• Pediatric Infection and Vaccine
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• v.4 no.2
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• pp.271-275
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• 1997

We experienced a case of Henoch-Sch$\ddot{o}$nlein purpura associated with Mycoplasma pneumoniae pneumonia in a 28 month old male who suffered from cough, abdominal pain and both leg swelling and pain. Physical examination showed varying sized purpura, characteristic of Henoch-Sch$\ddot{o}$nlein purpura, below both knee. Laboratory test revealed Mycoplasma pneumoniae antibody titer >1:2,560 and cold agglutinins titer 1:64. Chest X-ray showed peribronchial blurring in both lung fields. The patient was treated with midecamycin and prednisolone for 7 days and responded to the treatment well. The authors report a case of Henoch-Sch$\ddot{o}$nlein purpura with Mycoplasma pneumoniae pneumonia with brief review of related literatures.

• The Journal of Pediatrics of Korean Medicine
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• v.17 no.2
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• pp.75-83
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• 2003

Background : Henoch-Schonlein purpura is a small-vessel vasculitis characterized by palpable purpura, abdominal pain, hematuria, and arthalgia. The exact etiology remain unknown despite a long and intensive research, but the findings showes immune mechanism is involved in the pathogenesis of this disease. The main clinical manifestations are skin rash, abdominal symptoms, joint symptoms, and renal involvement. And the existence of renal involvement influences on the course and prognosis of the Henoch-Schonlein purpura Objective : To demonstrate the therapeutic effect of herbal medicine(Kamiguibiondamtang) on parents with Henoch-Schonlein purpura Method : We treated two cases of Henoch-Schonlein purpura in a nine-year old male and a twenty-year old female, who showed multiple petechiae and ecchymoses on both extrimities with Kamiguibiondamtang. Result : A nine-year old male recovered completely and a twenty-year old female improved. Conclusion : We repert that we had good effects of herbal medicine treatment on two cases of Henoch-Schonlein purpura.

• The Journal of Pediatrics of Korean Medicine
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• v.26 no.3
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• pp.12-19
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• 2012

Objectives The purpose of this study is to report the clinical effects of an oriental medical treatment on the patient with allergic purpura. Methods A 7-year-old female patient, who was suffering from the purpura on her extremities: swelling and arthralgia on her lower extremities, was treated by herb medicine, acupuncture and pediluvium. Results Treated only with oriental medicine, the patient's allergic symptoms were improved. When we checked back on her condition after 2 months later, she did not show any recurrence of the flares, and regained her health. Conclusions This study shows that oriental medical treatments are effective on allergic purpura, but further clinical studies are needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1303-1306
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• 2007

Idiopathic thrombocytopenic purpura(ITP) is an autoimmune disease which is related to antibodies against platelets. More than 95% of the patients progress into chronic type. Usually, IPT patients suffer form hypodermal bleeding, purpura, decreases in platelet counts. Purpura of legs, nosebleeds and oral ulcer may occur. In this study, herbal medicine, acupuncture and moxibustion in conjunction with cupping were applied to IPT patient based on the oriental medicine principle such as Lihyulyanggangeonbi-tang(理血養肝建脾湯). After the treatment, the patient improved better, and had no more inconvenient symptoms according to the follow-up research. So the result shows the possibility that oriental medical treatment may be applied to the IPT patient clinically.

• Childhood Kidney Diseases
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• v.1 no.1
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• pp.86-90
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• 1997

The author experienced a case of $Henoch-Sch\"{o}nlein$ purpura with epididymitis in a 6-year-old boy who was admitted to our hospital due to left scrotal pain and the relapse of purpura on lower extremities for 3 days. Scrotal ultrasonography on admission revealed homogenously enlarged left epididymal head and small amount of fluid collection in left tunical space. The size of left epididymal head decreased gradually with no more evidence of fluid collection on day 7 and recovered completely on day 21. The author reports a case of $Henoch-Sch\"{o}nlein$ purpura with epididymitis with brief review of related literatures.

• Childhood Kidney Diseases
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• v.1 no.2
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• pp.176-178
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• 1997

Henoch-Scholein purpura is a systemic vasculitis of small blood vessels. It is characterized by nonthrombocytopenic purpura, abdominal pain, arthralgia and renal involvement. In Henoch-Scholein purpura, severe abdominal pain may be relived by steroid, but occasionally unresponsive to steroid and conventional analgesics therapy. We tried IV-gamma globulin for severe abdominal pain, unresponsive to steroid, analgesics, and antispasmodics therapy in HSP, and experienced dramatic symptomatic improvement. So we report three cases of IVIG therapy against severe abdominal pain in HSP with a brief review of literatures

• Herbal Formula Science
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• v.24 no.1
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• pp.63-70
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• 2016

Objective This study is designed to investigate the effect of Korean medical therapy on Allergic purpura patients.Method This is a case report on a male and a female patients who has been suffering from allergic purpura. To reduce her symptoms, we provided with internal herbal medicine 2-3 times a day, acupuncture therapy 1-2 times a day.Results After series of treatments, the symptoms of allergic purpura were remarkably improved.Conclusions This study shows us that Korean medical treatments has remedial values for purpura patients. Hence, more studies should be demanded in Korean medicine for elevation of treatment rate.

• Herbal Formula Science
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• v.9 no.1
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• pp.137-163
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• 2001

From ancient times to Ching Dynasty, we studied the causes and oriental prescriptions of purpura for 23 oriental medical records. The results were obtained as follows ; 1. Purpura is a disease that raises the purplish speckle or speckle mass on the skin by blood overflowing between flesh and skin and belongs to speckle occurrence(Balban, 發斑) or blood symptom(Hyeoljeong, 血證). 2. At ancient times, purpura named Balban(發斑), Banjin(斑疹), Yin-yang dok(陰陽毒), Podoyeok(葡萄疫) and Bansa etc. 3. In oriental carse of purpura, Insufficient symptoms are gastric energy insufficiency and groundless frame, and Sufficient symptoms are heat-evil in stomach, blood heat, season's improper energy, yin-evil height and wind-heat with phlegm. 4. At oriental prescriptions on purpura, Insufficient symptom used Hwabantang(化斑湯) mostly, the next Hyunsam-seugmatang(玄蔘升麻湯), Jojungtang(調中湯), Seogakcheongdaeeum(犀角靑黛飮), Heuknowhan(黑奴丸) and Sufficient symptom used Jojungikgitang(調中益氣湯), Wibitang(胃脾湯), Daegeonjungtang(大建中湯), Hwanggi-geonjungtang etc. much. 5. The medicines for external use for purpura were Mil(蜜), Seungma(升麻t), Mangcho-jeodamjeup(芒硝猪膽汁), Geongal(乾葛), Seontae(蟬退), Chongbaek and Gangjeup(薑汁) etc., pregnant woman used jeongjeoni(井底泥). 6. The order of medicines were Seungma(升麻), Hwanggi, Insam(人蔘), Seokgo(石膏), Seogak(犀角), Hyunsam(玄蔘) and Chija(梔子) ect.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.2
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• pp.265-269
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• 1999

Thrombocytopenic patients without detectable bound antiplatelet antibody should be diagnosed with idiopathic thrombocytopenic purpura (ITP) if no other cause of their decreased platelet count could be found. More recently the term "autoimmune thrombocytopenic purpura (ATP) has supplanted ITP since the disease is related to the production of autoantibodies against one's own platelets. This entity should not be confused with isoimmune thrombocytopenic purpura (also called alloimmune thrombocytopenic purpura). In this cases maternal antiplatelet antibodies directed against the PLA 1 antigen on the fetal platelets causes severe fetal and neonatal thrombocytopenia in a situation analogous to Rheusus disease. Antibodies to the negatively charged phospholipids, lupus anticoagulant, and anticardiolipin have been linked to adverse pregnancy events. Pregnant women possessing these antibodies have an increased risk of spontaneous abortion, stillbirths, intrauterine fetal growth retardation, preterm birth, and arterial and venous thrombosis. Antiphospholipid antibodies decrease or may even disappear between pregnancies only to recur with increased activity in a subsequent pregnancy and lead to loss. We have experienced a case of antiphospholipid syndrome associated with autoimmune thrombocytopenic purpura in patient with recurrent spontaneous abortion. So we report this case with a brief review of literatures.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.7 no.1
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• pp.54-60
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• 2004

Purpose: Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a small-vessel vasculitic disease that most often affects the skin. Abdominal symptoms precede the typical purpuric rash of HSP in 14~36%. It is a challenge to diagnose HSP in the absence of a rash, because there are no biologic tests that can identify HSP with certainty, so we tried to find out the characteristic features of HSP gastroenteropathy without purpura before diagnosis. Methods: This study included 82 children with HSP who had been admitted or visited outward of the Department of Pediatrics, Pusan National University Hospital from 1995 to 2000. The cases that the onset of purpura preceded or coincided that of abdominal pain were defined as purpura-positive group. The cases that the onset of abdominal pain preceded purpura more than 1 week and purpura was not presented till diagnosed as HSP gastroenteropathy were defined as purpura-negative group. We compared and analyzed the clinical features of the two groups by reviewing the medical records retrospectively. To ensure the diagnosis of HSP gastroenteropathy, we conducted upper GI series, abdominal ultrasonogram, abdominal CT, endoscopy and/or skin biopsy. Results: The number of cases of purpura-positive group and purpura-negative group were 72 and 10, respectively. There is no difference between two groups in the incidence of clinical symptoms and laboratory findings. Children with HSP gastroenteropathy had characteristic erosive or ulcerative lesions in the stomach or duodenum on esophagogastroduodenoscopy, or mural thickening of the small bowel on abdominal ultrasonogram, CT or upper GI series. Skin biopsy revealed leukocytoclastic vasculitis in 3 of them, although biopsy specimen was taken from any areas of normal- appearing skin. In purpura-negative group, 9 patients improved by steroid therapy. Conclusion: In purpura-negative group, there is no diagnostic feature on the laboratory findings and clinical features. Therefore, to diagnose HSP gastroenteropathy in patients with abdominal pain in the absence of the characteristic rash, careful observation of clinical features and laboratory data, and prompt application of available diagnostic tools such as gastrointestinal endoscopy, radiologic study and skin biopsy are recommended. Early use of corticosteroid may reduce the suffering in these patients.