• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.43-48
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• 2000

In this study, a small punch creep(SP-Creep) test using miniaturized specimen$(10{\times}10{\times}0.5mm)$ has been described for the development of the newly semi-destructive creep test method for high temperature structural components such as headers and tubes of boiler turbine casino and rotor and reactor vessel. The SP-Creep testing technique has been applied to 2.25Cr-1Mo(STBA24) steel used widely as boiler tube material and the creep test temperature are varied at $550^{\circ}C{\sim}600^{\circ}C$. The overall deformations of SP-Creep curves are definitely depended with applied load and creep test temperature and show the creep behaviors of three steps like conventional uniaxial creep curves. The steady state creep rate${\delta}_{ss}$ of SP-Creep curve for miniaturized specimen increases with increasing creep temperature, but the exponential value with creep loading is decreased. The activation energy$(Q_{spc})$ during SP-Creep deformation with various test temperatures shows 605.7kJ/mol that is g.eater than 467.4kJ/mol reported in uniaxial creep test. This may be caused by the difference of stress states during creep deformation In two creep test. But from the experimental results, e.g. SP-Creep curve behaviors, the steady state creep rate${\delta}_{ss}$ with creep temperature, and the exponential value(n) with creep loading, it can be summarized that the SP-Creep test may be a useful test method to evaluate the creep properties of the heat resisting material.

• 열처리공학회지
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• 제9권1호
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• pp.34-44
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• 1996

Austenite stainless steel was produced by arc welding with current 650A, voltage 50V and welding speed 10cm/min. It was post-welded and then heat treated at $1,050^{\circ}C$ for 120min. And then it was immersed in water or in air. The microstructural changes, ferrite contents, mechanical properties, and stress corrosion cracking(SCC) were investigated. The SCC was studied in 42wt% boiling $MgCl_2$($140^{\circ}C$) under the constant stress using SCC elongation curve. The results showed that; 1. The as-welded spedimen seemed to increase ${\delta}$-ferrite content largely, and revealed continuous network of lathy and vermicular type. The post-welded heat treatment changed the morphologies of ferrite from continuous type to island type. 2. The as-welded, air and water quenched specimens had the ${\delta}$-ferrite content 9.7%, 3.2% and 2.1% respectively. We also showed that ${\delta}$-ferrite was Cr-rich and Ni-poor by EPMA. 3. The time of failure on the SCC was measured and it was used for corrosion elongation curve. The condition of SCC was investigated under $35kgf/mm^2$ load and the results were as follows; 4. The intergranullar cracking by stress corrosion was most distinct in weld metal while the transgranular cracking occurred in the air cooled specimen.

• 한국철도학회논문집
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• 제12권4호
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• pp.597-603
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• 2009

본 연구에서는 승차감을 목적함수로 하고 궤도부담력을 경계조건으로 하는 곡선부 평면선형의 최적설계 기법을 제시하였다. 평면선형 최적화시 중요한 변수인 곡선반경-완화곡선장은 엄주환 등(2009)에서 제시한 결정방법을 적용하였으며 승차감 평가방법은 영국 BSI(2006)에서 제시하는 곡선부 전용 승차감 평가방법인 $P_{CT}$방법을 활용하였다. 또한 한국형 고속전철 G7(KTX-II)모델을 이용한 차량/궤도선형 상호작용 해석을 수행하였다. 해석결과, 최적선형조건은 교각 I(곡선부 양 끝단 직선과 직선이 만나는 교차각) 크기 및 곡선반경-완화곡선장 조합에 따라 다름을 알 수 있었다. 또한 Kufver(1997) 등에서 제시하는 간략화 해석방법과 유사한 경향이 나타남을 알 수 있었으나, 대부분의 경우 동적해석결과 값이 크게 나타났다. 따라서 곡선부 최적선형 설계시 동적해석과 간략화 해석을 병행한다면 신속하고 신뢰성 높은 최적선형을 결정할 수 있을 것으로 판단된다.

• 약학회지
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• 제49권3호
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• pp.212-216
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• 2005

A rapid, sensitive and selective electrospray tandem mass spectrometric (ESI-LC/MS/MS) method for the quantitation of gliquidone in human plasma was developed. A bioavailability study of gliquidone tablet (30 mg gliquidone, Boehringer Ingelheim Korea Co.) was performed using the validated ESI-LC/MS/MS method. The dose of 30 mg of gliquidone (1 tablet) was orally administered to 9 healthy Korean subjects. After administration, blood was taken at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 7, 9, 12, 24, and 33 hour. The validation data were as follows; the standard curve was linear ($r^2$=0.999) over the concentration range of $10\~1000 ng/ml$. The coefficient of variation for intra- and inter-day assay were $8.30\~18.86$, and $2.19\~12.92\%$, respectively. The lower limit of quantification for gliquidone was 10 ng/ml. The pharmacokinetic parameters obtained were as follows; $AUC_t$ was 3861.17$\pm$1328.61 ng-hr/ml, $C_{max}$ was 831.02$\pm$227.99 ng/ml, $T_{max}$ was $2.94{\pm}0.77 hr,\;K_e$, was 0.19$\pm$0.06 1/hr, and $t_{l/2}$ was 4.47$\pm$3.52 hr. Based on the validated analytical method and pharmacokinetic parameters, a standard guideline of the bioavailability test of gliquidone dosage forms was prepared successfully and could be used for the bioequivalence test of gliquidone preparation.

• Journal of Forest and Environmental Science
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• 제10권1호
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• pp.38-48
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• 1994

강원도산(江原道産) 참나무과(科) 4수종(樹種)의 건조특성(乾燥特性)을 파악코져 $100^{\circ}C$에서 급속건조(急速乾燥)를 실시하여 건조중(乾燥中) 함수율(含水率)과 건조경과(乾燥經過), 초기할렬(初期割裂)(목구할렬(목구할렬(木口割裂))과 표면할렬(表面割裂)), 찌그러짐, 내부할렬(內部割裂) 등의 건조결함(乾燥缺陷)을 조사(調査)하여 추정건조(推定乾燥)스케쥴을 작성(作成)한 결과(結果)는 다음과 같다. 건조시간별(乾燥時間別) 건조중(乾燥中) 함수율(含水率)은 초기함수율(初期含水率)이 높은 판재(板材)일수록 급속(急速)한 곡선적(曲線的) 감소(減少)를 나타내었고 건조소요시간(乾燥所要時間)이 길었으며 굴참나무가 건조중(乾燥中) 할렬(割裂)의 발생량(發生量)이 가장 크게 나타났으며 구해진 추정건조(推定乾燥)스케쥴은 $T_5-C_2$였다. 또한 모든 수종(樹種)의 목리방향별(木理方向別) 수축율(收縮率)은 접선방향(接線方向)(T) > 방사방향(放射方向)(R) > 섬유방향(纖維方向)(L)의 순위(順位)였으며 급속건조법(急速乾燥法)에 의한 수축율(收縮率)이 정상적인 수축율(收縮率)보다 크게 나타났다.

• 한국산학기술학회논문지
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• 제16권1호
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• pp.165-172
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• 2015

본 연구의 목적은 로봇학습에 기반한 제니보 프로그램이 유아의 정서에 미치는 효과를 밝히는 데 있다. 본 연구의 목적을 달성하기 위하여 Y시 소재 유치원 2개 학급(교사 2명, 유아 44명)을 각각 실험집단과 비교집단으로 나눈 후, 실험집단을 대상으로 제니보를 이용하여, 5개의 메인메뉴로 구성된 20개의 하위 콘텐츠를 적용하였다. 두 집단을 대상으로 정서지능 평가검사를 사전 사후로 실시한 후, SPSS 18.0 통계분석프로그램을 이용한 t-검증과 관찰이 이루어졌다. 연구결과 첫째, 제니보는 유아의 정서에 긍정적인 영향을 미친 것으로 나타났다. 정서지능의 4가지 영역(정서인식 및 표현, 사고 촉진, 지식의 활용, 반영적 조절)에서 모두 유의미한 변화를 보였다. 둘째, 생체모방형 로봇은 동물이 수업에 친근하게 사용되는 것과 같이 유아에게 친근하게 다가갈 수 있었다. 셋째, 남아가 여아보다 로봇을 선호하는 경향이 강하다는 기존의 연구들과는 달리 제니보는 남녀유아 모두의 정서에 긍정적인 영향을 미쳤다. 이러한 연구결과는 유아를 위한 새로운 교육방법으로서 로봇의 도입을 긍정적으로 검토를 할 수 있고, 친숙한 동물형태의 생체모방형 로봇이 효과적으로 활용될 수 있으며, 로봇의 활용은 유아의 성별보다 개인적인 성향과 발달수준 등에 의해 고려되어야 함을 시사한다.

• Journal of Pharmaceutical Investigation
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• 제23권1호
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• pp.41-49
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• 1993

The bioequivalence of two omeprazole enteric-coated products was evaluated in 16 normal male volunteers (age 26-32 yr, body weight 57-75 kg) following single oral administration. Test product was enteric-coated KD-182 tablet (Chong Kun Dang Corp., Korea) and reference product was $Rosec^{\circledR}$ capsule containing enteric-coated pellets of omeprazole (Yuhan Corp., Korea). Both products contain 20 mg of omeprazole. One tablet or capsule of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study ($2\;{\times}\;2$ Latin square method). Average drug concetrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products(p>0.05); the area under the concentrationtime curve to last sampling time (8 hr) $(AUC_{0-8hr})$ $(1946.5{\pm}675.3\;vs\;2018.3{\pm}761.6\;ng{\cdot}hr/ml)$, AUC from time zero to infinite $(AUC_{o-\infty})$ $(2288.6{\pm}1212.8\;vs\;2264.9{\pm}1001.3\;ng{\cdot}hr/ml)$, maximum plasma concentration $(C_{max})$ $(772.5{\pm}283.3\;vs\;925.8{\pm}187.7\;ng/ml)$, time to maximum plasma concentration $(T_{max})$ $(2.38{\pm}1.06\;vs\;2.34{\pm}1.09\;hr)$, apparent elimination rate constant $(k_{\ell})$ $(0.5339{\pm}0.2687\;vs\;0.5769 {\pm}0.2184\;hr^{-I})$, apparent absorption rate constant $(k_a)$ $(1.1536{\pm}0.5278\;vs\;0.9739{\pm}0.9507 hr^{-1})$ and mean residence time (MRT) $(3.13{\pm}0.73\;vs \;3.41{\pm}1.04\;hr)$. The differences of mean $(AUC_{0-8hr})$, $C_{max}$, $T_{max}$ and MRT between the two products (3.69, 19.83, 1.32 and 8.99%, respectively) were less than 20%. The power $(1-{\beta})$ and treatment difference $(\triangle)$ for $AUC_{o-8hr}$ $C_{max}$ and MRT were more than 0.8 and less than 0.2, respectively. Although the power for $T_{max}$ was under 0.8, $T_{max}$ of the two products was not significantly different each other(p>0.05). These results suggest that the bioavailability of KD-182 tablet is not significantly different from that of $Rosec^{\circledR}$ capsule. Therefore, two products are bioequivalent based on the current results.

• Journal of Pharmaceutical Investigation
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• 제37권6호
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• pp.397-402
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• 2007

To evaluate the bioequivalence of two venlafaxine formulations, a standard 2-way randomized cross-over study was conducted in twenty-four healthy male Korean volunteers. A single oral dose of 75 mg of test formulation Venfaxine $OR^{(R)}$ (tablet) or reference formulation Efexor $XR^{(R)}$ (capsule) was administered with one-week washout period. Plasma concentrations of venlafaxine were assayed for over a period of 72 hours with a well validated method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS). The $mean{\pm}S.D$. of maximum concentration $(C_{max})$ and elimination half-life $(t_{1/2})$ were $64.7{\pm}28.5$ ng/mL, $9.2{\pm}3.0$ h, and $67.2{\pm}30.2$ ng/mL, $9.9{\pm}3.5$ h for test and reference formulations, respectively. Time to reach maximum concentration $(T_{max})$ expressed in median value (range), for the test and the reference, were 10 h (6-14) and 8h (4-12), respectively. Similarly, area under the plasma concentration-time curve, from time zero to last sampling time $(AUC_t)$ and from time zero to time infinity $(AUC_{inf})$, for test and reference formulations were $1185{\pm}755$, $1326{\pm}896$ and $1124{\pm}737$, $1185{\pm}755$ $ng{\cdot}h/mL$, respectively. The parametric 90% confidence intervals on the mean of the differences between the two formulations (test-reference) of the log transformed values of $AUC_t$, and $C_{max}$ were 0.9630 to 1.1383 and 0.8650 to 1.0446, respectively. The overall results indicate that the two formulations are bioequivalent and can be prescribe interchangeably.

• 한국산림과학회지
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• 제101권1호
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• pp.28-35
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• 2012

강우는 산사태를 야기하는 주된 요인으로 최근 우리나라에서 대부분의 산사태는 단기간의 집중호우로 인해 발생하고 있으나, 강우특성과 산사태 발생간의 관계는 아직 명확히 규명되지 못하고 있는 실정이다. 이 논문에서는 2011년 6월 7월에 남부지방과 중부지방에서 집중호우로 야기된 18개의 산사태를 대상으로 연속강우 개시 이후의 누적강우량(mm)과 강우강도(mm/hr) 및 선행강우량(mm)을 해석하여 산사태 발생과의 관계를 분석하였다. 그 결과, 산사태는 모두 연속강우 개시 이후 1~3일간의 집중호우에 의해 강우강도가 30 mm/hr이상, 혹은 누적강우량이 200 mm이상인 경우에 발생한 것으로 나타났다. 이는 산림청의 산사태 경보발령 기준을 상회하는 범위에서 발생한 것으로 나타났으며, 경상남도에서 보고된 산사태 발생영역과도 일치하였다. 또한, 강우개시 이후 산사태 발생까지의 소요시간(T)은 평균 강우강도(ARI)가 증가할수록 점차 단축되는 것으로 나타났으며, 이들 사이의 관계는 지수함수식 "T = $94.569{\cdot}exp$($-0.068{\cdot}ARI$)($R^2$=0.64, p<0.001)"로 도출되었다. 이러한 결과는 산림청의 산사태 주의보 경보발령 기준에 있어 중요한 근거가 될 수 있으며, 토사재해에 대한 경계피난체계 등의 비구조물 대책의 수립에도 기초자료를 제공할 수 있을 것으로 기대된다.

• Biomolecules & Therapeutics
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• 제6권2호
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• pp.219-224
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• 1998

The bioequivalence of two clarithromvcin products was evaluated with 16 normal male volunteers (age 23-28 yr, body weight 57.5-75.517g) following single oral dose. Test product was ReYon Clarithromycin tablets (ReYon Pharm. Corp., Korea) and reference product was Klarici $d_{R}$ tablets (Abbott Korea). Both products contain 250 mg of clarithromucin. One tablet of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study (2$\times$2 Latin square method). The determination of clarithromycin was accomplished using a modified agar well diffusion bioassay. As a result of the assay validation, the quantification of clarithromycin in human serum by this technique was possible down to 0.03$\mu$g/ml using 100$\mu$l of serum. The coefficient of variation (C.V.) was less than 10%. Average drug concentrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products P>0.05); the area under the curve to last sampling time (24 hr) (AU $Co_{24hr}$ (8.10$\pm$ 1.26 vs 8.22$\pm$ 1.627g . hr/ml), AUC from time zero to infinite (AU $Co_{\infty}$) (8.61 $\pm$ 1.28 vs 8.84$\pm$ 1.71 $\mu$g . hr/ml), maximum plasma concentration ( $C_{msx}$) (0.87$\pm$0.22 vs 0.88$\pm$0.19 $\mu$g/ml) and time to maximum plasma concentration ( $T_{max}$) (2.69 $\pm$0.48 vs 2.56$\pm$ 0.51 hr). The differences of mean AU $Co_{24h}$, $C_{msx}$ and $T_{msx}$ between the two products (1.44, 1.39, and 4.65%, respectively) were less than 20%. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $Co_{24hr}$, and $C_{max}$ were more than 0.8 and less than 0.2, respectivly. Although the power for $T_{max}$ was under 0.8, $T_{max}$. of the two products was not significantly different each other (p>0.05). These results suggest that the bioavailability of ReYon Clarithromycin tablets is not significantly different from that of Klarici $d_{R}$ tablets. Therefore, two products are bioequivalent based on the current results. results.sults.sults.s.s.s.s.s.s.s.