• 한국유체기계학회 논문집
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• 제9권2호
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• pp.39-43
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• 2006

The magnitude of the axial force acting on turbopump bearings has a great influence on the operational reliability and service life of a turbopump. In the turbopump under current investigation the cavity vanes are introduced to the pump shroud casing to control the axial thrust of the turbopump. To investigate the effect of the cavity vanes, 3D computational flow analyses for a propellant pump stage including an inducer, impeller, volute and secondary flow passages are performed with and without the vanes. The results show that the cavity vanes are very effective in reducing the magnitude of axial thrust without notable changes on the overall performance of the turbopump.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2005년도 연구개발 발표회 논문집
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• pp.354-358
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• 2005

The magnitude of the axial force acting on turbopump bearings has a great influence on the operational reliability and service life of a turbopump. In the turbopump under current investigation the cavity vanes are introduced to the pump shroud casing to control the axial thrust of the turbopump. To investigate the effect of the cavity vanes, 3D computational flow analyses for a propellant pump stage including an inducer, impeller, volute and secondary flow passages are performed with and without the vanes. The results show that the cavity vanes are very effective in reducing the magnitude of axial thrust without notable changes on the overall performance of the turbopump.

• 항공우주시스템공학회지
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• 제14권5호
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• pp.100-106
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• 2020

액체로켓엔진용 터보펌프는 작동 조건에서 캐비테이션 불안정성에 노출되며, 이는 터보펌프의 안정성에 영향을 미친다. 이를 확인하기 위해 터보펌프 조립체 시험 중 나타난 캐비테이션 불안정성의 특징을 살펴보았다. 시험 중 산화제펌프는 대표적인 캐비테이션 불안정성인 초조화 선회 캐비테이션과 부착 비대칭 캐비테이션에 노출되었다. 캐비테이션 불안정성이 발생되지 않는 조건에서 작동했던 연료펌프에서도 산화제펌프의 초조화 선회 캐비테이션에 의한 진동이 확인되었다.

• 한국항공우주학회지
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• 제34권4호
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• pp.70-75
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• 2006

액체로켓용 터보펌프의 설계과정에서 정확한 성능예측을 위해서 인듀서, 임펠러, 볼류트, 실 등의 펌프의 모든 부분을 포함한 유동해석을 수행하였다. 계산시간을 줄이기 위해서 인듀서와 임펠러는 주기조건을 사용하여 하나의 블레이드 통로만 해석하였으며, 인듀서와 임펠러, 임펠러와 볼류트 등의 상호작용은 정상적 해석법인 혼합면 기법을 사용하였다. 펌프의 모든 부분을 포함한 계산을 통하여 인듀서, 임펠러, 볼류트 등의 단독 유동해석을 통해서는 예측할 수 없는 펌프설계의 매우 중요한 부분인 축추력 등을 예측할 수 있었으며, 각 부품이 전체 성능에 미치는 영향을 자세히 파악할 수 있었다. 계산결과를 실험결과와 비교하였는데, 양정, 효율, 볼류트 외벽 압력분포 등에서 실험결과와 잘 일치하였다. 또한 실험으로 검증하지는 못하였지만, 축추력, 반경방향 힘 등의 예측값도 설계요구조건을 만족시키는 것으로 나타났다. 따라서 펌프의 전부분을 포함한 유동해석법은 터보펌프의 설계 및 성능예측에 매우 유용하게 적용될 수 있을 것으로 판단된다.

• 대한기계학회논문집
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• 제12권3호
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• pp.520-527
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• 1988

본 연구에서는 액체용 이젝터의 성능을 결정하는 여러가지 제약인자중 특히 레이놀즈수 변화에 따른 구동노즐의 면적비 및 목부길이가 액체용 이제터성능에 미치 는 영향을 체계적인 실험을 통하여 연구함으로써 기 개발된 CAD용 전산프로그램의 타 당성을 보다 세밀히 검토하고 이에 보완을 가하는데 연구의 목적이 있다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.216-227
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• 2004

A new cavitating model by using bubble size distribution based on bubbles-mass has been proposed. Both liquid and vapor phases are treated with Eulerian framework as a mixture containing minute cavitating bubbles. In addition vapor phase consists of various sizes of vapor bubbles, which are distributed to classes based on their mass. The bubble number-density for each class was solved by considering the change of the bubble-mass due to phase change as well as generation of new bubbles due to heterogeneous nucleation. In this method, the bubble-mass is treated as an independent variable, and the other dependent variables are solved in spatial coordinates and bubble-mass coordinate. Firstly, we employed this method to calculate bubble nucleation and growth in stationary super-heated liquid nitrogen, and bubble collapse in stationary sub-cooled one. In the case of bubble growth in super-heated liquid, bubble number-density of the smallest class based on its mass is increased due to the nucleation. These new bubbles grow with time, and the bubbles shift to larger class. Therefore void fraction of each class is increased due to the growth in the whole class. On the other hand, in the case of bubble collapse in sub-cooled liquid, the existing bubbles are contracted, and then they shift to smaller class. It finally becomes extinct at the smallest one. Secondly, the present method is applied to a cavitating flow around NACA00l5 foil. Liquid nitrogen and liquid oxygen are employed as working fluids. Cavitation number, $\sigma$, is fixed at 0.15, inlet velocities are changed at 5, 10, 20 and 50m/s. Inlet temperatures are 90K in case of liquid nitrogen, and 90K and 1l0K in case of liquid oxygen. 110K of oxygen is corresponding to the 90K of nitrogen because of the same relative temperature to the critical one, $T_{r}$=$T/T_c^{+}$. Cavitating flow around the NACA0015 foils was properly analyzed by using bubble size distribution. Finally, the method is applied to a cavitating flow in an inducer of the LE-7A hydrogen turbo-pump. This inducer has 3 spiral foils. However, for simplicity, 2D calculation was carried out in an unrolled channel at 0.9R cross-section. The channel moves against the fluid at a peripheral velocity corresponding to the inducer revolutions. Total inlet pressure, $Pt_{in}$, is set at l00KPa, because cavitation is not generated at a design point, $Pt_{in}$=260KPa. The bubbles occur upstream of the foils and collapse between them. Cavitating flow in the inducer was successfully predicted by using the bubble size distribution.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2007년도 제28회 춘계학술대회논문집
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• pp.309-312
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• 2007

액체 로켓의 추진제로 이용되는 극저온 유체는 발사체의 경량화를 위한 터보 펌프의 고속화로 인해 공동현상이 발생하게 된다. 그러나 극저온 유체는 등온 유체인 물과는 달리 낮은 액상/증기 밀도 비율을 가지며 온도에 민감한 잠열변화율을 갖게 된다. 이에 따라 극저온 유체에서 공동 현상이 발생하게 되면, 증발 냉각 현상이 발생하게 되어 공동 내부와 주 유체 사이의 온도 차이가 발생하게 된다. 따라서 이러한 극저온 유체의 특징을 반영해 주기 위해 기존의 경험적 공동 현상 모델을 수정하여 새로운 모델을 적용하였다. 또한 온도 변화에 따른 효과를 반영해 주기 에너지 방정식을 첨가 하였다.

• Journal of Digestive Cancer Research
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• 제6권1호
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• pp.6-10
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• 2018

The importance of signal transducer and activator of transcription 3 (STAT3) signaling in gastric carcinogenesis was firmly evaluated in the previous studies. Fully activated STAT3 induces various target genes involving tumor invasion and epithelial-mesenchymal transition (EMT), and mediates interaction between cancer cells and microenvironmental immune cells. Thus, suppression of STAT3 activity is an important issue for inhibition of gastric carcinogenesis and invasion. Unfortunately, data from clinical studies of direct inhibitor targeting STAT3 have been disappointing. SH2-containing protein tyrosine phosphatase 1 (SHP-1) effectively dephosphorylates and inhibits STAT3 activity, which has not been extensively studied gastric cancer research field. However, by summarizing recent data, it is evident that protein and gene expression of SHP-1 are minimal in gastric cancer cells, and induction of SHP-1 effectively downregulates phosphorylated STAT3 and inhibits cellular invasion in gastric cancer cells. Several SHP-1 inducers have been investigated in the experimental studies, including proton pump inhibitor, arsenic trioxide, and other natural compounds. Taken together, we suggest that modulation of SHP-1/STAT3 signaling axis may present a new way for treatment of gastric cancer, and development of effective SHP-1 inducer may be an important task in the future search field of gastric cancer.

• Archives of Pharmacal Research
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• 제28권10호
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• pp.1196-1202
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• 2005

Omeprazole (OMP) is a proton pump inhibitor used as an oral treatment for acid-related gastrointestinal disorders. In the liver, it is primarily metabolized by cytochrome P-450 (CYP450) isoenzymes such as CYP2C19 and CYP3A4. 5-Hyroxyomeprazole (5-OHOMP) and omeprazole sulfone (OMP-SFN) are the two major metabolites of OMP in human. Cimetidine (CMT) inhibits the breakdown of drugs metabolized by CYP450 and reduces, the clearance of coad-ministered drug resulted from both the CMT binding to CYP450 and the decreased hepatic blood flow due to CMT. Phenobarbital (PB) induces drug metabolism in laboratory animals and human. PB induction mainly involves mammalian CYP forms in gene families 2B and 3A. PB has been widely used as a prototype inducer for biochemical investigations of drug metabolism and the enzymes catalyzing this metabolism, as well as for genetic, pharmacological, and toxicological investigations. In order to investigate the influence of CMT and PB on the metabolite kinetics of OMP, we intravenously administered OMP (30 mg/kg) to rats intraperitoneally pretreated with normal saline (5 mL/kg), CMT (100 mg/kg) or PB (75 mg/kg) once a day for four days, and compared the pharmacokinetic parameters of OMP. The systemic clearance ($CL_{t}$) of OMP was significantly (p<0.05) decreased in CMT-pretreated rats and significantly (p<0.05) increased in PB-pretreated rats. These results indicate that CMT inhibits the OMP metabolism due to both decreased hepatic blood flow and inhibited enzyme activity of CYP2C19 and 3A4 and that PB increases the OMP metabolism due to stimulation of the liver blood flow and/or bile flow, due not to induction of the enzyme activity of CYP3A4.