• Title/Summary/Keyword: RIM

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Rim1α and Neurexin3 Regulate Synaptosomal Dopamine Release (Rim1α와 neurexin3의 시냅토좀 도파민 분비 조절)

  • Lee, Sang-Kyeong;Shim, Joo-Cheol;Kim, Young-Hoon;Kong, Bo-Geum;Seog, Dae-Hyun
    • Journal of Life Science
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    • v.19 no.9
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    • pp.1232-1238
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    • 2009
  • Neurotransmitter release is regulated by various proteins of the active zone in the presynaptic nerve terminals. Dopamine (DA) is an essential neurotransmitter associated with the pathophysiology of diverse behavioral and mental illness such as schizophrenia and drug addiction. We measured synaptosomal DA release of knockout (KO) mice which lacked major genes related to neurotransmitter release. Synaptosomal DA uptake and release were performed and measured using [$^3H$]-DA and superfusion experiments. 3 of the 17 KO mice exhibited altered DA release compared to their littermate controls. In $Rim1{\alpha}$ KO, [$^3H$]-DA release evoked by membrane depolarization significantly decreased. Both basal (physiological buffer-evoked) and membrane depolarization-evoked DA release significantly decreased in dopaminergic conditional KO of $Rim1{\alpha}{\beta}$. Dopaminergic conditional KO of neurexin3 demonstrated a significant increase of membrane depolarization-evoked DA release. These data explain the similarities and distinctions between DA and other classical neurotransmitters such as glutamate and GABA ($\gamma$-aminobutyric acid) release. In conclusion, $Rim1{\alpha}$ and neurexin3 may be important regulators of presynaptic DA release and related to disorders of the nervous system.

Revival Manufacturing Technique and Bonding Method for Jingdezhen White Porcelain with Metal Bound Rim (경덕진요 백자 구연부 금속 테두리의 제작기법 및 접착방법 재현)

  • Yang, Pil-Seung;Seo, Jeong-Ho;Hwang, Hyun-Sung
    • Journal of Conservation Science
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    • v.25 no.3
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    • pp.273-282
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    • 2009
  • As a result of investigating research papers concerning the metal bound rim decoration on four pieces of 'Bowl, white porcelain with impressed floral design and sliver bound rim' and one piece of 'Bowl, white porcelain with sliver bound rim' from among the Jingdezhen white porcelain, which are Sinan remains that are kept in a National museum of Korea. It was found that the material of the bound rim was not silver but tin, and lacquer was used as glue. Based on such a scientific analysis, this study conducted a reproduction test of the manufacturing technique and the bonding method of the metal bound rim attached to the upper tip of the china ware. As a way of reproducing the bound rim, the study was able to discover the best method in terms of the avoidance of loss of materials and the workability out of various cutting methods for tin plates, and it also discovered that the use of lacquer in mixture with soil showed a better workability than the use only of a lacquer ingredient in a test of the bonding method of a metal bound rim using lacquer. Also, in the test of a drying method, a bonding method after drying within a short time at a relatively high temperature was found to be more effective than the drying method after humidifying at a normal temperature, which is used in traditional lacquer ware preservation treatment.

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A Study on the Mapping Method of IEEE 11073 DIM/HL7 v3 RIM for Smart health-care (스마트폰 헬스케어를 위한 IEEE 11073 DIM/HL7 v3 RIM 매핑 방법에 대한 연구)

  • Kim, Jong-Pan;Jeon, Jae-Hwan;Oh, Am-Suk
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2012.05a
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    • pp.842-845
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    • 2012
  • 의료기기는 헬스케어 서비스를 위한 필수요소로 최근 의료와 관련된 스마트폰 애플리케이션의 증가와 함께 스마트폰과 연결되는 의료기기를 활용한 스마트 헬스케어가 대두되고 있다. 이러한 스마트 헬스케어는 현재 ISO/IEEE 11073 표준을 통해 의료기기와 게이트웨이를 연결하여 임상정보를 전송하고 게이트웨이는 HL7 CDA 표준 문서를 통해 전자 건강 기록 및 개인 건강 기록 시스템, 임상 워크플로우 및 임상 의사 결정 지원 시스템과 같은 유형의 의료 서비스 시스템과 연동하는 솔루션이다. ISO/IEEE 11073은 DIM(Domain Information Model)이라는 정보 모델을 기반으로 하며 HL7 v3인 CDA는 RIM(Reference Information Model)이 있기 때문에 상이한 인터페이스간의 매핑 매커니즘을 필요로 한다. 이에 본 논문에서는 스마트폰 환경에서 의료 응용 애플리케이션에서의 효율적인 의료기기 데이터 운용을 위해 RMIM(Refined Message Information Model) 기반의 IEEE 11073 DIM/HL7 v3 RIM 표준 인터페이스 변환 방법을 제안한다.

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Analysis of a Rim-Seal with a Semicircular Rib or Groove (반원형 리브 혹은 그루브가 부착된 림실에 대한 연구)

  • Lee, Chung-Suk;Moon, Mi-Ae;Kim, Kwang-Yong
    • The KSFM Journal of Fluid Machinery
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    • v.16 no.3
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    • pp.39-47
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    • 2013
  • Effect of semicircular rib or groove on the performance of a rim-seal was evaluated using three-dimensional Reynolds-averaged Navier-Stokes equations. The turbulence was modeled using the one-equation Spalart-Allmaras turbulence closure model. Reynolds number based on the axial chord of the turbine blade was 500,000 at the mainstream outlet. The numerical results for a sealing effectiveness was validated in comparison with experimental data. To examine the effect of the semicircular rib or groove on sealing effectiveness of the rim-seal, location and diameter of the rib or groove were selected as the parameters to be performed. The rim-seals with the semicircular groove showed a higher sealing effectiveness than that with the semicircular rib. The semicircular groove installed on the stator side showed best sealing effectiveness among the numerical simulation results.

Development of Hybrid RIM Mold to Form Outfit-part for Prototype-cars (시작차용 의장부품 성형을 위한 하이브리드 림 몰드 개발)

  • Yang, Hwa-Jun;Hwang, Po-Jung;Lee, Seok-Hee
    • Journal of the Korean Society for Precision Engineering
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    • v.18 no.3
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    • pp.75-83
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    • 2001
  • RIM(Reaction Injection Molding) is a widely used method to manufacture middle-large size outfit-part for a prototype car. The main advantage of RIM is the capability of manufacturing a small number of prototype parts with less cost and lead time than injection molding which is the most popular method to manufacture plastic parts. Generally, epoxy resin and RTV(Room Temperature Vulcanization) silicon are used as mold materials for RIM, and the selection of mold materials is usually depended upon the industrial environment of manufactures and it decides overall mold making process and part quality. This paper suggests a new mold making process by consolidating the advantages of epoxy resin and RTV silicon based RIM mold to enhance the parts quality while reducing the manufacturing cost and time and shows the competitiveness of the suggested process compared with conventional methods.

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Influence of Ring Gear Boundary Conditions on the Static Characteristics of Epicyclic Gear Trains with Manufacturing Errors (링기어의 경계조건이 가공오차를 가지는 유성기어열의 정특성에 미치는 영향)

  • Cheon, Gill-Jeong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.27 no.11
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    • pp.1949-1957
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    • 2003
  • A hybrid finite element analysis was used to analyze the influence of ring gear rim thickness and spline number on the static properties of a planetary gear system with manufacturing errors. Both of these parameters affected the bearing force and critical stress. The effect of changes in the rim thickness on the load sharing between the gears depended on the type of manufacturing error. Ring flexibility improved the load sharing between planetary gears only in systems with planet tooth thickness or planet tangential errors; for other types of error, ring flexibility worsened the load sharing. To improve load sharing, rim thickness and spline number should be controlled within a specific range. The minimum rim thickness limit should be determined considering not only the critical stress but also the load sharing. The effect of the ring gear boundary condition was more apparent in a system with errors than in a normal system.

MOTION RESISTANCE ANALYSIS OF A CIRCULAR STEEL WHEEL IN STICKY SOIL

  • Kishimoto, T.;Ohtomo, K.;Nishizaki, K.;Choe, J.S.;Jun, H.G.
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2000.11b
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    • pp.109-116
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    • 2000
  • The objective of this study is to measure rim surface adhesion and to calculate motion resistance produced by the adhesion acting on the rim section of a circular wheel under sticky soil condition. The mechanisms of generating motion resistance by the adhesion on a circular wheel were analyzed through wheel motion. Experiments were conducted in an indoor soil bin that contains loam soil. A circular steel wheel was used for experiments. A part of the wheel rim was cut off, and transducers which can measure normal and tangential forces were installed in this section. Calculated motion resistance at a part of the rim section was superposed for one wheel rotation as motion resistance produced by the rim surface adhesion. The motion resistance increased with increasing the dynamic load. Ratio of the motion resistance to total motion resistance measured by an axis transducer was about 23 to 46 % in this study.

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Case report of a solitary fibrofolliculoma on the alar rim

  • Jeong, Ho Yoon;Bae, Yong Chan
    • Archives of Craniofacial Surgery
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    • v.22 no.4
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    • pp.214-217
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    • 2021
  • Fibrofolliculoma is a benign tumor characterized by a smooth, dome-shaped papule of size 2-4 mm. Most fibrofolliculomas occur as multiple lesions, and very rarely, they are solitary. Herein, we report a case of solitary fibrofolliculoma found in the alar rim, without the typical characteristics of a fibrofolliculoma. A 42-year-old man visited the hospital with a protruding lesion that had occurred 1 year previously. A mass of size 5×7 mm was observed on the left alar rim. The tumor was dome-shaped and palpable. The patient did not have any similar lesions elsewhere. No family member was known to have such a lesion. An incisional biopsy was performed before surgery, and pathological examination revealed hyperkeratosis and dyskeratosis; however, an accurate diagnosis was not made. Complete resection was planned for the mass on the alar rim. The resected mass was subjected to permanent biopsy, and the pathological examination results led to the diagnosis of fibrofolliculoma. Therefore, when diagnosing a dome-shaped mass in the alar rim, despite the suspicion of a very rare disease, it is necessary to suspect fibrofolliculoma and consider the process from diagnostic examination to treatment.

Comparative investigation on both 『Eui Rim Chwal Yo』 and 『Dong Eui Bo Gam』 (『의림촬요(醫林撮要)』와 『동의보감(東醫寶鑑)』의 비교고찰(比較考察) -요통(腰痛)을 중심으로-)

  • Kim, Hong-kyoon
    • The Journal of Korean Medical History
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    • v.13 no.1
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    • pp.47-58
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    • 2000
  • Author have come to the conclusion that the contents in "Eui Rim Chwal Yo" are applied widely in "Dong Eui Bo Gam". Furthermore, "Eui Rim Chwal Yo" tends to have clear indication of sources unlike "Dong Eui Bo Gam"which does not. Further research into this factor is desirable in the future.

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