• 대한화장품학회:학술대회논문집
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• 대한화장품학회 1999년도 IFSCC . ASCS 학술대회 발표 논문
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• pp.57-64
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• 1999

Pericarpium castaneae extracts have variously potent activities, such as anti-oxidative activity and free radical scavenging activity. in vivo and in vivo studies both indicate that pericarpium castaneae extracts acts as a flee radical scavenger ($IC_{50}$/: 7.6$\mu\textrm{g}$/ml) stronger than gallic acid($IC_{50}$/: 12.5$\mu\textrm{g}$/ml) and ellagic acid($IC_{50}$/: 15$\mu\textrm{g}$/ml) which could prevent cutaneous UV damages and skin aging. The extracts showed a good effect as a anti-oxidant ($IC_{50}$/: 50$\mu\textrm{g}$/ml). It was shown that the appearance of wrinkle in human skin was reduced by topical application of pericarpium castaneae extracts. And the treatment of human skin with the extracts increased the elasticity and moisture of the skin. We investigated the effect of tile pericarpium castaneae extracts on production of extracellular matrix using cultured A431 fibroblast cells. The results indicated that the extracts had no detectable effect on collagen synthesis, But synthesis of cell adhesion protein was increased by the extracts. The results suggest that increase of cell adhesion protein synthesis by pericarpium castaneae extracts has closely related to reduction of wrinkle in skin.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.98-98
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• 2019

This study was expand the use of Citrus madurensis (Citrofortunella microcarpa), which is a good source of skin whitening and antioxidants activation cosmetics. The goal was to provide cosmeceutical activity data about the extraction yield and total phenol of this calamondin orange by optimizing the focused high ultrasound(INEFU) and ultrasound extraction(UE) conditions. Under optimal extraction conditions, which consisted of 1800W for 45min and 500W for 45 min, 21.55 and 13.27 % (w/w) of the highest extractions yield and polyphenol contents were obtained. For the skin whitening activity, tyrosinase inhibitory activity was observed at 69.24 % in the INEFU extracts, which was ca. 18 % higher than that of the UE extracts (58.82 %). To reduce melanin production in Clone M-3 cells, 86.9 % melanin production was observed following the addition of control, WE(water extraction) relative to the control without a sample, and 81.2 and 78.9 % were found in the UE and INEFU conditions. The highest total phenol secretion was conclusively obtained under the optimal conditions and resulted in a significant improvement of the cosmetic activities of Citrus madurensis(Citrofortunella microcarpa) extracts.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.686-697
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• 2003

A new colloidal silver (Ag) system is present in which a fine colloidal Ag is in situ deposited onto functionalized porous poly (ethylene glycol dimethacrylate) (poly (EGDMA)) microspheres. The effectiveness of Ag deposition was investigated considering the surface characteristics of poly (EGDMA) microspheres. The result reported in this study illustrates that the control of surface area and surface functionality (in this study, a hydroxyl group) of poly (EGDMA) microspheres is an important factor that determines practically the degree of deposition of colloidal Ag. The x-ray analysis showed that Ag nanoparticles were dispersed evenly inner and outer surfaces and had a face center cubic (fee) phase. In the preservative efficacy test, the Ag-containing poly (EGDMA) microspheres had a powerful anti-bacterial activity, showing a high potential for a new preservative in cosmetic industry.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 2006년도 제28회 동계학술발표회 논문집
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• pp.170-186
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• 2006

The guarantee funds for government policy fund, venture capital investment fund, technology guarantee debt are the core parts of the external financing system in the constant technology innovation company. However, the enterpriser's requirement to keep the technology innovation with minimized management intervention and policy maker's hope to advance technology development with clear operation of funds is enough to request for research of the project investment plan to the R&D project. This paper will analyze whether technology innovation company that creates cash flow prefers to the project investment as a financing program or not, and if prefers, what characters of company affect on this preference. The more the company that pursuit the additional R&D activity separated to on-going items becomes over the fixed size, the more prefers the project investment as future external fund-raising. Together with that, this paper suggests that we can apply the plan like special purpose vehicle, SWORD(Stock Warrant Off-Balance sheet R&D) and R&D Limited Partnership as R&D project investment policy, and improve the system itself.

• 서비스연구
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• 제13권1호
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• pp.144-158
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• 2023

기업과 정부의 연구개발(R&D: Research and Development) 투자는 지속적으로 증가해, 2021년 공공과 민간의 전체 연구개발비는 102조 1,352억 원으로 100조원을 돌파하였고, GDP 대비 R&D 투자 비중이 4.96%로 이스라엘에 이어 전 세계 2위 수준으로 나타났다. 본 연구는 100조원을 돌파한 국내 연구개발 투자의 R&D 생산성 제고 측면에서 국내 연구 서비스산업 현황과 연구개발(R&D) 혁신 생태계를 통계청의 기업활동조사 데이터를 바탕으로 분석하고 글로벌 연구 서비스산업과 기업 현황과 연구(R&D) 서비스 산업 지원을 위한 정부 정책을 조사 및 분석하였다. 특히, 본 연구에서는 기업활동조사 데이터를 바탕으로 업종별 연구개발(R&D) 서비스 외부 위탁에 대한 분석과 연도별 연구개발(R&D) 서비스 외부 위탁에 대한 조사를 통해 국내 연구(R&D) 서비스산업 현황에 대해 조사 분석하였다. 이를 통해 업종별 국내 연구(R&D) 서비스 산업 수요에 대한 주요 변화 추이를 제조업과 서비스업 관점에서 도출하였다. 분석 결과 국내 R&D 생태계는 전통적인 제조기업의 R&D 아웃소싱 수요가 정체된 것에 비해 서비스기업의 R&D 아웃소싱 수요가 급속도로 증가하고 있는 것으로 나타났다. 특히 국외 위탁기업이 지속적으로 확대되는 반면에 국내 연구개발 위탁 기업은 비중이 감소 추세를 보이고 있는 상태이다. 또한 서비스 업종별로 차별적인 특징을 보여주었다. 본 연구에서는 글로벌 연구 서비스 기업에 대한 조사와 연구(R&D) 서비스산업 지원 정책에 대한 분석을 바탕으로, 이러한 변화하는 기술 혁신과 연구(R&D) 서비스 수요에 대응하기 위해 제조기업과 서비스기업 R&D 아웃소싱 균형지원, 국내 연구개발 외부위탁 확대, 서비스업종 특화 R&D 아웃소싱 전략수립, 개방형 R&D 생태계 구축, 소재·부품·장비 전략과의 연계 혁신 방안을 제시하였다.

• 기술혁신학회지
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• 제12권3호
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• pp.564-581
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• 2009

본 연구에서는 기술표준원이 (주)코리아데이터네트워크에 의뢰하여 작성된 설문조사결과를 활용하여 기업의 표준화활동 결정요인을 분석하였다. 표준화활동을 유형(혹은 범주)에 따라 기업의 전사적 표준경영, 인증획득, 국내표준활용, 국제표준활용 등으로 구분하였고, 그 결정요인으로 기술혁신활동(R&D와 특허출원), 기업규모, 수출, 네트워크(산업특성), 기업조직특성 등을 고려하였다. 분석된 표본은 제조업에 속한 636개 기업으로 정성적 분석방법인 로지스틱 회귀모형(logistic regression)을 사용하였다. 분석결과, 첫째 기술혁신활동 변수 중 R&D집약도는 국제표준활용을 제외하고 표준화활동에 영향을 미치지 않는 것으로 나타났다. 둘째, 특허출원은 전사적 차원에서의 표준경영과 인증획득활동에 대해 정(+)의 유의한 효과를 보여 주었다. 셋째, 상대적으로 소기업과 대기업보다는 중간규모의 기업에서 전사적 차원에서의 표준경영자 인증획득활동이 활발하다는 역U자 가설이 성립하는 것으로 분석되었다. 넷째, 표준화에 대한 경영진의 관심은 모든 표준화활동의 유형에 대해서 중요한 결정요인으로 나타났다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.95-95
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• 2018

Uric acid is the end product of purine metabolism in human body, originating from hypoxanthine after enzyme catalysis by Xanthine oxidase (XOD). Hyperuricemia results as a result of either over-generation of uric acid or a reduction in its excretion. In silico modelling methods such as Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) prediction, Autodock 4.2.6 program were used to study the potential inhibitory compounds of XOD. Also we investigated the inhibition of XOD activity by using the extracts of Dendropanax morbifera and Rubus coreanus Miq spectrophotometrically. According to ADMET data, several compounds from D. morbifera and R. coreanus plants, were found to be more potent in inhibiting the XOD activity than allopurinol. XOD inhibitory activity is evaluated by quantifying the formation of uric acid by measuring the absorbance at 290 m ($A_{290}$).D. morbifera extract inhibited XOD activity at $250{\mu}g/ml$, however the extracts from R. coreanus has inhibited XOD activity at $25{\mu}g/ml$. The major compound of R. coreanus, ellagic acid significantly increased the inhibition rate from $9{\mu}g/ml$ and showed a 71% suppression rate at $15{\mu}g/ml$. Finally, these results suggested a potential inhibitory activities of the extracts from D. morbifera and R. coreanus Miq, but further research is needed to validate to ensure their safe usage as drug.

• Biomolecules & Therapeutics
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• 제18권2호
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• pp.191-196
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• 2010

In the course of screening for antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl- 2-picrylhydrazyl (DPPH), a total extract of the twigs of Stewartia koreana (Theaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of six phenolic compounds, ampelopsin (1), catechin (2), proanthocyanidin-A2 (3), fraxin (4), (2R, 3R)-taxifolin-3-${\beta}$-D-glucopyranoside (5), and (2S, 3S)-taxifolin-3-${\beta}$-D-glucopyranoside (6), as active principles. Their structures were elucidated by spectroscopic studies. Compounds 1-6 were isolated for the first time from this plant. Among them, three compounds 1-3 showed the significant antioxidative effects on DPPH, and riboflavin originated superoxide quenching activity. In riboflavin-nitrobluetetrazolium (NBT)-light system, compound 1 showed better superoxide quenching activity than vitamin C.

• Biomolecules & Therapeutics
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• 제11권3호
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• pp.196-199
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• 2003

The methanol extracts from 60 plant extracts were prepared and evaluated for their antioxidative activity. Arctium lappa, Diospyros kaki, Eugenia caryophyllata, Melia azedarach and Forsythia suspensa showed the inhibitory activity against lipid peroxidation. Caesalpinia sappan, Crataegus pinnatifida, Eugenia caryophyllata, Gleditsia japonica, Osmunda japonica, Rhus javanica and Sanguisorba officinalis showed the highest inhibitory activity against DPPH radical formation. In particular, Eugenia caryophyllata demonstrated strong inhibitory activity on the lipid peroxidation and free radicals. The results suggested that selected plant extracts have a potential as natural antioxidant.

• 기술혁신연구
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• 제13권3호
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• pp.77-100
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• 2005

This paper analyzes the determinants of firm's innovative activity, using Korean Innovation Survey (KIS) dataset. Especially, we focused on the role of external networks by partners(other firms or research institutions) in performing innovative activities. The product innovation, product improvement, and process innovation are used as proxies for innovative activity. The explanatory variables such as market concentration ratio, lagged profitability, foreign ownership, export ratio, firm's age, formal R&D activity, and industrial R&D intensity are also considered. With data from 1,124 firms for the two years (2000-2001), we estimated the logistic regression model. The finding is that the determinants of firm's innovative activities differ by type of innovations. We also found that the innovative behavior of SMEs differs from that of large firms. The result confirms that external networks have a strong positive effect on innovative activity. However, the network effects by partners vary across both firm size and type of innovations.