• Journal of Life Science
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• v.30 no.11
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• pp.939-946
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• 2020

Stroke is one of the leading causes of neurological disability worldwide and stroke patients exhibit a range of motor, cognitive, and psychiatric impairments. GPR88 is an orphan G protein-coupled receptor (GPCR) that is highly expressed in striatal medium spiny neurons; its deletion results in poor motor coordination and motor learning. There are currently no studies on the involvement of GPR88 in stroke or in post-stroke brain function recovery. In this study, we found a decrease in GPR88 protein and mRNA expression levels in an ischemic mouse model using Western blot and real-time PCR, respectively. In addition, we observed that, among the three types of cells derived from the brain (brain microvascular endothelial cells, BV2 microglial cells, and HT22 hippocampal neuronal cells), the expression of GPR88 was highest in HT22 neuronal cells, and that GPR88 expression was downregulated in HT22 cells under oxygen-glucose deprivation (OGD) conditions. Moreover, pretreatment with RTI- 13951-33 (10 mg/kg), a brain-penetrant GPR88 agonist, ameliorated brain injury following ischemia, as evidenced by improvements in infarct volume, vestibular-motor function, and neurological score. Collectively, our results suggest that GPR88 could be a potential drug target for the treatment of central nervous system (CNS) diseases, including ischemic stroke.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.123-126
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• 2011

최근 전투체계는 동시에 다수의 장비들 사이에 실시간으로 데이터를 전달해야 하는데, 이러한 특성을 만족하는 통신 미들웨어로서 OMG (Object Management Group)에서 정의한 데이터 분배 서비스 (DDS ; Data Distribution Service)가 적합하다. 이를 구현한 DDS 시스템에는 RTI의 NDDS, PrismTech의 OpenSplice, 충남대학교의 ReTicom 등이 있다. 이 중 NDDS와 OpenSplice는 데이터의 영속성을 지원하지만 ReTicom에서는 영속성을 아직 지원하지 못한다. 이를 해결함과 동시에 실시간성을 보장하기 위해서 ReTicom은 메인 메모리 기반의 객체 관계형 데이터베이스를 사용하여 구현중이다. 이를 위해서는 DDS의 객체 모델 데이터를 정의하는 IDL과 객체 관계형 데이터베이스의 데이터 타입 및 구조 등이 동일하지 않기 때문에 IDL과 객체 관계형 데이터베이스간의 데이터 타입 및 구조를 변환하는 메타 모델 변환 방법이 제공되어야 한다. 본 논문에서는 이러한 메타 모델 변환 방법을 해결하고자 IDL을 구조파악이 쉬운 XML 스키마로 변환 후 이를 객체 관계형 데이터베이스의 데이터 타입 및 구조 형태로 변환 해주는 방법을 제안한다.

• Journal of the Korea Society for Simulation
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• v.19 no.4
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• pp.219-233
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• 2010

The objective of the interoperation of L-V-C Simulation is to enable practical integration training by taking advantages and compensating disadvantages of simulation models, such as Live, Virtual and Constructive models. As a study on the interoperation of L-V-C simulation, this paper suggests effective interoperation method between Virtual and Constructive simulation models and demonstrates small-size intagrated combat training model through V-C Test-Bed.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup1
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• pp.79-84
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• 2016

Graphic health warnings (GHW) on tobacco packages have proven to be effective in increasing quit attempts among smokers and reducing initial smoking among adolescents. This research aimed to examine the relative importance of different attributes of graphic health warnings on tobacco packages in Viet Nam. A discrete choice experimental (DCE) design was applied with a conditional logit model. In addition, a ranking method was used to list from the least to the most dreadful GHW labels. With the results from DCE model, graphic type was shown to be the most important attribute, followed by cost and coverage area of GHW. The least important attribute was position of the GHW. Among 5 graphic types (internal lung cancer image, external damaged teeth, abstract image, human suffering image and text), the image of lung cancer was found to have the strongest influence on both smokers and non-smokers. With ranking method, the image of throat cancer and heart diseases were considered the most dreadful images. GHWs should be designed with these attributes in mind, to maximise influence on purchase among both smokers and non-smokers.

• Journal of the Korea Society for Simulation
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• v.22 no.4
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• pp.11-19
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• 2013

The Korean naval weapon systems, combat experiments establish the concept of Battle operations, and create the future of the new weapons system. Doctrine development and training as well as ranging from experiments for evaluate the performance of mission operations for combat experiments are used. The battle lab is effectively support tool for the Korean Naval battle experiments. The battle lab is through a dedicated testing facility and to build efficient and effective simulation-based acquisition supporting environment. In this paper, the ship / submarines C2 operations virtual simulator was developed to support the concept of Battle operations of naval combat experiments in training and tactical development. The ship C2 operations virtual simulator makes the anti-ship and anti-aircraft the engagement scenario for performed experiments using the SADM. The submarines C2 operations virtual simulator makes the anti-submarine engagement scenario for performed experiments using EAS. EAS System was created before reuse. EAS system by modifying the additional interfaces HLA-RTI has been reused. Reflected in the tactics and training after analysis of the results through the battle experiment. Also increase training fidelity through operator involvement. The anti-ship and anti-aircraft system architecture (SADM) and anti-submarine system architecture (EAS) requires unique design of system framework since two separate architectures should be integrated into a system. An C2 virtual linked architecture was used to integrate different system architecture. A C2 virtual linked software framework, designed that have integrated protocol for battle experimental linkage and battlefield visualization environment.