• 산업경영시스템학회지
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• 제46권spc호
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• pp.79-88
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• 2023

This research aims to validate the effectiveness of the "Specialized Entrepreneurship University Program," which was conducted as part of government entrepreneurship support initiatives from 2018 to 2022. Based on previous studies, a research model was derived consisting of three laboratory entrepreneurship support factors that influence program satisfaction and entrepreneurial outcomes (infrastructure support, educational mentoring support, and business linkage support). Surveys were collected and analyzed from 126 laboratory entrepreneurship firms participating in the program, and empirical analysis of the research model was conducted using SPSS 23.0 statistical software. The analysis results indicated that the three variables, namely infrastructure support, educational mentoring support, and business linkage support, were significant factors affecting program satisfaction, and program satisfaction was confirmed to influence entrepreneurial outcomes. Furthermore, it was found that the three business operation factors indirectly influenced entrepreneurial outcomes by partially mediating program satisfaction. This study is considered significant as an empirical study for the initial stage of the second-phase program enhancement, verifying the effectiveness of laboratory entrepreneurship support factors. The findings can be applied to similar government entrepreneurship support initiatives and contribute to the effective strategy and planning of stakeholders involved. The limitations of this study include the need for further research on the perception of the extent to which it contributes to entrepreneurial outcomes, emphasizing caution in interpreting the research model, and the necessity for expanding the survey population and improving survey items in future research.

• 한국콘텐츠학회논문지
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• 제17권11호
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• pp.331-341
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• 2017

최근 과학기술정보 콘텐츠 분석 기반의 R&D 전략 수립이 중요시됨에 따라 국내 외 과학기술 통계 정보를 수집, 범주화하여 DB를 구축하고 이를 증거 기반의 기초연구정책을 수립하는데 활용하고자 하였다. 국내 외 49종의 과학기술 관련 보고서 등 자료를 수집하여 6,446개 지표 추출, 877개 통계 정보로 범주화, 이중 208개를 집중 관리 통계로 도출하였다. 이렇게 구축된 DB의 활용성 제시를 위해 논문정보 관련 심층분석을 통해 제한적으로나마 우리나라 기초연구의 효과성을 보여주고자 하였다. 이를 위해, 고피인용 논문창출과 R&D 투자 간의 통계기반 분석과 고피인용 논문의 국내 외 지식맵 비교 분석을 실시하였다. 그 결과, 기초연구비 증가가 우리나라의 보편적 연구활동도와 세계적 연구성과 창출에 긍정적 영향을 미친 것으로 나타났다. 또한 순수기초연구분야로 간주되어온 수학, 물리, 화학이 신성장동력이라 불리는 AI, 청정에너지 등 기술 발전의 기반이 되어왔음을 알 수 있었다.

• Biomolecules & Therapeutics
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• 제26권2호
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• pp.201-209
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• 2018

G protein-coupled receptor 119 (GPR119) is expressed in the pancreas and gastrointestinal tract, and its activation promotes insulin secretion in the beta cells of the pancreatic islets as well as the secretion of glucagon-like peptide-1 (GLP-1) in intestinal L cells, consequently improving glucose-stimulated insulin secretion. Due to this dual mechanism of action, the development of small-molecule GPR119 agonists has received significant interest for the treatment of type 2 diabetes. We newly synthesized 1,2,4-triazolone derivatives of GPR119 agonists, which demonstrated excellent outcomes in a cyclic adenosine monophosphate (cAMP) assay. Among the synthesized derivatives, YH18968 showed cAMP=2.8 nM; in GLUTag cell, GLP-1secretion=2.3 fold; in the HIT-T15 cell, and insulin secretion=1.9 fold. Single oral administration of YH18968 improved glucose tolerance and combined treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor augmented the glucose lowering effect as well as the plasma level of active GLP-1 in normal mice. Single oral administration of YH18968 improved glucose tolerance in a diet induced obese mice model. This effect was maintained after repeated dosing for 4 weeks. The results indicate that YH18968 combined with a DPP-4 inhibitor may be an effective therapeutic candidate for the treatment of type 2 diabetes.

• 한국의류산업학회지
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• 제26권1호
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• pp.110-122
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• 2024

This study aims to cultivate specialized professionals equipped with practical skills essential for compliance with textile environmental regulations and analysis of harmful substances. This is achieved through the revision and restructuring of educational programs targeting workers in the chemical analysis industry. To address this, a survey was conducted among chemical industry workers in small and medium-sized enterprises (SMEs) to gauge the demand for educational programs. Specifically, a survey was conducted among 240 SME workers who participated in the 2022 education curriculum to identify their educational needs and specific requirements in the field. The research findings indicate that the majority of SMEs recognize the necessity of education in the chemical field and express a strong willingness to engage in the curriculum. Particularly emphasized was the need to enhance practical skills crucial for compliance with chemical environmental regulations. Consequently, adjustments were made to the curriculum, reallocating time and increasing the duration of practical training. This enables trainees to directly operate analysis machines and interpret results. Additionally, in response to further educational demands reflected by survey participants, the curriculum was expanded from five to six courses, with adjustments made to existing educational programs. Based on these research outcomes, practical educational methods tailored to SME requirements are proposed, aiming to bridge the gap between regulatory compliance and industry needs.

• 한국측량학회지
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• 제27권5호
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• pp.517-528
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• 2009

2006년 11월에 시작된 지능형국토정보기술혁신사업은 '유비쿼터스 국토실현을 위한 공간정보 기술혁신'이라는 목표를 실현하기 위해 기술 분야별 5개의 핵심과제로 구성되어 있으며 2012년 4월까지 정부출연금 약 1317억원, 민간부담금 약 446억원이 투입되는 대규모 R&D 사업이다. 본 사업에서는 개발된 연구성과물을 검증하기 위해 실제 환경에 적용, 통합, 전시하는 테스트베드 구축을 계획하고 있으며, 이를 통해 국가차원의 공간정보 상설 실험장을 확보하고자 한다. 현재 5개 핵심과제에서 개발되고 있는 연구성과물의 약 40%이상이 공간정보를 관측, 수집하는 다양한 센서를 사유하는 응용시스템들이며, 이러한 이기종 센서시스템간 통합 서비스를 제공하기 위해서는 상호운용성 확보가 가장 중요하고 시급한 문제이다. 본 논문에서는 지능형국토정보기술혁신사업에서 개발되고 있는 연구성과물의 통합 방안에 대해 살펴보고, 특히 센서관련 응용시스템간의 상호운용성 확보에 적절한 통합 방안을 센서웹을 통하여 제시하였다.

• 한국공간정보시스템학회 논문지
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• 제11권1호
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• pp.169-176
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• 2009

3차 국가GIS 사업의 유비쿼터스 GIS 핵심기술 개발 부분을 담당하는 지능형국토정보기술혁신 사업이 지난 2006년 11월부터 2011년 8월까지 정부출연금 약 1317억원, 민간부담금 약 446억원 규모로 수행되고 있다. 지능형국토정보기술혁신사업은 '유비쿼터스 국토실현을 위한 공간정보 기술혁신'이라는 목표를 실현하기 위해 기술 분야별로 5개 핵심과제와 1개 총괄과제로 구성되어 있는 대규모 R&D사업이다. 본 사업에서는 연구성과물의 현장적용, 통합, 전시를 위해 공동실험장 구축을 계획하고 있으며, 향후 국가적인 차원에서 차세대 u-GIS 공동실험장 확보를 목표로 하고 있다. 본 논문에서는 지능형국토정보기술혁신사업 총괄과제에서 수행중인 공동실험장 구축 계획에 대한 기본적인 방향, 계획, 그리고 공동실험장에 적용될 연구개발 성과물의 특성에 대해 논하고자 한다.

• Ocean and Polar Research
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• 제34권3호
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• pp.349-364
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• 2012

This study focuses on systematic structure of factors, which affect commercialization of ocean science and technology (OST), applying both grounded theory methodology (GTM) and semantic network analysis methodology (SNAM) by using in-depth interviews with 8 specialists previously experienced in the same field. This study further focuses on clarification of the distinctiveness and universality of commercialization factors on OST by comparatively analyzing on the commercialization factors of general sciences and technologies. Using SNAM, it was determined that commercialization success required connected support system, government support, technology marketing, technology power and characteristics of commercialized entities, which were identified as dominant factors. GTM presented an outcome that connected support systems among participants in commercialization and found that research institute strategies are significant factors in the core phenomenon of commercialization, while technology marketing, technology power and market-oriented technology are important conditions. In addition, the factors of technology, market, connection of participants and government support of commercialized entities are shown as equally important factors for commercialization of ocean science and technology. Secondly, SNAM results indicate that ocean science characteristics depend on a network of government support, research institute strategy, organization and manpower, capital power, and technology marketing, as these ocean science characteristics have been identified as significant factors in the GTM study. It has been determined that technology, market and government support should be connected in order for commercialization of ocean science and technology (OST). Moreover, commercialization methods, applied to the marketing of commercialization of ocean science and technology is differentiated from others since commercialization success is more relevant to these factors.

• 동의신경정신과학회지
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• 제33권4호
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• pp.401-424
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• 2022

Objectives: As effective treatments for dementia are lacking in Western medicine, complementary and alternative medicine (CAM) is considered a useful option. While the quality of life (QoL) is a vital outcome for patients with dementia, the QoL of patients receiving CAM for dementia remains ambiguous. This study aimed to determine the effect of CAM on QoL outcomes in dementia patients. Methods: A search was performed using the keywords "dementia," "Alzheimer's," "cognitive impairment," "Chinese," "Korean," "oriental," "herbal," "acupuncture," and "quality of life". All quantitative data were synthesized using R version 4.1.1. Results: Twenty-five randomized controlled trials (RCTs), 16 pre-post trials, and two cohort studies were selected for the systematic review. QoL in Alzheimer's disease (QOL-AD) (n=11, 25.6%) and geriatric QoL in dementia (GQOL-D, n=9, 20.9%) were the most utilized QoL instruments. Significant benefits in QoL were observed after receiving mind, body, combined mind and body, nursing, oriental medicine, and acupuncture therapies. In the meta-analysis, the combined effect was shown to significantly increase QOL-AD compared to before CAM interventions (standardized mean difference, SMD: 0.507; 95% confidence interval (CI), 0.191~0.824; p<0.01). The overall synthesized estimates in the GQOL-D showed a significantly improved QoL (SMD: 0.537, 95% CI: 0.238~0.837 p<0.01; one group; SMD: 1.465, 95% CI: 0.934~1.996, p<0.01). The seven studies assessing the cost-effectiveness of CAM reported uncertain outcomes. Conclusions: This study showed that CAM interventions benefited patients with dementia by improving their QoL. While additional standardized research is required, CAMs are suggested as effective clinical management for patients with dementia. They are also suggested as complementing therapies for these patients.

• 기술혁신연구
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• 제28권3호
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• pp.1-28
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• 2020

본 연구는 혁신효율성이 기업의 기업성과에 어떠한 영향을 미치는지를 분석하였다. 여기서 혁신효율성은 연구개발지출 또는 연구개발스톡에 대한 특허 출원수의 비율로 측정하였으며, 영업성과는 영업이익률과 영업현금흐름비율로 측정하였다. 2014년부터 2017년까지 한국거래소에 상장된 제조기업 1,880개(기업-연도)의 표본을 Hirshleifer et al(2013)의 분석 모형을 이용하여 분석하였다. 분석결과, 혁신효율성과 영업이익률 간의 유의한 양(+)의 관련성이 있는 것으로 나타났다. 또한 영업현금흐름비율로 측정한 성과 역시 혁신효율성과 유의한 양(+)의 관련성이 있는 것으로 나타났다. 이는 연구개발투자 대비 더 많은 특허 출원을 달성한, 즉 혁신효율성이 높은 기업들이 더 높은 기업성과를 달성하는 것을 의미한다. 추가적으로 R&D 집약기업과 R&D 비집약기업으로 나누어 분석하였다. 분석결과, R&D 집약기업에서는 혁신효율성이 영업이익률과 영업현금흐름비율에 유의한 양(+)의 관련성이 있는 것으로 나타났으며, R&D 비집약기업에서는 혁신효율성이 영업현금흐름비율에 유의한 양(+)의 관련성이 나타났다. 또한 전체 표본의 특허 출원 수 평균보다 많은 산업과 적은 산업으로 구분하여 추가분석을 실시한 결과, 특허 출원 수가 많은 산업에서는 혁신효율성이 영업이익률과 영업현금흐름비율에 유의한 양(+)의 관련성이 있는 것으로 나타났다. 특허 출원 수가 적은 산업에서는 혁신효율성이 영업이익률에 유의한 양(+)의 관련성이 있는 것으로 나타났다. 이상의 추가분석을 통해 기업의 R&D 집약도를 고려하고 산업별 특허 출원 수를 고려하여도 혁신효율성의 효과가 본 분석의 결과와 일관되게 나타나, 혁신효율성의 유용성이 있음을 확인하였다. 본 연구의 공헌점은 각 기업의 연구개발투자의 혁신효율성을 고려하였다는 데에 있다. 또한 본 연구의 결과는 투자자들이 기업의 평가할 때 단순히 연구개발지출만을 고려할 것이 아니라, 혁신효율성도 고려해야 한다는 시사점을 제시하고 있다.

• Journal of Nutrition and Health
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• 제34권4호
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• pp.426-432
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• 2001

Vitamin B(sub)12(cobalamin) is an essential nutrient in human and it is particularly important during pregnancy. Nevertheless very few studies have reported, concerning vitamin B(sub)12 in relation with reproduction. This study was conducted to evaluate the vitamin B(sub)12 nutrition status of Korean pregnant women and to investigate the relationship between serum vitamin B(sub)12 levels of maternal-umbilical cord blood and pregnancy outcomes. Dietary vitamin B(sub)12 intakes of the pregnants were estimated by semiquantitative frequency questionnaire. Serum vitamin B(sub)12 levels in both maternal blood and umbilical cord blood of 30 pregnant women at delivery were measured by radioimmunoassay. Mean vitamin B(sub)12 intake was 3.3$\pm$1.4$\mu\textrm{g}$/d which was 125.8% of the Korean RDA(2.6$\mu\textrm{g}$) for vitamin B(sub)12 level of umbilical cord blood was 607.8$\pm$282.9pg/ml, more than two fold of maternal vitamin B(sub)12 level 268.6$\pm$97.8pg/ml. This finding indicates that fetal uptake of vitamin B(sub)12 in the fetus may be due to an active transport mchanism across the placenta. Umbilical cord blood vitamin B(sub)12 levels were highly correlated with maternal levels($r^2$=0.548, p<0.001), showing that fetal vitamin B(sub)12 level is affected by maternal status. However there was no significant correlation between the serum vitamin B(sub)12 levels in maternal-umbilical cord blood and the pregnancy outcomes except for the birth weight. Maternal-umbilical serum vitamin B(sub)12 levels were the highest in the group of birth weight 3.0-3.5kg, and the lowest in the group of birthweight below 3.0kg. (Korean J Nutrition 34(4) : 426~432, 2001)