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The First Case of Novel Influenza A (H1N1) Fatality in Korea

  • Seol, Hee-Yun;Eom, Jung-Seop;Kim, Mi-Hyun;Cho, Woo-Hyun;Kim, Ji-Eun;Kim, Ki-Uk;Jeon, Doo-Soo;Park, Hye-Kyung;Kim, Yun-Seong;Lee, Min-Ki;Park, Soon-Kew
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.6
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    • pp.350-353
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    • 2010

  • Here we report the first fatality caused by H1N1 influenza virus infection with acute respiratory distress syndrome in Korea. A 55-year-old man presented at our emergency department with dyspnea, fever, diffuse myalgia and malaise. Bilateral lung air-space consolidation was detected on his initial chest radiograph combined with severe hypoxemia. He was supported by mechanical ventilation and treated with antibiotics. A nasopharyngeal aspirate was positive for influenza A rapid antigen and oseltamivir was started on day 3 of admission. The nasal swab sample was positive for influenza H1N1 virus by real-time reverse-transcriptase polymerase chain reaction. Despite aggressive treatment, he had refractory hypoxemia and uncontrolled septic shock. On day 5 of admission he went into cardiac arrest and expired.

  • https://doi.org/10.4046/trd.2010.68.6.350 인용 PDF KSCI

Ircinin-1 from the Sponge Sarcotragus Species Induces of Cell Proliferation and Apoptosis in the Human Skin Cancer Cells

  • Choi, Hye-Joung;Yee, Su-Bog;Park, Hwa-Sun;Chung, Sang-Woon;Park, Sang-Eun;Jung, Jee-Hyung;Kim, Nam-Deuk
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.256.1-256.1
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    • 2002

  • We investigated the anti-proliferative effects of a new compound. ircinin-1. from the sponge Sarcotragus sp. on SK-MEL -2 human skin cancer cells. From the data of MTT assay, cell viability was decreased by ircinin-1 in a dose-dependent manner. We observed that the anti-proliferative effect of ircinin-1 was due to the induction of apoptosis, which was confirmed by observing the morphological changes. the increased ratio of pro-apoptotic protein Bax to anti-apoptotic protein Bcl-2, and cleavage of poly(ADP-ribose) polymerase protein, via activation of caspase-3. (omitted)

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