• Genomics & Informatics
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• v.8 no.3
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• pp.108-115
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• 2010

Hypertension is the most prevalent disease worldwide and is itself a risk factor for cerebral, cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous genomewide association studies (GWASs) may be due to not only differences in study design and genetic or environmental background but also the difference in the power of analysis between continuous traits and discrete traits. We analyzed 352,228 single nucleotide polymorphisms (SNPs) in 8842 unrelated Koreans obtained from Ansan and Ansung cohorts. We performed a series of GWA analyses using three different phenotype models; young hypertensive cases (278 subjects) versus elderly normotensive controls (680 subjects); the upper 25% (2211 hypertensive cases) versus the lower 25% of the SBP distribution (2211 hypotensive controls); and finally SBP and DBP as continuous traits (8842 subjects). The numbers of young hypertensive cases and elderly normotensive controls were not large enough to achieve genomewide significance. The model comparing the upper 25% subjects to the lower 25% of subjects showed a power that was approximate to that of QTL analysis. Two neighboring SNPs of the ATP2B1 gene, rs17249754 (SBP, p=$2.53^{-10}$; DBP, p=$1.28{\times}10^{-8}$) and rs7136259 (SBP, p=$1.30{\times}10^{-9}$; DBP, p=$6.41{\times}10^{-8}$), were associated with both SBP and DBP. Interestingly, a SNP of the RPL6 gene, rs11066280, revealed a significant genomewide association with SBP in men only (p=$3.85{\times}10^{-8}$), and four SNPs located near the MAN2A1 gene showed a strong association with DBP only in elderly men aged 60-70 years (e.g., rs6421827, p=$4.86{\times}10^{-8}$). However, we did not observe any gene variant attaining genomewide significance consistently in the three phenotype models except for the ATP2B1 gene variants. In general, the association signal with blood pressure was stronger in women than in men. Genes identified in GWASs are expected to open the way for prevention, early diagnosis, and personalized treatment of hypertension.

• Journal of the Korea Furniture Society
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• v.17 no.1
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• pp.1-10
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• 2006

Movement behavior, shrinkage and equilibrium moisture content (EMC), in this experiment reflected a change of hygroscopicity mainly affected by continuously compressive load during radio-frequency/vacuum (RF/V) drying and humidity changes during equilibrating. As a result of interaction of the compressive load and moisture content changing under the RF/V condition, the shrinkages in loading direction were significantly increased while those perpendicular to loading direction were decreased. The shrinkages were affected most in tangential, and least in longitudinal direction. The shrinkages showed higher values in continuous drying than in intermittent drying. In the direction of increased shrinkage, all the movements were also increased, for example, the tangential movement for the loaded-RS and the radial movement for loaded-TS; in the direction of decreased shrinkage, all the movements except the tangential movement for the loaded-TS were decreased such as the tangential and radial movements for the loaded-ES, and the radial movement for the loaded-RS, comparing with those of the load-free. EMCs of the loaded specimens were all higher than that of the load-free specimen, and the highest for the loaded-TS, the lowest for the loaded-ES. The transverse hygroscopicity of specimen was reduced for the loaded-ES, but increased for the loaded-TS.

• Communications for Statistical Applications and Methods
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• v.10 no.1
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• pp.61-77
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• 2003

Due to the wide expansion of the internet, people can freely get information what they want with lesser efforts. However without adequate forms or rules to follow, it is getting more and more difficult to get necessary information. Because of seemingly chaotic status of the current web environment, it is sometimes called "Dizzy web" The user should wander from page to page to get necessary information. Therefore we need to construct system which properly recommends appropriate information for general user. The representative research field for this system is called Recommendation System(RS), The collaborative recommendation system is one of the RS. It was known to perform better than the other systems. When we perform the web user modeling or other web-mining tasks, the continuous feedback data is very important and frequently used. In this paper, we propose a collaborative recommendation system which can deal with the continuous feedback data and tried to construct the web page prediction system. We use a sojourn time of a user as continuous feedback data and combine the traditional model-based algorithm framework with the Support Vector Regression technique. In our experiments, we show the accuracy of our system and the computing time of page prediction compared with Pearson's correlation algorithm.algorithm.

• Journal of Astronomy and Space Sciences
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• v.6 no.1
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• pp.41-47
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• 1989

UBV photoelectric observations of RS CVn type variable star HD 8358 were made using the 61cm reflector at Sobaeksan Astronomical Observatory. The data were obtained on 15 nights from October 1987 to December 1988. Double peaks of maximum light is seen from the light curve and continuous change of phase in notified from the times of maximum lights. The colors of October, 1987 - January, 1988 observations are bluer in $\Delta(b-\upsilon)$, but redder in $\Delta(\upsilon$-b), than those of November -December, 1988 observations.

• Korean Journal of Agricultural and Forest Meteorology
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• v.4 no.3
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• pp.175-196
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• 2002

The increase of meteorological uncertainty and unstable fluctuation of its behavior due to the global warming affect the temporal variation and spatial distribution of water resources and water use patterns in agriculture. There have been steady efforts to understand hydrological components and deal with such water related problems. This paper reviews firstly, the future effect of water resources due to climate changes, secondly, recent progress for precipitation, evapotranspiration, soil moisture, and thirdly, GIS/RS based integrated information systems conducted by both researchers and government ministries. There should be continuous studies and investments to cope with climate changes, and to accomplish sustainable development with the help of agricultural water resources. Some research topics were suggested to attempt with substantial contents considering our present capability and situation.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.318-323
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• 2013

For fast and accurate motion of 6-axis articulated robot, more noble motion control strategy is needed. In general, the movement strategy of industrial robots can be divided into two kinds, PTP (Point to Point) and CP (Continuous Path). Recently, industrial robots which should be co-worked with machine tools are increasingly needed for performing various jobs, as well as simple handling or welding. Therefore, in order to cope with high-speed handling of the cooperation of industrial robots with machine tools or other devices, CP should be implemented so as to reduce vibration and noise, as well as decreasing operation time. This paper will realize CP motion (especially joint-linear) blending in 3-dimensional space for a 6-axis articulated (lab-manufactured) robot (called as "RS2") by using LabVIEW$^{(R)}$ (6) programming, based on a parametric interpolation. Another small contribution of this paper is the proposal of motion blending simulation technique based on Recurdyn$^{(R)}$ V7 and Solidworks$^{(R)}$, in order to figure out whether the joint-linear blending motion can generate the stable motion of robot in the sense of velocity magnitude at the end-effector of robot or not. In order to evaluate the performance of joint-linear motion blending, simple PTP (i.e., linear-linear) is also physically implemented on RS2. The implementation results of joint-linear motion blending and PTP are compared in terms of vibration magnitude and travel time by using the vibration testing equipment of Medallion of Zonic$^{(R)}$. It can be confirmed verified that the vibration peak of joint-linear motion blending has been reduced to 1/10, compared to that of PTP.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 1986.12a
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• pp.520.3-521
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• 1986

L-Lysine 생성균인 Corynebacterium glutamicum의 동종간 융합주 RS 99를 담체인 Alginate와 여기에 TiCl$_4$로부터 제조된 Titanium hydroxide를 혼합하여 각각 고정하고 이들의 Gel strength, 활성도 및 회분식 발효조건을 비교하였다. 그 결과 Alginate-Titanium hydroxide를 담체로 선정하여 고정화 C, glutamicum 융합주의 재사용성 및 안정성을 검토하였으며, Continuous-Flow Stirred-Tank Reactor를 구성하여 L-Lysine 의 연속발효를 시도하였다.

• Journal of the Korean Operations Research and Management Science Society
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• v.14 no.1
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• pp.119-130
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• 1989

This paper presents average travel time models automated warehousing system where the stacker crane transports only one pallet at a time with the tchebychev travel, I/O point is located at the cornor of the rack, and items are stored by the class-based storage assignment rule. In this study, the racks are treated as the continuous rectangle in time and a statistical approach was used to develop the models. In order to test the proposed models, average travel times determined by the models are compared with the true values for various rack shapes.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.2
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• pp.179-188
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• 1996

We study n-class-based storage policy for an automated storage/retrieval system (AS/RS) and derive the closed form expressions of expected travel times under single command cycle. In order to confirm the correctness of the derivations, we consider both discrete and continuous storage racks, and show that the expressions for expected travel times of discrete rack converge to those of continuous one. We also derive the expected travel times when the coordinate locations for storages or retrievals are triangularly distributed and we try to solve class layout problem using the obtained results. Numerical examples are given in case of 3-class-based storage policy.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.1
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• pp.75-82
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• 2010

Indoor cultivation plots for watermelon plant mostly have salt-accumulation problem because of continuous cropping especially with the heavy applications of chemical fertilizers. Thus, this study was conducted to investigate selected soil properties and watermelon growth condition as affected by the application of different farming practices in the salt-affected soils of greenhouse plots used for continuous watermelon production. Five different practice conditions in the experimental plots were applied, 1) a conventional farming practice (CFP), 2) a nitrogen-phosphorus-potassium (NPK) fertilizer management practice (FMP), and 3) the FMP with different amounts (5, 10, and 15 ton $ha^{-1}$)of fresh rice straw treatments (FMP-RS), for three years of study. As comparing with CFP plots, soil organic matter content gradually increased during the experimental years, whereas it decreased in the FMP only plot. Soil pH was not changed in the CFP and FMP plot, but it declined in the FMP-RS plots; however, it increased again from the third year in the FMP-RS plots with applying 10 and 15 ton $ha^{-1}$ of RS treatments. The concentrations of exchangeable cations, $Ca^{2+}$ and $Mg^{2+}$, except $K^+$, and water-soluble anions, ${NO_3}^-$, $Cl^-$, ${SO_4}^{2-}$ and ${PO_4}^{3-}$, markedly decreased in FMP and FMP-RS plots. In particular, the application of rice straw tended to significantly decrease the ion concentrations, especially most anions, in the first year, but there was no more decrease in the second and third study years. With relation to the ion concentrations, the changes of electrical conductivity (EC) after applying the management practices showed very similar to those of the ion concentrations. In addition, incidence of withered watermelon plant after applying the management practices dramatically declined from approximately 20% in the CFP plot to 3.5% in the FMP-RS plots. Water melon fruit weight was also improved by the management practices, especially FMP-RS. Therefore, the fertilizer and/or fresh rice straw application management practices are beneficial to improve salt-affected soils and watermelon plant growth condition.