• Proceedings of the Korean Biophysical Society Conference
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• 2001.06a
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• pp.22-22
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• 2001

At the eukaryotic replication fork, discontinuous synthesis of lagging strand DNA gives rise to Okazaki fragments carrying ribonucleotides derived from the primer RNA at their 5' ends. Efficient removal of these ribonucleotides is vital for maintaining genome integrity. In this report we show that the endonucleases Dna2 and Fen1 act sequentially to facilitate the complete removal of the primer RNA.(omitted)

• Proceedings of the Korea Information Processing Society Conference
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• 2019.10a
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• pp.872-875
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• 2019

우리나라의 수출입 화물 물량의 대부분은 항만을 통해 처리되고 있으며, 취급화물의 다양성과 선박의 대형화로 주변 국가들의 항만간 경쟁으로 심화되면서 항만 비용의 증가로 발생되고 있다. 이는 항만업무의 효율화와 생산성의 증가로 비용 감소효과를 바라볼 수 있는데, 4차 산업혁명의 주요 기술인 인공지능(OCR, AI알고리즘, 머신러닝, RPA등)의 기술 적용으로 개선할 수 있다. 본 연구에서는 이와 관련된 실질적 항만업무와 관련된 기술을 적용하여 업무의 효율화와 생산성 증가의 기술적 검증을 통해 항만의 경쟁력 강화와 국가 물류발전의 기술적 향상을 도모하고자 한다.

• Journal of Information Processing Systems
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• v.18 no.4
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• pp.480-488
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• 2022

Images of tobacco retail licenses have complex unstructured characteristics, which is an urgent technical problem in the robot process automation of tobacco marketing. In this paper, a novel recognition approach using a double attention mechanism is presented to realize the automatic recognition and information extraction from such images. First, we utilized a DenseNet network to extract the license information from the input tobacco retail license data. Second, bi-directional long short-term memory was used for coding and decoding using a continuous decoder integrating dual attention to realize the recognition and information extraction of tobacco retail license images without segmentation. Finally, several performance experiments were conducted using a largescale dataset of tobacco retail licenses. The experimental results show that the proposed approach achieves a correction accuracy of 98.36% on the ZY-LQ dataset, outperforming most existing methods.

• BMB Reports
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• v.56 no.2
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• pp.108-113
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• 2023

Cohesin is a ring-shaped protein complex that comprises the SMC1, SMC3, and α-kleisin proteins, STAG1/2/3 subunits, and auxiliary factors. Cohesin participates in chromatin remodeling, chromosome segregation, DNA replication, and gene expression regulation during the cell cycle. Mitosis-specific α-kleisin factor RAD21 and meiosis-specific α-kleisin factor REC8 are expressed in embryonic stem cells (ESCs) to maintain pluripotency. Here, we demonstrated that RAD21 and REC8 were involved in maintaining genomic stability and modulating chromatin modification in murine ESCs. When the kleisin subunits were depleted, DNA repair genes were downregulated, thereby reducing cell viability and causing replication protein A (RPA) accumulation. This finding suggested that the repair of exposed single-stranded DNA was inefficient. Furthermore, the depletion of kleisin subunits induced DNA hypermethylation by upregulating DNA methylation proteins. Thus, we proposed that the cohesin complex plays two distinct roles in chromatin remodeling and genomic integrity to ensure the maintenance of pluripotency in ESCs.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.249-251
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• 2021

본 논문에서는 WEB대상으로 UI테스트를 최초 설계할 때, 웹로그를 분석하여 사용자들의 패턴을 파악하고 자동으로 테스트 시나리오와 케이스를 설계하여 제공하는 시스템을 제안한다. 이 시스템은 메세지큐를 활용하여 로그 데이터를 효율적으로 수집할 수 있고, 분석 시스템과 사용자들이 사용하는 웹서버를 분리하여 로그분석으로 인한 시스템 과부하 현상을 예방 할 수 있다. 또한 로그분석을 통해 추출된 데이터를 통해 사용자들이 실제로 자주 사용하거나 사용했던 사용 경로를 이용하여 자동으로 테스트 시나리오와 테스트 케이스에 대한 자료들을 접할 수 있어 테스트 분석, 설계 과정에서의 소요되는 시간이 감축되는 것을 기대할 수 있으며, 실제 사용자들이 자주 이용하는 패턴으로 테스트 대상을 정할 수 있기 때문에 후에 테스트를 통한 결함이 조치가 된다면 사용자들이 결함 경험을 줄일 수 있을 것이라 기대한다.

• Clinical and Experimental Pediatrics
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• v.46 no.1
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• pp.67-75
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• 2003

Purpose : Intravascular stent implantation for the treatment of postoperative branch pulmonary artery(PA) stenosis has been used successfully. However, the cross sectional area of contralateral branch PA does not regress in spite of the successful dilation of the stenotic branch PA after stent implantation. We analyzed the morphologic and hemodynamic factors on the size of branch PA after successful stent implantation. Methods : The subjects in our study were 23 children who had undergone stent implantaion from Jan. 1995 to Jul. 2002 in the Division of Yonsei Pediatric Cardiology. We evaluated the cross sectional area index(CSAI) of branch PA before and after stent implantation at follow-up catheterization. We also investigated factors such as residual pulmonary stenosis, pulmonary regurgitation(PR), systolic pressure of right ventricle, and lung perfusion scan. Results : The CSAI of the RPA without stenosis changed from mean $238{\pm}17mm^2/BSA$ to mean $249{\pm}20mm^2/BSA$(P=0.47), but didn't regress. The CSAI of the LPA with stenosis was increased effectively by stent implantation from the mean $102{\pm}12mm^2/BSA$ to mean $125{\pm}11mm^2/BSA$(P< 0.05). At follow up after stent implantation, the CSAI of PA is correlated with the residual PR fraction after stent implantation. Conclusion : In a group with increased residual PR, CSAI of RPA was found to be significantly increased between the pre- and post-stages of stent implantation. So, we suspect that the pulmonary regurgitation remaining after right ventricle outlet tract(RVOT) dilatation surgery is correlated with the increase in CSAI of RPA.

• Journal of Astronomy and Space Sciences
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• v.31 no.1
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• pp.73-81
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• 2014

A package of space science instruments, dubbed the Instruments for the Study of Space Storms (ISSS), is proposed for the Next Generation Small Satellite-1 (NEXTSat-1), which is scheduled for launch in May 2016. This paper describes the instrument designs and science missions of the ISSS. The ISSS configuration in NEXTSat-1 is as follows: the space radiation monitoring instruments consist of medium energy particle detector (MEPD) and high energy particle detector (HEPD); the space plasma instruments consist of a Langmuir probe (LP), a retarding potential analyzer (RPA), and an ion drift meter (IDM). The space radiation monitoring instruments (MEPD and HEPD) measure electrons and protons in parallel and perpendicular directions to the geomagnetic field in the sub-auroral region, and they have a minimum time resolution of 50 msec for locating the region of the particle interactions with whistler mode waves and electromagnetic ion cyclotron (EMIC) waves. The MEPD measures electrons and protons with energies of tens of keV to ~400 keV, and the HEPD measures electrons with energies of ~100 keV to > ~1 MeV and protons with energies of ~10 MeV. The space plasma instruments (LP, RPA, and IDM) observe irregularities in the low altitude ionosphere, and the results will be compared with the scintillations of the GPS signals. In particular, the LP is designed to have a sampling rate of 50 Hz in order to detect these small-scale irregularities.

• The Journal of Korean Academy of Prosthodontics
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• v.48 no.3
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• pp.189-193
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• 2010

Purpose: This study was aimed to investigate the frequency of different classes of partial edentulism and the most frequently used design components of conventional removable partial dentures. Materials and methods: 63 patients who were treated with removable partial denture in Kyungpook National University hospital for 2003-2006 were selected. A total of 76 removable partial denture frameworks were investigated. Kennedy classification was used to identify the class of partial edentulism. Results: Results indicated that Kennedy class I removable partial dentures were the most frequently constructed. Most patients' cases were designed without modification areas. Conclusion: The most common type of direct retainer were the RPI clasp and RPA clasp in both maxilla and mandible. Lingual bar, linguoplate and anterior posterior palatal straps were the more frequently used mandibular and maxillary major connectors respectively. We did not have any case about Kennedy class IV patients.

• Research in Plant Disease
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• v.17 no.1
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• pp.25-31
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• 2011

Rust causes significant losses in the yield and quality of various crops. The development of new effective and environmentally benign agents against the pathogen is of great interest. In the course of searching a natural antifungal compound from medicinal plants, we found that the methanol extract of Angelica gigas roots had a potent control efficacy against wheat leaf rust (WLR) caused by Puccinia recondita. The antifungal substance was isolated from the methanol extract by silica gel column chromatography, alumina column chromatography and $C_{18}$ preparative HPLC. It was identified as decursinol angelate by EI-MS and $^1H$-NMR data. In in vivo test, decursinol angelate effectively suppressed the development of WLR and red pepper anthracnose (RPA) among the 6 plant diseases tested. In addition, the wettable powder-type formulation of ethyl acetate extract of A. gigas roots significantly suppressed the development of WLR. The crude extract containing decursinol angelate and the chemical appear to be a potential candidate for control of WLR. In addition, this is the first report on the in vivo antifungal activity of decursinol angelate against WLR as well as RPA.

• International Journal of Vascular Biomedical Engineering
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• v.1 no.2
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• pp.36-41
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• 2003

Both flow visualizations and computational fluid dynamics were performed to determine hemodynamics in a total cavopulmonary connection (TCPC) model for surgically correcting congenital heart defects. From magnetic resonance images, an anatomically correct glass model was fabricated to visualize steady flow. The total flow rates were 4, 6 and 8L/min and flow rates from SVC and IVC were 40:60. The flow split ratio between LPA and RPA was varied by 70:30, 60:40 and 50:50. A pressure-based finite-volume software was used to solve steady flow dynamics in TCPC models. Results showed that superior vena cava(SVC) and inferior vena cava(IVC) flow merged directly to the intra-atrial conduit, creating two large vortices. Significant swirl motions were observed in the intra-atrial conduit and pulmonary arteries. Flow collision or swirling flow resulted in energy loss in TCPC models. In addition, a large intra-atrial channel or a sharp bend in TCPC geometries could influence on energy losses. Energy conservation was efficient when flow rates in pulmonary branches were balanced. In order to increase energy efficiency in Fontan operations, it is necessary to remove a flow collision in the intra-atrial channel and a sharp bend in the pulmonary bifurcation.