• International Journal of Concrete Structures and Materials
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• v.9 no.3
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• pp.337-343
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• 2015

Previous studies have shown that the drying shrinkage of recycled aggregate concrete (RAC) is greater than that of natural aggregate concrete (NAC). Drying shrinkage is the fundamental reason for the cracking of concrete, and tensile creep caused by the restraint of drying shrinkage plays a significant role in the cracking because it can relieve the tensile stress and results in the delay of cracking occurrence. However, up till now, all research has been focusing on the compressive creep of RAC. Therefore, in this study, a uniaxial restrained shrinkage cracking test was executed to investigate the tensile creep properties caused by the restraint of drying shrinkage of RAC. The mechanical properties, such as compressive strength, tensile splitting strength, and Young's modulus of RAC were also investigated in this study. The results confirmed that the tensile creep of RAC caused by the restraint of shrinkage was about 20-30 % larger than that of NAC.

• Computers and Concrete
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• v.16 no.4
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• pp.643-667
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• 2015

3-dimentional precast recycled aggregate concrete (RAC) finite element models were developed by means of the platform OpenSees to implement sophisticated nonlinear model subjected to seismic loads. Efforts were devoted to the dynamic responses (including dynamic characteristics, acceleration amplifications, displacements, story drifts) and capacity curve. In addition, this study extended the prediction on dynamic response of precast RAC model by parametric study of material properties that represent the replacement percentage of recycled coarse aggregate (RCA). Principles and assumptions that represent characteristics of precast structure and influence of the interface between head of column and cast-in-place (CIP) joint on the stiffness of the joints was put forward and validated by test results. The comparison between simulated and tested results of the precast RAC frame shows a good correlation with most of the relative errors about 25% in general. Therefore, the adopted assumptions and the platform OpenSees are a viable approach to simulate the dynamic response of precast frames made of RAC.

• BMB Reports
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• v.40 no.4
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• pp.562-570
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• 2007

Soluble or cell-bound IL-1 receptor accessory protein (IL-1RAcP) does not bind IL-1 but rather forms a complex with IL-1 and IL-1 receptor type I (IL-1RI) resulting in signal transduction. Synthetic peptides to various regions in the Ig-like domains of IL-1RAcP were used to produce antibodies and these antibodies were affinity-purified using the respective antigens. An anti-peptide-4 antibody which targets domain III inhibited 70% of IL-$1\beta$-induced productions of IL-6 and PGE2 from 3T3-L1 cells. Anti-peptide-2 or 3 also inhibited IL-1-induced IL-6 production by 30%. However, antipeptide-1 which is directed against domain I had no effect. The antibody was more effective against IL-$1\beta$ compared to IL-$1\alpha$. IL-1-induced IL-6 production was augmented by coincubation with PGE2. The COX inhibitor ibuprofen blocked IL-1-induced IL-6 and PGE2 production. These results confirm that IL-1RAcP is essential for IL-1 signaling and that increased production of IL-6 by IL-1 needs the co-induction of PGE2. However, the effect of PGE2 is independent of expressions of IL-1RI and IL-1RAcP. Our data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 complex by binding to epitopes on domain III of the IL-1RI created following IL-1 binding to the IL-1RI.

• Journal of the Korea Society for Simulation
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• v.17 no.3
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• pp.53-62
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• 2008

This paper proposes a new implementational model based on the security model of Oracle for Web ontology. Recently, several access control models using relational database security model for access control to Web ontology have been developing, and one of the most representative access control model is the RAC model. However, the RAC model is based on the standard security model, and thus it does not provide a implementational model for practical relational database management systems. In this paper, we propose an implementational model based on Oracle which is widely used and providing various security policies. This paper shows the implementation and experimental evaluation. Especially, the proposed model uses the VPD security model of Oracle and support high application and usability.

• Molecules and Cells
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• v.37 no.4
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• pp.314-321
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• 2014

CDK2 is a key regulator of cell cycle progression. In this study, we screened for miRNAs targeting CDK2 using a luciferase-3'-untranslated region reporter assay. Among 11 hit miRNAs, miR-509-3p reduced CDK2 protein levels and significantly inhibited cancer cell growth. Microarray, Western blotting, and luciferase reporter analyses revealed additional targets of miR-509-3p, including Rac1 and PIK3C2A. Overexpression of miR-509-3p induced G1 cell-cycle arrest and inhibited colony formation and migration. RNAi experiments indicated that the growth-inhibitory effects of miR-509-3p may occur through down-regulation of CDK2, Rac1, and PIK3C2A. Targeting of multiple growth regulatory genes by miR-509-3p may contribute to effective anti-cancer therapy.

• Journal of Power System Engineering
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• v.16 no.3
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• pp.29-36
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• 2012

The computational flow analysis using LES technique was introduced to investigate the flow field improvement of an indoor RAC chassis consisting of a rear-guider, a stabilizer and a cross-flow fan. This unsteady three-dimensional numerical analysis was carried out by the commercial SC/Tetra software. The edge blocks were adopted in this study as a tool for the flow field improvement of an indoor RAC. In view of the results so far achieved, the edge blocks cause the center of an eccentric vortex to be stable along all length of a cross-flow fan, and then, the static pressure and the velocity vector show a stable distributions. In consequence, because the edge blocks eliminate a reverse flow near the edges, an exhausting flow becomes to be stable and uniform.

• Journal of the Korean Chemical Society
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• v.31 no.2
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• pp.168-177
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• 1987

The equilibria of chemical reaction between $\alpha$-Ni(rac-[14]-decane)$^{2+}$ and polar solvents(L; ANT, MFA, DMSO, DMF, and DMA) have been investigated by the spectrophotometric method at $25^{\circ}C$. (The equilibrium constants($K_1$) of) the first step in ANT, MFA, DMSO, DMF, and DMA were 31.0, 27.5, 21.3 15.9, and 6.4, respectively. The smallness of equilibrium constants ($K_2$) of the second step compared with $K_1$, was observed. $\alpha$-Ni(rac-[14]-dacane)$^{2+}$ + L $\leftrightharpoons$ [$\alpha$-Ni(rac-[14]-decane){\cdot}L]$^{2+}$ : $K_1$.[$\alpha$-Ni(rac-[14]-decane){\cdot}L)$^{2+}$+ L $\leftrightharpoons$ [$\alpha$-Ni(rac-[14]-decane){\cdot}$L_2$)$^{2+}$ :$K_2$. The relationship between d-d absorption energy and half-wave potential of complex ions at ACT was considered. Macrocyclic ligands increasing d-d transition energy caused half-wave potentials of Ni(II)-macrocycle to be shifted more positively. The half-wave potentials for Ni(rac-1[14]7-diene)$^{2+}$, Ni(meso-1[14]7-diene)$^{2+}$, Ni(1[14]4-diene)$^{2+}$, $\alpha$-Ni(rac-[14]-decane)$^{2+}$, ${\beta}-Ni(rac-[14]-decane)$^{2+}$, and Ni(meso-[14]-decane)$^{2+}$ reductions were -1.419, -1.431, -1.450, -1.473, and -1.480 (V vs. SCE), respectively. The d-d transition energies ($\nu_{max},\;cm^{-1}$) of the Ni(meso-[14]-decane)$^{2+}$ isomer were discussed with the dielectric constant (${\varepsilon}/{\varepsilon}_0$) of the various solvents, $\nu_{max}(cm^{-1})$ increased with increasing ${\varepsilon}/{\varepsilon}_0$.

• Polymer(Korea)
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• v.25 no.4
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• pp.468-475
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• 2001

For copolymerization of ethylene and norbornene initiated by various metallocene catalysts such as $rac-Et(Ind)_2ZrCl_2,\;rac-Me_2Si(Ind)_2ZrCl_2,\;rac-Me_2Si(Cp)_2ZrCl_2,\;and\;(n-BuCp)_2ZrCl_2$ with modified methylaluminoxane(MMAO) cocatalyst, the ${\alpha}$-olefins such as 1-hexene(H), 1-octene and 1-decene were added as a 3rd monomer. In this situation, the effects of the polymerization condition, the catalyst structure as well as the structure and the amount of added ${\alpha}$-olefin on the catalyst activity as well as the properties and structure of polymer were examined. As results, it was found that the catalyst activity and thermal property of polymer depended on not only catalyst structure but also ${\alpha}$-olefin structure. For $rac-Et(Ind)_2ZrCl_2/MMAO$ catalyst system, it was possible to get high activity and controllable $T_g$ of polymer. Among ${\alpha}$-olefins, H as a 3rd monomer exhibited the maximum enhancement in catalyst activity.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.144-144
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• 2003

• Molecules and Cells
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• v.26 no.4
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• pp.396-403
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• 2008

The first ORF of the ARV S1133 S1 segment encodes the nonstructural protein p10, which is responsible for the induction of cell syncytium formation. However, p10-dependent signaling during syncytium formation is fully unknown. Here, we show that dominant negative RhoA, Rho inhibitor C3 exoenzyme, ROCK/Rho-kinase inhibitor Y-27632 and Rac1 inhibitor NSC23766 inhibit p10-mediated cell fusion. p10 over-expression is concomitant with activation and membrane translocation of RhoA and Rac1, but not cdc42. RhoA and Rac1 downstream events, including JNK phosphorylation and transcription factor AP-1 and $NF-{\kappa}B$ activation, as well as MLC expression and phosphorylation are simultaneously activated by p10. p10 point mutant T13M possessed 20% fusion-inducing ability and four p10 fusion-deficient mutants V15M, V19M, C21S and L32A reduced or lost their ability to activate RhoA and Rac1 signaling. We conclude that p10-mediated syncytium formation proceeds by utilizing RhoA and Rac1-dependent signaling.