• Archives of Pharmacal Research
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• 제23권1호
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• pp.72-78
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• 2000

The general pharmacological properties of YJA20379-1 2-dimethylamino-4,5-dihydrothiazolo[4,5:3,4]pyridol[1,2-a]benzoimidazole, a novel proton pump inhibitor with antiulcer activities were investigated in mice, rats, guinea pigs and rabbits. YJA20379-2 at oral doses of 50, 100 and 200 mg/kg did not affect the general behaviour, hexobarbital hypnosis and motor coordination in mice. The drug did not have analgesic or anticonvulsant action at 200 mg/kg. Locomotor activity and body temperature were not influenced at 100 mg/kg. At a concentration up to 2{\times}10^{-4} g/ml$, YJA20379-2 did not produce any contraction or relaxation of isolated preparations, such as the rat fundus, the guinea pig ileum and the rat uterus, and did not antagonize the contractile response to several spasmogens, such as histamine, acetylcholine, serotonin and oxytocin. At dosages up to 200 mg/kg p.o. YJA20379-2 did not affect the pupil size of mice. Intestinal propulsion of mice was not affected up to 200 mg/kg p.o. and the drug did not affect urinary excretion at 100 mg/kg p.o. These results indicate that at dosages up to 100 gm/kg p.o. YJA20379-2 was found not to affect this pharmacological profile. However, at 200 mg/kg the drug lowered body temperature and showed decreased in locomotor activity and urine volume.

• 한국안광학회지
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• 제14권2호
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• pp.35-39
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• 2009

목적: 본 연구는 각막지형검사기의 각막형상을 이용하여 각막수차를 구현하는 프로그램을 개발하고자 하며, 개발된 프로그램을 이용하여 저니케 다항식(Zernike Polynomial)으로 파면과 각막수차를 구현하고자 한다. 방법: 각막지형검사기인 ORBSCAN의 각막형상 데이터로부터 각막의 형상을 재구성하기 위해 저니케 다항식을 사용하였으며, 이때 동공의 유효구경은 6 mm를 고려하였다. 구현된 각막형상으로부터 광선추적을 사용하여 동일한 광학적 거리의 파면을 구현하는 프로그램을 개발하였으며, 파면으로부터 6차 28항의 저니케 계수로 각막수차를 구현하였다. 결론: 본 연구에서는 각막지형검사기의 각막형상으로부터 각막의 수차와 파면을 구현하는 프로그램을 개발하였으며, 이러한 결과는 각막지형검사기 개발과 콘택트렌즈 및 OK렌즈 처방에 유용하게 적용될 수 있으리라 사료된다.

• 대한인간공학회지
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• 제31권2호
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• pp.371-377
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• 2012

Objective: The aim of this study is to investigate effect of driver's cognitive distraction on driver's physiological state and driving performance, and then to determine parameters appropriate for detecting the cognitive distraction. Background: Driver distraction is a major cause of traffic accidents and poses a serious threat to traffic safety due to ever increasing use of in-vehicle information systems and mobile phones during driving. Cognitive distraction, among four different types of distractions, prevents a driver from processing traffic information correctly and adapting to change in surround vehicle behavior in time. However, the cognitive distraction is more difficult to detect because it normally does not involve significant change in driver behavior. Method: A full-scale driving simulator was used to create virtual driving environment and situations. Participants in the experiment drove the driving simulator in three different conditions: attentive driving with no secondary task, driving and conducting secondary task of adding numbers, and driving and conducting secondary task of conversing with an experimenter. Parameters related with driver's physiological state and driving performance were measured and analyzed for their change. Results: The experiment results show that driver's cognitive distraction, induced by secondary task of addition and conversation during driving, increased driver's cognitive workload, and indeed brought change in driver's physiological state and degraded driving performance. Conclusion: The galvanic skin response, pupil size, steering reversal rate, and driver reaction time are shown to be statistically significant for detecting cognitive distraction. The appropriate combination of these parameters will be used to detect the cognitive distraction and estimate risk of traffic accidents in real-time for a driver distraction warning system.

• 한국안광학회지
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• 제9권1호
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• pp.135-143
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• 2004

우리 몸은 연령의 증가에 따라 눈과 시력에 노화가 나타난다. 본 연구에서는 안구의 연령에 따른 변화를 노인들을 대상으로 조사하여 연령의 증가에 따른 전안부와 후안부 대한 해부생리학적 변화를 고찰하고자 한다. 광주지역 50-79세 사이의 노령자 219명을 대상으로 문진, 외안부 검사, 시력검사, 눈꺼풀 틈새의 높이와 넓이, 가시홍채직경, 동공크기 등을 측정하였다. 연령의 증가에 따라 50대 이상에서는 눈꺼풀 결막, 각막, 전안방, 홍채, 수정체, 유리체, 맥락막, 망막 및 신경, 암순옹, 대비감도, 굴절이상 등에서 변화가 나타남을 알 수 있다. 눈꺼풀 틈새의 높이와 넓이는 연령의 증가로 젊은이 보다 좁아 졌으나 각막의 수평직경은 거의 변화가 없는 것으로 조사되었다. 따라서 노인의 안구와 시력에 대한 해부생리학적인 정확한 이해가 있어야 노인환자의 안경처방이나 시력관리를 완벽하게 할 수 있을 것으로 사료된다.

• Journal of Korean Neurosurgical Society
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• 제51권2호
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• pp.86-90
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• 2012

Objective : Life-threatening hemispheric stroke is associated with a high mortality and morbidity. Decompressive hemicraniectomy has been regarded as an effective treatment option for refractory intracranial hypertension. Here, we reported the clinical course of 5 children with decompressive craniectomy and duroplasty after non-traumatic refractory intracranial hypertension. Methods : Four toddlers and one preschool-girl were included in this study; there were 3 boys and 2 girls with a mean age of 34.6 months (range 17-80). Decompressive craniectomy including duroplasty was performed in cases of dilatation of pupil size after intensified standard medical therapy had proven insufficient. All children had a Pediatric Glasgow Coma Scale score <8 at pre-operation state. The mean time-point of craniectomy after stroke attack was 12 hours (range 4-19). Results : During the long-term follow-up period (mean 47.6 months), no children died. One year later, when we checked their Glasgow Outcome Scale scores, only one toddler received a score of 4 (moderate disability). But the others had good recoveries although they had minor physical or mental deficits. According to the Pediatric Cerebral Performance Category Scale, 4 children received a score of 2 (mild disability). Conclusion : Despite our small cases, we suggest that decompressive hemicraniectomy and duroplasty is an acceptable and life-saving treatment for refractory intracranial hypertension after unilateral hemispheric stroke in toddlers and preschool children.

• Current Optics and Photonics
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• 제2권1호
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• pp.59-68
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• 2018

Opto-acoustic systems provide structural and functional information regarding biological tissues. Conventional opto-acoustic systems typically employ continuous or pulsed lasers as transmission sources. Compared to lasers, light emitting diodes (LEDs) are cost-effective and relatively portable excitation sources but are non, coherent. Therefore, in this study, a relatively low cost lens - a type of Ramsden eyepiece - was specially designed to theoretically calculate the illumination and achieve a constant brightness across the pupil of an eye. In order to verify the capability of the developed light-emitting diode-acoustic (LEDA) systems, we carried out experiments on bovine and bigeye tuna eyeball samples, which are of similar size to the human eye, using low frequency (10 MHz) and high frequency (25 MHz) ultrasound transducers. High frequency ultrasound transducers are able to provide higher spatial resolution compared to low frequency ultrasound transducers at the expense of penetration depth. Using the 10 MHz and 25 MHz ultrasound transducers, acceptable echo signals (3.82, 3.94, and 5.84 mV at 10 MHz and 282, 1557, 2356 mV at 25 MHz) from depth greater than 3 cm and 6 cm from the anterior surface of the eye were obtained. We thereby confirmed that the LEDA system using a pulsed LED with the designed Ramsden eyepiece lens, used in conjunction with low and high frequency ultrasound transducers, has the potential to be a cost-effective alternative method, while providing adequate acoustic signals from bovine and bigeye tuna ocular areas.

• Journal of Korean Biological Nursing Science
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• 제15권4호
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• pp.210-218
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• 2013

Purpose: The purpose of this study was to identify the characteristics and nursing activities of severe trauma patients regarding damaged body parts in Busan Regional Emergency Medical Center. Methods: A survey using a 'trauma patient information questionnaire and a list of nurse activities' was conducted with 133 patients over 15 points ISS on EMR from June 1, 2011 to May 31, 2012. The collected data were analyzed by the SPSS/WIN 12.0 program. Results: Almost all of the subjects were men, and the mean age was 48.8. The amount of road traffic accidents was 60.4%, and the mean RTS and ISS were 6.08, and 23.14 points. Nursing activities in common were airway management, assessment of LOC & GCS, and EKG monitoring. Most of head and neck trauma patients were cared for manasing using intracranial pressure: each patience had the following assessed: pupil size and light reflex, they were checked the leak of CSF, kept $30^{\circ}$ head elevation, and administered medications. Some of chest trauma patients were treated for chest tube and central venous catheter insertion. Partial abdominal trauma patients were administered analgesic and cared for using arterial pressure measurement. Part of the limbs and pelvis trauma patients were given a blood transfusion. Conclusion: Based on the results, the characteristics and nursing activities were specific according to the specific damaged body parts.

• 인터넷정보학회논문지
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• 제18권1호
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• pp.21-26
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• 2017

본 논문에서는 홍채정보로 개인인증을 위한 USB-OTG(Uiversal Serial Bus On-the-go) 영상인식 모듈을 설계한다. 개인인증을 위해 사용자가 스마트 폰 버튼을 누를 필요가 없도록 스마트 기기를 안면주위의 여러 장의 안면영상을 획득 후, 눈 깜박임에 의한 화소 값 차로 안면과 홍채영역을 검색하는 영상인식 알고리듬을 제안한다. 본 연구에서는 인접한 눈을 뜬 영상과 눈을 감은 영상을 감지한 안면과 홍채 영상의 프레임 화소 값의 차이를 사용한다. 또한, 홍채 영역분할에 의한 동공과 홍채영역 위치를 빠르게 찾을 수 방법을 활용한다. 제안한 빠른 홍채영역의 위치탐색은 눈 영역의 적정한 그리드 크기에 의해 결정할 수 있다. 안면과 홍채영역의 제한된 영역을 탐색하는 홍채인식 카메라 모듈의 USB-OTG 인터페이스 통한 인접영상의 프레임 차이에 의해 검출할 수 있도록 설계하였다. 이로서 스마트 디바이스 사용자가 홍채 인식을 위해 눈을 깜빡이지 않고 대기해야 하는 불편함을 제거함으로써 사용자 편의성을 증대시킬 것으로 기대한다.

• 디자인학연구
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• 제20권2호
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• pp.5-16
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• 2007

The main objective of our research is analyzing user's emotional changes while using a product, to reveal the influence of usability on human emotions. In this study we have extracted some emotional words that can come up during user interaction with a product and reveal emotional changes through three methods. Finally, we extracted 88 emotional words for measuring user's emotions expressed while using products. And we categorized the 88 words to form 6 groups by using factor analysis. The 6 categories that were extracted as a result of this study were found to be user's representative emotions expressed while using products. It is expected that emotional words and user's representative emotions extracted in this study will be used as subjective evaluation data that is required to measure user's emotional changes while using a product. Also, we proposed the effective methods for measuring user's emotion expressed while using a product in the environment which is natural and accessible for the field of design, by using the emotion mouse and the Eyegaze. An examinee performs several tasks with the emotion mouse through the mobile phone simulator on the computer monitor connected to the Eyegaze. While testing, the emotion mouse senses user's EDA and PPG and transmits the data to the computer. In addition, the Eyegaze can observe the change of pupil size. And a video camera records user's facial expression while testing. After each testing, a subjective evaluation on the emotional changes expressed by the user is performed by the user him/herself using the emotional words extracted from the above study. We aim to evaluate the satisfaction level of usability of the product and compare it with the actual experiment results. Through continuous studies based on these researches, we hope to supply a basic framework for the development of interface with consideration to the user's emotions.

• 대한인간공학회지
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• 제30권1호
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• pp.195-202
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• 2011

Objective: The aim of this study is to investigate and review the previous researches about objective measuring fatigue caused by visual stimuli. Also, we analyze possibility of alternative visual fatigue measurement methods using facial expression recognition and gesture recognition. Background: In most previous researches, visual fatigue is commonly measured by survey or interview based subjective method. However, the subjective evaluation methods can be affected by individual feeling's variation or other kinds of stimuli. To solve these problems, signal and image processing based visual fatigue measurement methods have been widely researched. Method: To analyze the signal and image processing based methods, we categorized previous works into three groups such as bio-signal, brainwave, and eye image based methods. Also, the possibility of adopting facial expression or gesture recognition to measure visual fatigue is analyzed. Results: Bio-signal and brainwave based methods have problems because they can be degraded by not only visual stimuli but also the other kinds of external stimuli caused by other sense organs. In eye image based methods, using only single feature such as blink frequency or pupil size also has problem because the single feature can be easily degraded by other kinds of emotions. Conclusion: Multi-modal measurement method is required by fusing several features which are extracted from the bio-signal and image. Also, alternative method using facial expression or gesture recognition can be considered. Application: The objective visual fatigue measurement method can be applied into the fields of quantitative and comparative measurement of visual fatigue of next generation display devices in terms of human factor.