• Title/Summary/Keyword: Pyrazolothiadiazines

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Synthesis and Anti-HIV Evaluation of the Novel 2-(m-Chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines

  • Yan, Ren-Zhang;Liu, Xin-Yong;Xu, Wen-Fang;Pannecouque, Christophe;Witvrouw, Myriam;Clercq, Erik De
    • Archives of Pharmacal Research
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    • v.29 no.11
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    • pp.957-962
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    • 2006

  • A novel series of 2-(m-Chlorobenzyl)-4-substituted-1, 1, 3-trioxo-2H, 4H-pyrazolo[4, 5-e][1, 2, 4] thiadiazines (7a-k) were synthesized, and evaluated for their anti-HIV replication in MT-4 cell cultures. Compound (7a) showed activity against HIV-1-induced cytopathicity, with an $EC_{50}$ value of $45.6\;{\mu}M$, but none of the compounds exhibited inhibitory activity against HIV-2.

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