• The Korean Journal of Physiology and Pharmacology
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• v.20 no.3
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• pp.245-251
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• 2016

The objective of this study was to externally validate a new dosing scheme for busulfan. Thirty-seven adult patients who received busulfan as conditioning therapy for hematopoietic stem cell transplantation (HCT) participated in this prospective study. Patients were randomized to receive intravenous busulfan, either as the conventional dosage (3.2 mg/kg daily) or according to the new dosing scheme based on their actual body weight (ABW) ($23{\times}ABW^{0.5}mg\;daily$) targeting an area under the concentration-time curve (AUC) of $5924{\mu}M{\cdot}min$. Pharmacokinetic profiles were collected using a limited sampling strategy by randomly selecting 2 time points at 3.5, 5, 6, 7 or 22 hours after starting busulfan administration. Using an established population pharmacokinetic model with NONMEM software, busulfan concentrations at the available blood sampling times were predicted from dosage history and demographic data. The predicted and measured concentrations were compared by a visual predictive check (VPC). Maximum a posteriori Bayesian estimators were estimated to calculate the predicted AUC ($AUC_{PRED}$). The accuracy and precision of the $AUC_{PRED}$ values were assessed by calculating the mean prediction error (MPE) and root mean squared prediction error (RMSE), and compared with the target AUC of $5924{\mu}M{\cdot}min$. VPC showed that most data fell within the 95% prediction interval. MPE and RMSE of $AUC_{PRED}$ were -5.8% and 20.6%, respectively, in the conventional dosing group and -2.1% and 14.0%, respectively, in the new dosing scheme group. These findings demonstrated the validity of a new dosing scheme for daily intravenous busulfan used as conditioning therapy for HCT.

• Journal of Korea Water Resources Association
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• v.40 no.10
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• pp.811-821
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• 2007

The intensity-duration-frequency (IDF) curves by Talbot, Sherman and Japanese type formulas are widely used in South Korea since the parameters are easily estimated. However, these IDF curves' accuracies are relatively worse than those of the IDF curves developed by Lee et al. (1993) and Heo et al. (1999), and different parameters for the given return periods should be computed. In this study, parameter estimation method for the IDF curve by Heo et al. (1999) is suggested using genetic algorithm (GA). Quantiles computed by at-site frequency analysis using the rainfall data of 22 rainfall gauges operated by Korea Meteorological Administration are employed to estimate the parameters of IDF curves and minimizing root mean squared error (RMSE) and relative RMSE (RRMSE) of observed and computed quantiles are used as objective functions of GA. The comparison of parameter estimation methods between the empirical regression analysis and the suggested method show that the IDF curve in which the parameters are estimated by GA using RRMSE as an objective function is superior to the IDF curves using RMSE.

• Horticultural Science & Technology
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• v.29 no.3
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• pp.181-186
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• 2011

To predict the bud bursting date of 'Campbell Early' grapevines, the bud developmental rate (DVR) models were constructed. The DVRs for bud bursting were calculated from the demanded times at controlled air temperatures. The DVRs were examined on the 'Campbell Early' grapevines incubated in three different temperatures at 4.6, 11.8, and $16.6^{\circ}C$. The DVR increased exponentially or linearly on the air temperature with a slope of about 0.0019. The DVR equations were computed as $DVR=0.0249+0.0020e^{0.1654x}$ or DVR = 0.0019x + 0.0187. These DVR equations offered developmental indices and predicted dates for bud bursting with air temperature data. The DVR equations were validated to the bud bursting data observed in the field. When bud bursting dates were calculated with daily temperature data, the root mean squared error (RMSE) between the observed and the predicted dates was less than 4 days. When those were calculated with hourly temperature data, on the other hand, the RMSE was less than 3 days. These results suggest that the DVR models are useful to predict bud bursting date of 'Campbell Early' grapevines.

• Journal of Korea Water Resources Association
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• v.46 no.11
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• pp.1129-1140
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• 2013

Precipitation is one of the important factors in the hydrological cycle. It needs to understand accurate of spatial precipitation field because it has large spatio-temporal variability. Precipitation data obtained through the Tropical Rainfall Monitoring Mission (TRMM) 3B43 product is inaccurate because it has 25 km space scale. Downscaling of TRMM 3B43 product can increase the accuracy of spatial precipitation field from 25 km to 1 km scale. The relationship between precipitation and the normalized difference vegetation index(NDVI) (1 km space scale) which is obtained from the Moderate Resolution Imaging Spectroradiometers (MODIS) sensor loaded in Terra satellite is variable at different scales. Therefore regression equations were established and these equations apply to downscaling. Two renormalization strategies, Geographical Difference Analysis (GDA) and Geographical Ratio Analysis (GRA) are implemented for correcting the differences between remote sensing-derived and rain gauge data. As for considering the GDA method results, biases, the root mean-squared error (RMSE), MAE and Index of agreement (IOA) is equal to 4.26 mm, 172.16 mm, 141.95 mm, 0.64 in 2009 and 17.21 mm, 253.43 mm, 310.56 mm, 0.62 in 2011. In this study, we can see the 1km spatial precipitation field map over Korea. It will be possible to get more accurate spatial analysis of the precipitation field through using the additional rain gauges or radar data.

• Environmental Engineering Research
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• v.25 no.4
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• pp.479-487
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• 2020

Current assumptions are used in the formulation of pseudo-first (PFO) and second-order (PSO) models to describe the kinetic data of filtration based on ideal operating conditions. This paper presents a new model developed with pseudo n^th order and based on real assumption. A comparison was performed between PFO, PSO and the new model to highlight their performance and the optimisation of the pseudo-order equation, using MATLAB software. Adsorption characteristic of bovine serum albumin adsorption on the track-etched membrane are used as a medium based on protein filtration data were extracted from the literature for different concentrations to demonstrate the comparison between PFO/PSO and the new model. The pseudo first and second-order kinetic models were applied to test the experimental data and they did not provide reasonable values. The results show that the predicted values are consistent with experimental values giving a good correlation coefficient R² = 0.997 and a minimum root mean squared error RMSE = 0.0171. Indeed, the experimental results follow the new model and the optimal pseudo equation order n = 1.115, the most suitable curves for the new model. As a result, we used different experimental adsorption data from the literature to examine and check the applicability and validity of the model.

• Journal of the Korea Organic Resources Recycling Association
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• v.21 no.2
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• pp.88-96
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• 2013

The objective of this research was to evaluate the suitability of sigmoidal and firstorder kinetic equations for simulating the methane production from solid wastes. The sigmoidal kinetic equations used were modified Gompertz and Logistic equations. Statistical criteria used to evaluate equation performance were analysis of goodness-of-fit (Residual sum of squares, Root mean squared error and Akaike's Information Criterion). Akaike's Information Criterion (AIC) was employed to compare goodness-of-fit of equations with same and different numbers of parameters. RSS and RMSE were decreased for first-order kinetic equation with lag-phase time, compared to the first-order kinetic equation without lag-phase time. However, first-order kinetic equations had relatively higher AIC than the sigmoidal kinetic equations. It seemed that the sigmoidal kinetic equations had better goodness-of-fit than the first-order kinetic equations in order to simulate the methane production.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.224-224
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• 2017

지구온난화로 인한 기후변화 등으로 안전한 하천구조물을 설계하기 위해서는 신뢰할 수 있는 홍수량 산정이 필요하다. 신뢰할 수 있는 홍수량 산정을 위해서는 정도 높은 과거 수문자료가 필요하나 국내의 많은 중소 규모유역이 미계측 유역 또는 과거 수문자료 부족으로 신뢰 할 수 있는 홍수량 산정이 어려운 실정이다. 본 연구에서는 미계측 유역의 홍수량 산정을 위하여 확률분포모형(PDM)의 매개변수 지역화를 수행하였다. 매개변수 지역화 연구를 수행하기 위하여, 금강 25개 유역을 대상으로 유역별 9~18개의 단기홍수수문사상을 선정하였다. 선정된 단기홍수수문사상을 확률분포모형에 적용하기위하여, MCAT (Monte Carlo Analysis Toolbox)을 활용하여 검정 및 검증을 수행하였으며, 목적함수는 수문곡선 모든 구간을 반영하는 NSE (Nash Sutcliffe Efficiency)와 고유량 부분을 반영하는 RMSE (Root Mean Squared Error) - FH를 적용하였다. 각각의 목적함수에 대하여 검정 모형 매개변수와 유역 특성인자의 다중 선형회귀식을 강우유출모형 매개변수 지역화 모형으로 제시하였다. 매개변수 지역화 결과의 평가를 위하여 청주 유역을 미계측 유역으로 가정하였다. 청주 유역에 대하여 지역화 매개변수를 적용한 결과, 17개의 사상 중 11개의 사상에서 NSE 목적함수 값이 0.5이상으로 전체적인 수문곡선의 경향성을 보였으며, 첨두 홍수량은 17개 사상 중 11개 사상에서 관측 첨두 홍수량 값의 20%이내를 제시하여 적합한 결과를 제시하였다. 또한 금강 25개 유역에 Jackknife 방법으로 검정 결과 관측 첨두 홍수량 값 20%이내의 성능을 보이는 사상이 56%를 포함하고 있어 의미있는 지역화 모형을 제시하였다고 판단된다. 본 연구에서 제시한 매개변수 지역화 방법은 미계측 유역의 유출모의에 활용될 수 있음을 확인하였다.

• Asian Journal of Business Environment
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• v.13 no.2
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• pp.9-20
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• 2023

Purpose: This study aims to map the spatial distribution of poverty using nighttime light satellite images as a proxy indicator of economic activities and infrastructure distribution in D.I Yogyakarta, Indonesia. Research design, data, and methodology: This study uses official poverty statistics (National Socio-economic Survey (SUSENAS) and Poverty Database 2015) to compare satellite imagery's ability to identify poor urban areas in D.I Yogyakarta. National Socioeconomic Survey (SUSENAS), as poverty statistics at the macro level, uses expenditure to determine the poor in a region. Poverty Database 2015 (BDT 2015), as poverty statistics at the micro-level, uses asset ownership to determine the poor population in an area. Pearson correlation is used to identify the correlation among variables and construct a Support Vector Regression (SVR) model to estimate the poverty level at a granular level of 1 km x 1 km. Results: It is found that macro poverty level and moderate annual nighttime light intensity have a Pearson correlation of 74 percent. It is more significant than micro poverty, with the Pearson correlation being 49 percent in 2015. The SVR prediction model can achieve the root mean squared error (RMSE) of up to 8.48 percent on SUSENAS 2020 poverty data.Conclusion: Nighttime light satellite imagery data has potential benefits as alternative data to support regional poverty mapping, especially in urban areas. Using satellite imagery data is better at predicting regional poverty based on expenditure than asset ownership at the micro-level. Light intensity at night can better describe the use of electricity consumption for economic activities at night, which is captured in spending on electricity financing compared to asset ownership.

• Computers and Concrete
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• v.31 no.2
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• pp.85-95
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• 2023

Natural pozzolans are used as additives in cement to develop more durable and high-performance concrete. Pozzolanic activity index (PAI) is important for assessing the performance of a pozzolan as a binding material and has an important effect on the compressive strength, permeability, and chemical durability of concrete mixtures. However, the determining of the 28 days (short term) and 90 days (long term) PAI of concrete mixtures is a time-consuming process. In this study, to reduce extensive experimental work, it is aimed to predict the short term and long term PAIs as a function of the chemical compositions of various natural pozzolans. For this purpose, the chemical compositions of various natural pozzolans from Central Anatolia were determined with X-ray fluorescence spectroscopy. The mortar samples were prepared with the natural pozzolans and then, the short term and the long term PAIs were calculated based on compressive strength method. The effect of the natural pozzolans' chemical compositions on the short term and the long term PAIs were evaluated and the PAIs were predicted by using multiple linear regression (MLR) and adaptive neuro-fuzzy inference system (ANFIS) model. The prediction model results show that both reactive SiO₂ and SiO₂+Al₂O₃+Fe₂O₃ contents are the most effective parameters on PAI. According to the performance of prediction models determined with metrics such as root mean squared error (RMSE) and coefficient of correlation (R²), ANFIS models are more feasible than the multiple regression model in predicting the 28 days and 90 days pozzolanic activity. Estimation of PAIs based on the chemical component of natural pozzolana with high-performance prediction models is going to make an important contribution to material engineering applications in terms of selection of favorable natural pozzolana and saving time from tedious test processes.

• Computers and Concrete
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• v.34 no.2
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• pp.247-265
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• 2024

Measuring the fracture toughness of concrete in laboratory settings is challenging due to various factors, such as complex sample preparation procedures, the requirement for precise instruments, potential sample failure, and the brittleness of the samples. Therefore, there is an urgent need to develop innovative and more effective tools to overcome these limitations. Supervised learning methods offer promising solutions. This study introduces seven machine learning algorithms for predicting concrete's effective fracture toughness (K-eff). The models were trained using 560 datasets obtained from the central straight notched Brazilian disc (CSNBD) test. The concrete samples used in the experiments contained micro silica and powdered stone, which are commonly used additives in the construction industry. The study considered six input parameters that affect concrete's K-eff, including concrete type, sample diameter, sample thickness, crack length, force, and angle of initial crack. All the algorithms demonstrated high accuracy on both the training and testing datasets, with R² values ranging from 0.9456 to 0.9999 and root mean squared error (RMSE) values ranging from 0.000004 to 0.009287. After evaluating their performance, the gated recurrent unit (GRU) algorithm showed the highest predictive accuracy. The ranking of the applied models, from highest to lowest performance in predicting the K-eff of concrete, was as follows: GRU, LSTM, RNN, SFL, ELM, LSSVM, and GEP. In conclusion, it is recommended to use supervised learning models, specifically GRU, for precise estimation of concrete's K-eff. This approach allows engineers to save significant time and costs associated with the CSNBD test. This research contributes to the field by introducing a reliable tool for accurately predicting the K-eff of concrete, enabling efficient decision-making in various engineering applications.