• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1541-1544
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• 2003

In this study, embodying reliability block diagram based on the web and reliability analysis technology are developed. RBD(reliability Block Diagram) represents the functional relation between elements in any product. Among relations between elements. there are serial, parallel, bridge, and stand by, etc. Advantages of developed system are integrated datum about reliability (NPRD, EPRD, MIL-HDBK 217F, NSWC. OREDA. Bellcore, and domestic institutes & companies datum). graphic user interface for convenience, and the various service analyzes the failure history data of parts.

• Sleep Medicine and Psychophysiology
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• v.2 no.1
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• pp.3-12
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• 1995

In the International Classification of Sleep Disorders(ICSD), REM sleep behavior disorder(RBD) and nightmares are classified as 'parasomnias usually associated with REM sleep'. RBD can be defined as the intermittent absence of REM sleep EMG atonia and the appearance of the elaborate motor activity associated with dream mentation. Bilateral pontine tegmental lesions in cats induce RBD-like behavior, but in human cases, more than 60% are idiopathic. Polysomnograpy shows characteristic findings in REM sleep and treatment with clonazepam is highly effective. With nightmares as long, frightening dream decreasing with age, their persistence or apperance in adults is related with certain drugs, trauma, personality and psychotic episode. Psychotherapy, behavior techniques or medication is used for treatment, but all of nightmares do not require treatment.

• Journal of Institute of Control, Robotics and Systems
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• v.7 no.3
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• pp.263-268
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• 2001

A new control scheme s proposed for the control of reactive batch distillation (RBD) column. A nonlinear wave model captures the essential dynamic behavior of the RBD process. The proposed control scheme is based on both Generic Model Control(GNC) and nonlinear wave model. The control scheme uses a profile position of the column as a controlled variable. Ethanol esterification process using RBD is chosen as an example process. Tight control of the distillate purity is obtained with the use of the proposed control scheme.

• Sleep Medicine and Psychophysiology
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• v.11 no.1
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• pp.37-43
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• 2004

Objective: The purpose of this paper is to study the possible differences in clinical and polysomnographic findings, depending on the presence or absence of subjective complaints of abnormal sleep behavior, in patients with RWA on polysomnography. Method: We reviewed patient records and polysomnographic data of patients referred to the Sleep Laboratory at Seoul National University Hospital from June 1996 through October 2002. We defined the manifest RBD group (n=32) as patients having both complaints of abnormal sleep behavior and RWA on polysomnography. The latent RBD group (n=20) consisted of patients who exhibited RWA on polysomnography but did not complain of abnormal sleep behavior. The clinical characteristics and polysomnographic findings between the two groups were compared and analyzed. Results: Fifty-two subjects had RWA, as detected by polysomnography (42 males and 10 females, mean age of $55.1{\pm}19.1\;years$). Subjects in the manifest RBD group were significantly older than those in the latent RBD group ($61.59{\pm}13.5$ vs. $44.70{\pm}2.76\;years$, independent t-test, p<0.01). More subjects in the manifest RBD group exhibited abnormal REM behavior on polysomnography than did subjects in the latent RBD group (81.3 vs. 50.0%, Fisher's exact test, p<0.05). No significant differences between the groups were found in the prevalence of brain disorders and primary sleep disorders, gender proportion, and sleep architecture. Conclusion: No difference in sleep architecture was found between the manifest and the latent RBD groups. Only age and the presence of abnormal sleep behavior on polysomnography differentiated the two groups. We suggest that RWA on polysomnography without complaints of abnormal sleep behavior may be early manifestation of manifest RBD. Attention to RWA on polysomnography is necessary to help prevent full-blown RBD from developing.

• Microbiology and Biotechnology Letters
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• v.39 no.2
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• pp.140-145
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• 2011

Porcine epidemic diarrhea virus (PEDV) infection causes acute enteritis with lethal watery diarrhea resulting in a high mortality rate in piglets. As with the other members of group 1 coronaviruses, PEDV also utilizes the host aminopeptidase N (APN) as the major cellular receptor for entry into target cells. The coronavirus spike (S) protein is known to interact with the cellular surface for viral attachment and the S1 domain of all characterized coronaviruses contains a receptor-binding domain (RBD) that mediates a specific high-affinity interaction with their respective cellular receptors. Although the RBDs of several coronaviruses have been mapped, the location of the PEDV RBD has to date not been defined. As a first step toward the identification of the region of the S protein of the PEDV that is critical for recognition with the cellular receptor, we generated a series of S1-truncated variants and examined their abilities to bind to the porcine APN (pAPN) receptor. Our data indicate that the N-terminus of the S1 domain is required for pAPN association. The results from the present study may assist in our understanding of the molecular interactions between the PEDV S protein and the pAPN receptor.

• Journal of Microbiology and Biotechnology
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• v.32 no.10
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• pp.1335-1343
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• 2022

COVID-19 is an emerging disease that poses a severe threat to global public health. As such, there is an urgent demand for vaccines against SARS-CoV-2, the virus that causes COVID-19. Here, we describe a virus-like nanoparticle candidate vaccine against SARS-CoV-2 produced by an E. coli expression system. The fusion protein of a truncated ORF2-encoded protein of aa 439~608 (p170) from hepatitis E virus CCJD-517 and the receptor-binding domain of the spike protein from SARS-CoV-2 were expressed, purified and characterized. The antigenicity and immunogenicity of p170-RBD were evaluated in vitro and in Kunming mice. Our investigation revealed that p170-RBD self-assembled into approximately 24 nm virus-like particles, which could bind to serum from vaccinated people (p < 0.001) and receptors on cells. Immunization with p170-RBD induced the titer of IgG antibody vaccine increased from 14 days post-immunization and was significantly enhanced after a booster immunization at 28 dpi, ultimately reaching a peak level on 42 dpi with a titer of 4.97 log₁₀. Pseudovirus neutralization tests showed that the candidate vaccine induced a strong neutralizing antibody response in mice. In this research, we demonstrated that p170-RBD possesses strong antigenicity and immunogenicity and could be a potential candidate for use in future SARS-CoV-2 vaccine development.

• The Journal of the Acoustical Society of Korea
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• v.41 no.2
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• pp.242-253
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• 2022

When the source waveform is unknown, the Green's function can be estimated by Ray-based Blind Deconvolution (RBD) based on the simple array signal processing. In previous papers, RBD was successfully demonstrated using simulation and experiments in shallow water environment. In this paper, we investigate the applicability of RBD for a long-range communication (e.g., 30 km, 60 km, and 90 km) in a deep water environment (1,000 m ~), using experimental data conducted in the east of Pohang, South Korea, in October 2018. Data results are presented to demonstrate Green's function estimation of a communication signal (2.2 kHz ~ 2.9 kHz) using a 16-element, 42-m long vertical array. The results show that the Green's function estimated from RBD is comparable to that of matched filter result. Additional communication performance at a maximum range of 90 km will be also presented.

• Journal of the Korean Institute of Gas
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• v.17 no.1
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• pp.49-55
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• 2013

Large scale systems, the facilities for the production of power, gas and chemical, have the complex structures. Most systems require the high reliability for the improvement of process efficiency, but it is difficult to analyze the reliability of processes with complex structures. In this study, we investigated reliability path of chemical process with k-out-of-n system by reliability block diagram(RBD) and calculated the reliability of process through the failure enumeration method of reliability path. This method should help in analyzing the reliability of k-out-of-n system.

• Journal of the Korea Safety Management & Science
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• v.13 no.3
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• pp.45-53
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• 2011

The research proposes seven elimination rules of redundant gates and blocks in Fault Tree Analysis (FTA) and Reliability Block Diagram (RBD). The computational complexity of cut sets and path sets is NP-hard. In order to reduce the complexity of Minimal Cut Set (MCS) and Minimal Path Set (MPS), the paper classifies generation algorithms. Moreover, the study develops six implementation steps which reflect structural importance (SI) and reliability importance (RI) from Reliability Centered Maintenance (RCM) that a priority of using the functional logic among components is to reduce (improve) the system unavailability (or availability). The proposed steps include efficient generation of state structure function by Rare Event Enumeration (REA). Effective use of importance measures, such as SI and ill measures, is presented based on the number and the size of MCS and MPS which is generated from the reference[5] of this paper. In addition, numerical examples are presented for practitioners to obtain the comprehensive understanding of six steps that is proposed in this research.

• Tunnel and Underground Space
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• v.10 no.3
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• pp.469-474
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• 2000

In this study, RBD(Rock Blasting Design) program was developed to perform easily on plans of rock blasting. This program has abilities as follows, that is, the test blasting plan, the bench blasting plan, and the blasting vibration analysis. The value of geological property and blasting constants was offered by database, input value of variety constants repeatedly is planned out, faster and easier. And a value of input constant may be used by user for necessity.