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Synthesis of Polymers in Supercritical Carbon Dioxide (초임계 유체를 이용한 고분자 합성 연구)

  • Lee, Hyun-Suk;Kim, Jin-Woong
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.36 no.1
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    • pp.17-32
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    • 2010
  • This review shows the design and the development of new $CO_2$-soluble hydrocarbon copolymers which can be used as effective stabilizers for successful dispersion polymerizations of bio-compatible materials in supercritical carbon dioxide ($scCO_2$). The basic concepts of supercritical fluid including its solvent properties and applications in polymer synthesis are described. We report the facile synthesis of highly soluble hydrocarbon based copolymers, prepared with good control via controlled free radical polymerization from readily accessible and commercially available monomers. The phase behaviour of these materials was monitored in pure $CO_2$ to investigate how the molecular weights and the composition of the copolymers affect their solubility in $CO_2$. Their activity as a stabilizer was then tested in dispersion polymerization of N-vinyl pyrrolidone in $CO_2$ at various reaction conditions to identify the key parameters required for a successful dispersion stabilization of growing PVP particles. Some prospective potentials of this research which can be applied in developing new polymer materials in an environmentally-friendly fashion for use in cosmetics are also discussed.

Seismic pounding between adjacent buildings considering soil-structure interaction

  • Raheem, Shehata E Abdel;Alazrak, Tarek M.A.;AbdelShafy, Aly G.A.;Ahmed, Mohamed M.;Gamal, Yasser A.S.
    • Earthquakes and Structures
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    • v.20 no.1
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    • pp.55-70
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    • 2021
  • In urban cities, buildings were built in the neighborhood, these buildings influence each other through structure-soilstructure interaction (SSSI) and seismic pounding due to limited separation distance in-between. Generally, the effects of the interaction between soil and structure are disregarded during seismic design and analysis of superstructure. However, the system of soil-base adversely changes structural behavior and response demands. Thus, the vibration characteristics plus the seismic response of a building are not able to be independent of those in adjacent buildings. The interaction between structure, soil, and structure investigates the action of the attendance of adjacent buildings to the others by the interaction effect of the sub-soil under dynamic disturbances. The main purpose of this research is to analyze the effects of SSSI and seismic pounding on the behavior of adjacent buildings. The response of a single structure or two adjacent structures with shallow raft base lying on soft soil are studied. Three dimensions finite element models are developed to investigate the effects of pounding; gap distance; conditions of soil; stories number; a mass of adjacent building and ground excitation frequency on the seismic responses and vibration characteristics of the structures. The variation in the story displacement, story shear, and story moment responses demands are studied to evaluate the presence effect of the adjacent buildings. Numerical results acquired using conditions of soil models are compared with the condition of fixed support and adjacent building models to a single building model. The peak responses of story displacement, story moment, and story shear are studied.

The Immunosuppressive Potential of Cholesterol Sulfate Through T Cell Microvilli Disruption

  • Jeong-Su Park;Ik-Joo Chung;Hye-Ran Kim;Chang-Duk Jun
    • IMMUNE NETWORK
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    • v.23 no.3
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    • pp.29.1-29.23
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    • 2023
  • Cholesterol (CL) is required for various biomolecular production processes, including those of cell membrane components. Therefore, to meet these needs, CL is converted into various derivatives. Among these derivatives is cholesterol sulfate (CS), a naturally produced CL derivative by the sulfotransferase family 2B1 (SULT2B1), which is widely present in human plasma. CS is involved in cell membrane stabilization, blood clotting, keratinocyte differentiation, and TCR nanocluster deformation. This study shows that treatment of T cells with CS resulted in the decreased surface expression of some surface T-cell proteins and reduced IL-2 release. Furthermore, T cells treated with CS significantly reduced lipid raft contents and membrane CLs. Surprisingly, using the electron microscope, we also observed that CS led to the disruption of T-cell microvilli, releasing small microvilli particles containing TCRs and other microvillar proteins. However, in vivo, T cells with CS showed aberrant migration to high endothelial venules and limited infiltrating splenic T-cell zones compared with the untreated T cells. Additionally, we observed significant alleviation of atopic dermatitis in mice injected with CS in the animal model. Based on these results, we conclude that CS is an immunosuppressive natural lipid that impairs TCR signaling by disrupting microvillar function in T cells, suggesting its usefulness as a therapeutic agent for alleviating T-cell-mediated hypersensitivity and a potential target for treating autoimmune diseases.

The Mobile Game Using a Jeju's Traditional Raft 'Tewoo': 'TewooGwang' (제주 전통 떼배인 '테우'를 이용한모바일 게임 : 테우광)

  • Oh, Jae-Hyuk;Lim, Ji-Hoon;Ko, Seok-Ha;Kim, Dong-Yun;Kim, Keun-Hyung;Kim, Seong-Baeg
    • Proceedings of the Korea Contents Association Conference
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    • 2006.11a
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    • pp.176-179
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    • 2006
  • Tewoo refers to a traditional group of Jeju's rafts for fishing in the rough Jeju sea in the past. We propose a mobile game called 'TewooGwang' based on a fishing boat called 'Tewoo', which has a scenario of conquering the Jeju sea using unique characters symbolizing the Jeju's ocean culture. This game is a new game, which uses a character of the fishing boat 'Tewoo', the background based on only Jeju's features, the high portability of PDA, and multimedia technology. It is different from simple sports games and has various game scenarios according to interactions of Tewoo character. The structure of this game represents a storytelling, which integrates Jeju culture into cyberspace. There are stories in this game and users also can make their own stories. Thus, this game enables hi-directional communications. It presents an imaginative space, which can induce a conflictive structure made by each user, and spatial provability. Many young Jeju tourists will enjoy it because this game provides a dynamic story. Furthermore, we can contribute to serving the value-added Jeju culture of being upgraded one step through this Jeju culture based game.

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p53 Nuclear Accumulation as a Possible Biomarker for Biological Radio-dosimetry in Oral Mucosal Epithelial Cells

  • Kim, Youn-Young;Kim, Jong-il;Kim, Jin;Yook, Jong-In;Kim, The-Hwan;Son, Young-Sook
    • BMB Reports
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    • v.34 no.2
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    • pp.123-129
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    • 2001
  • Cellular response to ionizing radiation is affected by cell types, radiation doses, and post-irradiation time. Based on the trypan blue dye exclusion assay in normal oral mucosal cells (OM cells), a 48 h post-irradiation was sufffcient and an adequate time point for the evaluation of radiation sensitivity Its $LD_{50}$ was approximately 1.83 Gy To investigate possible biomarkers useful for the biological radiodosimetry of normal epithelial cells (p53, c-fos, cyclin D1, cdc-2, pRb) EGF receptor phosphorylation and Erk activation were evaluated at different radiation doses and different post-irradiation times. From 0.5 Gy, p53 was accumulated in the nucleus of basal cells of the OM raft culture at 4 h post-irradiation and sustained up to 24 h post-irradiation, which suggests that radiation-induced apoptosis or damage repair was not yet completed. The number of p53 positive cells and biosynthesis of p53 were correlated with radiation doses. Both cyclin D1 and c-fos were only transiently induced within 1 h post-irradiation. Cyclin D1 was induced at all radiation doses. However, cfos induction was highest at 0.1 Gy, approximately 7.3 fold more induction than the control, whose induction was reduced in a reverse correlation with radiation dose. The phosphorylation pattern of cdc-2 and pRb were unaffected by radiation. In contrast to A431 tails overexpressing the EGF receptor approximately 8.5 fold higher than normal epithelial, the OM cells reduced the basal level of the EGF receptor phosphorylation in a radiation dose dependent fashion. In conclusion, among radiation-induced biomolecules, the p53 nuclear accumulation may be considered for the future development of a useful marker far biological radiodosimetry in normal epithelial tissue since it was sustained for a longer period and showed a dose response relationship. Specific c-fos induction at a low dose may also be an important finding in this study It needs to be studied further for the elucidation of its possible connection with the low dose radio-adaptive response.

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Classification of Fishing Gear (어구의 분류)

  • 김대안
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.32 no.1
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    • pp.33-41
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    • 1996
  • In order to obtain the most favourable classification system for fishing gears, the problems in the existing systems were investigated and a new system in which the fishing method was adopted as the criterion of classification and the kinds of fishing gears were obtained by exchanging the word method into gear in the fishing methods classified newly for eliminating the problems was established. The new system to which the actual gears are arranged is as follows ; (1)Harvesting gear \circled1Plucking gears : Clamp, Tong, Wrench, etc. \circled2Sweeping gears : Push net, Coral sweep net, etc. \circled3Dredging gears : Hand dredge net, Boat dredge net, etc. (2)Sticking gears \circled1Shot sticking gears : Spear, Sharp plummet, Harpoon, etc. \circled2Pulled sticking gears : Gaff, Comb, Rake, Hook harrow, Jerking hook, etc. \circled3Left sticking gears : Rip - hook set line. (3)Angling gears \circled1Jerky angling gears (a)Single - jerky angling gears : Hand line, Pole line, etc. (b)Multiple - jerky angling gears : squid hook. \circled2Idly angling gears (a)Set angling gears : Set long line. (b)Drifted angling gears : Drift long line, Drift vertical line, etc. \circled3Dragged angling gears : Troll line. (4)Shelter gears : Eel tube, Webfoot - octopus pot, Octopus pot, etc. (5)Attracting gears : Fishing basket. (6)Cutoff gears : Wall, Screen net, Window net, etc. (7)Guiding gears \circled1Horizontally guiding gears : Triangular set net, Elliptic set net, Rectangular set net, Fish weir, etc. \circled2Vertically guiding gears : Pound net. \circled3Deeply guiding gears : Funnel net. (8)Receiving gears \circled1Jumping - fish receiving gears : Fish - receiving scoop net, Fish - receiving raft, etc. \circled2Drifting - fish receiving gears (a)Set drifting - fish receiving gears : Bamboo screen, Pillar stow net, Long stow net, etc. (b)Movable drifting - fish receiving gears : Stow net. (9)Bagging gears \circled1Drag - bagging gears (a)Bottom - drag bagging gears : Bottom otter trawl, Bottom beam trawl, Bottom pair trawl, etc. (b)Midwater - drag gagging gears : Midwater otter trawl, Midwater pair trawl, etc. (c)Surface - drag gagging gears : Anchovy drag net. \circled2Seine - bagging gears (a)Beach - seine bagging gears : Skimming scoop net, Beach seine, etc. (b)Boat - seine bagging gears : Boat seine, Danish seine, etc. \circled3Drive - bagging gears : Drive - in dustpan net, Inner drive - in net, etc. (10)Surrounding gears \circled1Incomplete surrounding gears : Lampara net, Ring net, etc. \circled2Complete surrounding gears : Purse seine, Round haul net, etc. (11)Covering gears \circled1Drop - type covering gears : Wooden cover, Lantern net, etc. \circled2Spread - type covering gears : Cast net. (12)Lifting gears \circled1Wait - lifting gears : Scoop net, Scrape net, etc. \circled2Gatherable lifting gears : Saury lift net, Anchovy lift net, etc. (13)Adherent gears \circled1Gilling gears (a)Set gilling gears : Bottom gill net, Floating gill net. (b)Drifted gilling gears : Drift gill net. (c)Encircled gilling gears : Encircled gill net. (d)Seine - gilling gears : Seining gill net. (e)Dragged gilling gears : Dragged gill net. \circled2Tangling gears (a)Set tangling gears : Double trammel net, Triple trammel net, etc. (b)Encircled tangling gears : Encircled tangle net. (c)Dragged tangling gears : Dragged tangle net. \circled3Restrainting gears (a)Drifted restrainting gears : Pocket net(Gen - type net). (b)Dragged restrainting gears : Dragged pocket net. (14)Sucking gears : Fish pumps.

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An Application of Construction Sequence Analysis for Checking Structural Stability of High-Rise Building under Construction (초고층 건물의 시공 중 구조적 안정성 검토를 위한 시공단계해석의 적용)

  • Eom, Tae-Sung;Kim, Jae-Yo
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.22 no.3
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    • pp.211-221
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    • 2009
  • With recent trends of super-tallness, atypical plan shapes and zoning constructions in high-rise buildings, a structural stability of the building under construction is arising as a key issue for design and construction plan. To ensure the structural stability under construction, the differential column shortening of vertical members, the lateral displacement of tower frames, and differential settlement of raft foundation by unbalanced distributions of a tower self-weight before the completion of a lateral load resisting system should be checked by construction sequence analysis, which should be performed by systematic combinations with structural health monitoring, construction compensation program, and construction panning. This paper presents the scheme of zone-based construction sequence analysis by using the existing commercial analysis program, to check the stability of high-rise building under construction. This scheme is applied to 3-dimensional structural analysis for a real high-rise building under construction. The analysis includes real construction zoning plans and schedules as well as creep and shrinkage effects and time-dependent properties of concrete. The simplified construction sequence and assumed material properties were continuously updated with the change on construction schedule and correlations with in-situ measurement data.

A Comparative Study of Structural Analysis on DCM Improved by Pile and Block Type (말뚝식과 블록식이 혼합된 시멘트혼합처리공법(DCM)의 구조체 해석 비교 연구)

  • Shin, Hyun Young;Kim, Byung Il;Kim, Kyoung O;Han, Sang Jae
    • Journal of the Korean Geotechnical Society
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    • v.30 no.4
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    • pp.5-19
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    • 2014
  • In this study, the structural analysis is performed on the method of shallow block and deep cement mixing pile, and then their characteristics and associated behaviors were analyzed. In the case of continuous beam analysis, the predicted settlement was very small, and shear force and bending stress are somewhat overestimated. The frame method is similar to numerical analysis in the internal force shallow block and long pile, but because the settlement of pile is underestimated, the additional calculation using the reaction of the long pile is necessary. For soil arching method and piled raft foundation method, the excessive axial force of long pile was predicted because the load sharing of pile is very large compared to the other methods. In the behavior of the shallow block and deep pile method, the settlement of shallow block and contact pressure are much in the center than the edge. In the estimating method considering the interaction between improved material and ground, the load sharing of the soil-cement pile ranges from 20% to 45%, and the stress ratio is 2.0~5.0 less than piled DCM. The maximum member forces at the boundary conditions of pile head are similar, but in fixed head the axial force and vertical displacement are different in accordance with pile arrangement.

A Study on the Dominant Driving Force of Plate Movement presented in the High School Earth Science Textbooks (고등학교 지구과학 교과서에 제시된 판 이동의 주된 원동력에 대한 고찰)

  • Jeon, Taehwan;Seo, Ki-Weon;Lee, Gyuho
    • Journal of the Korean earth science society
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    • v.37 no.1
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    • pp.62-77
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    • 2016
  • In the early model of plate tectonics, the plate was depicted as a passive raft floating on the convecting mantle and carried away by the mantle flow. At the same time, ridge push at spreading boundaries and drag force exerted by the mantle on the base of lithosphere were described as the dominant driving forces of plate movements. However, in recent studies of plate tectonics, it is generally accepted that the primary force driving plate motion is slab pull beneath subduction zones rather than other forces driven by mantle convection. The current view asserts that the density contrast between dense oceanic lithosphere and underlying asthenosphere is the substance of slab pull. The greater density of oceanic slab allows it to sink deeper into mantle at trenches by gravitational pull, which provides a dominant driving force for plate motion. Based on this plate tectonics development, this study investigated the contents of plate tectonics in high school Earth Science textbooks and how they have been depicted for the last few decades. Results showed that the early explanation of plate movement driven by mantle convection has been consistently highlighted in almost all high school textbooks since the 5th curriculum, whereas most introductory college textbooks rectified the early theory of plate movement and introduced a newly accepted theory in revised edition. Therefore, we suggest that the latest theory of plate tectonics be included in high school textbooks so that students get updated with recent understanding of it in a timely manner.

STUDIES ON MARINE BACTERIA IN KOREAN COASTAL WATERS 1. On the distribution of marine bacteria in the Coast of Chung-Mu (한국연안의 해양미생물의 분포에 관한 연구 1. 충무연안의 분포에 관하여)

  • LEE Won-Jae
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.10 no.1
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    • pp.31-36
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    • 1977
  • The monthly distribution of marine bacteria in the coastal waters of Chung-Mu was investigated from April, 1976 to March, 1977. The aim of this study was to obtain basic data for the prevention of food poisoning and for the efficient aquaculture of the area. Samples of sea water, mud, fish and shell fish were taken every month. The results are as follows: 1. One thousand four hundred and twenty-six strains were isolated from 732 samples of sea water, mud, fish and shell fish. They were 450 strains of Pseudomonas fluorescens, 422 strains of Achromobacter liquefacience, 72 strains of Vibrio parahaemolyticus, 234 strain of Vibrio alginolyticus, and 248 strains of Proteus vulgaris. 2. V. parahaemolyticus occupied $9.84\%$ of the total samples and $52\%$ of them were found in the sea water and mud. 3. The muds sampled districtly beneath the aquaculture raft contained much gas. They seemed to originate from the deposition of excretion of shell fish. The fatness of the shell fish was low where the gas was abundant. 4. It was .found that the shell fish with low fatness contained much Vibrio sp. 5. Regional distribution shows that marine bacteria were abundant in the order of station 10, 9, 8, 11, 1. The area around station 9 was polluted by reclamation of the area, and station 8 showed the influence of the excrement treat tank located nearly.

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