• Journal of Korean Elementary Science Education
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• v.26 no.4
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• pp.440-448
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• 2007

The purpose of this study is to examine elementary students' conceptions of magnetic fields around various magnets by drawing tasks. A total of 105 elementary students from the 3rd and 6th grade levels were asked to draw how iron filings would arrange around magnets. We classified their drawings of magnetic field lines with some criteria to identify conceptions of magnetic forces and checked them through interviewing about their representative drawing. Through analyzing drawings, we discovered that 40% of elementary students drew the correct arrangement of iron filings around a bar magnet. In the case of two bar magnets in opposite directions, 33% of them drew correct patterns of iron dust and around two magnets in the same direction only 20% did well. Only 2.9% and 7.6% of students presented the correct drawings of magnetic fields near a disc and a horseshoe magnet. While 3rd grade students were supposed to be poor in drawings of magnetic fields around a loose and a dense coil which was not learned about, only 31% and 23% of 6th grade students who have just studied electromagnetism properly drew patterns of iron dust. This shows that only one quarter of students understood the magnetic filed lines even after instruction of electromagnetism. Many of 6th grade students learned a solenoid becomes just as a permanent magnet, but very few of them correctly drew a magnetic field line could distinguish between the iron dust around a loose and dense coil. After interviewing students, it is found that students consider magnetic forces to be existed only in parts of magnet because many of them drew magnetic field line of a specific areas around magnets. Students had misconceptions that magnetic forces exist only on the poles not in the middle around a horseshoe magnet. Also the disc-shape magnet made students to reveal various types of misconceptions: N- and S-poles are mixed in a whole magnet and right part of a disc-shape magnet is N-pole, left part is S-pole. Students who had not studied magnetic fields of around a magnet and electromagnets could not draw the correct patterns of iron dust suggest that it is indispensable for students to teach how patterns of iron filings would represent a visual image of magnetic fields in order to understand magnetic fields.

• Korean Journal of Head & Neck Oncology
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• v.30 no.2
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• pp.53-61
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• 2014

Background and Objectives : Anaplastic thyroid carcinoma(ATC) is a rare but highly aggressive thyroid malignancy that is associated with an extremely poor survival despite the best multidisciplinary care. BRAF(V600E) mutation is detected in about a quarter of ATC, but unlike its high treatment response to selective BRAF inhibitor (PLX4032) in metastatic melanoma, the treatment response of ATC is reported to be low. The purpose of this study is to investigate the innate resistance mechanism responsible for this low treatment response to BRAF inhibitor and its effect on epithelial-mesenchymal transition(EMT). Materials and Methods : Two ATP cell lines, 8505C and FRO were selected and treated with PLX4032 and its drug sensitivity and effects on cell migration and EMT were examined and compared. Further investigation on the changes in signals responsible for the different treatment response to PLX4032 was carried out and the same experiment was performed on both orthotopic and ectopic xenograft mouse models. Results : FRO cell line was more sensitive to PLX4032 treatment compared to 8505C cell line. The resistance to BRAF inhibition in 8505C was due to increased expression of EGFR. Effective inhibition of both EGFR and p-AKT was achieved after dual treatment with BRAF inhibitor(PLX4032) and EGFR inhibitor(Erlotinib). Similar results were confirmed on in vivo study. Conclusion : EGFR-mediated reactivation of the PI3K/AKT pathway and MAPK pathway contributes to the relative insensitivity of BRAF(V600E) mutant ATC cells to PLX4032. Dual inhibition of BRAF and EGFR leads to sustained treatment response including cell invasiveness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.635-639
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• 2016

In the devices used in the microwave frequency band, the gain decreases as the frequency increases due to the parasitic component. To compensate for these characteristics, a linear gain equalizer with an opposite slope is needed in wideband systems, such as those used for electronic warfare. In this study, a linear gain equalizer that can be used in the 18 ~ 40GHz band is designed and fabricated. Circuit design and momentum design (optimizations) were carried out to reduce the errors between design and manufacturing. A thin film process is used to minimize the parasitic components within the implementation frequency band. A sheet resistance of 100 ohm/square was employed to minimize the wavelength variation due to the length of the thin film resistor. This linear gain equalizer is a structure that combines a quarter wavelength-resonator on a series microstrip line with a resistor. All three 1/4 wavelength short resonators were used. The fabricated linear gain equalizer has a loss of more than -5dB at 40GHz and a 6dB slope in the 18 ~ 40GHz band. By using the manufactured gain equalizer in a multi-stage connected device such as an electronic warfare receiver, the gain flatness degradation with increasing frequency can be reduced.

• The Journal of the Acoustical Society of Korea
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• v.33 no.2
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• pp.102-110
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• 2014

The effect of a bonding layer on the performance of a quarter-wave (${\lambda}/4$) mode PVDF ultrasound transducer having not only a piezoelectric layer but also a non-piezoelectric layer between two electrodes was analyzed. The equivalent circuit of a transmission line model by Kikuchi et al.[Sound of IEICE, 55-A, 331-338 (1981)] was introduced for the analysis. The validity of the model was confirmed by comparison with a KLM model for three postulated adhesion cases of a $80{\mu}m$ thick piezoelectric PVDF film to a copper (Cu) backer. The pulse-echo responses of five PVDF transducers, each fabricated with a different thickness ($5{\mu}m{\sim}20{\mu}m$) of the bonding layer, were measured and the results were compared with those by simulation. The two results were in good agreement with each other and it was noted that the effect of the bonding layer on the performance of the transducer could be analyzed by the Kikuchi model. In detail, the $20{\mu}m$ bonding layer decreased the center frequency and the bandwidth by about 19.7 % and 25.0 %, respectively, and increased the insertion loss by 57.2 %.