• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.spc
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• pp.79-88
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• 2023

This research aims to validate the effectiveness of the "Specialized Entrepreneurship University Program," which was conducted as part of government entrepreneurship support initiatives from 2018 to 2022. Based on previous studies, a research model was derived consisting of three laboratory entrepreneurship support factors that influence program satisfaction and entrepreneurial outcomes (infrastructure support, educational mentoring support, and business linkage support). Surveys were collected and analyzed from 126 laboratory entrepreneurship firms participating in the program, and empirical analysis of the research model was conducted using SPSS 23.0 statistical software. The analysis results indicated that the three variables, namely infrastructure support, educational mentoring support, and business linkage support, were significant factors affecting program satisfaction, and program satisfaction was confirmed to influence entrepreneurial outcomes. Furthermore, it was found that the three business operation factors indirectly influenced entrepreneurial outcomes by partially mediating program satisfaction. This study is considered significant as an empirical study for the initial stage of the second-phase program enhancement, verifying the effectiveness of laboratory entrepreneurship support factors. The findings can be applied to similar government entrepreneurship support initiatives and contribute to the effective strategy and planning of stakeholders involved. The limitations of this study include the need for further research on the perception of the extent to which it contributes to entrepreneurial outcomes, emphasizing caution in interpreting the research model, and the necessity for expanding the survey population and improving survey items in future research.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.331-341
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• 2017

As increasing the importance of the R&D strategy planning based on S&T evidence, the S&T DB was conducted to develop appropriate basic research support strategies by collecting 49 multiple-nations' statistics and information, extracting 6446 raw data, categorizing 877 indicators including 208 core indicators. An statistical and knowledge map analysis using the highly cited publication-related indicators was conducted to examine the expansion of DB utilization by demonstrating effectiveness of Korea's basic research. As a result, basic research investment have a strong influence on creating outstanding R&D outcomes and on producing a foundation of various S&T based-growth engines.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.201-209
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• 2018

G protein-coupled receptor 119 (GPR119) is expressed in the pancreas and gastrointestinal tract, and its activation promotes insulin secretion in the beta cells of the pancreatic islets as well as the secretion of glucagon-like peptide-1 (GLP-1) in intestinal L cells, consequently improving glucose-stimulated insulin secretion. Due to this dual mechanism of action, the development of small-molecule GPR119 agonists has received significant interest for the treatment of type 2 diabetes. We newly synthesized 1,2,4-triazolone derivatives of GPR119 agonists, which demonstrated excellent outcomes in a cyclic adenosine monophosphate (cAMP) assay. Among the synthesized derivatives, YH18968 showed cAMP=2.8 nM; in GLUTag cell, GLP-1secretion=2.3 fold; in the HIT-T15 cell, and insulin secretion=1.9 fold. Single oral administration of YH18968 improved glucose tolerance and combined treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor augmented the glucose lowering effect as well as the plasma level of active GLP-1 in normal mice. Single oral administration of YH18968 improved glucose tolerance in a diet induced obese mice model. This effect was maintained after repeated dosing for 4 weeks. The results indicate that YH18968 combined with a DPP-4 inhibitor may be an effective therapeutic candidate for the treatment of type 2 diabetes.

• Fashion & Textile Research Journal
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• v.26 no.1
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• pp.110-122
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• 2024

This study aims to cultivate specialized professionals equipped with practical skills essential for compliance with textile environmental regulations and analysis of harmful substances. This is achieved through the revision and restructuring of educational programs targeting workers in the chemical analysis industry. To address this, a survey was conducted among chemical industry workers in small and medium-sized enterprises (SMEs) to gauge the demand for educational programs. Specifically, a survey was conducted among 240 SME workers who participated in the 2022 education curriculum to identify their educational needs and specific requirements in the field. The research findings indicate that the majority of SMEs recognize the necessity of education in the chemical field and express a strong willingness to engage in the curriculum. Particularly emphasized was the need to enhance practical skills crucial for compliance with chemical environmental regulations. Consequently, adjustments were made to the curriculum, reallocating time and increasing the duration of practical training. This enables trainees to directly operate analysis machines and interpret results. Additionally, in response to further educational demands reflected by survey participants, the curriculum was expanded from five to six courses, with adjustments made to existing educational programs. Based on these research outcomes, practical educational methods tailored to SME requirements are proposed, aiming to bridge the gap between regulatory compliance and industry needs.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.5
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• pp.517-528
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• 2009

Korean Land Spatialization Program (KLSP) is a R&D program of the National GIS Project for developing ubiquitous GIS technologies under control of Ministry of Land, Transport and Maritime Affairs. The first program from 2006 to 2012, initiated with $132 million of national fund and $42 million of private matching fund. Aiming 'Innovation of the GIS technology for the ubiquitous Korean land', KLSP consists of five core research projects and one research coordination project. The coordination project's purpose is to practically utilize and commercialize the results of core research projects. Korean Land Spatialization Group (KLSG) is planning a test-bed for testing, integrating, and exhibit- ing the KLSP's outcomes. Integrations of the outcomes are mandatory for the successful KLSG Test-Bed. The main objective of this paper is to introduce KLSP test-bed and three methodologies for integration of the outcomes in KLSP. As a plan of integrations, especially, this paper proposes SWE SOS (Sensor Observation Service) prototype to achieve interoperability of the geo-sensor networks.

• Journal of Korea Spatial Information System Society
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• v.11 no.1
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• pp.169-176
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• 2009

Korean Land Spatialization Program(KLSP) is the R&D program of the National GIS Project for developing ubiquitous GIS core technologies under control of Ministry of Land, Transport and Maritime Affairs(MLTM). The first program of KLSP, from 2006 to 2012, initiated with $132 million (US dollars) of national fund and $42 million of matching fund. KLPS which aims 'Innovation of the GIS technology for the ubiquitous Korean land' consists of 5 core research projects and 1 research coordination project to practically utilize and commercialize the results of core research. Korean Land Spatialization Group(KLSG) is planning the KLSP proving ground for testing, integrating, exhibiting the KLSP's outcomes. In the near future, this proving ground would be utilized as a national ubiquitous GIS proving ground. The key objective of this paper is to present the conceptual designs and basic plans. In addition, this paper discusses characteristics of the outcomes which are applied to KLSP proving ground.

• Ocean and Polar Research
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• v.34 no.3
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• pp.349-364
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• 2012

This study focuses on systematic structure of factors, which affect commercialization of ocean science and technology (OST), applying both grounded theory methodology (GTM) and semantic network analysis methodology (SNAM) by using in-depth interviews with 8 specialists previously experienced in the same field. This study further focuses on clarification of the distinctiveness and universality of commercialization factors on OST by comparatively analyzing on the commercialization factors of general sciences and technologies. Using SNAM, it was determined that commercialization success required connected support system, government support, technology marketing, technology power and characteristics of commercialized entities, which were identified as dominant factors. GTM presented an outcome that connected support systems among participants in commercialization and found that research institute strategies are significant factors in the core phenomenon of commercialization, while technology marketing, technology power and market-oriented technology are important conditions. In addition, the factors of technology, market, connection of participants and government support of commercialized entities are shown as equally important factors for commercialization of ocean science and technology. Secondly, SNAM results indicate that ocean science characteristics depend on a network of government support, research institute strategy, organization and manpower, capital power, and technology marketing, as these ocean science characteristics have been identified as significant factors in the GTM study. It has been determined that technology, market and government support should be connected in order for commercialization of ocean science and technology (OST). Moreover, commercialization methods, applied to the marketing of commercialization of ocean science and technology is differentiated from others since commercialization success is more relevant to these factors.

• Journal of Oriental Neuropsychiatry
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• v.33 no.4
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• pp.401-424
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• 2022

Objectives: As effective treatments for dementia are lacking in Western medicine, complementary and alternative medicine (CAM) is considered a useful option. While the quality of life (QoL) is a vital outcome for patients with dementia, the QoL of patients receiving CAM for dementia remains ambiguous. This study aimed to determine the effect of CAM on QoL outcomes in dementia patients. Methods: A search was performed using the keywords "dementia," "Alzheimer's," "cognitive impairment," "Chinese," "Korean," "oriental," "herbal," "acupuncture," and "quality of life". All quantitative data were synthesized using R version 4.1.1. Results: Twenty-five randomized controlled trials (RCTs), 16 pre-post trials, and two cohort studies were selected for the systematic review. QoL in Alzheimer's disease (QOL-AD) (n=11, 25.6%) and geriatric QoL in dementia (GQOL-D, n=9, 20.9%) were the most utilized QoL instruments. Significant benefits in QoL were observed after receiving mind, body, combined mind and body, nursing, oriental medicine, and acupuncture therapies. In the meta-analysis, the combined effect was shown to significantly increase QOL-AD compared to before CAM interventions (standardized mean difference, SMD: 0.507; 95% confidence interval (CI), 0.191~0.824; p<0.01). The overall synthesized estimates in the GQOL-D showed a significantly improved QoL (SMD: 0.537, 95% CI: 0.238~0.837 p<0.01; one group; SMD: 1.465, 95% CI: 0.934~1.996, p<0.01). The seven studies assessing the cost-effectiveness of CAM reported uncertain outcomes. Conclusions: This study showed that CAM interventions benefited patients with dementia by improving their QoL. While additional standardized research is required, CAMs are suggested as effective clinical management for patients with dementia. They are also suggested as complementing therapies for these patients.

• Journal of Technology Innovation
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• v.28 no.3
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• pp.1-28
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• 2020

This study examines whether the firm with high innovation efficiency realizes high operating performance. We measured innovation efficiency by the ratio of patent applications for R&D expenditure or R&D stock and measured operating performance by the ratio of operating income or operating cash flow to total assets for the following year. The sample consists of 1,880 manufacturing firm-years, which listed on the Korean Exchange between 2014 and 2017. We analyze the effect of innovation efficiency on operating performance using a model of Hirshleifer et al. (2013) results show that both innovation efficiency variables have a significantly positive relationship with the total asset operating margin. Besides, the following year's performance, measured by the total asset operating cash flow ratio, also shows a positive relationship with the two innovation efficiency variables at the 5% and 1% significance levels, respectively. The results indicate that high innovation efficiency firms that link the outcomes of R&D to more patent applications realize higher operating performance. Also, we divided the R&D-intensive and non-R&D-intensive industries and performed the same analysis. As a result, the innovation efficiency has a significant positive effect on operating margin in both industries. However, the effect of innovation efficiency on the operating cash flow is only significant in R&D-intensive industries. This study suggests that the effects of innovation efficiency are more consistent in the R&D-intensive industry. Additionally, we divided the high patent application and low patent applications industries and performed the same analysis. As a result, the innovation efficiency has a significant positive effect on operating margin in both industries. This study suggests that the effects of innovation efficiency are more consistent in the high patent application industry. We show that a firm's innovation efficiency is a critical factor for a firm's performance, while prior studies on the R&D performance have not considered the innovation efficiency of each firm. The evidence suggests that firms not only consider R&D expenditures but also improve the performance of companies by increasing innovation efficiency. Investors need to consider their innovation efficiency when evaluating the value of firms.

• Journal of Nutrition and Health
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• v.34 no.4
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• pp.426-432
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• 2001

Vitamin B(sub)12(cobalamin) is an essential nutrient in human and it is particularly important during pregnancy. Nevertheless very few studies have reported, concerning vitamin B(sub)12 in relation with reproduction. This study was conducted to evaluate the vitamin B(sub)12 nutrition status of Korean pregnant women and to investigate the relationship between serum vitamin B(sub)12 levels of maternal-umbilical cord blood and pregnancy outcomes. Dietary vitamin B(sub)12 intakes of the pregnants were estimated by semiquantitative frequency questionnaire. Serum vitamin B(sub)12 levels in both maternal blood and umbilical cord blood of 30 pregnant women at delivery were measured by radioimmunoassay. Mean vitamin B(sub)12 intake was 3.3$\pm$1.4$\mu\textrm{g}$/d which was 125.8% of the Korean RDA(2.6$\mu\textrm{g}$) for vitamin B(sub)12 level of umbilical cord blood was 607.8$\pm$282.9pg/ml, more than two fold of maternal vitamin B(sub)12 level 268.6$\pm$97.8pg/ml. This finding indicates that fetal uptake of vitamin B(sub)12 in the fetus may be due to an active transport mchanism across the placenta. Umbilical cord blood vitamin B(sub)12 levels were highly correlated with maternal levels($r^2$=0.548, p<0.001), showing that fetal vitamin B(sub)12 level is affected by maternal status. However there was no significant correlation between the serum vitamin B(sub)12 levels in maternal-umbilical cord blood and the pregnancy outcomes except for the birth weight. Maternal-umbilical serum vitamin B(sub)12 levels were the highest in the group of birth weight 3.0-3.5kg, and the lowest in the group of birthweight below 3.0kg. (Korean J Nutrition 34(4) : 426~432, 2001)