• Genomics & Informatics
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• 제8권3호
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• pp.108-115
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• 2010

Hypertension is the most prevalent disease worldwide and is itself a risk factor for cerebral, cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous genomewide association studies (GWASs) may be due to not only differences in study design and genetic or environmental background but also the difference in the power of analysis between continuous traits and discrete traits. We analyzed 352,228 single nucleotide polymorphisms (SNPs) in 8842 unrelated Koreans obtained from Ansan and Ansung cohorts. We performed a series of GWA analyses using three different phenotype models; young hypertensive cases (278 subjects) versus elderly normotensive controls (680 subjects); the upper 25% (2211 hypertensive cases) versus the lower 25% of the SBP distribution (2211 hypotensive controls); and finally SBP and DBP as continuous traits (8842 subjects). The numbers of young hypertensive cases and elderly normotensive controls were not large enough to achieve genomewide significance. The model comparing the upper 25% subjects to the lower 25% of subjects showed a power that was approximate to that of QTL analysis. Two neighboring SNPs of the ATP2B1 gene, rs17249754 (SBP, p=$2.53^{-10}$; DBP, p=$1.28{\times}10^{-8}$) and rs7136259 (SBP, p=$1.30{\times}10^{-9}$; DBP, p=$6.41{\times}10^{-8}$), were associated with both SBP and DBP. Interestingly, a SNP of the RPL6 gene, rs11066280, revealed a significant genomewide association with SBP in men only (p=$3.85{\times}10^{-8}$), and four SNPs located near the MAN2A1 gene showed a strong association with DBP only in elderly men aged 60-70 years (e.g., rs6421827, p=$4.86{\times}10^{-8}$). However, we did not observe any gene variant attaining genomewide significance consistently in the three phenotype models except for the ATP2B1 gene variants. In general, the association signal with blood pressure was stronger in women than in men. Genes identified in GWASs are expected to open the way for prevention, early diagnosis, and personalized treatment of hypertension.

• 한국가구학회지
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• 제17권1호
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• pp.1-10
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• 2006

Movement behavior, shrinkage and equilibrium moisture content (EMC), in this experiment reflected a change of hygroscopicity mainly affected by continuously compressive load during radio-frequency/vacuum (RF/V) drying and humidity changes during equilibrating. As a result of interaction of the compressive load and moisture content changing under the RF/V condition, the shrinkages in loading direction were significantly increased while those perpendicular to loading direction were decreased. The shrinkages were affected most in tangential, and least in longitudinal direction. The shrinkages showed higher values in continuous drying than in intermittent drying. In the direction of increased shrinkage, all the movements were also increased, for example, the tangential movement for the loaded-RS and the radial movement for loaded-TS; in the direction of decreased shrinkage, all the movements except the tangential movement for the loaded-TS were decreased such as the tangential and radial movements for the loaded-ES, and the radial movement for the loaded-RS, comparing with those of the load-free. EMCs of the loaded specimens were all higher than that of the load-free specimen, and the highest for the loaded-TS, the lowest for the loaded-ES. The transverse hygroscopicity of specimen was reduced for the loaded-ES, but increased for the loaded-TS.

• Communications for Statistical Applications and Methods
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• 제10권1호
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• pp.61-77
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• 2003

Due to the wide expansion of the internet, people can freely get information what they want with lesser efforts. However without adequate forms or rules to follow, it is getting more and more difficult to get necessary information. Because of seemingly chaotic status of the current web environment, it is sometimes called "Dizzy web" The user should wander from page to page to get necessary information. Therefore we need to construct system which properly recommends appropriate information for general user. The representative research field for this system is called Recommendation System(RS), The collaborative recommendation system is one of the RS. It was known to perform better than the other systems. When we perform the web user modeling or other web-mining tasks, the continuous feedback data is very important and frequently used. In this paper, we propose a collaborative recommendation system which can deal with the continuous feedback data and tried to construct the web page prediction system. We use a sojourn time of a user as continuous feedback data and combine the traditional model-based algorithm framework with the Support Vector Regression technique. In our experiments, we show the accuracy of our system and the computing time of page prediction compared with Pearson's correlation algorithm.algorithm.

• Journal of Astronomy and Space Sciences
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• 제6권1호
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• pp.41-47
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• 1989

RS CVn형 변광성 Hㅇ 8358을 1987년 10우러부터 1988년 12월까지 총 15일간 소백산천문대의 61cm 반사망원경으로 UBV 광전관측을 하여 새로운 광도 곡선을 얻었다. 우리의 광도곡선에서는 두 개의 극대광도가 보였다. 한편, 극대광도가 관측된 날들의 극대 시각들을 조사한 결과, 그때의 위상이 계속 변함을 알았다. 또한 1987년 10월 -1988년 1월의 관측 값에 비해서, 1988년 11월 -12월의 관측 값이 $\Delta(b-\upsilon)$는 청색화해졌으나 $\Delta(u-b)$는 적생화해졌다.

• 한국농림기상학회지
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• 제4권3호
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• pp.175-196
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• 2002

The increase of meteorological uncertainty and unstable fluctuation of its behavior due to the global warming affect the temporal variation and spatial distribution of water resources and water use patterns in agriculture. There have been steady efforts to understand hydrological components and deal with such water related problems. This paper reviews firstly, the future effect of water resources due to climate changes, secondly, recent progress for precipitation, evapotranspiration, soil moisture, and thirdly, GIS/RS based integrated information systems conducted by both researchers and government ministries. There should be continuous studies and investments to cope with climate changes, and to accomplish sustainable development with the help of agricultural water resources. Some research topics were suggested to attempt with substantial contents considering our present capability and situation.

• 한국생산제조학회지
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• 제22권2호
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• pp.318-323
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• 2013

For fast and accurate motion of 6-axis articulated robot, more noble motion control strategy is needed. In general, the movement strategy of industrial robots can be divided into two kinds, PTP (Point to Point) and CP (Continuous Path). Recently, industrial robots which should be co-worked with machine tools are increasingly needed for performing various jobs, as well as simple handling or welding. Therefore, in order to cope with high-speed handling of the cooperation of industrial robots with machine tools or other devices, CP should be implemented so as to reduce vibration and noise, as well as decreasing operation time. This paper will realize CP motion (especially joint-linear) blending in 3-dimensional space for a 6-axis articulated (lab-manufactured) robot (called as "RS2") by using LabVIEW$^{(R)}$ (6) programming, based on a parametric interpolation. Another small contribution of this paper is the proposal of motion blending simulation technique based on Recurdyn$^{(R)}$ V7 and Solidworks$^{(R)}$, in order to figure out whether the joint-linear blending motion can generate the stable motion of robot in the sense of velocity magnitude at the end-effector of robot or not. In order to evaluate the performance of joint-linear motion blending, simple PTP (i.e., linear-linear) is also physically implemented on RS2. The implementation results of joint-linear motion blending and PTP are compared in terms of vibration magnitude and travel time by using the vibration testing equipment of Medallion of Zonic$^{(R)}$. It can be confirmed verified that the vibration peak of joint-linear motion blending has been reduced to 1/10, compared to that of PTP.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 1986년도 추계학술대회
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• pp.520.3-521
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• 1986

L-Lysine 생성균인 Corynebacterium glutamicum의 동종간 융합주 RS 99를 담체인 Alginate와 여기에 TiCl$_4$로부터 제조된 Titanium hydroxide를 혼합하여 각각 고정하고 이들의 Gel strength, 활성도 및 회분식 발효조건을 비교하였다. 그 결과 Alginate-Titanium hydroxide를 담체로 선정하여 고정화 C, glutamicum 융합주의 재사용성 및 안정성을 검토하였으며, Continuous-Flow Stirred-Tank Reactor를 구성하여 L-Lysine 의 연속발효를 시도하였다.

• 한국경영과학회지
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• 제14권1호
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• pp.119-130
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• 1989

This paper presents average travel time models automated warehousing system where the stacker crane transports only one pallet at a time with the tchebychev travel, I/O point is located at the cornor of the rack, and items are stored by the class-based storage assignment rule. In this study, the racks are treated as the continuous rectangle in time and a statistical approach was used to develop the models. In order to test the proposed models, average travel times determined by the models are compared with the true values for various rack shapes.

• 대한산업공학회지
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• 제22권2호
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• pp.179-188
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• 1996

We study n-class-based storage policy for an automated storage/retrieval system (AS/RS) and derive the closed form expressions of expected travel times under single command cycle. In order to confirm the correctness of the derivations, we consider both discrete and continuous storage racks, and show that the expressions for expected travel times of discrete rack converge to those of continuous one. We also derive the expected travel times when the coordinate locations for storages or retrievals are triangularly distributed and we try to solve class layout problem using the obtained results. Numerical examples are given in case of 3-class-based storage policy.

• 한국토양비료학회지
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• 제43권1호
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• pp.75-82
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• 2010

수박재배에 적합한 양분함량보다 약 3배 이상 높고, 7년간 수박을 연작해온 시설 재배지에서 시비관리 및 생볏짚을 연용하면서 토양 중 염류경감 효과와 수박시들음증 발생률을 조사하였다. 시험은 관행구, 시비관리구, 시비관리 및 5, 10, 15 ton $ha^{-1}$ 생볏짚 처리구로 나누어 3년간 실시하였다. 유기물함량은 예상할 수 있는 바와 같이 대부분의 처리구에서 지속적으로 증가하였으며, 단지 시비관리구에서만 감소하였다. 토양 pH는 관행구 및 시비관리구에서는 변화가 거의 없었고, 시비관리-볏짚처리구에서 감소하는 경향을 보였다. 그러나 시험 3년차부터 10, 15 ton $ha^{-1}$ 시비관리-볏짚처리구에서 다시 증가하는 경향을 보였다. 치환성 양이온 즉 $Ca^{2+}$, $Mg^{2+}$, $K^+$, 중 $Ca^{2+}$과 $Mg^{2+}$의 함량과 수용성 음이온, ${NO_3}^-$, $Cl^-$, ${SO_4}^{2-}$, ${PO_4}^{3-}$의 함량은 시비관리구 및 시비관리-볏짚처리구에서 상당히 감소하는 경향을 보였다. 그러나 시비관리-볏짚처리구에서 생볏짚의 처리량과는 관계없이 시험 1년차에 많은 양이 감소한 후, 2~3년차에서는 더 이상 감소하지 않는 것으로 나타났다. 또한 치환성 $K^+$ 함량은 시비관리구에서 다고 감소하는 경향을 보였으나 다른 처리구에서는 시험기간 동한 거의 변화하지 않았다. 그리고 이러한 양이온과 음이온의 함량변화와 관계가 깊은 전기전도도(EC)를 조사한 결과 수용성 음이온 함량변화와 같은 경향을 보이며 감소하였다. 또한 수박생육과 관련하여 수박시들음증 발생률은 관행구에서 최고 약 20%까지 발생하였으나, 시비관리와 함께 생볏짚을 10 ton $ha^{-1}$ 이상 사용하면 최고3.5%까지 급격히 감소하였다.