• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.514-523
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• 2021

Objective : Aneurysm volume quantification (AVQ) using the equation of ellipsoid volume is widely used although it is inaccurate. Furthermore, AVQ with 3-dimensional (3D) rendered data has limitations in general use. A novel universal method for AVQ is introduced for any diagnostic modality and application to any shape of aneurysms. Methods : Relevant AVQ studies published from January 1997 to June 2019 were identified to determine common methods of AVQ. The basic idea is to eliminate the normal artery volume from 3D model with the aneurysm. After Digital Imaging and Communications in Medicine (DICOM) data is converted and exported to stereolithography (STL) file format, the 3D STL model is modified to remove the aneurysm and the volume difference between the 3D model with/without the aneurysm is defined as the aneurysm volume. Fifty randomly selected aneurysms from DICOM database were used to validate the different AVQ methods. Results : We reviewed and categorized AVQ methods in 121 studies. Approximately 60% used the ellipsoid method, while 24% used the 3D model. For 50 randomly selected aneurysms, volumes were measured using 3D Slicer, RadiAnt, and ellipsoid method. Using 3D Slicer as the reference, the ratios of mean difference to mean volume obtained by RadiAnt and ellipsoid method were -1.21±7.46% and 4.04±30.54%, respectively. The deviations between RadiAnt and 3D Slicer were small despite of aneurysm shapes, but those of ellipsoid method and 3D Slicer were large. Conclusion : In spite of inaccuracy, ellipsoid method is still mostly used. We propose a novel universal method for AVQ that is valid, low cost, and easy to use.

• Food Science and Biotechnology
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• v.18 no.2
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• pp.565-569
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• 2009

This study was conducted to evaluate the effects of different preparation methods on the recovery and quantification of ginsenosides in raw Korean ginseng (Panax ginseng C.A. Meyer). Eight major ginsenosides ($Rb_1$, $Rb_2$, $Rb_3$, Rc, Rd, Re, Rf, and $Rg_1$) were analyzed by high performance liquid chromatography (HPLC), after which the recovery and repeatability of the extraction of those ginsenosides using 3 different preparation methods were compared [A. direct extraction (DE) method, hot MeOH extraction/evaporation/direct dissolution; B. solid phase extraction (SPE) method, hot MeOH extraction/evaporation/dissolution/$C_{18}$ cartridge adsorption/MeOH elution; C. liquid-liquid extraction (LLE) method, hot MeOH extraction/evaporation/dissolution/n-BuOH fractionation]. Use of the DE method resulted in a significantly higher recovery of total ginsenosides than other methods and a relatively clear peak resolution. Use of the SPE and LLE methods resulted in clearer peak resolution, but lower ginsenoside recovery than the DE method. The LLE method showed the lowest ginsenoside recovery and repeatability among the 3 methods. Given that the DE method employed only extraction, evaporation, and a dissolution step (avoiding complicate and time consuming purification), this technique may be an effective method for the preparation and quantification of ginsenosides from raw Korean ginseng.

• Journal of Ginseng Research
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• v.36 no.2
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• pp.205-210
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• 2012

For quality control of components in Korean red ginseng powder and extract, a new method for simultaneous quantification of 12 ginsenosides ($Rg_1$, Re, Rf, $Rh_1$, $Rg_2$[S], $Rg_2$[R], $Rb_1$, Rc, $Rb_2$, Rd, $Rg_3$[S], and $Rg_3$[R]) was studied. Compared to the official method for quantification of marker substances (ginsenosides $Rg_1$ and $Rb_1$), the proposed methods were guaranteed by in-house method validation. Several criteria such as linearity, specificity, precision and accuracy were evaluated. For red ginseng powder, recovery (averaging 95% to 105%) was calculated, and analysis of variance was carried out to estimate the relative standard deviation (0.20% to 2.12%). For red ginseng extract, the average recovery rate was 90% to 99% and the relative standard deviation was 0.39% to 2.40%. These results indicate that the proposed method could be used in the laboratory for determination of 12 ginsenosides in red ginseng powder and extract. In addition, this method was found to be suitable for quality control of ginseng products and potentially offer time and cost benefits.

• Journal of the Korean Wood Science and Technology
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• v.36 no.5
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• pp.33-41
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• 2008

This study was aimed to develop the knot quantification method to predict bending strength, using x-ray scanner. The bending strength prediction model was proposed in this paper. The model was based on Knot Depth Ratio (KDR) and closely-spaced knot was taken into account. The previous paper reported that KDR is the ratio of the knot and transit zone to the lumber thickness. Even though KDR involves transit zone, it was verified that the ratio of the moment of inertia for knot to gross cross section ($I_k/I_g$) based on KDR was a good predictor for bending strength of lumber. To take closely-spaced knot into account, a projection method was also proposed. This projection method improved the predictive accuracy significantly. It showed coefficient of determinant of 0.65 and root mean square error (RMSE) of 9.17.

• Annals of Clinical Neurophysiology
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• v.17 no.2
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• pp.53-60
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• 2015

Skin biopsy with investigation of small nerve fiber in human epidermis and dermis has been proven to be a useful method for demonstration of small fiber neuropathy. Quantification of intraepidermal nerve fiber density using anti-Protein Gene Product 9.5 (PGP 9.5) antibody is standardized method to diagnose the small fiber neuropathy. Skin biopsy method also makes it possible to differentiate the type of nerve fibers by using different antibodies. Quantification of dermal structures with different type of nerve fibers could be used to invest pathophysiologic mechanism of diseased state.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2012.05a
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• pp.364-366
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• 2012

Quantification of acoustic amplification in a model chamber has been studied for combustion stabilization induced by passive control devices. DMD(Dynamic mode Decomposition) method is adopted and the results from method are compared with those from damping factor approach. The model chamber has a faceplate with baffled injectors, where damping factor has its maximum at a specific baffle gap. They show a good agreement with the results from the previous method.

• Mass Spectrometry Letters
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• v.14 no.3
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• pp.104-109
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• 2023

Anabolic-androgenic steroids (AAS) are used illegally to enhance muscle development and increase strength and power. In this study, a reliable, and sensitive quantitative method was developed and validated using heptafluorobutyric acid anhydride (HFPA) derivatives for the simultaneous detection of prohibited AAS (testosterone [TS], boldenone [BD], 5α-estrane-3β,17α-diol [EAD]) using gas chromatography-tandem mass spectrometry (GC-MS/MS). For processing the samples, solid phase extraction, methanolic hydrolysis, and liquid-liquid extraction were used. For detection using mass spectrometry, the multiple reaction monitoring (MRM) mode was used with the electron ionization (EI) positive mode. The method was evaluated for selectivity, linearity, lower limit of quantification, intra- and inter-day precision, accuracy, and stability. The results showed that the method was accurate and reproducible for the quantitation of the three steroids. The developed method was finally applied to the analysis of a suspect gelding urine sample received from the Asian Quality Assurance Program (AQAP).

• Korean System Dynamics Review
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• v.16 no.2
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• pp.75-100
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• 2015

The purpose of this study is to analyze causation of Ecosystem service's trade-off(ES trade-off) and to establish baseline data for wise spatial planning and management. In order to understand why and how ES trade-off occurs, systems thinking and causal loops were employed. The causal loop of ecosystem service creation cycle includes profits quantification process, decision making process, spatial planning and management process, and ecosystem services creation process. The profits quantification process has a limitation that all ecosystem service categories were not included in profits quantification, because quantification method for cultural services is insufficient. These problems led to unequal discussion opportunity in decision making process. ES trade-off occurs through transition of ecosystem function in spatial scale and temporal scale. In spatial scale, land-use variation and resource-use variation contribute to change an ecosystem function for different ES category by spatial planning and management. In temporal scale, a change of an ecosystem function for different ES category is influenced by ecological succession, seasonal change and land cover variation, which are parameter from environmental features. This study presented that spatial planning and management should ecosystem service assessment in order to enhance balanced ecosystem services.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.790-802
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• 2022

Large-scale reactor simulation often requires the use of Monte Carlo calculation techniques to estimate important reactor parameters. One drawback of these Monte Carlo calculation techniques is they inevitably result in some uncertainty in calculated quantities. The present study includes parametric uncertainty quantification (UQ) and sensitivity analysis (SA) on the Advanced Test Reactor Critical (ATRC) facility housed at Idaho National Laboratory (INL) and addresses some complications due to Monte Carlo uncertainty when performing these analyses. This approach for UQ/SA includes consideration of Monte Carlo code uncertainty in computed sensitivities, consideration of uncertainty from directly measured parameters and a comparison of results obtained from brute-force Monte Carlo UQ versus UQ obtained from a surrogate model. These methodologies are applied to the uncertainty and sensitivity of k_eff for two sets of uncertain parameters involving fuel plate geometry and fuel plate composition. Results indicate that the less computationally-expensive method for uncertainty quantification involving a linear surrogate model provides accurate estimations for k_eff uncertainty and the Monte Carlo uncertainty in calculated k_eff values can have a large effect on computed linear model parameters for parameters with low influence on k_eff.

• Journal of the Korean Society of Safety
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• v.38 no.6
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• pp.72-78
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• 2023

The purpose of this paper is to derive a quantified approach for Operator Manual Actions (OMAs) based on the existing fire Human Reliability Analysis (HRA) methodology developed by the Korea Atomic Energy Research Institute (KAERI). The existing fire HRA method was reviewed, and supplementary considerations for OMA quantification were established through a comparative analysis with NUREG-1852 criteria and the review of the existing literature. The OMA quantification approach involves a timeline that considers the occurrence of Multiple Spurious Operations (MSOs) during a Main Control Room Abandonment (MCRA) determination and movement towards the Remote Shutdown Panel (RSP) in the event of a Main Control Room (MCR) fire. The derived failure probability of an OMA from the approach proposed in this paper is expected to enhance the understanding of its reliability. Therefore, it allows moving beyond the deterministic classification of "reliable" or "unreliable" in NUREG-1852. Also, in the event of a nuclear power plant fire where multiple OMAs are required within a critical time range, it is anticipated that the OMA failure probability could serve as a criterion for prioritizing OMAs and determining their order of importance.