• 생물정신의학
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• 제29권2호
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• pp.33-39
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• 2022

Objectives The early growth response 3 (EGR3) gene located in chromosome 8p21.3 is one of the susceptibility loci in many psychiatric disorders. EGR3 gene plays critical roles in signal transduction in the brain, which is involved in neuronal plasticity, neuronal development, learning, memory, and circadian rhythms. Recent studies have suggested EGR3 as a potential susceptibility gene for bipolar disorder (BPD). However, this requires further replication with an independent sample set. Methods To investigate the genetic role of EGR3 in Korean patients, we genotyped six single-nucleotide polymorphisms (SNPs) in the chromosome region of EGR3 in 1076 Korean BPD patients and 773 healthy control subjects. Results Among the six examined SNPs of EGR3 (rs17088531, rs1996147, rs3750192, rs35201266, rs7009708, rs1008949), SNP rs35201266, rs7009708, rs1008949 showed a significant association with BPD (p = 0.0041 for rs35201266 and BPD2, p = 0.0074 for rs1008949 and BPD, p = 0.0052 for rs1008949 and BPD1), which withstand multiple testing correction. In addition, the 'G-C-C-C' and 'G-C-G-C' haplotypes of EGR3 were overrepresented in the patients with BPD (p = 0.0055, < 0.0001, respectively) and the 'G-T-G-C' haplotype of EGR3 was underrepresented in patients with BPD (p = 0.0040). Conclusions In summary, our study supports the association of EGR3 with BPD in Korean population sample, and EGR3 could be suggested as a compelling susceptibility gene in BPD.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 하계종합학술대회 논문집(1)
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• pp.113-116
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• 2001

Reed-Solomon(RS) code is the most powerful burst error correcting code. In Ois paper, the architecture for the adaptive RS encoder adaptable for multi QoS requirements or time-varying channel environments has been designed. In the adaptive RS code, the message length k and the error correction capability t are allowed to be variable so that the block length n is also variable. We proposed the architecture of the adaptive RS encoder by designing the optimal structure of Galois fields multiplier with comparison of fixed multiplier and variable multiplier. The proposed architecture is implemented in VHDL and verified with the simulation tool

• 디지털융복합연구
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• 제12권3호
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• pp.269-275
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• 2014

Eureka 147 디지털오디오방송(DAB) 시스템은 CD 품질의 오디오 전송을 위하여 유럽에서 개발되었으나 한국에서는 이러한 DAB 시스템을 기반으로 하여 오디오뿐 만 아니라 비디오 신호도 전송할 목적으로 지상파 디지털 멀티미디어방송(T-DMB) 시스템을 개발하였다. 이러한 T-DMB 시스템의 성능 향상을 목적으로 본 논문에서는 양립성을 위해 기존 T-DMB 시스템 표준안에 정의된 펑쳐링 절차와 평처링 벡터를 이용하면서 터보 부호가 적용된 2가지 형태의 새로운 터보부호화된 T-DMB 시스템 모델을 제시한다. 첫 번째 모델 (Type 1)은 기존의 RS 코드, 콘볼류션 인터리빙, RCPC 코드를 터보코드로 대체시킨 것이며 두 번째 모델(Type 2)은 기존 RCPC 만을 터보부호로 대체시킨 모델이다. 시뮬레이션 결과 제안된 모델은 단지 2회 반복만으로도 상당한 성능 향상을 얻을 수 있음을 알 수 있었으며 또한 두 번째 모델은 첫 번째 모델에 비해 약간 우수한 성능을 보이고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8197-8201
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• 2014

Background: Telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes located on chromosome 5p15.33 are known to influence the susceptibility to various cancers. Here, we examined the association of TERT and CLPTM1L single nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC). Materials and Methods: Genotyping of TERT SNP rs2736098 and CLPTM1L SNP rs401681 was performed using TaqMan allelic discrimination assays in a case-control study of 201 HCC cases and 210 controls in a Chinese male population. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression analyses. Results: Both the rs2736098 T allele of TERT and the rs401681 T allele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605, 95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively). Individuals carrying both TERT and CLPTM1L risk genotypes had an even higher risk of HCC (adjusted OR=4.420, 95%CI= 2.319-8.425). The TERT rs2736098 T allele was also significantly associated with the level of the HCC clinical indicator alpha-fetoprotein (P=0.026). Conclusions: Our results show that genetic variants of TERT and CLPTM1L may contribute to HCC susceptibility in Chinese males.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.41-44
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• 2015

Based on genome-wide association studies (GWAS) a linkage between several variants such as single nucleotide polymorphisms (SNPs) in intron 3 of SMAD7 (mothers against decapentaplegic homolog7) were, rs12953717, rs4464148 and rs4939827 has been noted for susceptibility to colorectal cancer (CRC). In this study we investigated the relationship of rs12953717 and rs4464148 with risk of CRC among 487 Iranian individuals based on a case-control study. Genotyping of SNPs was performed by PCR-RFLP and for confirming the outcomes, 10% of genotyping cases were sequenced with RFLP. Comparing the case and control group, we have found significant association between the rs4464148 SNP and lower risk of CRC. The AG genotype showed decreased risk with and odds ratio of 0.635 (adjusted OR=0.635, 95% CI: 0.417-0.967, p=0.034). There was no significant difference in the distribution of SMAD7 gene rs12953717 TT genotype between two groups of the population evaluated (adjusted OR=1.604, 95% CI: 0.978-2.633, p=0.061). On the other hand, rs12953717 T allele showed a statistically significant association with CRC risk (adjusted OR=1.339, 95% CI: 1.017-1.764, p=0.037). In conclusion, we found a significant association between CRC risk and the rs4464148 AG genotype. Furthermore, the rs12953717 T allele may act as a risk factor. This association may be caused by alternative splicing of pre mRNA. Although we observed a strong association with rs4464148 GG genotype in affected women, we did not detect the same association in CRC male patients.

• Clinical and Experimental Reproductive Medicine
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• 제17권1호
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• pp.21-28
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• 1990

19-nortestosterone(NORA)와 19-norandrostenedione(NT)는 정소내 aromatization과정중 중간 대사물로 검출된다. 본 연구는 이들을 장기간 투여하여 정소 및 부속기관의 무게, 혈청내 testosterone(T)의 농도, 정자형성에 미치는 영향을 조사하였다. NORA, NT 및 TE를 $300/50{\mu}l$농도로 주당 3회씩 12주간 정소에 직접 주사(intratesticular injection, i.t.)하였다. 또한 GnRH antagonist(RS68439)를 처리하여 혈청내 생식소자극호르몬 (GTH)을 감소시킨후 위 호르몬들을 동일방법으로 처리하여 이들의 보상작용을 조사하였다. NORA는 정소무게를 감소시키지 않았으나 GnRH antagonist를 처리하여 감소된 정소무게를 현저하게 보상하였다(P<0.05). NORA, NT, TE는 모두 부속기관의 무게를 증가시켰으며, RS68439가 감소시킨 부속기관의 무게를 현저히 증가시켰다. 그러나 이들은 부정소(epididymis)에는 영향을 주지않았으며 RS68439처리군에서는 보상작용을 나타내었다. 이들의 처리로 혈청내 LH농도는 완전히 감소하였으나 FSH의 농도에는 영향을 나타내지 않았다. 그리고 혈청내 T의 농도를 증가시켰다. NORA는 정자형성과정중 7단계의 spermatid의 수를 현저히 감소시켰다. 위 결과로 보아 NORA는 GnRH antagonist로 FSH의 분비가 억제된 쥐의 FSH분비를 촉진하며, T의 농도를 증가시켜 정자형성과정을 억제하는 것으로 추론된다.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2004년도 정기총회 및 학술대회
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• pp.107-111
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• 2004

본 논문에서는 PC 기반 지상파 DMB(Terrestrial Digital Multimedia Broadcasting, T-DMB) 수신기를 위한 오류에 견고한 SW 구현에 대해 설명한다. 이 수신기는 PC 외부에 T-DMB 신호를 안테나로 수신하여 복조하고 채널 복호하는 프론트 엔드(front-end) 수신 모듈을 이용, USB를 통하여 RS(Reed-Solomon) 부호화된 MPEG-2 TS(Transport Stream) 데이터를 읽어 들여 RS 복호, TS 역다중화, 비디오 보호, 오디오 복호 등의 SW 처리 과정을 거쳐 디스플레이 상에 수신 내용을 표시하게 된다. 수신기가 실용적으로 동작하기 위해서는, 수신된 비트스트림이 예상하지 못한 형태일 때도 오동작하거나 멈춰 서지 않아야 한다. 수신된 비트스트림에는 채널 비트 오류로 인해 훼손된 부분이 있을 수 있으며, 송출 시에 잘못 제작된 비트스트림도 있을 수 있다. 본 논문에서는 우선 RS 복호를 수행하여 정정 가능한 범위까지 오류를 정정하고, 검출되었으나 정정하지 못한 오류 또는 비트스트림 제작 시의 오류로 인한 비트스트림 구문 오류를 검출하여 오류 처리를 수행하며, 이로 인한 화질 손상을 숨기기 위해 프리즈 프레임(freeze-frame)을 수행하도록 하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7965-7970
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• 2014

One of the goals of tumor immunotherapy is to generate immune cells with potent anti-tumor activity through in vitro techniques using peripheral blood collected from patients. However, cancer patients generally have poor immunological function. Thus using patient T cells, which have reduced in vitro proliferative capabilities and less tumor cell killing activity to generate lymphokine-activated killer (LAK) cells, fails to achieve optimal clinical efficacy. Interleukin-2 (IL-2) is a potent activating cytokine for both T cells and natural killer cells. Thus, this study aimed to identify optimal donors for allogeneic LAK cell immunotherapy based on single nucleotide polymorphisms (SNP) in the IL-2 and IL-2R genes. IL-2 and IL-2R SNPs were analyzed using HRM-PCR. LAK cells were derived from peripheral blood mononuclear cells by culturing with IL-2. The frequency and tumor-killing activity of LAK cells in each group were analyzed by flow cytometry and tumor cell killing assays, respectively. Regarding polymorphisms at IL-2-330 (rs2069762) T/G, LAK cells from GG donors had significantly greater proliferation, tumor-killing activity, and IFN-${\gamma}$ production than LAK cells from TT donors (P<0.05). Regarding polymorphisms at IL-2R rs2104286 A/G, LAK cell proliferation and tumor cell killing were significantly greater in LAK cells from AA donors than GG donors (P<0.05). These data suggest that either IL-2-330(rs2069762)T/G GG donors or IL-2R rs2104286 A/G AA donors are excellent candidates for allogeneic LAK cell immunotherapy.

• Journal of Ecology and Environment
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• 제41권12호
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• pp.336-344
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• 2017

Background: Because of climate change, interest in the development of carbon pools has increased. In agricultural ecosystems, which can be more intensively managed than forests, measures to control carbon dioxide ($CO_2$) emission and absorption levels can be applied relatively easily. However, crop residues may be released into the atmosphere by decomposition or combustion. If we can develop scientific management techniques that enable these residues to be stocked on farmland, then it would be possible to convert farmlands from carbon emission sources to carbon pools. We analyzed and investigated soil respiration (Rs) rate characteristics according to input of carbonized residue of red peppers (Capsicum annuum L.), a widely grown crop in Korea, as a technique for increasing farmland carbon stock. Results: Rs rate in the carbonized biomass (CB) section was $226.7mg\;CO_2\;m^{-2}h^{-1}$, which was 18.1% lower than the $276.9mg\;CO_2\;m^{-2}h^{-1}$ from the red pepper residue biomass (RB) section. The Rs rate of the control was $184.1mg\;CO_2\;m^{-2}h^{-1}$. In the following year, Rs in the CB section was $204.0mg\;CO_2\;m{-2}h^{-1}$, which was 38.2% lower than the $330.1mg\;CO_2\;m^{-2}h^{-1}$ from the RB section; the control emitted $198.6mg\;CO_2\;m^{-2}h^{-1}$. Correlation between Rs and soil temperature ((Ts) at a depth of 5 cm) was $R^2=0.51$ in the RB section, which was higher than the other experimental sections. A comparison of annual decomposition rates between RB and CB showed a large difference, 41.4 and 9.7%, respectively. The results showed that carbonization of red pepper residues reduced the rates of decomposition and Rs. Conclusions: The present study confirmed that the Rs rate can be reduced by carbonization of residue biomass and putting it in the soil and that the Rs rate and Ts (5 cm) were positively correlated. Based on the results, it was determined that approximately $1.2t\;C\;ha^{-1}$ were sequestered in the soil in the first year and $3.0t\;C\;ha^{-1}$ were stored the following year. Therefore, approximately $1.5t\;C\;ha^{-1}year^{-1}$ are expected to be stocked in the soil, making it possible to develop farmlands into carbon pools.

• 한국지리정보학회지
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• 제6권3호
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• pp.61-72
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• 2003

최근 다양한 센서정보의 민간 활용이 가능해지면서 고해상도 위성영상정보를 현실문제에 적용하려는 수요가 증가하고 있다. 1990년대 말부터 미국 등에서도 위성영상정보를 교통 문제에 실제적으로 적용하고자 하는 연구가 본격적으로 추진되고 있으며, 이러한 연구는 RS-T(remote sensing in transportation)라는 분야로 특성화되는 추세에 있다. 또한 이러한 연구는 이미 산업적 활용단계에 있는 GIS-T(GIS for transportation)와 연계되어 위성영상정보의 활용을 증대시키는데 기여하고 있다. 본 연구에서는 이러한 추세를 반영하여 RS-T를 개관한 뒤, 고해상도 위성영상정보를 이용한 도시교통 환경분석이 가능하도록 교통중력 모델에 기반하여 교통지리학에서 제안되어 온 몇 가지의 정량적 접근성지수 추출 알고리즘을 위성 영상정보를 보조자료로 하여 적용할 수 있도록 ArcView-GIS 환경의 확장 프로그램으로 시험적으로 구현하였으며, 시험 구현 모델 중에서 Ingram 모델과 G&G 모델을 이용하여 접근성지수 추출에 대한 적용하는 사례를 제시하고자 하였다. 적용 결과로서 도출된 정량적 지수정보는 분석 대상지역에 대한 교통접근성의 특성을 파악하는 데 활용이 가능하며, 시계열 위성자료를 적용하는 경우에는 주기적 도시교통 통계정보로 이용되어 광역적 교통계획을 위한 자료로 이용이 될 수 있을 것으로 생각된다.