed to further develop/modulate $\beta$-lapachone for treatment of human cancers that over-express NQO1.

• Imaging Science in Dentistry
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• 제38권1호
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• pp.7-15
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• 2008

Purpose: This study provides comparative measurements of absorbed and effective doses for newly developed cone beam computed tomography (CT) in comparison with these doses for conventional CT. Materials and Methods: Thermoluminescent dosimeter rods (TLD rod: GR-200, Thermo Fisher Scientific Inc., Waltham, MA, USA) were placed at 25 sites throughout the layers of Male ART Head and Neck Phantom (Radiology Support Devices Inc., Long Beach, USA) for dosimetry. Implagraphy, DCT Pro (Vatech Co., Hwasung, Korea) units, SCT-6800TXL (Shimadzu Corp., Kyoto, Japan), and Crane x 3+(Soredex Orion Corp., Helsinki, Finland) were used for radiation exposures. Absorption doses were measured with Harshaw 3500TLD reader (Thermo Fisher Scientific Inc., Waltham, MA, USA). Radiation weighted doses and effective doses were measured and calculated by 2005 ICRP tissue weighting factors. Results: Absorbed doses in Rt. submandibular gland were 110.57 mGy for SCT 6800TXL (Implant), 24.56 mGy for SCT 6800TXL (3D), 22.39 mGy for Implagraphy 3, 7.19 mGy for DCT Pro, 5.96 mGy for Implagraphy 1, 0.70 mGy for Cranex 3+. Effective doses $(E_{2005draft)$ were 2.551 mSv for SCT 6800TXL (Implant), 1.272 mSv for SCT 6800TXL (3D), 0.598 mSv for Implagraphy 3, 0.428 mSv for DCT Pro and 0.146 mSv for Implagraphy 1. These are 108.6, 54.1, 25.5, 18.2 and 6.2 times greater than panoramic examination (Cranex 3+) doses (0.023mSv). Conclusion: Cone beam CT machines recently developed in Korea, showed lower effective doses than conventional CT. Cone beam CT provides a lower dose and cost alternative to conventional CT, promising to revolutionize the practice of oral and maxillofacial radiology.

• Nuclear Engineering and Technology
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• 제2권2호
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• pp.97-106
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• 1970

원자력연구, 개발, 응용 및 이용사업이 시작된지 10년이 된 오늘날, 방사선을 포함한 오염사고등이 수많이 일어났고(Tablet 참조) 이들 방사선 사고로 인하여 인체 및 시설, 기구등에 까지도 자그마한 피해나마 장해 및 손상을 주었을 것이다. 이들 방사선 사고 가운데 비교적 주요한 4건의 방사선 피폭을 포함한 신체오염 사고, 말하자면 1) Cobalt-60 gamma선으로 부터의 전신피폭사고 (130 rem), 2) iodine-131에 의한 실험실내의 표면오염사고(13 mrad/hr), 3) 기체상의 iodine-131로 인한 전신오염 사고(흡입때문에 갑상선에 집적된 방사능량: 0.36$\mu$Ci) 4) 치료용 Radium 선원의 누출로 인한 Capsule이 텅빈사고［3 mg(\ulcorner)］, 등에 대하여 발견하는 즉시 최대의 노력과 최소의 비용으로써 조사, 측정하고 아울러 사고의 확대를 줄이기 위하여 가능한 모든 조처를 취하였으며, 사고의 요인분석, 평가를 하였다.

• Safety and Health at Work
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• 제2권2호
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• pp.122-134
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• 2011

Objectives: Seven cases of malignant lymphohematopoietic (LHP) disorder were claimed to have developed from occupational exposure at two plants of a semiconductor company from 2007 to 2010. This study evaluated the possibility of exposure to carcinogenic agents for the cases. Methods: Clinical courses were reviewed with assessing possible exposure to carcinogenic agents related to LHP cancers. Chemicals used at six major semiconductor companies in Korea were reviewed. Airborne monitoring for chemicals, including benzene, was conducted and the ionizing radiation dose was measured from 2008 to 2010. Results: The latency of seven cases (five leukemiae, a Non-Hodgkin's lymphoma, and an aplastic anemia) ranged from 16 months to 15 years and 5 months. Most chemical measurements were at levels of less than 10% of the Korean Occupational Exposure Limit value. No carcinogens related to LHP cancers were used or detected. Complete-shielded radiation-generating devices were used, but the ionizing radiation doses were 0.20-0.22 uSv/hr (background level: 0.21 ${\mu}Sv/hr$). Airborne benzene was detected at 0.31 ppb when the detection limit was lowered as low as possible. Ethylene oxide and formaldehyde were not found in the cases' processes, while these two were determined to be among the 263 chemicals in the list that was used at the six semiconductor companies at levels lower than 0.1%. Exposures occurring before 2002 could not be assessed because of the lack of information. Conclusion: Considering the possibility of exposure to carcinogenic agents, we could not find any convincing evidence for occupational exposure in all investigated cases. However, further study is needed because the semiconductor industry is a newly developing one.

• Journal of Radiation Protection and Research
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• 제11권1호
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• pp.57-64
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• 1986

우라늄, 플루토늄 및 그 자핵종(子核種)으로부터 방출(放出)되는 저(低)에너지감마선(線) 또는 저(低)에너지영역(領域)의 X-선(線)스펙트럼으로부터의 필름배지 개인피폭선량해석(個人被曝線量解析) 및 평가(評價)에 필요(必要)한 기술자료(技術資料)를 제공(提供)하였다. 필름배지는 한국핵연료개발공단(韓國核燃料開發公團)(현(現) 한국(韓國)에너지연구소(硏究所))에서 개발(開發)한 것이며, 저(低)에너지표준선원(標準線源)은 방사선량강도(放射線量强度)의 손실(損失)을 최소(最少)로 유지(維持)하면서 가능(可能)한 한 X-선(線)스펙트럼폭(幅)을 금속(金屬)필터로 좁게 줄인 X-선(線)을 이용(利用)하였다. 그 결과(結果) 얻은 X-선(線)에너지는 49 keV, 154 keV 및 256 keV 이었으며, 이 값은 Kramer의 이론적계산결과(理論的計算結果)와 잘 일치(一致)하였다. 이들 에너지 군별(群別) X-선(線)의 필름광학밀도(光學密度)와 선량(線量)과의 관계(關係)는 Matrix 법(法)으로 해석(解析)하여 측정광학밀도(測定光學密度)로부터 저(低)에너지 X-선(線)의 개인피폭선량(個人被曝線量)을 직접(直接) 환산(換算)할 수 있게 되었다. 이 결과(結果)는 국내(國內) 방사선작업(放射線作業) 종사자(從事者)들의 개인피폭선량측정자료(個人被曝線量測定資料)의 균질성(均質性) 향상(向上)에 기여(寄與)하게 될 것이다.

• ALGAE
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• 제18권1호
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• pp.13-20
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• 2003

Two isolated Antarctic marine diatoms, Chaetoceros neogracile VanLandingham and Stellarima microtrias (Ehrenberg) Hasle and Sims were examined to show changes of growth and uptake rate of nitrate due to UV-B irradiance. Chlorophyll (chl) a concentration was regarded as the growth index of diatom. The diatoms were treated with UV-B radiation and cultured for 4 days under cool-white fluorescent light without UV-B radiation. Two levels of UV-B exposures were applies: 1 and 6 W $m^{-2}$. Durations of UV-B treatment were 20, 40 and 60 minutes under 6 W $m^{-2}$ and 1, 2, 3, 4 and 5 hrs under 1 W $m^{-2}$. The control groups were cultured at the same time without UV-B radiation. The growth rates of two diatoms decreased under 1 and 6 W $m^{-2}$ UV-B irradiances than that of control group. After 4 days, chl a concentrations of C. neogracile were increased more than 4 times from 133 μgo$l^{-1}$ to 632 μgo$l^{-1}$ in control group. However, the concentration of experimental groups under 1 W $m^{-2}$ UV-B were only increased from 139 μgo$l^{-1}$ to 421 μgo$l^{-1}$ during one hour and the chl a concentrations were decreased from 144 μgo$l^{-1}$ to 108 μgo$l^{-1}$ during five hour. Growth of diatom dramatically more decreased under 6 W $m^{-2}$ UV-B than 1 W $m^{-2}$ UV-B. The chl a concentration of experimental groups under 6 W $m^{-2}$ UV-B for one hour was only increased from 111 μgo$l^{-1}$ to 122 μgo$l^{-1}$. In the case of S. microtrias showed also similar pattern to C. neogracile by UV-B radiation. The uptake rates of nitrate by the two strains were decreased abruptly under 6 W $m^{-2}$ UV-B irradiances. When two strains were treated under 1 and 6 W $m^{-2}$ UV-B during one hour, the strains were only continued growth and uptake of nitrate under 1 W $m^{-2}$ UV-B. This experimental evidence shows that exposure to UV-B radiation especially to high irradiance of UV-B decreases diatom survival and causes lower decrease of nutrient concentrations by microalgae in Antarctic water. Furthermore, evidence suggests that microalgal communities confined to near-surface waters in Antarctica will be harmed by increased UV-B radiation, thereby altering the dynamics of Antarctic marine ecosystems.

• Journal of Radiation Protection and Research
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• 제30권4호
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• pp.185-196
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• 2005

의료 목적으로 X선 촬영이나 CT, PET과 같은 진단방사선 피폭은 불가피하지만 선진국에서 의료 방사선이 최대의 인공 피폭원을 구성하고 있고 또 빠르게 증가하는 경향에 있음을 고려하면 의료상 피폭의 특성이나 그 결과로 인한 환자 선량 크기를 이해하는 것은 매우 중요하다. 이에 2002년도를 기준으로 단위 진료행위별 선량과 국내 의료보험 통계자료를 결합하여 방사선 진료절차별 집단선량과 1인당 유효선량 평가하였다. 절차의 유효선량 값은 NRPB 보고서, ICRP 80, MIRDOSE3.1 및 우리가 독립적으로 산출한 자료들로부터 편집하였다. 평가 결과 연간 집단선량은 진단방사선 22880man-Sv, 핵의학 4560man-Sv로서 총 27440 man-Sv로 나타났으며 따라서 인구 4770만 명을 나눈 1인당 연평균 의료상 피폭선량은 0.58mSv였다. 이 집단선량은 2002년 16기의 원전을 가동한 우리나라의 직업상피폭 70man-Sv보다 크게 많다. 특히 CT 촬영만의 집단선량도 9960man-Sv에 이름은 주목할 일이다. 이 결과는 국가의 방사선방호 정책이 의료에서 환자선량 최적화에 보다 주목해야 함을 시사한다.

• 대한디지털의료영상학회논문지
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• 제11권1호
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• pp.15-20
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• 2009

Far reducing medical radiation exposure and managing patient doses, Entrance surface doses(ESDs) were measured at Diagnostic Radiology Department in ASAN medical center, also we determined and compared with the Diagnostic Reference Level(DRL) of some other countries. ESDs were measured far the most common types of X-ray procedures, such as chest PA, lumbar spine AP, lumbar spine lateral, Pelvis AP, Skull PA. ESDs were measured by Glass dosimeter and Unfors Xi meter. Those were applied collimation center of phantom's entrance skin surface. The results of ESDs were compared Glass dosimeter with Unfors Xi meter. Those were measured within 5% statistical difference. It seemed well agreement at two devices. In most cases ESDs measured far the different types of X ray procedures were found to be lower than the DRL of IAEA, but ESDs on chest PA, lumbar spine AP, lumbar spine lateral, Pelvis AP, Skull PA were proximity ar excesses at DRL of advanced country. Through this study, we need an investigation and improvement at present diagnostic radiology exam system. Also, radiologists make an effort to reduce patient dose and having a technical skill.

• 자원ㆍ환경경제연구
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• 제14권1호
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• pp.1-24
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• 2005

진술선호법 연구의 질을 좌우하는 결정적인 요소 중의 하나는 설문지 디자인이다. 본 연구는 Choice Experiments(속성가치선택법) 연구결과의 합리성을 제고함과 아울러 타당성을 검정하기 위한 기술적인 방법으로서 선택질문(choice questions)과 유사한 '예제'를 이용하는 방법에 관하여 논한다. 라돈(radon) 방사능 저감에 대한 지불의사 추정 사례를 이용하였다. 비합리적인 응답을 가려내기 위한 '예제' 디자인을 이용한 사례에서, 설문지 디자인에 관하여 논한 후 한다. 비합리적 응답의 색출 및 제거는 모형의 설명력 증대를 가져왔다. 한편 설문디자인의 영향을 직접적으로 받는 발산적(divergent) 타당성은 닻효과(anchoring effect) 검증을 중심으로 논하였다. 예제의 내용을 기술적으로 디자인하여 두 부차표본들을 만들고 이에 대한 추정모형들간의 동질성을 평가함으로써 닻효과를 검증하였다. 다양한 닻효과 검증 결과는 혼재되었다. 예제 디자인의 장단점에 대해서도 논하였다.