• Journal of Chest Surgery
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• v.29 no.6
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• pp.626-631
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• 1996

The forty patients with carcirLoma of the esophagus or cardia seen at National Medical Center between November 1983 and April 1994 underwent surgical exploration. The esophagogastrectomy was carried out in 29 of 40 patients, one case through right thoracotomy, the others through left thoracotomy. Two patients underwent colon bypass surgeries due to upper esophageal cancer Transhiatal esop agectomy was performed In one case. Feeding gastrostomy or feeding jejunostomy were performed in 8 patients due to the advanced stage or malnutrition. In this report, we evaluated the long-term results in the 28 patients who underwent esophagogastrectomy for palliation through the left thoracotomy. There were 25 men(89%) and 3 women(11 %), and the mean age was 58.65$\pm$7.15 years(range, 46 to 73 years). The most frequent preoperative symptoms included dysphagia (22), weight loss (15), chest pain (6), vomiting (1), and hoarsness (1). Twenty-three patients had sqamous cell cancers of mid-and lower esophagus and five adenocarcionomas of cardia. One patient died in the hospital within 30 days of the op- eration for a hospital mortality rate of ).7%, Cause of death was sepsis due to anastomotic leakage. There were five additional complications in five patients; acute respiratory distress syndrome (1), post-op- erative bleeding (1), diaphragmatic hernia (1), acute renal failure (1) and late raft stenosis (1). The one year, 1틴o years, and three years acturial survival rate were 75.6$\pm$9.5%, 43.2$\pm$ 11.6%, 21.6: 10.5$\circledcirc$ re- spectively. The average survival was 21.8 months. The data from this study suggest that esophagogastrectomy through the left thoracotomy can achieve resonable long-term palliation for carci- noma of the esophagus. The operation can be performed with a low operative mortality and few serious postoperative complications.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.12
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• pp.1543-1548
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• 2011

Structural analysis is performed to design anchor straps for a large-scale-liquefied-natural-gas (LNG) storage tank with corner protection and an inner tank by considering structural integrity. Anchor straps made of 9% nickel steel are attached to the inner tank, corner protection, and concrete raft to prevent the failure of the inner tank during both normal and emergency operating conditions. Two finite element (FE) models were analyzed in this study. One is a stand-alone model of the anchor strap, while the other is an extended model of the substructure of the anchor strap, inner tank, and corner protection. Three-dimensional shell elements are used to effectively assess the bending and axial behavior of structures. The Tresca stress values in each part of the two models are calculated for operation under five different load-condition cases: normal operation, leakage of the LNG, hydro test, and two earthquake conditions.

• Geomechanics and Engineering
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• v.20 no.2
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• pp.87-101
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• 2020

The construction of combined pile-raft foundations is considered as the main option in designing foundations in high-rise buildings, especially in soils close to the ground surface which do not have sufficient bearing capacity to withstand building loads. This paper deals with the geotechnical report of the Northern Fereshteh area of Tabriz, Iran, and compares the characteristics of the single pile foundation with the two foundations of pile group and geogrid. Besides, we investigate the effects of five principal parameters including pile diameter and length, the number of geogrid layers, the depth of groundwater level, and pore water pressure on vertical consolidation settlement and pore water pressure changes over a year. This study assessed the mechanism of the failure of the soil under the foundation using numerical analysis as well. Numerical analysis was performed using the two-dimensional finite element PLAXIS software. The results of fifty-four models indicate that the diameter of the pile tip, either as a pile group or as a single pile, did not have a significant effect on the reduction of the consolidation settlement in the soil in the Northern Fereshteh Street region. The optimum length for the pile in the Northern Fereshteh area is 12 meters, which is economically feasible. In addition, the construction of four-layered ten-meter-long geogrids at intervals of 1 meter beneath the deep foundation had a significant preventive impact on the consolidation settlement in clayey soils.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.5
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• pp.349-356
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• 2009

We previously reported that glial cell line-derived neurotropic factor (GDNF) receptor ${\alpha}$ 1 (GFR ${\alpha}$ 1) is a direct target of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1). In the present study, we further analyzed the physiological roles of Ape1/Ref-1-induced GFR ${\alpha}$ 1 expression in Neuro2a mouse neuroblastoma cells. Ape1/Ref-1 expression caused the clustering of GFR ${\alpha}$ 1 immunoreactivity in lipid rafts in response to GDNF. We also found that Ret, a downstream target of GFR ${\alpha}$ 1, was functionally activated by GDNF in Ape1/Ref-1-expressing cells. Moreover, GDNF promoted the proliferation of Ape1/Ref-1-expressing Neuro2a cells. Furthermore, GFR ${\alpha}$ 1-specific RNA experiments demonstrated that the downregulation of GFR ${\alpha}$ 1 by siRNA in Ape1/Ref-1-expressing cells impaired the ability of GDNF to phosphorylate Akt and PLC ${\gamma}$-1 and to stimulate cellular proliferation. These results show an association between Ape1/Ref-1 and GDNF/GFR ${\alpha}$ signaling, and suggest a potential molecular mechanism for the involvement of Ape1/Ref-1 in neuronal proliferation.

• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.558-564
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• 2013

A simple and effective method is introduced to synthesize a series of polystyrene-b-poly(oligo(ethylene oxide) monomethyl ether methacrylate)-b-polystyrene (PSt-b-POEOMA-b-PSt) triblock copolymers. The structures of PSt-b-POEOMA-b-PSt copolymers were characterized by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance ($^1H$ NMR) spectroscopy. The molecular weight and molecular weight distribution of the copolymer were measured by gel permeation chromatography (GPC). Furthermore, the self-assembling and drug-loaded behaviours of three different ratios of PSt-b-POEOMA-b-PSt were studied. These copolymers could readily self-assemble into micelles in aqueous solution. The vitamin E-loaded copolymer micelles were produced by the dialysis method. The micelle size and core-shell structure of the block copolymer micelles and the drug-loaded micelles were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The thermal properties of the copolymer micelles before and after drug-loaded were investigated by different scanning calorimetry (DSC). The results show that the micelle size is slightly increased with increasing the content of hydrophobic segments and the micelles are still core-shell spherical structures after drug-loaded. Moreover, the glass transition temperature (Tg) of polystyrene is reduced after the drug loaded. The drug loading content (DLC) of the copolymer micelles is 70%-80% by ultraviolet (UV) photolithography analysis. These properties indicate the micelles self-assembled from PSt-b-POEOMA-b-PSt copolymers would have potential as carriers for the encapsulation of hydrophobic drugs.

• Magazine of the Korea Concrete Institute
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• v.20 no.6
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• pp.28-35
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• 2008

The Burj Dubai Project will be the tallest structure ever built by man; when completed the tower will be more than 700 meter tall and more than 160 floors. While the early integration of aerodynamic shaping and wind engineering considerations played a major role in the architectural massing and design of this multi-use/residential tower, where mitigating and taming the dynamic wind effects was one of the most important design criteria, the material selection for the structural systems of the tower was also a major consideration and required detailed evaluation of the material technologies and skilled labor available in the market at the time Concrete was selected for its strength, stiffness, damping, redundancy, moldability, free fireproofing, speed of construction, and cost effectiveness. In addition, the design challenges of using concrete for the design of the structural system components will be addressed. The focus on this paper will also be on the early planning of the concrete works of the Burj Dubai Project.

• Journal of the Korean Society for Marine Environment & Energy
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• v.5 no.1
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• pp.68-75
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• 2002

This study were observed to the conditions of organic pollution applying to tile environmental assessments based on macrobenthos around the raft culture ground which became an issue by organic matter input in Jinhae Bay. Three stations, mussel farm, oyster farm and the control station on which rarely culture activities were fixed and have analyzed to the sediment characteristics and macrobenthic communities. Muddy substrates between 6.0 and 6.60 on mean grain size have prevailed to the bottom layer in all stations. The highest organic matter content of 2.8% was observed to the mussel farm while the lowest one of 1.5% was recorded on the control area. As a total, 79 species from seven phyla were identified. Comparing to shell farms, the control station have composed to more diversified community structure. In the mussel and the oyster farm, opportunistic species, living in high organic contents area, Lumbrineris longifolia, Heteromastus. filiformis in polychaetes and Corophium sinense in amphipod were dominated. As results on environmental assessment, in spite of changing to the species composition and densities seasonally, the mussel farm have recorded only to moderately polluted condition.

• Bulletin of the Korean Chemical Society
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• v.18 no.9
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• pp.922-928
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• 1997

The conformational transition of poly(L-proline) (PLP), Form Ⅱ → Form Ⅰ and the intermolecular aggregation of the product, Form Ⅰ, during and after the transition in water-propanol (1:7, 1:9, 1:15.7, and 1:29 v/v) were studied. For the study, the viscosity change and excess light scattering intensity were measured in the course of the transition which was determined by the Form Ⅰ fraction, fI of the sample solution. For the PLP sample of molecular weight Mv=31,000 the experimental results show that the reaction course is roughly divided into three regions: in the first region [fI=0.27 to 0.40 (- [α]D=400 to 330)], the conformational change of Form Ⅱ → Form Ⅰ occurs with decrease of viscosity, in the second region [fI=0.40 to 0.80 (- [α]D=330 to 120)], a partial side-by-side (p-S-S) type aggregation in which Form Ⅰ blocks interact with each other, which induces the increase of viscosity, starts to occur, and in the third region [fI=0.80 to 1.00 (- [α]D=120 to 15)], a side-by-side type (raft like) aggregation of Form Ⅰ or an end-to-end (E-E) type aggregation occurs according to the solvent situation, i.e., in a water-rich medium [water-propanol (1:9 or 1:7 v/v)], the (S-S) type aggregation with a gross decrease in viscosity occurs while in a water-poor medium [water-propanol (1:29 or 1:15.7 v/v), the (E-E) type aggregation with a large increase in viscosity occurs. The (S-S) type aggregation was promoted at high temperatures. Based on the structure of PLP, a reasonable mechanism for the (p-S-S) and (S-S) aggregation which occurs with the transition of Form Ⅱ → Form Ⅰ is considered. The suggested mechanism was also supported by the result of chain length effect of PLP for the aggregation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.17-32
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• 2010

This review shows the design and the development of new $CO_2$-soluble hydrocarbon copolymers which can be used as effective stabilizers for successful dispersion polymerizations of bio-compatible materials in supercritical carbon dioxide ($scCO_2$). The basic concepts of supercritical fluid including its solvent properties and applications in polymer synthesis are described. We report the facile synthesis of highly soluble hydrocarbon based copolymers, prepared with good control via controlled free radical polymerization from readily accessible and commercially available monomers. The phase behaviour of these materials was monitored in pure $CO_2$ to investigate how the molecular weights and the composition of the copolymers affect their solubility in $CO_2$. Their activity as a stabilizer was then tested in dispersion polymerization of N-vinyl pyrrolidone in $CO_2$ at various reaction conditions to identify the key parameters required for a successful dispersion stabilization of growing PVP particles. Some prospective potentials of this research which can be applied in developing new polymer materials in an environmentally-friendly fashion for use in cosmetics are also discussed.

• Earthquakes and Structures
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• v.20 no.1
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• pp.55-70
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• 2021

In urban cities, buildings were built in the neighborhood, these buildings influence each other through structure-soilstructure interaction (SSSI) and seismic pounding due to limited separation distance in-between. Generally, the effects of the interaction between soil and structure are disregarded during seismic design and analysis of superstructure. However, the system of soil-base adversely changes structural behavior and response demands. Thus, the vibration characteristics plus the seismic response of a building are not able to be independent of those in adjacent buildings. The interaction between structure, soil, and structure investigates the action of the attendance of adjacent buildings to the others by the interaction effect of the sub-soil under dynamic disturbances. The main purpose of this research is to analyze the effects of SSSI and seismic pounding on the behavior of adjacent buildings. The response of a single structure or two adjacent structures with shallow raft base lying on soft soil are studied. Three dimensions finite element models are developed to investigate the effects of pounding; gap distance; conditions of soil; stories number; a mass of adjacent building and ground excitation frequency on the seismic responses and vibration characteristics of the structures. The variation in the story displacement, story shear, and story moment responses demands are studied to evaluate the presence effect of the adjacent buildings. Numerical results acquired using conditions of soil models are compared with the condition of fixed support and adjacent building models to a single building model. The peak responses of story displacement, story moment, and story shear are studied.