• Journal of Environmental Science International
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• v.20 no.9
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• pp.1165-1182
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• 2011

The evaluation of potential submarine groundwater is an important research topic for exploring an alternative water resource. Two different approaches, water budget analysis and Rn mass balance method, were employed to investigate the annual variation of submarine groundwater discharge in 2010 at a marine watershed located at the south-eastern part of Korean Peninsula. In order to obtain reliable hydrological data during study period, temporal and spatial variations of rainfall and soil moisture had been collected and hydro-meterological data such as temperature, humidity and wind speed were collected The runoff response was simulated using SCS-CN method with spatial distributions of landuse and soil texture from GIS analysis. Six different methods were used to estimate the monthly variation of evapotranspiration and field measurements of soil moisture were used to account for the infiltration. Comparisons of infiltration and surface runoff between simulation and water balance with measurements showed coincidence. The water budget analysis and Rn mass balance method provide mean daily submarine groundwater as 5.35 and 4.07 $m^3/m/day$ in 2010, respectively.

• The Journal of Korean Academic Society of Nursing Education
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• v.6 no.1
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• pp.64-76
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• 2000

The purpose of this study is to identify the difference in learning styles, learning stages, and preferred nursing specialties between two groups of nursing programs, regular BSN and RN-BSN. The survey instrument was a simplified version of the Kolb's Learning-Style Instrument which was developed by the researcher, a self- reported learning style questionnaire with twelve questions related to the four learning stages. The sample of the study was the 218 nursing students in a university in Korea which consisted of 58 junior and 67 senior students in the regular BSN program, and 58 junior and 35 senior students in the RN-BSN program. Main findings of the study were as the following. 1) Over all, the major learning style was either the diverger or the accomodator; the most preferred learning stage was the concrete experience and the leastly preferred learning stage was the abstractive conceptualization learning stage; and the most preferred nursing specialty in the future was the clinical nursing. 2) Students in the BSN program preferred four learning stages with rather equal proportion, whereas the students in the RN-BSN program preferred the concrete experience learning stage as high as 60.3% and the abstractive conceptualization learning stage as low as 9.5%. 3)For the future career, the junior students of both programs preferred clinical and educational nursing areas, and the senior students of both programs preferred clinical and research areas. The main reason of the difference seemed to result from the different courses such as Health Education or Teaching Method for the juniors and the Nursing Research for the seniors of both groups. Because the sample of the study was limited to a university, it is difficult to generalize the study results for the entire nursing students in Korea. Continuous studies with larger numbers of nursing students and nurse educators, and experimental studies measuring the effects of new curricula are needed for the future.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8741-8747
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• 2014

Purpose: We aimed to investigate the associations between polymorphisms of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagonist (IL-1RN) and prostate cancer (PCa) risk. Materials and Methods: A comprehensive search for articles of MEDLINE and EMBASE databases and bibliographies of retrieved articles published up to August 3, 2014 was performed. Methodological quality assessment of the trials was based on a standard quality scoring system. The meta-analysis was performed using STATA 12.0. Results: We included 9 studies (1 study for IL-1A, 5 studies for IL-1B, and 3 studies for IL-1RN), and significant association was found between polymorphisms of IL-1B-511 (rs16944) as well as IL-1B-31 (rs1143627) and PCa risk. IL-1B-511 (rs16944) polymorphism was significantly associated with PCa risk in homozygote and recessive models, as well as allele contrast (TT vs CC: OR, 0.74; 95%CI, 0.58-0.94; P=0.012; TT vs TC+CC; OR, 0.79; 95%CI, 0.63-0.98; P=0.033; T vs C: OR, 0.86; 95%CI, 0.77-0.96; P=0.008). The association between IL-1B-31 (rs1143627) polymorphism and PCa risk was weakly significant under a heterozygote model (OR, 1.35; 95%CI, 1.00-1.80; P=0.047). Conclusions: Sequence variants in IL-1B-511 (rs16944) and IL-1B-31 (rs1143627) are significantly associated with PCa risk, which provides additional novel evidence that proinflammatory cytokines and inflammation play an important role in the etiology of PCa.

• Analytical Science and Technology
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• v.14 no.3
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• pp.212-220
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• 2001

This study was performed to establish the analytical method of radium and radon in various environmental samples with the ${\gamma}$-ray spectrometry. The major problem in the measurements of low level ${\gamma}$-ray, such as environmental radioactivity, is the fluctuation of ${\gamma}$-ray background spectrum. To overcome this problem, a nitrogen gas was filled up in the detector chamber to reduce the background counts due to airborne radioactivities, i.e., $^{214}Pb$ and $^{214}Bi$, the daughters of $^{222}Rn$ in air. When nitrogen gas flowed around the detector, peak counts of ${\gamma}$-rays from the daughters of $^{222}Rn$ decreased about 80% below 1 MeV and about 20~50% above 1 MeV. The use of nitrogen purging results in approximately tenfold increment of sensitivity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.12A
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• pp.1165-1171
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• 2008

In this paper, a pilot emitting amplify-and-forward relay and its beamforming schemes, OBF (overall beamforming) and RBF (hop-by-hop beamforming), are proposed for two-hop relaying systems. The OBF performs beamforming with respect to a overall channel from a source node (SN) to a destination node (DN) through a relay node (RN), while the proposed RBF performs two independent beamformings: from the SN to the RN and from the RN to the DN. From our analytic and numerical results, it is shown that bit-error-rate (BER) performance of the proposed RBF is better than that of the OBF scheme since the RBF system can estimate channel more proper than the CBF system, which is verified by deriving and comparing the mean square errors of the channel estimation.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.05a
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• pp.377-380
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• 2018

인간의 추론 능력이란 문제에 주어진 조건을 보고 문제 해결에 필요한 것이 무엇인지를 논리적으로 생각해 보는 것으로 문제 상황 속에서 일정한 규칙이나 성질을 발견하고 이를 수학적인 방법으로 법칙을 찾아내거나 해결하는 능력을 말한다. 이러한 인간인지 능력과 유사한 인공지능 시스템을 개발하는데 있어서 핵심적 도전은 비구조적 데이터(unstructured data)로부터 그 개체들(object)과 그들간의 관계(relation)에 대해 추론하는 능력을 부여하는 것이라고 할 수 있다. 지금까지 딥러닝(deep learning) 방법은 구조화 되지 않은 데이터로부터 문제를 해결하는 엄청난 진보를 가져왔지만, 명시적으로 개체간의 관계를 고려하지 않고 이를 수행해왔다. 최근 발표된 구조화되지 않은 데이터로부터 복잡한 관계 추론을 수행하는 심층신경망(deep neural networks)은 관계추론(relational reasoning)의 시도를 이해하는데 기대할 만한 접근법을 보여주고 있다. 그 첫 번째는 관계추론을 위한 간단한 신경망 모듈(A simple neural network module for relational reasoning) 인 RN(Relation Networks)이고, 두 번째는 시각적 관찰을 기반으로 실제대상의 미래 상태를 예측하는 범용 목적의 VIN(Visual Interaction Networks)이다. 관계 추론을 수행하는 이들 심층신경망(deep neural networks)은 세상을 객체(objects)와 그들의 관계(their relations)라는 체계로 분해하고, 신경망(neural networks)이 피상적으로는 매우 달라 보이지만 근본적으로는 공통관계를 갖는 장면들에 대하여 객체와 관계라는 새로운 결합(combinations)을 일반화할 수 있는 강력한 추론 능력(powerful ability to reason)을 보유할 수 있다는 것을 보여주고 있다. 본 논문에서는 관계 추론을 수행하는 심층신경망(deep neural networks) 중에서 Sort-of-CLEVR 데이터 셋(dataset)을 사용하여 RN(Relation Networks)의 성능을 재현 및 관찰해 보았으며, 더 나아가 파라미터(parameters) 튜닝을 통하여 RN(Relation Networks) 모델의 성능 개선방법을 제시하여 보았다.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.2
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• pp.72-75
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• 2011

Purpose: The HSV1-tk reporter gene system is the most widely used system because of its advantage is that it is possible to monitor directly without the introduction of a separate reporter gene in case of HSV1-tk suicide gene therapy. This study was performed to automate 9-(4-[$^{18}F$] Fluoro-3-hydroxymethylbutyl) guanine ([$^{18}F$] FHBG) that are widely used as substrate for the HSV1-tk reporter gene in living organisms with positron emission tomography (PET) and find the optimized conditions of synthesis. Materials and Methods: Fully automated synthesis of [$^{18}F$] FHBG was performed using Explora-RN (CTI, USA) module. We have changed of reaction time (3, 5, 10 min) and temperature (110, 120, $130^{\circ}C$) for the optimized conditions of synthesis. Also we experimented to find the optimal concentration of precursor (5, 7, 10 mg). Results: [$^{18}F$] FHBG was purified by HPLC system and collected at around 10-12 min. Synthesis using Explora-RN module showed a $32.0{\pm}1.2%$ yield of radiochemical (decay corrected), the purity was greater than 98%. And the entire synthesis time was less than 48 min. Temperature of the highest synthesis yield was $130^{\circ}C$, reaction time was 5 minutes and concentration of precursor was 10 mg (recommended volume in manual) (n=36). In contrast to radiochemical yield of precursor 10 mg ($32{\pm}1.2%$), yield of 5 and 7 mg precursor was unstable. Conclusion: Automation of [$^{18}F$] FHBG synthesis at Explora-RN module has been completed. In addition, we were able to obtain optimized reaction time, temperature and concentration of precursor. Therefore this study would be provided more rapid synthesis and higher radiochemical yield.

• Journal of the Korean Society of Groundwater Environment
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• v.6 no.2
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• pp.59-65
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• 1999

Both the groundwater changes due to different pumping rates and the geochemistry of thermal waters in the Suanbo area are considered in this study. The observation of groundwater level change since 1991 shows that the change is directly correlated with pumping rates of thermal waters and reveals the retardation of ca. 5 weeks after pumping. The hydrogeological aquifer in the area is under reducing condition. The thermal waters are of Na-HCO$_3$ type. and are alkaline (pH=8.5∼8.7) with low TDS values (274∼284 mg/l) and high concentrations of Na (68∼72 mg/l). F (6.4∼8.9 mg/l), and HCO$_3$(136∼146 mg/l). Oxygen and hydrogen isotope ratios of thermal water indicate a meteoric water origin. The activities of Rn-222 and Ra-226 in both thermal water and local groundwater were determined to delineate possible geochemical controls on the Rn-222 and Ra-226. The Rn-222 concentrations are several orders of magnitude greater than the Ra-226 concentrations. The concentrations of Rn-222 range from 190 to 7.490 pCi/1 with an average of 2,522 pCil/l. and those of Ra-226 average 0.32 pCi/1 with the range from 0.25 to 0.42 pCi/1. The concentrations of Rn-222 and Ra-226 are inversely correlated with EC and alkalinity. The pH it positively correlated with Ra-226. The correlation between Rn-222 and Ra-226 is poor. Thermal waters in the study area are produced from highly fractured phyllite. The thermal water qualify. CSAMT (controled-source audiofrequency magnetotelluric) prospecting, and petrological evidences, however, indicate that the heat is possibly transmitted through deep normal faults reaching a deep granite batholith, and the phyllite acts only as a groundwater pathway.

• The Journal of Engineering Geology
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• v.31 no.4
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• pp.659-669
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• 2021

The purpose of this study is to elucidate the relationship between occurrence of natural radioactive materials such as ²³⁸U and ²²²Rn and original mixing ratio of helium isotope of groundwater from various geology, and to suggest the underground aquifer environment from helium original mixing data. 9 groundwater samples were collected from five study areas, and ²³⁸U, Rn-222 and helium isotope were analyzed. A high ²³⁸U content of the range of 218~477 ㎍ /L in the groundwater occurs in the twomica granite. ⁴He air-crust mixing ratio and the Rn-222 content show a rough relation, that is, Rn-222 content increases according to the increase of ⁴He crust mixing ratio. Because of helium and radon are an inert gas, their behavior in underground environment is assumed as an analogous. The ²³⁸U content and He isotope in groundwater does not show any distinct correlation. The groundwater can be classified as three groups (air, air-crust mixing, crust-mantle mixing origin) on the diagram of ³He/⁴He vs ⁴He/²⁰Ne, which is composed of original mixing line from air-crust-mantle end members. This original mixing of helium can provide the information of underground aquifer characteristic such as the connection with surface environment or isolation condition from air environment.

• IMMUNE NETWORK
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• v.4 no.1
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• pp.16-22
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• 2004

Background: To develop a novel treatment strategy for hepatitis B virus infection, a major cause of liver chirosis and cancer, we aimed to make human monoclonal antibodies inhibiting RNase H activity of P protein playing in important role in HBV replication. In this regard, phage display technology was employed and demonstrated as an efficient cloning method for human monoclonal antibody. So this study analysed the usability of human monoclonal antibody as protein based gene therapy. Methods: RNase H of HBV was expressed as fusion protein with maltose binding protein and purified with amylose resin column. Single chain Fv (scFv) phage antibody library was constructed by PCR cloning using total RNAs of PBMC from 50 healthy volunteers. Binders to RNase H were selected with BIAcore 2000 from the constructed library, and purified as soluble antibody fragment. The affinity and sequences of selected antibody fragments were analyzed with BIAcore and ABI automatic sequencer, respectively. And finally RNase H activity inhibiting assay was carried out. Results: Recombinant RNase H expressed in E. coli exhibited an proper enzyme activity. Naive library of $4.46{\times}10^9cfu$ was screened by BIAcore 2000. Two clones, RN41 and RN56, showed affinity of $4.5{\times}10^{-7}M$ and $1.9{\times}10^{-7}M$, respectively. But RNase H inhibiting activity of RN41 was higher than that of RN56. Conclusion: We cloned human monoclonal antibodies inhibiting RNase H activity of P protein of HBV. These antibodies can be expected to be a good candidate for protein-based antiviral therapy by preventing a replication of HBV if they can be expressed intracellularly in HBV-infected hepatocytes.