• Molecules and Cells
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• v.41 no.6
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• pp.562-574
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• 2018

The tazarotene-induced gene 1 (TIG1) protein is a retinoidinducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.18 no.6 s.121
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• pp.620-628
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• 2007

An H-sector horn antenna has a constant beam coverage characteristic and it can be useful for application to a wide band phased array antenna system. In this paper, we designed a broadband E-plane H-sector horn phased-array antenna, which has a 3:1 bandwidth and ${\pm}60^{\circ}$ beam steering capability. An H-sector hem antenna was designed to have $30{\sim}50^{\circ}$ half-power beam width in the principal H-plane. The active reflection coefficient including mutual coupling was calculated using a waveguide simulator, and the active reflection characteristic was improved by mutual coupling over wide frequency range. Using these results, an $8{\times}1$ H-sector phased array antenna was fabricated. The measurement results for the half-power beam width in the principal H-plane and the active reflection coefficient showed a good agreement with the simulation results. The peak-value pattern in the steered radiation beams also agreed well with the active element pattern. The measured active reflection coefficients within the beam steering range are mostly less than 0.3 over the 3:1 frequency range.

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.4
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• pp.463-470
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• 2014

Stealth technology of combat aircraft is most significant capability in recent air battlefield. As the detector of IR missiles is being developed, IR stealth capability which is evaluated by IR signature level become more important than it was in previous generation. Among IR signature of aircraft from various sources, aerodynamic heating dominates in long-wavelength IR spectrum of $8{\sim}12{\mu}m$. Skin temperature change by aerodynamic heating which is derived by effects of Mach number and structure. The 4th and 5th generation aircraft are selected for calculation of the skin temperature, and its height and velocity in numerical conditions are 10,000 m and Ma 0.9~1.9 respectively. Aircraft skin temperature is calculated by computing convection of fluid and conduction, convection and radiation of surface. As the aircraft accelerates to higher Mach number, maximum skin temperature increases more rapidly than average temperature and temperature distribution changes in more sharp, interactive ways. The 4th generation aircraft whose shape is more complex than that of the 5th generation aircraft have complicated temperature distribution. On the other hand, the 5th generation aircraft whose shape is relatively simple shows plain temperature distribution and lower skin temperature in terms of both average and maximum value.

• Journal of Microbiology and Biotechnology
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• v.29 no.9
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• pp.1349-1360
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• 2019

Chronic exposure to ultraviolet (UV) radiation, regarded as a major cause of extrinsic aging or photoaging characterized by wrinkle formation and skin dehydration, exerts adverse effects on skin by causing the overproduction of reactive oxygen species. Agastache rugosa Kuntze, known as Korean mint, possesses a wide spectrum of biological properties including anti-oxidation, anti-inflammation, and anti-atherosclerosis. Previous studies have reported that A. rugosa protected human keratinocytes against UVB irradiation by restoring the anti-oxidant defense system. However, the anti-photoaging effect of A. rugosa extract (ARE) in animal models has not yet been evaluated. ARE was orally administered to hairless mice at doses of 100 or 250 mg/kg/day along with UVB exposure for 12 weeks. ARE histologically improved UVB-induced wrinkle formation, epidermal thickening, erythema, and hyperpigmentation. In addition, ARE recovered skin moisture by improving skin hydration and transepidermal water loss (TEWL). Along with this, ARE increased hyaluronic acid levels by upregulating HA synthase genes. ARE markedly increased the density of collagen and the amounts of hydroxypoline via two pathways. First, ARE significantly downregulated the mRNA expression of matrix metalloproteinases responsible for collagen degradation by inactivating the mitogen-activated protein kinase/activator protein 1 pathway. Second, ARE stimulated the transforming growth factor beta/Smad signaling, consequently raising the mRNA levels of collagen-related genes. In addition, ARE not only increased the mRNA expression of anti-oxidant enzymes but also decreased inflammatory cytokines by blocking the protein expression of nuclear factor kappa B. Collectively, our findings suggest that A. rugosa may be a potential preventive and therapeutic agent for photoaging.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.33 no.6
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• pp.375-382
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• 2020

Owing to the rapid development of infrared guided weapon systems, the threat to aircraft survivability is constantly increasing, and research on infrared stealth technologies are being conducted to ensure aircraft survival. In this study, we analyze the minimum infrared signature of an aircraft according to its flight altitude by considering the characteristics of infrared guided missiles, which detect the contrast signature between the aircraft and background. We conducted computational fluid dynamics simulations for the convective coefficient, and heat transfer simulations were performed considering convection, conduction, and radiation for flight conditions. Thus, we obtained the surface temperature distribution of the aircraft and analyzed the aircraft infrared signature based on the flow characteristics around it. Furthermore, the optimum emissivity for the minimum infrared signature was derived, and the effect of the infrared signature was analyzed when this optimum emissivity was applied to the fuselage surface for each flight condition.

• Journal of Aerospace System Engineering
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• v.17 no.4
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• pp.110-117
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• 2023

In this paper, the optimal placement of the rotary wing's communication and navigation antennas was evaluated by measuring their performance through ground simulations and flight tests. To select the mounting position of the communication and navigation antenna on the helicopter, after considering the shape and characteristics of the airframe, the radiation patterns, coupling analysis, equipment operation profiles, and antenna type analysis were performed for the aircraft-mounted antenna. Based on the analysis results, a procedure for sequentially performing voltage standing wave ratio (VSWR) measurement and antenna pattern test was established through ground and flight tests of the antenna. The systematic performance measurement method and procedure proposed in this paper were verified through ground and flight tests of the Light Armed Helicopter (LAH) system.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.4
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• pp.341-350
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• 2015

Skin carrys out protective role against harmful outer environment assaults including ultraviolet radiation, heavy metals and oxides. Especially, ultraviolet-B (UVB) light causes inflammatory reactions in skin such as sun burn and erythma and stimulates melanin pigmentation. Furthermore, the influx of UVB into skin cells causes DNA damage in keratinocytes and dermal fibroblasts, inhibition of extracellular matrix (ECM) synthesis which leads to a decrease in elasticity of skin and wrinkle formation. It also damages dermal connective tissue and disrupts the skin barrier function. Prolonged exposure of human skin to UVB light is well known to trigger severe skin lesions such as cell death and carcinogenesis. Haloarcula vallismortis is a halophilic microorganism isolated from the Dead Sea, Its growth characteristics have not been studied in detail yet. It generally grows at salinity more than 10%, but the actual growth salinity usually ranges between 20 to 25%. Because H. vallismortis is found mainly in saltern or salt lakes, there could exist defense mechanisms against strong sunlight. One of them is generation of additional ATP using halorhodopsin which absorbs photons and produces energy by potential difference formed by opening the chloride ion channel. It often shows a color of pink or red because of their high content of carotenoid pigments and it is considered to act as a defense mechanism against intense UV irradiation. In this study, the anti-inflammatory effect of the halophilic microorganism, H. vallismortis, extract was investigated. It was found that H. vallismortis extract had protective effect on DNA damage induced by UV irradiation. These results suggest that the extract of halophilic bacterium, H. vallismortis could be used as a bio-sunscreen or natural sunscreen which ameliorate the harmful effects of UV light with its anti-inflammatory and DNA protective properties.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.3
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• pp.253-260
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• 2016

This paper proposes a planar Log-Periodic Dipole Array(LPDA) antenna with light-weight supporting structure for installing on an aircraft. The proposed antenna is designed by applying a planar skeleton supporting structure that has light-weight for an aircraft and is capable of withstanding structural vibration. The material of the planar skeleton supporting structure is a Polyether ether ketone(Peek) which has excellent characteristics on strength and temperature. The proposed antenna is fabricated by attaching the radiating elements of the LPDA on both sides of the supporting structure. The changed input impedance due to the dielectric material of the supporting structure was compensated for by controlling the distance and length of several radiating elements. The 10-dB return loss bandwidths of the designed planar LPDA antenna with light-weight supporting structure are obtained as 0.4~3.1 GHz(7.3:1) in the simulation and 0.41~3.5 GHz(8.2:1) in the measurement. The average gains in 0.5~3 GHz band are 6.77 dBi in the simulation and 6.55 dBi in the measurement. Therefore, we confirm that the designed antenna is appropriate to be installed on an aircraft due to its light-weight structure and wideband directional radiation characteristics.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.5 s.108
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• pp.476-482
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• 2006

In this paper, a multimode feed horn antenna is suggested for a high power microwave(HPM) antenna system. The proposed HPM feed horn antenna which is connected with a mode converter is located between source and reflector antenna. A multimode feed horn antenna which has reduced -25 dB beamwidth is designed and fabricated for miniaturization of reflector antenna because -25 dB beamwidth which is determined by considering spillover of feed horn antenna decides a size of reflector in case of HPM. As a result, feed system which uses the multimode feed horn antenna has high gain about 27 dBi and return loss is less than -22 dB at 10 GHz. The measured -25 dB beamwidths of the radiation pattern at vertical, horizontal-plane equal to $20.24^{\circ},\;28.92^{\circ}$ which is less than about $10^{\circ}$ beamwidth of conventional feed system. Thus the suggested feed hem antenna is suitable to feed horn for miniaturization of HPM antenna system.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.8
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• pp.640-647
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• 2014

Infrared signature of aircraft exhaust plume is the critical factor for aircraft survivability. To improve the military aircraft survivability, the accurate prediction of infrared signature for the propulsion system is needed. The numerical analysis of thermal fluid field for nozzle inflow, free stream flow, and plume region is conducted by using the in-house code. Weighted Sum of Gray Gases Model based on Narrow Band with regrouping is adopted to calculate the spectral infrared signature emitted from aircraft exhaust plume. The accuracy and reliability of the developed code are validated in the one-dimensional band model. It is found that the infrared radiant intensity is relatively more strong in the plume through the analysis, the results show the different characteristic of the spectral infrared signature along the temperature, the partial pressure, and the species distribution. The continuous spectral radiant intensity is shown near the nozzle exit due to the emission from the nozzle wall.