• Korean Journal of Radiology
• /
• v.19 no.6
• /
• pp.1187-1195
• /
• 2018

Objective: To compare correlations between pulmonary function test (PFT) results and different reconstruction algorithms and to suggest the optimal reconstruction protocol for computed tomography (CT) quantification of low lung attenuation areas and airways in healthy individuals. Materials and Methods: A total of 259 subjects with normal PFT and chest CT results were included. CT scans were reconstructed using filtered back projection, hybrid-iterative reconstruction, and model-based IR (MIR). For quantitative analysis, the emphysema index (EI) and wall area percentage (WA%) were determined. Subgroup analysis according to smoking history was also performed. Results: The EIs of all the reconstruction algorithms correlated significantly with the forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) (all p < 0.001). The EI of MIR showed the strongest correlation with FEV1/FVC (r = -0.437). WA% showed a significant correlation with FEV1 in all the reconstruction algorithms (all p < 0.05) correlated significantly with FEV1/FVC for MIR only (p < 0.001). The WA% of MIR showed the strongest correlations with FEV1 (r = -0.205) and FEV1/FVC (r = -0.250). In subgroup analysis, the EI of MIR had the strongest correlation with PFT in both eversmoker and never-smoker subgroups, although there was no significant difference in the EI between the reconstruction algorithms. WA% of MIR showed a significantly thinner airway thickness than the other algorithms ($49.7{\pm}7.6$ in ever-smokers and $49.5{\pm}7.5$ in never-smokers, all p < 0.001), and also showed the strongest correlation with PFT in both ever-smoker and never-smoker subgroups. Conclusion: CT quantification of low lung attenuation areas and airways by means of MIR showed the strongest correlation with PFT results among the algorithms used, in normal subjects.

• Journal of the Korean Society of Radiology
• /
• v.18 no.2
• /
• pp.135-144
• /
• 2024

Ultrasonography examination has limitations in quantifying hepatic fat quantification. Therefore, this study aimed to experimentally demonstrate whether changes in signal attenuation during ultrasound imaging can be quantified using simulated hepatic phantoms to assess hepatic fat content. Additionally, we aimed to evaluate the potential of ultrasound imaging for diagnosing hepatic fatty liver by analyzing the relationship between hepatic fat content and signal intensity in ultrasound images. In this study, we developed a total of five stimulated hepatic phantoms by homogeneously mixing water and oil. We confirmed the fat content of the phantoms using magnetic resonance imaging (MRI) and ultrasound imaging, and measured signal intensity according to distance in ultrasound images to analyze the correlation and mean comparison between fat content and signal intensity. We observed that as the fat content increased, the ultrasound penetration intensity decreased, confirming the potential for quantifying hepatic fat content using ultrasound. Additionally, the analysis of the correlation between the measured fat content using MRI and the signal intensity measured in ultrasound images showed a high correlation. Statistical analysis in our study confirmed that as the fat content increased, the slope representing signal during ultrasound imaging (US-GRE) decreased. In this study, it was statistically confirmed that the US-GRE value of ultrasound images gradually decreases as the fat content increases, and it is believed that US-GRE can serve as a biomarker expressing fatty liver content.

• Proceedings of the Safety Management and Science Conference
• /
• 2005.05a
• /
• pp.279-290
• /
• 2005

The purpose of this study is to attempt a Analysis of a pointed-end Equipment Arm Safety-Accident for Fault Tree Analysis. Three major techniques were used first problem is Z-Model by which accident Analysis & prevention of a pointed-end Industry can be made, Fault Tree Analysis(FTA) bywhich quantification of a pointed-end Equipment accident Analysis can be made it 5 years in past and the third, manual-written by which minimal cut set to accident can be Identified. A example has been made of issue point a pointed-end Equipment that the Arm in loader happen to Injuries. According to the Analysis lack of safety knowledge, unsafety-behavior seem to be the primal cause of accident. Comparision of the accident cause to actual report demonstratesthat the FTA a efficient tool for Industrial Accident prevention.

• Nuclear Engineering and Technology
• /
• v.55 no.10
• /
• pp.3787-3800
• /
• 2023

Reactivity Initiated Accident (RIA) scenarios require special attention using advanced simulation techniques due to their complexity and importance for nuclear power plant (NPP) safety. While the conservative approach has traditionally been used for safety analysis, it may lead to unrealistic results which calls for the use of best estimate plus uncertainty (BEPU) approach, especially with the current advances in computational power which makes the BEPU analysis feasible. In this work an Uncontrolled Control Element Assembly (CEA) Withdrawal at Full Power accident scenario is analyzed using the BEPU approach by loosely coupling the thermal hydraulics best-estimate system code (RELAP5/SCDAPSIM/MOD3.4) to the statistical analysis software (DAKOTA) using a Python interface. Results from the BEPU analysis indicate that a realistic treatment of the accident scenario yields a larger safety margin and is therefore encouraged for accident analysis as it may enable more economic and flexible operation.

• Journal of Food Hygiene and Safety
• /
• v.31 no.3
• /
• pp.194-200
• /
• 2016

Aflatoxins and ochratoxin A (AFTs and OTA) are secondary fungal metabolites produced by several moulds, mainly by Aspergillus flavus by Aspergillus ochraceus and Penicillium verrucosum, and these toxins can be transferred to animals and humans through the ingestion of contaminated feed and food. This study was to develop the analytical method for determination the levels of AFTs ($B_1$, $B_2$, $G_1$ and $G_2$) and OTA in pork. The AFTs and OTA were analyzed simultaneously by electrospray ionization in positive ion mode and mass reaction monitoring (MRM) after solid phase extract (SPE) columns clean-up. Performance characteristics, such as accuracy, precision, linear range, limit of detection (LOD) and quantification (LOQ), were also determined. Matrix-matched standard calibration was used for quantification, obtaining the recoveries in the range of 67.3~108.2% with the relative standard deviations of < 20%. Limits of detection and quantification were also estimated, obtaining the limits of quantification ranged in $0.7{\sim}1.3{\mu}g/kg$. The results of the inter-day study, which was performed with pork samples for 3 days, showed an accuracy of 92.0~109.9%. The precisions (expressed as relative standard deviation values) for the inter day variation were 2.6~17.8%. The method developed in this study was able to carry out the analysis with the satisfactory intensity and accuracy.

• Journal of the Korean Vacuum Society
• /
• v.7 no.3
• /
• pp.176-186
• /
• 1998

Pure Pt, Co and their alloy thin films with three different compositions (Pt66-Co34, Pt40-Co60 and Pt18-Co82) were deposited on Si(100) wafers and proposed as a set of certified reference materials (CRM) for the quantification and standardization of surface compositional analysis. The compositions of the binary alloy thin films were controlled by in-situ XPS analyses and the certified compositions of the films have been determined by ICP-AES and RBS analyses after thin film growth. Through comparison of the compositions determined by in-situ XPS with those by ICP, relatively accurate compositions could be obtained with a matrix effect correction. Standard deviations of XPS and AES round robin tests with the Pt-Co alloy thin films were large up to about 4%. On the other hand, the average compositions of the Pt-Co alloy thin films by two methods were in a good agreement within 1%. The formation of a Pt rich surface layer by ion beam sputtering indicates that the surface modification by preferential sputtering must be understood for a better compositional analysis.

• Journal of Pharmaceutical Investigation
• /
• v.37 no.3
• /
• pp.179-186
• /
• 2007

A simple, sensitive and selective liquid chromatographic/tandem mass spectrometric method (LC-MS/MS) was developed and validated for doxifluridine and 5-fluorouracil (5-FU) quantification in dog heparinized plasma. Sample preparation was based on liquid-liquid extraction using a mixture of isopropanol/ethyl acetate (1/9 v/v) to extract doxifluridine, 5-FU and 5-chlorouracil (5-CU, an internal standard) from plasma. Chromatography was performed on a C-18 analytical column and the retention times were 2.7, 1.5 and 1.7 min for doxifluridine, 5-FU and 5-CU, respectively with shorter analysis time within 5 min than previously reported methods. The ionization was optimized using ESI negative mode and selectivity was achieved by tandem mass spectrometric analysis by multiple reaction monitoring (MRM) using the transformations of m/z 244.8>107.6, 129.0>42.0 and 144.9>42.1 for doxifluridine, 5-FU and 5-CU, respectively. The achieved low limit of quantification was 20.0 ng/mL and the assay exhibited linear range of 20-2000 ng/mL ($R^2>0.99957$ for doxifluridine and $R^2>0.99857$ for 5-FU), using $100{\mu}L$ of plasma. Accuracy and precision of quality control samples for both doxifluridine and 5-FU met KFDA and FDA Guidance criteria of 15% for accuracy with coefficients of variation less than 15%. This method demonstrated adequate sensitivity, specificity, accuracy, precision and stability to support the simultaneous analysis of doxifluridine and 5-FU in dog plasma samples in pharmacokinetic and bioequivalence studies.

• Science of Emotion and Sensibility
• /
• v.12 no.4
• /
• pp.451-460
• /
• 2009

This study had been carried out based on the users' behavioral pattern in order to survey characteristics of bus station, a public facility. As a detailed analysis, quantification theory type 3 was performed based on 50 number of samples installed at each local governments as targets in order to evaluate bus station attributes and to survey its characteristics. As a result of this experiment, it was revealed that installation pattern of bus station would differ depending on characteristics of four axis of migrating population density, functionality and simplicity, metropolitan city of densely populated companies, local city with strong locality, the front of school with dense migrating population, secluded rural village, specific place like museum, rural area with dense migrating population. Therefore, in this study, detailed items were suggested comprehensively so that the design considering local environment and users' characteristics, in addition to modeling features of bus stations suitable for local characteristics, could be progressed. If any design and model complying with local environmental features based on above contents should be applied, bus station would be assessed by the users more positively in the future.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.30 no.6
• /
• pp.17-25
• /
• 2003

The physical components of a river, such as water surface width/river width ratio, water level, and flow velocity vary according to different flowrates. Moreover, the riverside landscapes are greatly affected by the change of physical components of the stream or river. This paper provides an analysis of the influence of changing physical components of a river on the riverside landscape using a survey-based quantification method. The questionnaire was developed based on current literature, and was submitted to 326 people who each visited a representative station along the riverside.This survey was implemented three times at each representative station during periods of different flowrates. The results of this analysis and survey have Produced an understanding of the relationship between the variation of physical components and riverside landscapes. Survey results about the flow comparison are summarized as follows. Viewing riverside landscapes, most respondents are sensitive to the change of the flow velocity and prefer high water levels to low water levels. As a whole, respondents prefer abundant stream flows and moderate flow velocity in which they can perceive the flow of water. The minimum instream flows for riverside landscapes is estimated at each representative station by using a survey-based quantification method, and the estimated results of some representative stations were greater than the mean monthly flow at each station. The result of this analysis shows that establishing minimum instream flows for riverside landscapes is not only a technical problem, but also a legal problem. Therefore, in the to establish the instream flows in a river, the estimated results have to be considered as a relative standard. Regarding the survey results, respondents' satisfaction level didn't show any clear inclination according to the variation of various hydraulic properties. In determining the minimum instream flow using such an inquiry method, the structure of riverside scenery may vary according to the change of seasons or months. Therefore, to determine a consistent general inclination about the flow rate, it is necessary to have more detailed flow rates for each season or month combined with more inquiries.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.9 no.2
• /
• pp.167-176
• /
• 1999

A new analytical procedure for the measurement of monomeric isocyanates and total isocyanate group in workplaces has been investigated. The method described herd involves derivatization of the isocyanate sample upon collection with the reagent 9-anthracenylmethyl 1-piperazinecarboxylate (PAC). Laboratory investigations have demonstrated that excess PAC reagent can be satisfactorily removed from PAC-derivatized monomeric isocyanates-a requirement for the success f the analytical procedure. After removal of excess PAC reagent, the PAC derivatives of butyl isocyanate, phenyl isocyanate, HDI, MDI, and TDI were reacted with sodium thiomethoxide to convert them all to 9-anthracenylmethyl methyl sulfide (AMMS). Total isocyanate group was determined by HPLC analysis and quantification of the single AMMS peak. This circumvents many of the disadvantages associated with current HPLC methods. There were no longer problems associated with quantifying late-eluting peaks and analysis times were very short. A single detector was used for quantification because a standard of the analyte existed and the retention time could be determined. Because all species were converted to a single analyte, the problem of variability of response factors among different species was averted. Finally, there were no complex chromatograms to interpret. Monomers of other individual species were measured by analysis of the sample before the individual species were converted to AMMS. The favorable performance of PAC warrants its further study as a reagent for the determination of total isocyanate group in air.