• Proceedings of the Korea Information Processing Society Conference
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• 2008.05a
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• pp.1155-1158
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• 2008

MIPv6(Mobile IPv6)는 이동노드(mobile node, MN)의 이동성(mobility)를 고려하여 만들어진 프로토콜로 이동노드와 상대노드(correspondent node, CN)간의 효율적인 통신을 위해 경로 최적화 기능을 제공하며, 이를 통해 두 노드가 홈 링크를 통하지 않고도 직접 통신할 수 있다. 이때 경로 최적화를 위해 바인딩 갱신(binding update)과정을 수행하며, MIPv6는 RR(return routability)를 통해 바인딩 갱신을 보호한다. 하지만 RR을 통한 바인딩 갱신은 거짓된 바인딩 갱신 공격에 취약하다. 본 논문에서는 RR과정의 취약점을 보완하는 HT-RR메커니즘을 제안한다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.5
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• pp.1384-1396
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• 1998

This paper ivestigates the performance of a relative rate (RR) switch algorithm for the rate-based available bit rate (ABR) flow control in asynchronous transfer mode (ATM) networks. A RR switch may notify the network congestion status to the source by suing the congestion indication (CI) bit or no increase (NI)bit in the backward RM (BRM) cells. A RR switch can be differently implemented according to the congestion detectio and notification methods. In this paper, we propose three implementation schemes for the RR switch with different congestion detection and notification methods, and analyze the allowed cell rate (ACR) of a source and the queue length of a switch in steady state. In addition, we derive the upper and lower bounds for the maximum and minimum queue lengths for each scheme respectively, and evaluate the effects of the ABR parameter values on the queue length. Furthermore, we suggest the range of the rage increase factor (RIF) and rate decrease factor (RDF) parameter values which can prevent buffer overflow and underflow at a switch.

• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.431-437
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• 2014

Synthetic compounds that are used in the clinic to regulate skin hyperpigmentation, such as arbutin, hydroquinone, and kojic acid, are only moderately effective. But, their use is limited by side effects. As part of an effort to overcome the limitations, we developed resveratrol-enriched rice (RR) using genetic engineering technique. Each of resveratrol and rice has been reported to produce anti-melanogenic effects. Therefore, we hypothesized that RR would show more anti-melanogenic effects than those of resveratrol or rice alone. Anti-melanogenic effect of RR was done by using melan-a mouse melanocytes. The depigmenting efficacy was then observed following topical application of the RR to UVB-stimulated hyperpigmented dorsal skin of guinea pigs. Treatment with RR extract resulted a $21.4{\pm}0.7%$ decrease in tyrosinase expression at melan-a cells. Colorimetric analysis showed a significantly lower depigmenting value by day 9 following treatment with RR in UVB-irradiated guinea pigs the dorsal skin (p<0.01), indicating that RR produced a depigmentation effect. By staining with Fontana-Masson stain, we found that the RR-treated group had more effect histopathologically in epidermal melanin production than resveratrol or rice alone-treated group. RR was associated with reduction in the levels of microphthalmia-associated transcription factor (MITF), and downregulation of tyrosinase and tyrosinase-related protein (TRP-2) expression, leading to inhibit epidermal melanin production by western blot analysis. This study suggests that the resveratrol-enriched rice may be a promising candidate in regulating skin pigmentation with UVB exposure.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.8
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• pp.1079-1084
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• 2006

To determine whether a link exists between reproductive seasonality and the structure of the melatonin receptor 1A (MTNR1A) gene, the latter was studied in nonseasonal estrous breeds (Small Tail Han and Hu ewes) and seasonal estrous breeds (Dorset, Suffolk and German Mutton Merino ewes). A large fragment of the exon 2 of the MTNR1A gene was amplified and a uniform fragment of 824 bp was obtained in 239 ewes of five breeds. The 824 bp PCR product was digested with restriction endonucleases Mnl I and Rsa I, and checked for the presence of restriction sites. The presence (allele M) or absence (allele m) of an Mnl I site at base position 605 led to three genotypes MM (236 bp/236 bp), Mm (236 bp/303 bp) and mm (303 bp/303 bp) in five sheep breeds. The presence (allele R) or absence (allele r) of a Rsa I site at base position 604 led to three genotypes RR (267 bp/267 bp), Rr (267 bp/290 bp) and rr (290 bp/290 bp) in five sheep breeds. Frequencies of MM and RR genotypes were obviously higher, and frequencies of mm and rr genotypes were obviously lower in nonseasonal estrous sheep breeds than in seasonal estrous sheep breeds. Sequencing revealed four mutations (G453T, G612A, G706A, C891T) in mm genotype compared to MM genotype and one mutation (C606T) in rr genotype compared to RR genotype. For polymorphic Mnl I and Rsa I cleavage sites, the differences of genotype distributions were very highly significant (p<0.01) between Small Tail Han ewes and seasonal estrous sheep breeds. In each group, no significant difference (p>0.05) was detected. These results preliminarily showed an association between MM, RR genotypes and nonseasonal estrus in ewes and an association between mm, rr genotypes and seasonal estrus in ewes.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.5
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• pp.1047-1054
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• 2012

Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, and its risk increases with age. Conventionally, the way of detecting AF was the time·frequency domain analysis of RR variability. However, the detection of ECG signal is difficult because of the low amplitude of the P wave and the corruption by the noise. Also, the time·frequency domain analysis of RR variability has disadvantage to get the details of irregular RR interval rhythm. In this study, we describe an atrial fibrillation pattern analysis based on symbolization and information entropy. We transformed RR interval data into symbolic sequence through differential partition, analyzed RR interval pattern, quantified the complexity through Shannon entropy and detected atrial fibrillation. The detection algorithm was tested using the threshold between 10ms and 100ms on two databases, namely the MIT-BIH Atrial Fibrillation Database.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.14 no.5
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• pp.49-56
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• 2004

An Internet draft, named RR(Return Routability) protocol, proposed to IETF mobileip WG, in order to establish an optimal path to MN(Mobile Node) by securely sending the BU(Binding Update) message to CN(Correspondent Node). However, it has some problems with initiating the protocol by the MN: it causes to increases in communication load in the home network, to increases communication delay between MN and CN, and increases in communication load due to unnecessary message exchanges. To resolve the problems, this paper proposes an alternative scheme for the RR protocol in MIPv6. The proposed scheme is devised to start the protocol by HA on receiving the first packet from CN. It decreases the route optimization overhead by reducing the number of BU messages as well as the communication time. Beside these advantages, this scheme provides the same security grade as the original RR protocol.

• Journal of the Korean Chemical Society
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• v.45 no.6
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• pp.524-531
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• 2001

Micro-HPLC/IS/MS after solid phase extraction has been employed to enhance the accu-racy in the determination of toxic microcystins, such as microcystin-LR, -YR and -RR. The absorbance at 238 nm in HPLC/UV and characteristic spectra of 135 m/z and $[M+H]^+$ m/z in MS have been widely monitored to identify those microcystin-LR, -YR and -RR. In this study, new lines at 507 m/z for LR, 520 m/z for RR and 532 m/z for YR have been additionally detected in the micro-HPLC/IS/MS spectrum, corresponding to double charge. The micro-HPLC/IS/MS methodology has been applied to investigate the presence of the toxic microcystins in Taecheong lake.

• Korean Journal of Head & Neck Oncology
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• v.27 no.2
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• pp.190-197
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• 2011

Background and Objective : Radiation resistance(RR) is one of main determinants of treatment outcome in oral squamous cell carcinoma(OSCC), but accurate prediction of RR is difficult. We aim to establish RR OSCC cell lines and identify genes related with RR by a measurement of altered gene expression after inducing RR. Material and Methods : OSCC cell lines, SCC15, SCC25 and QLL1, were treated with 2Gy radiation per session, and parts of them were alive in finally accumulated dosage of 60Gy through 30 times repetition of radiotherapy for inducing RR cell lines. We compared results of cDNA array and proteomics in non-radiated cell lines and RR cell lines to detect changes of gene expression. Western blot was used for the validation of results. Results : cDNA array revealed 265 commonly up-regulated genes and 268 commonly down-regulated genes in 3 RR cell lines comparing their non-radiated counterpart. Among them, 30 cancer related genes were obtained. Proteomics showed 51 commonly altered protein expressions in 3 RR cell lines and 18 cancer related proteins were obtained. Among the detected genes, we found NM23-H1 and PA2G4 were over-expressed in both cDNA array and proteomics. Western blot showed increased expression of NME1 in RR cell lines but not in PA2G4. Conclusion: We concluded that NM23-H1 may be a candidate of RR related gene and over-expression of NM23-H1 could be a biomarker to predict RR in OSCC.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.10
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• pp.2551-2561
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• 2014

Several algorithms have been developed to detect AFIB(Atrial Fibrillation) which either rely on the linear and frequency analysis. But they are more complex than time time domain algorithm and difficult to get the consistent rule of irregular RR interval rhythm. In this study, we propose algorithm for optimal value detection of irregular RR interval for AFIB classification based on linear analysis. For this purpose, we detected R wave, RR interval, from noise-free ECG signal through the preprocessing process and subtractive operation method. Also, we set scope for segment length and detected optimal value and then classified AFIB in realtime through liniar analysis such as absolute deviation and absolute difference. The performance of proposed algorithm for AFIB classification is evaluated by using MIT-BIH arrhythmia and AFIB database. The optimal value indicate ${\alpha}=0.75$, ${\beta}=1.4$, ${\gamma}=300ms$ in AFIB classification.

• Proceedings of the Korean Statistical Society Conference
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• 2005.05a
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• pp.239-244
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• 2005

In this paper, we examine the problem of estimating the sensitive characteristics and behaviors in a multinomial randomized response (RR) model. We analyze this problem through a Bayesian perspective and develop a Bayesian multinomial RR model in survey study. The Bayesian inference of multinomial RR model is a new approach to RR models.