• Journal of Physiology & Pathology in Korean Medicine
• /
• v.33 no.4
• /
• pp.191-197
• /
• 2019

This study aims to evaluate the effects of the root bark of Morus alba (RMA) on the regulation of the Hippo-YAP pathway. Hippo-YAP signaling is a critical regulator in controlling organ size and tissue homeostasis. Hippo, the serine/threonine kinase phosphorylate the LATS. Phosphorylated LATS then phosphorylates and inactivates the YAP and TAZ, which are two closely related transcriptional co-activator. Here we report RMA activates the Hippo signaling, thereby inhibits the YAP/TAZ activity. First, we examine the cytotoxic effects of RMA by MTT assay. RMA was cytotoxic at concentrations higher than $50{\mu}g/ml$ in HEK293A cells. The reporter gene assay was performed to measure the activity of TEAD, a key transcription factor that controls cell growth and proliferation. RMA significantly suppressed the luciferase activity. By phos-taq gel shift assay, and western blotting, we showed that RMA enhanced the phosphorylation of YAP in wild type cells, but not in LATS1/2 knock out cells, which means RMA activates classical Hippo pathway. RMA induced the cytoplasmic sequestration of YAP. RMA also suppressed the mRNA expression of CTGF and CYR61; the two major YAP dependent genes. Taken together, RMA is considered to be a good candidate for proliferative disease such as cancer, by facilitating cell death through activating the Hippo signaling pathway.

• Journal of Korean Society of Water and Wastewater
• /
• v.25 no.3
• /
• pp.349-357
• /
• 2011

This study has an objective to estimate effect on water-quality enhancement by removal of contaminated river-bed material using a two-dimensional numerical modeling in the Seonakdong River, the Pyunggang River and the Maekdo River. RMA2 and RMA4 models were used for flow and contaminant transport simulation, respectively. After the analysis of the effects of flow restoration plan for the Seonakdong River system made by Lee et al (2008), simulation have been performed about scenarios which contains operations of the Daejeo Gate, the Noksan Gate, the Makdo Gate (on planning), and the Noksan Pumping Station. Because there is no option for elution from bed sediment in the RMA4 model, a simple technique has been used for initial condition modification for elution. The analyses revealed that the effect on water quality improvement due to dredging of bed sediment seemed to be less than 10 % of the total effect. The most efficient measure for the water quality improvement of the river system was the linked operation of water-gates and pumping station.

• Applied Chemistry for Engineering
• /
• v.10 no.3
• /
• pp.450-455
• /
• 1999

Unsaturated diol (UD) was prepared from the esterification of maleic anhydride with diethylene glycol (DEG). Unsaturated polyesters modified with rosin (UPMR) or with rosin maleic anhydride adduct (RMA) from 2-hydroxyethylmethacrylate (HEMA) and rosin (UPMRH) were prepared by the reaction of UD with RMA or RMA-HEMA. After crosslinking of UPMR and UPMRH with styrene and methylmethacrylate (MMA), respectively, solvent resistance, tensile strength, and adhesion property of the resins were measured. UPMR crosslinked with styrene or MMA shows an excellent resistance to water and acid. Solvents resistance and tensile strength of UPMR using styrene as crosslinking agent were increased compared with those of UPMR using MMA as crosslinking agent. UPMRH showed better solvents resistance and tensile strength than UPMR. Adhesion strengths of UPMR crosslinked with styrene and MMA were 1.61 and 3.02 MPa, and those of UPMRH were 2.32 and 3.89 MPa, respectively.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2009.05a
• /
• pp.885-889
• /
• 2009

국가하천 함평천은 전라남도 함평군과 무안군 등 2개 군에 걸쳐 위치하고 있는 영산강의 제1지류로서 동측으로는 고막원천, 서측으로는 서해안, 북측으로는 영광군이 위치하고 있으며, 남측으로는 영산강 본류와 접하고 있다. 전라남도 함평군 함평읍, 엄다면, 학교면 사이에 위치한 함평 세계 나비 곤충 엑스포장 옆의 함평 2지구 하천환경정비사업 구간을 구하도 복원사업 구간으로 설정하였다. 이 연구는 함평 2지구 하천환경정비사업 구간에서 수리학적 영향을 검토할 목적으로 수행하였다. 평면 이차원 모형을 사용하여 흐름 변화를 분석하였다. 흐름 계산은 RMA2 모형을 사용하였으며, 유속과 수위의 평면적 변화를 분석하였다. 또한, 평면 이차원 모형 적용 결과를 통해 하도 폐색 가능성을 분석하였다. 하도의 사행화와 분리하도를 구성하여 다양한 유속 분포를 보였으며, 분리하도 구간은 1 $m^3/s$ 이상의 유량을 유지하고 있어 하도 폐색은 발생하지 않을 것으로 판단되었다. 퇴적 및 침식에 의한 하도의 직선화가 되지 않도록 적절한 재료의 선택하여야 할 것으로 판단된다.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2007.05a
• /
• pp.1277-1281
• /
• 2007

1차원 수치해석망은 수위관측소와 우량관측소를 경계로 광역모형을 구성하고 HEC-RAS를 이용하여 부정류 해석을 실시하였다. 그 결과로 얻은 유량과 수위자료는 2차원 해석 모형인 RMA-2의 경계조건으로 적용하였다. 또한 수치지형도를 이용하여 2차원 격자망을 구성하고 RMA-2를 적용하여 수리특성을 분석하였다. 광역모형의 구성에 의한 HEC-RAS 부정류 해석 결과 제방설치 전과 후의 수리특성의 변화는 그리 크게 나타나지 않았다. 또한 RMA-2 해석 결과 계획홍수량 초과하는 홍수에서 대상유역에서 제방설치 전과 후의 변화는 통수단면적의 감소에 따른 빠른 흐름과 수위의 변화를 가져왔으나 그 크기는 현저하지 않음을 보여준다.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.12 no.2
• /
• pp.15-24
• /
• 2016

GPS(Global Positioning System) location tracking is a method for taking the precise coordinates after the coordinates are obtained by a GPS receiver, and displaying them on the map. In this paper with WAVE(Wireless Access for Vehicular Environment) simulation, we show that various services such as vehicle tracking service, real-time road conditions service and logistics can go tracking service, control and operation services according to the vehicle position and the traveling direction by using the GPS position data. A vehicle tracking system using GPS is automatically able to manage multiple RCP when exchanging data between RMA and the RCP, and it provides rapid requests and responses. To verify that multiple sessions between RMA and RM, as well as multiple sessions between RMA and RCP are able to be implemented, we take RMA as a RCP application on an OBU, until the RMA is receiving data response from corresponding RM. As a result of this experiment, we show that the response speeds of single session between RMA and RM using 1, 2, 3, and 4 kbyte unit data are similar, 62.32ms, 62.65ms, 63.02ms, and 63.48ms, respectively. Likewise, those of 128 muliple sessions using 1, 2, 3, and 4 kbyte unit data are not much more time difference, 298.08ms, 302.21ms, 322.85ms, and 329.62ms, respectively.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2008.05a
• /
• pp.1418-1423
• /
• 2008

연안이나 하천 등에서 공사 시 준설작업으로 인해 많은 양의 부유토사가 발생되며 발생된 부유 토사의 이송 확산은 수환경에 변화를 초래한다. 따라서 준설작업에 있어 부유토사물의 이송 확산 범위를 사전에 예측하고 대비책을 세우는 것이 중요하다. 부유토사는 준설작업 시 Cutter Head가 해저면에 닿는 순간부터 작동을 멈출 때까지 계속하여 발생하며, 이러한 과정들이 반복되면서 많은 양의 토사가 발생한다. 이렇게 발생한 부유토사는 수체흐름에 따라 움직이는데 조류가 있는 연안에서는 시간에 따라 흐름이 달라지게 된다. 본 연구에서는 2차원 수치모형인 RMA2, RMA4를 이용하여 부유토사의 확산과정을 모의하고 준설현장에서 부유토사흐름을 실측하여 비교하였다.

• 한국방재학회:학술대회논문집
• /
• 2010.02a
• /
• pp.95.1-95.1
• /
• 2010

본 연구에서는 만곡하천에서 본류와 지류의 합류각에 따른 수치모의 결과를 이용하여 합류부에서의 유속변화를 파악하는데 목적이 있다. 적용대상지역은 조양강과 용탄천 합류부로서, 만곡하천에 지류가 합류하며 유량이 적은 지류의 합류부에서 유속변화가 나타나는 지역이다. 합류부에서의 지류의 합류각에 따른 유속변화량을 알아보기 위하여 지류의 합류각을 $30^{\circ},\;60^{\circ},\;90^{\circ},\;120^{\circ}$로 바꾸어 수치모의를 실시하였고, 수치모의는 상용 2차원 수치모형인 RMA-2를 이용하였다. 합류부에서 지류의 합류각이 커짐에 따라 합류점의 유속이 느려지고, 유속이 감소하는 범위가 넓어짐을 알 수 있었다.

• Korean Journal of Environmental Agriculture
• /
• v.18 no.1
• /
• pp.18-23
• /
• 1999

A numerical model of flow velocity in the standing water system is presented. This model(RMA-2), based on the 2-dimensional unsteady momentum and continuity equations, uses finite element techniques to simulate the distribution of velocity over a spatial location of lakes. The present model represents an improvement over existing numerical water quality models in that it can model the unsteady state and can, therefore, cope with time with a spatial location of standing waters such as lakes and large reservoirs. The model thus allows the engineer to do more accurate estimation of water flows and thus water qualities in standing waters where directions and velocities of the flow become more important for the simulation of the water quality than in running waters. Tests for the data collected in the lake "Paldang" indicates that the model works well under limited circumstances. However, to be more accurate estimation of velocity with the present model, accumulation of data for the measurement of velocities and renovation of geometrical conditions of the lake would be needed.

• The Journal of the Korea Contents Association
• /
• v.9 no.1
• /
• pp.400-406
• /
• 2009

In this study, in order to find the movement of polluted substance that is flown into the river and the characteristics of dispersion, the experiment that used the RI (Radioactive Isotope) tracer in the river was undertaken, and by using the experiment result, the figure modelling was undertaken to analyze the general type of pollutant dispersion. In addition, in order to calculate more accurate dispersion range and moving time, the experiment was done in about 2km from the measuring points of Namdae Stream around the Yongdam Dam of the upper Geum River to the lower stream. In order to find out the flow of river and dispersion of polluted substance, RMA (Resource Modeling Associates)-2 and RMA-4 program are used in study. The site experiment using the RI was implemented for the experiment in the applied area and the same area, and the distance between each zone was set for 1km with the slight difference for site situation and measured the density date of one second distance through the NaI apparatus to measure the density data of one second interval. On the basis of this measured data, it is compared and analyzed with the result of figure copy of the models to make the comparison and analysis of density distribution following the change in expansion coefficient that makes great influence on expansion range and dispersion in natural rivers.