• 한국잠사곤충학회지
• /
• 제51권2호
• /
• pp.123-129
• /
• 2013

The purpose of this study is to investigate the effects of supplementation of mulberry powder, mulberry extract and silkworm powder during the 8 weeks of resistance exercise on muscle increase of rats. Fifty males, Sprague-Dawley rat, were randomly divided into 5 groups: CON(control group, n = 10), REG(resistance exercise group, n = 10), MP REG(mulberry powder intake and resistance exercise group, n = 10), ME REG(mulberry extract intake and resistance exercise group, n = 10) and SP REG(silkworm powder intake and resistance exercise group, n = 10). After climbing the ladder without weights during the 1 week of adaptation period, the rats in the resistance exercise group were trained to climb a 0.98-m vertical(80 degree incline) ladder with weights in their tail during 7 weeks(10 times each day, 2 days per week). After exercise, the skeletal muscle was extracted from the flexor hallucis longus. The absolute weight of skeletal muscle was measured by the electronic balance and the relative weight of skeletal muscle about the weight was calculated. The strength and density of legs muscle were analyzed by the computed tomography scan. After 8 weeks of resistance exercise, the absolute weight of skeletal muscle wasn't significant, but it increased in MP REG 8%, ME REG 8% and SP REG 10% compared to REG. The relative weight of skeletal muscle increased significantly in SP REG compared to REG (p < 0.05). Additionally, there was a significant increase of density and strength of the forelegs in SP REG compared to CON (p < 0.05). However, there was no significant increase of density and strength of the hind legs. In conclusion, regular resistance exercise made rats muscle increase and there was more muscle increase effected by providing silkworm.

• 한국지구과학회지
• /
• 제32권7호
• /
• pp.732-749
• /
• 2011

본 연구에서는 HadGEM2-AO 자료를 처방한 RegCM4를 이용하여 CORDEX 동아시아 영역에 대한 27년(1979-2005)간의 장기적분을 수행하였고, 기온과 강수에 대한 모의성능을 분석하였다. RegCM4는 전반적으로 기온의 공간분포, 계절 및 경년변동을 현실성 있게 잘 모의한 반면, 강수의 경우 시 공간 분포를 적절히 모의하지 못하였다. 특히, RegCM4는 동아시아 여름몬순에 의한 강수대를 위도 $30^{\circ}N$ 이하에서 정체하게 모의하면서 여름철 남한의 강수를 매우 과소하게 모의하였다. HadGEM2-AO를 적용한 RegCM4는 기온모의에서는 재분석자료를 처방한 경우와 유사한 모의성능을 보이지만, 강수모의에서는 현저히 낮은 모의성능을 보였다. 이는 여름철 남서풍을 상대적으로 저위도에 치우치게 모의하는 HadGEM2-AO의 특성이 RegCM4에 영향을 주어 동아시아 여름몬순 강수대의 발달-쇠퇴과정을 RegCM4가 적절히 모의하지 못하면서 나타난 결과로 판단된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권6호
• /
• pp.2699-2703
• /
• 2012

The functional significance of the proteasome activator $REG{\gamma}$ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by $REG{\gamma}$ for proteasomal degradation. It has been proposed that the role of the $REG{\gamma}$ in the pathogenesis of cancer is cell- and context-specific. In this study, we aimed to explore the potential involvement of $REG{\gamma}$ in laryngeal carcinomas, comparing protein expression in tumor and adjacent tissues by immunohistochemical staining and Western blot analysis. We also characterized the correlation between the expression of $REG{\gamma}$ and the previously identified substrates p53 and p21. We showed that $REG{\gamma}$ was abnormally highly expressed in cancer tissues. Statistical analysis revealed that there was a positive relationship between the level of $REG{\gamma}$ and the expression of p53 and p21. Our study suggests that $REG{\gamma}$ overexpression can facilitate the growth of laryngeal cancer cells.

• Molecules and Cells
• /
• 제44권9호
• /
• pp.647-657
• /
• 2021

As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumour-derived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression.

• 한국정보시스템학회지:정보시스템연구
• /
• 제30권1호
• /
• pp.65-84
• /
• 2021

Purpose Based on the development of artificial intelligence and big data technologies, the RegTech has been emerged to reduce regulatory costs and to enable efficient supervision by regulatory bodies. The word RegTech is a combination of regulation and technology, which means using the technological methods to facilitate the implementation of regulations and to make efficient surveillance and supervision of regulations. The purpose of this study is to describe the recent adoption of RegTech and to provide basic examples of applying RegTech to capital market regulations. Design/methodology/approach English-based ontology and deep learning technologies are quite developed in practice, and it will not be difficult to expand it to European or Latin American languages that are grammatically similar to English. However, it is not easy to use it in most Asian languages such as Korean, which have different grammatical rules. In addition, in the early stages of adoption, companies, financial institutions and regulators will not be familiar with this machine-based reporting system. There is a need to establish an ecosystem which facilitates the adoption of RegTech by consulting and supporting the stakeholders. In this paper, we provide a simple example that shows a procedure of applying RegTech to recognize and interpret Korean language-based capital market regulations. Specifically, we present the process of converting sentences in regulations into a meta-language through the morpheme analyses. We next conduct deep learning analyses to determine whether a regulatory sentence exists in each regulatory paragraph. Findings This study illustrates the applicability of RegTech-based ontology and deep learning technologies in Korean-based capital market regulations.

• 한국통계학회:학술대회논문집
• /
• 한국통계학회 2005년도 춘계 학술발표회 논문집
• /
• pp.73-77
• /
• 2005

본 논문은 시계열에 내재된 설${\cdot}$추석 등 음력 명절효과의 존재를 검정하기 위해 RegARIMA 모형의 잔차에 대한 t-검정 통계량을 제시하였으며 Box-plot에 의한 그래프적 진단을 시도하였다. 제시된 t-검정 결과를 X-12-ARIMA의 AICC-사전검정 및 RegARIMA 모형에 의해 추정된 명절효과 회귀계수의 t-값과 비교하였다. 사용된 명절효과 변수는 Bell과 Hillmer(1983)의 명절효과 변수이다.

• 대한지역사회영양학회지
• /
• 제12권2호
• /
• pp.160-167
• /
• 2007

This study was performed to investigate the effects of regular exercise on dietary factors and obesity indices among 407 healthy adult males subjects. Subjects were classified into regular exercise group (REG) and irregular exercise group (IREG). Two hundred and thirteen subjects of REG excercised regularly 3 times (more than 30 minutes/time) per week during more than last 1 month or more. One hundred and ninety-four of IREG (n = 194) didn't regularly exercise during the last 1 month. Obesity indices were BMI (Body Mass Index), WHR (Waist Hip Ratio) and PIBW (Percentage of Ideal Body Weight). And the mean BMI, WHR and PIBW of REG were (22.1, 0.90 and 105.8) significantly lower than those of IREG (25.7, 0.98 and 117.7) respectively. The mean daily starches, seeds, meats, eggs, fish, milk, fats and processed food intakes of REG were significantly lower than those of IREG And the mean daily vegetables, mushrooms and beverages intakes of the IREG were significantly lower than REG. Energy intake of REG and IREG were 1968.2 kcal and 1978.9 kcal respectively. Vitamin C intake of IREG was significantly lower than REG. But niacin and cholesterol intake of REG were significantly lower than the IREG. Exercise regularity was positively related with obesity indices and dietary factors. Therefore, it is necessary to exercise regularly to prevent obesity and cardiovascular disease in Korean adult males.

• 응용통계연구
• /
• 제27권7호
• /
• pp.1257-1268
• /
• 2014

KTX에 등장에 따라 국내 여객시장은 KTX 시장을 중심으로 변화가 이루어졌다. 이에 따라 KTX 이용 여객의 수요예측은 열차 운영에 있어서 매우 중대한 사안이다. 본 논문에서는 여러 시계열 모형의 비교를 통해 KTX 이용 여객의 수요와 연관이 있는 요일과 공휴일, 명절을 어떠한 형태로 고려할 것인지 연구하였다. 모형 간 예측력을 비교하기 위하여 Mean Absolute Percentage Errors (MAPE)를 사용하였으며, 1달간의 단기간 예측에 있어서 변동성을 고려해줄 수 있는 Reg-AR-GARCH 모형이 우수한 예측력을 나타냈으며, 1달을 초과한 기간의 예측에서는 Reg-ARMA 모형이 우수한 예측력을 나타냈다.

• 대한의용생체공학회:의공학회지
• /
• 제10권1호
• /
• pp.25-32
• /
• 1989

In this study, Rheoencephalography( REG ) was designed and constructed. Using the cons- tructed instrument cerebral blood flow(CBF) of left and right brain, CBF change by posture, and reproducibility were studied. Followings are important results. Relative CBF could be measured noninvasively and continuously. Since reproducibility of the constructed REG was found to be quite high (4%), the accuracy of the instrument itself was proved. REG can be easily applied for testing the effect of drugs for the patients with cerebral vessel diseases since it is quite sensitive to the relative changes of CBF. Various cerebral diseases can be diagnosed by analyzing the REG waveforms. The area of restricted cerebral blood vessels can be located by arranging the electrode configuration. Comparative studies with the standard techinques of measuring CBF are needed to verify the accuracy of REG. Further studies on optimal electrode configuration and various artifacts are also necessary.

• 한국지역사회생활과학회지
• /
• 제19권2호
• /
• pp.191-199
• /
• 2008

The purpose of this study was to obtain an understanding of the effect of regular exercise on obesity indices, the psychosocial wellbeing index, dietary factors and exercise regularity among 146 healthy mothers and 146 their daughters. "Mother" subjects were divided into two groups classified as regular exercise group(REG) and none exercise group(NEG). The exercise regularity of REG's daughters(30.8%) and of NEG's daughters (2.0%) was significantly different(p<0.001). The Obesity Indices(Body Mass Index (BMI), Waist Hip Ratio(WHR) and Percentage of Ideal Body Weight(PIBW)) of NEG's daughters were significantly higher than those of REG's daughters(p<0.001). But the psychosocial wellbeing index was not significantly different between REG's daughters and NEG's daughters. Intake of total energy, protein, fat, Ca, niacin and Fe were significantly different(p<0.001) between REG's daughters and NEG's daughters. Especially, vitamin C intake of REG's daughters was significantly higher than that of NEG's daughters(p<0.001). The exercise regularity of mothers was mainly related with Obesity Indices and nutrient intake in their daughters. Therefore, it might be necessary to maintain exercise regularity to prevent obesity and diet related problems in mothers and their daughters.